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Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders.

Sohal VS, Rubenstein JLR.

Mol Psychiatry. 2019 Sep;24(9):1248-1257. doi: 10.1038/s41380-019-0426-0. Epub 2019 May 14. Review.


VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks.

Lee AT, Cunniff MM, See JZ, Wilke SA, Luongo FJ, Ellwood IT, Ponnavolu S, Sohal VS.

Neuron. 2019 Jun 19;102(6):1223-1234.e4. doi: 10.1016/j.neuron.2019.04.001. Epub 2019 Apr 30.


Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion.

Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS.

Neuron. 2019 Jun 5;102(5):944-959.e3. doi: 10.1016/j.neuron.2019.03.042. Epub 2019 Apr 25.


Ultrasonic sculpting of virtual optical waveguides in tissue.

Chamanzar M, Scopelliti MG, Bloch J, Do N, Huh M, Seo D, Iafrati J, Sohal VS, Alam MR, Maharbiz MM.

Nat Commun. 2019 Jan 9;10(1):92. doi: 10.1038/s41467-018-07856-w.


Author Correction: The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.

Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.

Nat Commun. 2018 Dec 3;9(1):5205. doi: 10.1038/s41467-018-07637-5.


An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood.

Kirkby LA, Luongo FJ, Lee MB, Nahum M, Van Vleet TM, Rao VR, Dawes HE, Chang EF, Sohal VS.

Cell. 2018 Nov 29;175(6):1688-1700.e14. doi: 10.1016/j.cell.2018.10.005. Epub 2018 Nov 8.


Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.

Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, Nord AS, Willsey AJ, Chen B, State MW, Sohal VS, Rubenstein JLR.

Neuron. 2018 Nov 21;100(4):831-845.e7. doi: 10.1016/j.neuron.2018.09.027. Epub 2018 Oct 11.


Coordinated neuronal ensembles in primary auditory cortical columns.

See JZ, Atencio CA, Sohal VS, Schreiner CE.

Elife. 2018 Jun 5;7. pii: e35587. doi: 10.7554/eLife.35587.


The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms.

Incontro S, Díaz-Alonso J, Iafrati J, Vieira M, Asensio CS, Sohal VS, Roche KW, Bender KJ, Nicoll RA.

Nat Commun. 2018 May 25;9(1):2069. doi: 10.1038/s41467-018-04439-7. Erratum in: Nat Commun. 2018 Dec 3;9(1):5205.


Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex.

Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S.

J Neurotrauma. 2018 Oct 15;35(20):2425-2434. doi: 10.1089/neu.2018.5731. Epub 2018 Jul 2.


Roles of Prefrontal Cortex and Mediodorsal Thalamus in Task Engagement and Behavioral Flexibility.

Marton TF, Seifikar H, Luongo FJ, Lee AT, Sohal VS.

J Neurosci. 2018 Mar 7;38(10):2569-2578. doi: 10.1523/JNEUROSCI.1728-17.2018. Epub 2018 Feb 7.


A Shared Vision for Machine Learning in Neuroscience.

Vu MT, Adalı T, Ba D, Buzsáki G, Carlson D, Heller K, Liston C, Rudin C, Sohal VS, Widge AS, Mayberg HS, Sapiro G, Dzirasa K.

J Neurosci. 2018 Feb 14;38(7):1601-1607. doi: 10.1523/JNEUROSCI.0508-17.2018. Epub 2018 Jan 26. Review.


A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Ullman JC, Yang J, Sullivan M, Bendor J, Levy J, Pham E, Silm K, Seifikar H, Sohal VS, Nicoll RA, Edwards RH.

Nat Commun. 2018 Jan 23;9(1):330. doi: 10.1038/s41467-017-02716-5.


Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.

Athilingam JC, Ben-Shalom R, Keeshen CM, Sohal VS, Bender KJ.

Elife. 2017 Dec 5;6. pii: e31991. doi: 10.7554/eLife.31991.


Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior.

Brumback AC, Ellwood IT, Kjaerby C, Iafrati J, Robinson S, Lee AT, Patel T, Nagaraj S, Davatolhagh F, Sohal VS.

Mol Psychiatry. 2018 Oct;23(10):2078-2089. doi: 10.1038/mp.2017.213. Epub 2017 Nov 7.


Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.

Vogt D, Cho KKA, Shelton SM, Paul A, Huang ZJ, Sohal VS, Rubenstein JLR.

Cereb Cortex. 2018 Nov 1;28(11):3868-3879. doi: 10.1093/cercor/bhx248.


The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/- mice.

von Schoubye NL, Frederiksen K, Kristiansen U, Petersen AV, Dalby NO, Grunnet M, Jensen HS, Jespersen T, Sohal VS, Perrier JF.

