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Items: 1 to 50 of 67

1.

Ossiculoplasty: A Prospective Study on 50 Patients Using Various Graft Materials.

Lamba GK, Sohal BS, Goyal JP.

Indian J Otolaryngol Head Neck Surg. 2019 Nov;71(Suppl 2):1140-1146. doi: 10.1007/s12070-018-01571-0. Epub 2019 Jan 3.

PMID:
31750139
2.

Correction to "Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma".

Sandham DA, Barker L, Brown L, Brown Z, Budd D, Charlton SJ, Chatterjee D, Cox B, Dubois G, Duggan N, Hall E, Hatto J, Leblanc C, Maas J, Manini J, Profit R, Riddy D, Ritchie C, Sohal B, Shaw D, Stringer R, Sykes DA, Thomas M, Turner KL, Watson SJ, West R, Willard E, Williams G, Willis J.

ACS Med Chem Lett. 2017 Sep 1;8(9):987. doi: 10.1021/acsmedchemlett.7b00353. eCollection 2017 Sep 14.

3.

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma.

Sandham DA, Barker L, Brown L, Brown Z, Budd D, Charlton SJ, Chatterjee D, Cox B, Dubois G, Duggan N, Hall E, Hatto J, Maas J, Manini J, Profit R, Riddy D, Ritchie C, Sohal B, Shaw D, Stringer R, Sykes DA, Thomas M, Turner KL, Watson SJ, West R, Willard E, Williams G, Willis J.

ACS Med Chem Lett. 2017 Apr 25;8(5):582-586. doi: 10.1021/acsmedchemlett.7b00157. eCollection 2017 May 11. Erratum in: ACS Med Chem Lett. 2017 Sep 01;8(9):987.

4.

Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet?

Argikar UA, Dumouchel JL, Kramlinger VM, Cirello AL, Gunduz M, Dunne CE, Sohal B.

J Pharm Sci. 2017 Sep;106(9):2276-2281. doi: 10.1016/j.xphs.2017.03.008. Epub 2017 Mar 18. Review.

PMID:
28322939
5.

1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats.

Stringer RA, Weber E, Tigani B, Lavan P, Medhurst S, Sohal B.

Drug Metab Dispos. 2014 Jul;42(7):1117-24. doi: 10.1124/dmd.113.056408. Epub 2014 Apr 11.

PMID:
24727486
6.

Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist.

Stringer RA, Weber E, Culshaw A, McKenna J, Williams G, Rose J, Sohal B.

Xenobiotica. 2014 Oct;44(10):902-12. doi: 10.3109/00498254.2014.907458. Epub 2014 Apr 3.

PMID:
24697490
7.

Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.

Stringer RA, Williams G, Picard F, Sohal B, Kretz O, McKenna J, Krauser JA.

Drug Metab Dispos. 2014 May;42(5):954-62. doi: 10.1124/dmd.114.057265. Epub 2014 Mar 10.

PMID:
24616265
8.

Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan.

Klichko V, Sohal BH, Radyuk SN, Orr WC, Sohal RS.

Biochem J. 2014 Apr 1;459(1):127-35. doi: 10.1042/BJ20131370.

PMID:
24444354
9.

Clinico-pathological study of 50 cases of tumours of larynx.

Sharma DK, Sohal BS, Bal MS, Aggarwal S.

Indian J Otolaryngol Head Neck Surg. 2013 Jul;65(Suppl 1):29-35. doi: 10.1007/s12070-011-0420-6. Epub 2011 Dec 13.

10.

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.

Sandham DA, Arnold N, Aschauer H, Bala K, Barker L, Brown L, Brown Z, Budd D, Cox B, Docx C, Dubois G, Duggan N, England K, Everatt B, Furegati M, Hall E, Kalthoff F, King A, Leblanc CJ, Manini J, Meingassner J, Profit R, Schmidt A, Simmons J, Sohal B, Stringer R, Thomas M, Turner KL, Walker C, Watson SJ, Westwick J, Willis J, Williams G, Wilson C.

Bioorg Med Chem. 2013 Nov 1;21(21):6582-91. doi: 10.1016/j.bmc.2013.08.025. Epub 2013 Aug 22.

PMID:
24021582
11.

An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model.

