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Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD.

Eapen MS, Sharma P, Sohal SS.

Eur Respir J. 2019 Oct 10;54(4). pii: 1901641. doi: 10.1183/13993003.01641-2019. Print 2019 Oct. No abstract available.


There can be smoke without fire: warranted caution in promoting electronic cigarettes and heat not burn devices as a safer alternative to cigarette smoking.

McAlinden KD, Sohal SS, Sharma P.

ERJ Open Res. 2019 Aug 12;5(3). pii: 00114-2019. doi: 10.1183/23120541.00114-2019. eCollection 2019 Jul.


Epithelial-mesenchymal transition is driven by transcriptional and post transcriptional modulations in COPD: implications for disease progression and new therapeutics.

Eapen MS, Sharma P, Gaikwad AV, Lu W, Myers S, Hansbro PM, Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2019 Jul 18;14:1603-1610. doi: 10.2147/COPD.S208428. eCollection 2019.


New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways.

Atto B, Eapen MS, Sharma P, Frey U, Ammit AJ, Markos J, Chia C, Larby J, Haug G, Weber HC, Mabeza G, Tristram S, Myers S, Geraghty DP, Flanagan KL, Hansbro PM, Sohal SS.

Clin Sci (Lond). 2019 Jul 25;133(14):1663-1703. doi: 10.1042/CS20181009. Print 2019 Jul 31. Review.


Cytokines expression levels from tissue, plasma or serum as promising clinical biomarkers in adenocarcinoma of the prostate: a systematic review of recent findings.

Singh J, Sohal SS, Lim A, Duncan H, Thachil T, De Ieso P.

Ann Transl Med. 2019 Jun;7(11):245. doi: 10.21037/atm.2019.05.31. Review.


Inhaled corticosteroids attenuate epithelial mesenchymal transition: implications for COPD and lung cancer prophylaxis.

Lu W, Sharma P, Eapen MS, Sohal SS.

Eur Respir J. 2019 Jul 11;54(1). pii: 1900778. doi: 10.1183/13993003.00778-2019. Print 2019 Jul. No abstract available.


The Zinc Transporter Zip7 Is Downregulated in Skeletal Muscle of Insulin-Resistant Cells and in Mice Fed a High-Fat Diet.

Norouzi S, Adulcikas J, Henstridge DC, Sonda S, Sohal SS, Myers S.

Cells. 2019 Jul 1;8(7). pii: E663. doi: 10.3390/cells8070663.


The effectiveness of immunosuppressive cyclosporin in attenuating the progression of interstitial lung diseases.

Eapen MS, Gaikwad AV, Thompson IE, Lu W, Myers S, Sharma P, Sohal SS.

J Thorac Dis. 2019 May;11(Suppl 9):S1139-S1142. doi: 10.21037/jtd.2019.04.44. No abstract available.


Quantitative assessment of breast cancer liver metastasis expansion with patient-derived xenografts.

Alzubi MA, Sohal SS, Sriram M, Turner TH, Zot P, Idowu M, Harrell JC.

Clin Exp Metastasis. 2019 Jun;36(3):257-269. doi: 10.1007/s10585-019-09968-z. Epub 2019 May 8.


Separation of breast cancer and organ microenvironment transcriptomes in metastases.

Alzubi MA, Turner TH, Olex AL, Sohal SS, Tobin NP, Recio SG, Bergh J, Hatschek T, Parker JS, Sartorius CA, Perou CM, Dozmorov MG, Harrell JC.

Breast Cancer Res. 2019 Mar 6;21(1):36. doi: 10.1186/s13058-019-1123-2.


Targeting the Zinc Transporter ZIP7 in the Treatment of Insulin Resistance and Type 2 Diabetes.

Adulcikas J, Sonda S, Norouzi S, Sohal SS, Myers S.

Nutrients. 2019 Feb 15;11(2). pii: E408. doi: 10.3390/nu11020408. Review.


IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette.

Sohal SS, Eapen MS, Naidu VGM, Sharma P.

ERJ Open Res. 2019 Feb 11;5(1). pii: 00159-2018. doi: 10.1183/23120541.00159-2018. eCollection 2019 Feb.


