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Independent control of the thermodynamic and kinetic properties of aptamer switches.

Wilson BD, Hariri AA, Thompson IAP, Eisenstein M, Soh HT.

Nat Commun. 2019 Nov 7;10(1):5079. doi: 10.1038/s41467-019-13137-x.


A Dual-Sensing DNA Nanostructure with an Ultrabroad Detection Range.

Kang B, Park SV, Soh HT, Oh SS.

ACS Sens. 2019 Oct 25;4(10):2802-2808. doi: 10.1021/acssensors.9b01503. Epub 2019 Oct 10.


Click-Particle Display for Base-Modified Aptamer Discovery.

Gordon CKL, Wu D, Pusuluri A, Feagin TA, Csordas AT, Eisenstein MS, Hawker CJ, Niu J, Soh HT.

ACS Chem Biol. 2019 Dec 20;14(12):2652-2662. doi: 10.1021/acschembio.9b00587. Epub 2019 Oct 12.


High-Fidelity Nanopore Sequencing of Ultra-Short DNA Targets.

Wilson BD, Eisenstein M, Soh HT.

Anal Chem. 2019 May 21;91(10):6783-6789. doi: 10.1021/acs.analchem.9b00856. Epub 2019 May 10.


Shape-based separation of synthetic microparticles.

Mage PL, Csordas AT, Brown T, Klinger D, Eisenstein M, Mitragotri S, Hawker C, Soh HT.

Nat Mater. 2019 Jan;18(1):82-89. doi: 10.1038/s41563-018-0244-9. Epub 2018 Dec 10.


Treating Tumors at Low Drug Doses Using an Aptamer-Peptide Synergistic Drug Conjugate.

Pusuluri A, Krishnan V, Lensch V, Sarode A, Bunyan E, Vogus DR, Menegatti S, Soh HT, Mitragotri S.

Angew Chem Int Ed Engl. 2019 Jan 28;58(5):1437-1441. doi: 10.1002/anie.201812650. Epub 2018 Dec 21.


Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity.

Gordon CKL, Eisenstein M, Soh HT.

ACS Sens. 2018 Dec 28;3(12):2574-2580. doi: 10.1021/acssensors.8b00945. Epub 2018 Dec 6.


Smartphone-based pathogen diagnosis in urinary sepsis patients.

Barnes L, Heithoff DM, Mahan SP, Fox GN, Zambrano A, Choe J, Fitzgibbons LN, Marth JD, Fried JC, Soh HT, Mahan MJ.

EBioMedicine. 2018 Oct;36:73-82. doi: 10.1016/j.ebiom.2018.09.001. Epub 2018 Sep 20.


Strategies for Creating Structure-Switching Aptamers.

Feagin TA, Maganzini N, Soh HT.

ACS Sens. 2018 Sep 28;3(9):1611-1615. doi: 10.1021/acssensors.8b00516. Epub 2018 Aug 29.


Direct Selection of Fluorescence-Enhancing RNA Aptamers.

Gotrik M, Sekhon G, Saurabh S, Nakamoto M, Eisenstein M, Soh HT.

J Am Chem Soc. 2018 Mar 14;140(10):3583-3591. doi: 10.1021/jacs.7b10724. Epub 2018 Mar 5.


Strategy for Generating Sequence-Defined Aptamer Reagent Sets for Detecting Protein Contaminants in Biotherapeutics.

McGivney JB 4th, Csordas AT, Walker FM, Bagley ER, Gruber EM, Mage PL, Casas-Finet J, Nakamoto MA, Eisenstein M, Larkin CJ, Strouse RJ, Soh HT.

Anal Chem. 2018 Mar 6;90(5):3262-3269. doi: 10.1021/acs.analchem.7b04775. Epub 2018 Feb 13.


Dual-reporter SERS-based biomolecular assay with reduced false-positive signals.

Chuong TT, Pallaoro A, Chaves CA, Li Z, Lee J, Eisenstein M, Stucky GD, Moskovits M, Soh HT.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9056-9061. doi: 10.1073/pnas.1700317114. Epub 2017 Aug 7.


Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization.

Niu J, Lunn DJ, Pusuluri A, Yoo JI, O'Malley MA, Mitragotri S, Soh HT, Hawker CJ.

Nat Chem. 2017 Jun;9(6):537-545. doi: 10.1038/nchem.2713. Epub 2017 Jan 30.


Multiparameter Particle Display (MPPD): A Quantitative Screening Method for the Discovery of Highly Specific Aptamers.

Wang J, Yu J, Yang Q, McDermott J, Scott A, Vukovich M, Lagrois R, Gong Q, Greenleaf W, Eisenstein M, Ferguson BS, Soh HT.

Angew Chem Int Ed Engl. 2017 Jan 16;56(3):744-747. doi: 10.1002/anie.201608880. Epub 2016 Dec 9.


High-Throughput Discovery of Aptamers for Sandwich Assays.

Csordas AT, Jørgensen A, Wang J, Gruber E, Gong Q, Bagley ER, Nakamoto MA, Eisenstein M, Soh HT.