Neurosci Lett. 2018 Jan 1;662:29-35. doi: 10.1016/j.neulet.2017.10.004. Epub 2017 Oct 5.


Dopamine D2 Receptors Modulate Pyramidal Neurons in Mouse Medial Prefrontal Cortex through a Stimulatory G-Protein Pathway.

Robinson SE, Sohal VS.

J Neurosci. 2017 Oct 18;37(42):10063-10073. doi: 10.1523/JNEUROSCI.1893-17.2017. Epub 2017 Sep 14.


Tonic or Phasic Stimulation of Dopaminergic Projections to Prefrontal Cortex Causes Mice to Maintain or Deviate from Previously Learned Behavioral Strategies.

Ellwood IT, Patel T, Wadia V, Lee AT, Liptak AT, Bender KJ, Sohal VS.

J Neurosci. 2017 Aug 30;37(35):8315-8329. doi: 10.1523/JNEUROSCI.1221-17.2017. Epub 2017 Jul 24.


D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.

Clarkson RL, Liptak AT, Gee SM, Sohal VS, Bender KJ.

J Neurosci. 2017 Jun 14;37(24):5846-5860. doi: 10.1523/JNEUROSCI.0310-17.2017. Epub 2017 May 18.


Immediate Mood Scaler: Tracking Symptoms of Depression and Anxiety Using a Novel Mobile Mood Scale.

Nahum M, Van Vleet TM, Sohal VS, Mirzabekov JJ, Rao VR, Wallace DL, Lee MB, Dawes H, Stark-Inbar A, Jordan JT, Biagianti B, Merzenich M, Chang EF.

JMIR Mhealth Uhealth. 2017 Apr 12;5(4):e44. doi: 10.2196/mhealth.6544.


Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures.

Khoshkhoo S, Vogt D, Sohal VS.

Neuron. 2017 Jan 18;93(2):291-298. doi: 10.1016/j.neuron.2016.11.043. Epub 2016 Dec 29.


Serotonin 1B Receptors Regulate Prefrontal Function by Gating Callosal and Hippocampal Inputs.

Kjaerby C, Athilingam J, Robinson SE, Iafrati J, Sohal VS.

Cell Rep. 2016 Dec 13;17(11):2882-2890. doi: 10.1016/j.celrep.2016.11.036.


DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling.

Martin PM, Stanley RE, Ross AP, Freitas AE, Moyer CE, Brumback AC, Iafrati J, Stapornwongkul KS, Dominguez S, Kivimäe S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders SJ, Zuo Y, Sohal VS, Cheyette BNR.

Mol Psychiatry. 2018 Feb;23(2):467-475. doi: 10.1038/mp.2016.184. Epub 2016 Oct 18.


Energy-Looping Nanoparticles: Harnessing Excited-State Absorption for Deep-Tissue Imaging.

Levy ES, Tajon CA, Bischof TS, Iafrati J, Fernandez-Bravo A, Garfield DJ, Chamanzar M, Maharbiz MM, Sohal VS, Schuck PJ, Cohen BE, Chan EM.

ACS Nano. 2016 Sep 27;10(9):8423-33. doi: 10.1021/acsnano.6b03288. Epub 2016 Sep 7.


Making the Right Connections.

Lee AT, Sohal VS.

Biol Psychiatry. 2016 Oct 1;80(7):502-3. doi: 10.1016/j.biopsych.2016.08.002. No abstract available.


The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex.

Wu PR, Cho KKA, Vogt D, Sohal VS, Rubenstein JLR.

Cereb Cortex. 2017 Sep 1;27(9):4303-4313. doi: 10.1093/cercor/bhw230.


Stressing out the Social Network.

Kirkby LA, Sohal VS.

Neuron. 2016 Jul 20;91(2):210-3. doi: 10.1016/j.neuron.2016.07.009. Review.


Correlations between prefrontal neurons form a small-world network that optimizes the generation of multineuron sequences of activity.

Luongo FJ, Zimmerman CA, Horn ME, Sohal VS.

J Neurophysiol. 2016 May 1;115(5):2359-75. doi: 10.1152/jn.01043.2015. Epub 2016 Feb 17.


Neural Oscillations and Synchrony in Brain Dysfunction and Neuropsychiatric Disorders: It's About Time.

Mathalon DH, Sohal VS.

JAMA Psychiatry. 2015 Aug;72(8):840-4. doi: 10.1001/jamapsychiatry.2015.0483. Review.


Putative Microcircuit-Level Substrates for Attention Are Disrupted in Mouse Models of Autism.

Luongo FJ, Horn ME, Sohal VS.