Live Cell Mass Accumulation Measurement Non-Invasively Predicts Carboplatin Sensitivity in Triple-Negative Breast Cancer Patient-Derived Xenografts.

Murray GF, Turner TH, Leslie KA, Alzubi MA, Guest D, Sohal SS, Teitell MA, Harrell JC, Reed J.

ACS Omega. 2018 Dec 31;3(12):17687-17692. doi: 10.1021/acsomega.8b02224. Epub 2018 Dec 19.


Impact of Maternal Air Pollution Exposure on Children's Lung Health: An Indian Perspective.

Saha P, Johny E, Dangi A, Shinde S, Brake S, Eapen MS, Sohal SS, Naidu V, Sharma P.

Toxics. 2018 Nov 16;6(4). pii: E68. doi: 10.3390/toxics6040068. Review.


Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies.

Eapen MS, Sharma P, Thompson IE, Lu W, Myers S, Hansbro PM, Sohal SS.

Lab Invest. 2019 Feb;99(2):150-157. doi: 10.1038/s41374-018-0146-0. Epub 2018 Nov 19. Review.


Chronic Obstructive Pulmonary Disease and Lung Cancer: Underlying Pathophysiology and New Therapeutic Modalities.

Eapen MS, Hansbro PM, Larsson-Callerfelt AK, Jolly MK, Myers S, Sharma P, Jones B, Rahman MA, Markos J, Chia C, Larby J, Haug G, Hardikar A, Weber HC, Mabeza G, Cavalheri V, Khor YH, McDonald CF, Sohal SS.

Drugs. 2018 Nov;78(16):1717-1740. doi: 10.1007/s40265-018-1001-8. Review.


Autophagy Activation in Asthma Airways Remodeling.

McAlinden KD, Deshpande DA, Ghavami S, Xenaki D, Sohal SS, Oliver BG, Haghi M, Sharma P.

Am J Respir Cell Mol Biol. 2019 May;60(5):541-553. doi: 10.1165/rcmb.2018-0169OC.


Dysfunctional Immunity and Microbial Adhesion Molecules in Smoking-induced Pneumonia.

Eapen MS, Sharma P, Moodley YP, Hansbro PM, Sohal SS.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):250-251. doi: 10.1164/rccm.201808-1553LE. No abstract available.


The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved histidine-rich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum.

Adulcikas J, Norouzi S, Bretag L, Sohal SS, Myers S.

Comput Biol Med. 2018 Sep 1;100:196-202. doi: 10.1016/j.compbiomed.2018.07.007. Epub 2018 Jul 18.


Apoptosis signal-regulating kinase 1 inhibition attenuates human airway smooth muscle growth and migration in chronic obstructive pulmonary disease.

Eapen MS, Kota A, Vindin H, McAlinden KD, Xenaki D, Oliver BG, Deshpande DA, Sohal SS, Sharma P.

Clin Sci (Lond). 2018 Jul 31;132(14):1615-1627. doi: 10.1042/CS20180398. Print 2018 Jul 31.


MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice.

Perera AP, Fernando R, Shinde T, Gundamaraju R, Southam B, Sohal SS, Robertson AAB, Schroder K, Kunde D, Eri R.

Sci Rep. 2018 Jun 5;8(1):8618. doi: 10.1038/s41598-018-26775-w.


sE-cadherin and sVE-cadherin indicate active epithelial/endothelial to mesenchymal transition (EMT and EndoMT) in smokers and COPD: implications for new biomarkers and therapeutics.

Eapen MS, Myers S, Lu W, Tanghe C, Sharma P, Sohal SS.

Biomarkers. 2018 Nov;23(7):709-711. doi: 10.1080/1354750X.2018.1479772. Epub 2018 Jun 19. No abstract available.


The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.

Stammnitz MR, Coorens THH, Gori KC, Hayes D, Fu B, Wang J, Martin-Herranz DE, Alexandrov LB, Baez-Ortega A, Barthorpe S, Beck A, Giordano F, Knowles GW, Kwon YM, Hall G, Price S, Pye RJ, Tubio JMC, Siddle HVT, Sohal SS, Woods GM, McDermott U, Yang F, Garnett MJ, Ning Z, Murchison EP.