Anal Chem. 2016 Nov 15;88(22):10842-10847. Epub 2016 Nov 4.


In Vitro Selection of pH-Activated DNA Nanostructures.

Fong FY, Oh SS, Hawker CJ, Soh HT.

Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15258-15262. doi: 10.1002/anie.201607540. Epub 2016 Nov 3.


Advancements in Aptamer Discovery Technologies.

Gotrik MR, Feagin TA, Csordas AT, Nakamoto MA, Soh HT.

Acc Chem Res. 2016 Sep 20;49(9):1903-10. doi: 10.1021/acs.accounts.6b00283. Epub 2016 Aug 15.


Controlled drug release to cancer cells from modular one-photon visible light-responsive micellar system.

Poelma SO, Oh SS, Helmy S, Knight AS, Burnett GL, Soh HT, Hawker CJ, Read de Alaniz J.

Chem Commun (Camb). 2016 Aug 18;52(69):10525-8. doi: 10.1039/c6cc04127b.


Rapid and Label-Free Strategy to Isolate Aptamers for Metal Ions.

Qu H, Csordas AT, Wang J, Oh SS, Eisenstein MS, Soh HT.

ACS Nano. 2016 Aug 23;10(8):7558-65. doi: 10.1021/acsnano.6b02558. Epub 2016 Jul 11.


Thousand-fold volumetric concentration of live cells with a recirculating acoustofluidic device.

Jakobsson O, Oh SS, Antfolk M, Eisenstein M, Laurell T, Soh HT.

Anal Chem. 2015 Aug 18;87(16):8497-502. doi: 10.1021/acs.analchem.5b01944. Epub 2015 Jul 30.


Integrated electrochemical microsystems for genetic detection of pathogens at the point of care.

Hsieh K, Ferguson BS, Eisenstein M, Plaxco KW, Soh HT.

Acc Chem Res. 2015 Apr 21;48(4):911-20. doi: 10.1021/ar500456w. Epub 2015 Mar 18.


Array-based discovery of aptamer pairs.

Cho M, Oh SS, Nie J, Stewart R, Radeke MJ, Eisenstein M, Coffey PJ, Thomson JA, Soh HT.

Anal Chem. 2015 Jan 6;87(1):821-8. doi: 10.1021/ac504076k. Epub 2014 Dec 11.


Synthetic aptamer-polymer hybrid constructs for programmed drug delivery into specific target cells.

Oh SS, Lee BF, Leibfarth FA, Eisenstein M, Robb MJ, Lynd NA, Hawker CJ, Soh HT.

J Am Chem Soc. 2014 Oct 22;136(42):15010-5. doi: 10.1021/ja5079464. Epub 2014 Oct 7.


Transformation of personal computers and mobile phones into genetic diagnostic systems.

Walker FM, Ahmad KM, Eisenstein M, Soh HT.

Anal Chem. 2014 Sep 16;86(18):9236-41. doi: 10.1021/ac5022419. Epub 2014 Aug 31.


Aptamer-based cell imaging reagents capable of fluorescence switching.

Jung YK, Woo MA, Soh HT, Park HG.

Chem Commun (Camb). 2014 Oct 21;50(82):12329-32. doi: 10.1039/c4cc03888f.


Target-controlled formation of silver nanoclusters in abasic site-incorporated duplex DNA for label-free fluorescence detection of theophylline.

Park KS, Oh SS, Soh HT, Park HG.

Nanoscale. 2014 Sep 7;6(17):9977-82. doi: 10.1039/c4nr00625a.


MPBind: a Meta-motif-based statistical framework and pipeline to Predict Binding potential of SELEX-derived aptamers.

Jiang P, Meyer S, Hou Z, Propson NE, Soh HT, Thomson JA, Stewart R.

Bioinformatics. 2014 Sep 15;30(18):2665-7. doi: 10.1093/bioinformatics/btu348. Epub 2014 May 28.


Particle display: a quantitative screening method for generating high-affinity aptamers.

Wang J, Gong Q, Maheshwari N, Eisenstein M, Arcila ML, Kosik KS, Soh HT.

Angew Chem Int Ed Engl. 2014 May 5;53(19):4796-801. doi: 10.1002/anie.201309334. Epub 2014 Mar 18.


Simultaneous elimination of carryover contamination and detection of DNA with uracil-DNA-glycosylase-supplemented loop-mediated isothermal amplification (UDG-LAMP).

Hsieh K, Mage PL, Csordas AT, Eisenstein M, Soh HT.

Chem Commun (Camb). 2014 Apr 11;50(28):3747-9. doi: 10.1039/c4cc00540f. Epub 2014 Feb 28.


Accurate zygote-specific discrimination of single-nucleotide polymorphisms using microfluidic electrochemical DNA melting curves.

Yang AH, Hsieh K, Patterson AS, Ferguson BS, Eisenstein M, Plaxco KW, Soh HT.

Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3163-7. doi: 10.1002/anie.201310059. Epub 2014 Feb 12.


Real-time, aptamer-based tracking of circulating therapeutic agents in living animals.