Biol Psychiatry. 2016 Apr 15;79(8):667-75. doi: 10.1016/j.biopsych.2015.04.014. Epub 2015 Apr 28.


Of Mice, Men, and Microbial Opsins: How Optogenetics Can Help Hone Mouse Models of Mental Illness.

Marton TF, Sohal VS.

Biol Psychiatry. 2016 Jan 1;79(1):47-52. doi: 10.1016/j.biopsych.2015.04.012. Epub 2015 Apr 23. Review.


The parvalbumin/somatostatin ratio is increased in Pten mutant mice and by human PTEN ASD alleles.

Vogt D, Cho KKA, Lee AT, Sohal VS, Rubenstein JLR.

Cell Rep. 2015 May 12;11(6):944-956. doi: 10.1016/j.celrep.2015.04.019. Epub 2015 Apr 30.


Gamma rhythms link prefrontal interneuron dysfunction with cognitive inflexibility in Dlx5/6(+/-) mice.

Cho KK, Hoch R, Lee AT, Patel T, Rubenstein JL, Sohal VS.

Neuron. 2015 Mar 18;85(6):1332-43. doi: 10.1016/j.neuron.2015.02.019. Epub 2015 Mar 5.


Identifying pathways leading to prefrontal GABA-ergic interneuron dysfunction in schizophrenia.

Sohal VS.

Am J Psychiatry. 2014 Sep;171(9):906-9. doi: 10.1176/appi.ajp.2014.14060750. No abstract available.


A class of GABAergic neurons in the prefrontal cortex sends long-range projections to the nucleus accumbens and elicits acute avoidance behavior.

Lee AT, Vogt D, Rubenstein JL, Sohal VS.

J Neurosci. 2014 Aug 27;34(35):11519-25. doi: 10.1523/JNEUROSCI.1157-14.2014.


Optogenetic approaches for investigating neural pathways implicated in schizophrenia and related disorders.

Cho KK, Sohal VS.

Hum Mol Genet. 2014 Sep 15;23(R1):R64-8. doi: 10.1093/hmg/ddu225. Epub 2014 May 13. Review.


Pyramidal neurons in prefrontal cortex receive subtype-specific forms of excitation and inhibition.

Lee AT, Gee SM, Vogt D, Patel T, Rubenstein JL, Sohal VS.

Neuron. 2014 Jan 8;81(1):61-8. doi: 10.1016/j.neuron.2013.10.031. Epub 2013 Dec 19.


Chronic reduction in inhibition reduces receptive field size in mouse auditory cortex.

Seybold BA, Stanco A, Cho KK, Potter GB, Kim C, Sohal VS, Rubenstein JL, Schreiner CE.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13829-34. doi: 10.1073/pnas.1205909109. Epub 2012 Jul 2.


Synaptic activity unmasks dopamine D2 receptor modulation of a specific class of layer V pyramidal neurons in prefrontal cortex.

Gee S, Ellwood I, Patel T, Luongo F, Deisseroth K, Sohal VS.

J Neurosci. 2012 Apr 4;32(14):4959-71. doi: 10.1523/JNEUROSCI.5835-11.2012.


Insights into cortical oscillations arising from optogenetic studies.

Sohal VS.

Biol Psychiatry. 2012 Jun 15;71(12):1039-45. doi: 10.1016/j.biopsych.2012.01.024. Epub 2012 Mar 3. Review.


Responsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy.

Sohal VS, Sun FT.

Neurosurg Clin N Am. 2011 Oct;22(4):481-8, vi. doi: 10.1016/


Neocortical excitation/inhibition balance in information processing and social dysfunction.

Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K.

Nature. 2011 Jul 27;477(7363):171-8. doi: 10.1038/nature10360.


Ultrafast optogenetic control.

Gunaydin LA, Yizhar O, Berndt A, Sohal VS, Deisseroth K, Hegemann P.

Nat Neurosci. 2010 Mar;13(3):387-92. doi: 10.1038/nn.2495. Epub 2010 Jan 17.


Parvalbumin neurons and gamma rhythms enhance cortical circuit performance.

Sohal VS, Zhang F, Yizhar O, Deisseroth K.

Nature. 2009 Jun 4;459(7247):698-702. doi: 10.1038/nature07991. Epub 2009 Apr 26.


Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons.

Sohal VS, Pangratz-Fuehrer S, Rudolph U, Huguenard JR.

J Neurosci. 2006 Apr 19;26(16):4247-55.


Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types.

Sohal VS, Huguenard JR.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18638-43. Epub 2005 Dec 8.


Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations.

Sohal VS, Keist R, Rudolph U, Huguenard JR.

J Neurosci. 2003 May 1;23(9):3649-57.

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