Cancer Cell. 2018 Apr 9;33(4):607-619.e15. doi: 10.1016/j.ccell.2018.03.013.


Characterizing the efficacy of cancer therapeutics in patient-derived xenograft models of metastatic breast cancer.

Turner TH, Alzubi MA, Sohal SS, Olex AL, Dozmorov MG, Harrell JC.

Breast Cancer Res Treat. 2018 Jul;170(2):221-234. doi: 10.1007/s10549-018-4748-4. Epub 2018 Mar 12.


Understanding novel mechanisms of microbial pathogenesis in chronic lung disease: implications for new therapeutic targets.

Eapen MS, Sohal SS.

Clin Sci (Lond). 2018 Feb 8;132(3):375-379. doi: 10.1042/CS20171261. Print 2018 Feb 14. Review.


Inhaled corticosteroids and increased microbial load in COPD: potential role of epithelial adhesion molecules.

Sohal SS.

Eur Respir J. 2018 Jan 31;51(2). pii: 1702257. doi: 10.1183/13993003.02257-2017. Print 2018 Feb. No abstract available.


Airway Basal Cell Reprogramming and Epithelial-Mesenchymal Transition: A Potential Key to Understanding Early Chronic Obstructive Pulmonary Disease.

Sohal SS.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1644-1645. doi: 10.1164/rccm.201712-2450LE. No abstract available.


Zinc stimulates glucose oxidation and glycemic control by modulating the insulin signaling pathway in human and mouse skeletal muscle cell lines.

Norouzi S, Adulcikas J, Sohal SS, Myers S.

PLoS One. 2018 Jan 26;13(1):e0191727. doi: 10.1371/journal.pone.0191727. eCollection 2018.


Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent?

Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2017 Dec 4;12:3425-3427. doi: 10.2147/COPD.S154897. eCollection 2017. No abstract available.


Zinc transporters and insulin resistance: therapeutic implications for type 2 diabetes and metabolic disease.

Norouzi S, Adulcikas J, Sohal SS, Myers S.

J Biomed Sci. 2017 Nov 20;24(1):87. doi: 10.1186/s12929-017-0394-0. Review.


Advanced Non–Small-Cell Lung Cancer.

Sohal SS, Walters EH.

N Engl J Med. 2017 Nov 16;377(20):1998-9. doi: 10.1056/NEJMc1712794. No abstract available.


Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD).

Eapen MS, Hansbro PM, McAlinden K, Kim RY, Ward C, Hackett TL, Walters EH, Sohal SS.

Sci Rep. 2017 Oct 17;7(1):13392. doi: 10.1038/s41598-017-13888-x.


Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease.

Sohal SS, Hansbro PM, Shukla SD, Eapen MS, Walters EH.

Chest. 2017 Oct;152(4):899-900. doi: 10.1016/j.chest.2017.05.024. No abstract available.


Essential need for rethink of COPD airway pathology: implications for new drug approaches for prevention of lung cancer as well as small airway fibrosis.

Sohal SS, Walters EH.

Int J Chron Obstruct Pulmon Dis. 2017 Sep 7;12:2677-2679. doi: 10.2147/COPD.S149092. eCollection 2017. No abstract available.


β-catenin, Twist and Snail: Transcriptional regulation of EMT in smokers and COPD, and relation to airflow obstruction.

Mahmood MQ, Walters EH, Shukla SD, Weston S, Muller HK, Ward C, Sohal SS.

Sci Rep. 2017 Sep 7;7(1):10832. doi: 10.1038/s41598-017-11375-x.


Airway inflammation in chronic obstructive pulmonary disease (COPD): a true paradox.

Eapen MS, Myers S, Walters EH, Sohal SS.

Expert Rev Respir Med. 2017 Oct;11(10):827-839. doi: 10.1080/17476348.2017.1360769. Epub 2017 Aug 2. Review.