Jarman ER, Khambata VS, Cope C, Jones P, Roger J, Ye LY, Duggan N, Head D, Pearce A, Press NJ, Bellenie B, Sohal B, Jarai G.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):158-69. doi: 10.1165/rcmb.2013-0174OC.

PMID:
23977848
12.

Schwannomas of head and neck and review of literature.

Sharma DK, Sohal BS, Parmar TL, Arora H.

Indian J Otolaryngol Head Neck Surg. 2012 Jun;64(2):177-80. doi: 10.1007/s12070-011-0248-0. Epub 2011 Apr 11.

13.

Role of Elicitors in Inducing Resistance in Plants against Pathogen Infection: A Review.

Thakur M, Sohal BS.

ISRN Biochem. 2013 Jan 28;2013:762412. doi: 10.1155/2013/762412. eCollection 2013. Review.

14.

Isolated Sphenoid Pyocele with Thornwaldt's Cyst of Nasopharynx.

Singh D, Sohal BS, Aggarwal S.

Indian J Otolaryngol Head Neck Surg. 2011 Jul;63(Suppl 1):140-1. doi: 10.1007/s12070-011-0256-0. Epub 2011 May 3.

15.

Expression of multiple copies of mitochondrially targeted catalase or genomic Mn superoxide dismutase transgenes does not extend the life span of Drosophila melanogaster.

Mockett RJ, Sohal BH, Sohal RS.

Free Radic Biol Med. 2010 Dec 15;49(12):2028-31. doi: 10.1016/j.freeradbiomed.2010.09.029. Epub 2010 Oct 19.

16.

Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.

Radyuk SN, Rebrin I, Klichko VI, Sohal BH, Michalak K, Benes J, Sohal RS, Orr WC.

Free Radic Biol Med. 2010 Dec 15;49(12):1892-902. doi: 10.1016/j.freeradbiomed.2010.09.014. Epub 2010 Oct 19.

17.

Prospective study of myringoplasty using different approaches.

Sharma DK, Singh S, Sohal BS, Singh B.

Indian J Otolaryngol Head Neck Surg. 2009 Dec;61(4):297-300. doi: 10.1007/s12070-009-0086-5. Epub 2010 Jan 9.

18.

Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.

Atack JR, Wong DF, Fryer TD, Ryan C, Sanabria S, Zhou Y, Dannals RF, Eng WS, Gibson RE, Burns HD, Vega JM, Vessy L, Scott-Stevens P, Beech JS, Baron JC, Sohal B, Schrag ML, Aigbirhio FI, McKernan RM, Hargreaves RJ.

J Pharmacol Exp Ther. 2010 Jan;332(1):17-25. doi: 10.1124/jpet.109.157909. Epub 2009 Sep 24.

PMID:
19779131
19.

The plasma-occupancy relationship of the novel GABAA receptor benzodiazepine site ligand, alpha5IA, is similar in rats and primates.

Atack JR, Eng WS, Gibson RE, Ryan C, Francis B, Sohal B, Dawson GR, Hargreaves RJ, Burns HD.

Br J Pharmacol. 2009 Jul;157(5):796-803. doi: 10.1111/j.1476-5381.2009.00216.x. Epub 2009 Apr 30.

20.

Life span extension in mice by food restriction depends on an energy imbalance.

Sohal RS, Ferguson M, Sohal BH, Forster MJ.

J Nutr. 2009 Mar;139(3):533-9. doi: 10.3945/jn.108.100313. Epub 2009 Jan 13.

21.

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Kilford PJ, Stringer R, Sohal B, Houston JB, Galetin A.

Drug Metab Dispos. 2009 Jan;37(1):82-9. doi: 10.1124/dmd.108.023853. Epub 2008 Oct 2.

PMID:
18832476
22.

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding.

Waters NJ, Jones R, Williams G, Sohal B.

J Pharm Sci. 2008 Oct;97(10):4586-95. doi: 10.1002/jps.21317.

PMID:
18300299
23.

Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats.

McDonald LM, Sheppard WF, Staveley SM, Sohal B, Tattersall FD, Hutson PH.

Psychopharmacology (Berl). 2008 May;197(4):591-600. doi: 10.1007/s00213-008-1077-z. Epub 2008 Feb 9.