Epithelial-mesenchymal transition, a spectrum of states: Role in lung development, homeostasis, and disease.

Jolly MK, Ward C, Eapen MS, Myers S, Hallgren O, Levine H, Sohal SS.

Dev Dyn. 2018 Mar;247(3):346-358. doi: 10.1002/dvdy.24541. Epub 2017 Jul 21. Review.


Epithelial-Mesenchymal Transition: A Necessary New Therapeutic Target in Chronic Obstructive Pulmonary Disease?

Sohal SS, Eapen MS, Ward C, Walters EH.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):393-394. doi: 10.1164/rccm.201704-0771LE. No abstract available.


Airway inflammation and inhaled corticosteroids in COPD.

Sohal SS, Eapen MS, Ward C, Walters EH.

Eur Respir J. 2017 Jun 15;49(6). pii: 1700289. doi: 10.1183/13993003.00289-2017. Print 2017 Jun. No abstract available.


Epithelial Mesenchymal Transition in Chronic Obstructive Pulmonary Disease, a Precursor for Epithelial Cancers: Understanding and Translation to Early Therapy.

Sohal SS, Hansbro PM, Walters EH.

Ann Am Thorac Soc. 2017 Sep;14(9):1491-1492. doi: 10.1513/AnnalsATS.201705-387LE. No abstract available.


ERBB3: A potential serum biomarker for early detection and therapeutic target for devil facial tumour 1 (DFT1).

Hayes DA, Kunde DA, Taylor RL, Pyecroft SB, Sohal SS, Snow ET.

PLoS One. 2017 Jun 7;12(6):e0177919. doi: 10.1371/journal.pone.0177919. eCollection 2017.


Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD.

Eapen MS, McAlinden K, Tan D, Weston S, Ward C, Muller HK, Walters EH, Sohal SS.

Respirology. 2017 Aug;22(6):1125-1132. doi: 10.1111/resp.13021. Epub 2017 Mar 22.


Epithelial and endothelial cell plasticity in chronic obstructive pulmonary disease (COPD).

Sohal SS.

Respir Investig. 2017 Mar;55(2):104-113. doi: 10.1016/j.resinv.2016.11.006. Epub 2017 Feb 21. Review.


Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease.

Mahmood MQ, Ward C, Muller HK, Sohal SS, Walters EH.

Med Oncol. 2017 Mar;34(3):45. doi: 10.1007/s12032-017-0900-y. Epub 2017 Feb 14.


Zinc and Gastrointestinal Disorders: A Role for the Zinc Transporters Zips and ZnTs.

Myers S, Shastri MD, Adulcikas J, Sohal SS, Norouzi S.

Curr Pharm Des. 2017;23(16):2328-2332. doi: 10.2174/1381612823666170124115850. Review.


The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL).

Shukla SD, Mahmood MQ, Weston S, Latham R, Muller HK, Sohal SS, Walters EH.

Respir Res. 2017 Jan 5;18(1):6. doi: 10.1186/s12931-016-0483-8.


Characterisation of colonic dysplasia-like epithelial atypia in murine colitis.

Randall-Demllo S, Fernando R, Brain T, Sohal SS, Cook AL, Guven N, Kunde D, Spring K, Eri R.

World J Gastroenterol. 2016 Oct 7;22(37):8334-8348.


Inhaled corticosteroid normalizes some but not all airway vascular remodeling in COPD.

Soltani A, Walters EH, Reid DW, Shukla SD, Nowrin K, Ward C, Muller HK, Sohal SS.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 22;11:2359-2367. eCollection 2016.


Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis.

Mahmood MQ, Reid D, Ward C, Muller HK, Knight DA, Sohal SS, Walters EH.

Respirology. 2017 Jan;22(1):133-140. doi: 10.1111/resp.12882. Epub 2016 Sep 11.


Ventilatory efficiency slope as a predictor of suitability for surgery in chronic obstructive pulmonary disease patients with lung cancer.

Eapen MS, Grover R, Ahuja K, Williams A, Sohal SS.

Ann Transl Med. 2016 Aug;4(15):296. doi: 10.21037/atm.2016.07.20. No abstract available.

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