PMID:
18264695
24.

Sulfonamide derivatives of bridgehead substituted bicyclo[4.2.1]nonanes as gamma-secretase inhibitors.

Sparey T, Clarke E, Hannam J, Harrison T, Madin A, Shearman M, Sohal B.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):375-9. Epub 2007 Oct 22.

PMID:
18061448
25.

Effect of long-term caloric restriction on oxygen consumption and body temperature in two different strains of mice.

Ferguson M, Sohal BH, Forster MJ, Sohal RS.

Mech Ageing Dev. 2007 Oct;128(10):539-45. Epub 2007 Aug 2.

26.

Contribution of specific binding to the central benzodiazepine site to the brain concentrations of two novel benzodiazepine site ligands.

Pike A, Cook SM, Watt AP, Scott-Stevens P, Rosahl TW, McKernan RM, Pym LJ, Guiblin A, Moyes C, Sohal B, Atack JR.

Biopharm Drug Dispos. 2007 Sep;28(6):275-82.

PMID:
17570124
27.

Gaboxadol, a selective extrasynaptic GABA(A) agonist, does not generalise to other sleep-enhancing drugs: a rat drug discrimination study.

McDonald LM, Sheppard WF, Staveley SM, Sohal B, Tattersall FD, Hutson PH.

Neuropharmacology. 2007 Mar;52(3):844-53. Epub 2006 Dec 29.

PMID:
17196996
28.

Utility of long-term cultured human hepatocytes as an in vitro model for cytochrome p450 induction.

Meneses-Lorente G, Pattison C, Guyomard C, Chesné C, Heavens R, Watt AP, Sohal B.

Drug Metab Dispos. 2007 Feb;35(2):215-20. Epub 2006 Nov 8.

PMID:
17093007
29.

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

Elliott JM, Carling RW, Chambers M, Chicchi GG, Hutson PH, Jones AB, MacLeod A, Marwood R, Meneses-Lorente G, Mezzogori E, Murray F, Rigby M, Royo I, Russell MG, Sohal B, Tsao KL, Williams B.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5748-51. Epub 2006 Sep 6.

PMID:
16950620
30.

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.

Elliott JM, Carling RW, Chicchi GG, Crawforth J, Hutson PH, Jones AB, Kelly S, Marwood R, Meneses-Lorente G, Mezzogori E, Murray F, Rigby M, Royo I, Russell MG, Shaw D, Sohal B, Tsao KL, Williams B.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5752-6. Epub 2006 Sep 6.

PMID:
16950617
31.

A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

Lewis RT, Blackaby WP, Blackburn T, Jennings AS, Pike A, Wilson RA, Hallett DJ, Cook SM, Ferris P, Marshall GR, Reynolds DS, Sheppard WF, Smith AJ, Sohal B, Stanley J, Tye SJ, Wafford KA, Atack JR.

J Med Chem. 2006 Apr 20;49(8):2600-10.

PMID:
16610803
32.

Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.

Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, Ferris P, Stanley J, Lincoln R, Tye SJ, Sheppard WF, Sohal B, Pike A, Dominguez M, Atack JR, Castro JL.

J Med Chem. 2006 Feb 23;49(4):1235-8.

PMID:
16480260
33.

Rat pharmacokinetics and pharmacodynamics of a sustained release formulation of the GABAA alpha5-selective compound L-655,708.

Atack JR, Pike A, Clarke A, Cook SM, Sohal B, McKernan RM, Dawson GR.

Drug Metab Dispos. 2006 May;34(5):887-93. Epub 2006 Feb 2.

PMID:
16455808
34.

Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.

Goodacre SC, Street LJ, Hallett DJ, Crawforth JM, Kelly S, Owens AP, Blackaby WP, Lewis RT, Stanley J, Smith AJ, Ferris P, Sohal B, Cook SM, Pike A, Brown N, Wafford KA, Marshall G, Castro JL, Atack JR.

J Med Chem. 2006 Jan 12;49(1):35-8.

PMID:
16392789
35.

Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

Jennings AS, Lewis RT, Russell MG, Hallett DJ, Street LJ, Castro JL, Atack JR, Cook SM, Lincoln R, Stanley J, Smith AJ, Reynolds DS, Sohal B, Pike A, Marshall GR, Wafford KA, Sheppard WF, Tye SJ.

Bioorg Med Chem Lett. 2006 Mar 15;16(6):1477-80. Epub 2006 Jan 4.

PMID:
16386900
36.

7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: a functionally selective gamma-aminobutyric acid(A) (GABA(A)) alpha2/alpha3-subtype selective agonist that exhibits potent anxiolytic activity but is not sedating in animal models.

Carling RW, Madin A, Guiblin A, Russell MG, Moore KW, Mitchinson A, Sohal B, Pike A, Cook SM, Ragan IC, McKernan RM, Quirk K, Ferris P, Marshall G, Thompson SA, Wafford KA, Dawson GR, Atack JR, Harrison T, Castro JL, Street LJ.

J Med Chem. 2005 Nov 17;48(23):7089-92.

PMID:
16279764
37.

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, Whiting P, Dawson GR, McKernan RM.

J Pharmacol Exp Ther. 2006 Jan;316(1):410-22. Epub 2005 Sep 23.

PMID:
16183706
38.

Cyclic sulfamide gamma-secretase inhibitors.

Sparey T, Beher D, Best J, Biba M, Castro JL, Clarke E, Hannam J, Harrison T, Lewis H, Madin A, Shearman M, Sohal B, Tsou N, Welch C, Wrigley J.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4212-6.

PMID:
16054361
39.

Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417.

Scott-Stevens P, Atack JR, Sohal B, Worboys P.

Biopharm Drug Dispos. 2005 Jan;26(1):13-20.

PMID:
15578749
40.

Effect of caloric restriction on life span of the housefly, Musca domestica.

Cooper TM, Mockett RJ, Sohal BH, Sohal RS, Orr WC.

FASEB J. 2004 Oct;18(13):1591-3. Epub 2004 Aug 19.

PMID:
15319362
41.

Pleomorphic adenoma of submandibular gland.

Sohal BS, Verma SK, Gill GP, Kumar H.

Indian J Otolaryngol Head Neck Surg. 2004 Jul;56(3):216-7. doi: 10.1007/BF02974354. No abstract available.

42.

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, Marshall G, Pillai GV, Castro JL, Atack JR, MacLeod AM.

J Med Chem. 2004 Jul 1;47(14):3642-57.

PMID:
15214791
43.

Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, Collinson N, Dawson GR, Castro JL, MacLeod AM.

J Med Chem. 2004 Apr 22;47(9):2176-9.

PMID:
15084116
44.

Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.

Crawforth J, Atack JR, Cook SM, Gibson KR, Nadin A, Owens AP, Pike A, Rowley M, Smith AJ, Sohal B, Sternfeld F, Wafford K, Street LJ.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1679-82.

PMID:
15026049
45.

Decreased expression of Cu-Zn superoxide dismutase 1 in ants with extreme lifespan.

Parker JD, Parker KM, Sohal BH, Sohal RS, Keller L.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3486-9. Epub 2004 Mar 1.

46.

An evaluation of a low-density DNA microarray using cytochrome P450 inducers.

Meneses-Lorente G, de Longueville F, Dos Santos-Mendes S, Bonnert TP, Jack A, Evrard S, Bertholet V, Pike A, Scott-Stevens P, Remacle J, Sohal B.

Chem Res Toxicol. 2003 Sep;16(9):1070-7.

PMID:
12971794
47.

3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.

Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, Atack JR, McKernan RM, Thompson SA, Wafford K, Dawson GR, Pike A, Sohal B, Tsou NN, Ball RG, Castro JL.

J Med Chem. 2002 Apr 25;45(9):1887-900.

PMID:
11960500
48.

Biochemical assay of superoxide dismutase activity in Drosophila.

Mockett RJ, Bayne AC, Sohal BH, Sohal RS.

Methods Enzymol. 2002;349:287-92. No abstract available.

PMID:
11912918
49.

Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster.

Mockett RJ, Orr WC, Rahmandar JJ, Sohal BH, Sohal RS.

Exp Gerontol. 2001 Mar;36(3):441-63.

PMID:
11250117
50.

Reversible effects of long-term caloric restriction on protein oxidative damage.

Forster MJ, Sohal BH, Sohal RS.

J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):B522-9.

PMID:
11078084

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