Ferguson BS, Hoggarth DA, Maliniak D, Ploense K, White RJ, Woodward N, Hsieh K, Bonham AJ, Eisenstein M, Kippin TE, Plaxco KW, Soh HT.

Sci Transl Med. 2013 Nov 27;5(213):213ra165. doi: 10.1126/scitranslmed.3007095.


Electrochemical real-time nucleic acid amplification: towards point-of-care quantification of pathogens.

Patterson AS, Hsieh K, Soh HT, Plaxco KW.

Trends Biotechnol. 2013 Dec;31(12):704-12. doi: 10.1016/j.tibtech.2013.09.005. Epub 2013 Oct 24. Review.


In vitro selection of shape-changing DNA nanostructures capable of binding-induced cargo release.

Oh SS, Plakos K, Xiao Y, Eisenstein M, Soh HT.

ACS Nano. 2013 Nov 26;7(11):9675-83. doi: 10.1021/nn404079v. Epub 2013 Nov 4.


Quantitative selection and parallel characterization of aptamers.

Cho M, Soo Oh S, Nie J, Stewart R, Eisenstein M, Chambers J, Marth JD, Walker F, Thomson JA, Soh HT.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18460-5. doi: 10.1073/pnas.1315866110. Epub 2013 Oct 28.


Development of an efficient targeted cell-SELEX procedure for DNA aptamer reagents.

Meyer S, Maufort JP, Nie J, Stewart R, McIntosh BE, Conti LR, Ahmad KM, Soh HT, Thomson JA.

PLoS One. 2013 Aug 13;8(8):e71798. doi: 10.1371/journal.pone.0071798. eCollection 2013.


Microfluidic chip-based detection and intraspecies strain discrimination of Salmonella serovars derived from whole blood of septic mice.

Patterson AS, Heithoff DM, Ferguson BS, Soh HT, Mahan MJ, Plaxco KW.

Appl Environ Microbiol. 2013 Apr;79(7):2302-11. doi: 10.1128/AEM.03882-12. Epub 2013 Jan 25.


Controlling the function of DNA nanostructures with specific trigger sequences.

Deborggraeve S, Dai JY, Xiao Y, Soh HT.

Chem Commun (Camb). 2013 Jan 14;49(4):397-9. doi: 10.1039/c2cc36878a. Epub 2012 Nov 28.


Acoustophoretic sorting of viable mammalian cells in a microfluidic device.

Yang AH, Soh HT.

Anal Chem. 2012 Dec 18;84(24):10756-62. doi: 10.1021/ac3026674. Epub 2012 Dec 6.


Single-round, multiplexed antibody mimetic design through mRNA display.

Olson CA, Nie J, Diep J, Al-Shyoukh I, Takahashi TT, Al-Mawsawi LQ, Bolin JM, Elwell AL, Swanson S, Stewart R, Thomson JA, Soh HT, Roberts RW, Sun R.

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12449-53. doi: 10.1002/anie.201207005. Epub 2012 Nov 4.


Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution.

Ahmad KM, Xiao Y, Soh HT.

Nucleic Acids Res. 2012 Dec;40(22):11777-83. doi: 10.1093/nar/gks899. Epub 2012 Oct 4.


Influence of target concentration and background binding on in vitro selection of affinity reagents.

Wang J, Rudzinski JF, Gong Q, Soh HT, Atzberger PJ.

PLoS One. 2012;7(8):e43940. doi: 10.1371/journal.pone.0043940. Epub 2012 Aug 28.


Selection strategy to generate aptamer pairs that bind to distinct sites on protein targets.

Gong Q, Wang J, Ahmad KM, Csordas AT, Zhou J, Nie J, Stewart R, Thomson JA, Rossi JJ, Soh HT.

Anal Chem. 2012 Jun 19;84(12):5365-71. doi: 10.1021/ac300873p. Epub 2012 Jun 8.


Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care through microfluidic electrochemical quantitative loop-mediated isothermal amplification.

Hsieh K, Patterson AS, Ferguson BS, Plaxco KW, Soh HT.

Angew Chem Int Ed Engl. 2012 May 14;51(20):4896-900. doi: 10.1002/anie.201109115. Epub 2012 Apr 4.


Quantification of transcription factor binding in cell extracts using an electrochemical, structure-switching biosensor.

Bonham AJ, Hsieh K, Ferguson BS, Vallée-Bélisle A, Ricci F, Soh HT, Plaxco KW.

J Am Chem Soc. 2012 Feb 22;134(7):3346-8. doi: 10.1021/ja2115663. Epub 2012 Feb 10.


Wash-free, electrochemical platform for the quantitative, multiplexed detection of specific antibodies.

White RJ, Kallewaard HM, Hsieh W, Patterson AS, Kasehagen JB, Cash KJ, Uzawa T, Soh HT, Plaxco KW.

Anal Chem. 2012 Jan 17;84(2):1098-103. doi: 10.1021/ac202757c. Epub 2012 Jan 3.


Screening of peptide libraries against protective antigen of Bacillus anthracis in a disposable microfluidic cartridge.

Kogot JM, Zhang Y, Moore SJ, Pagano P, Stratis-Cullum DN, Chang-Yen D, Turewicz M, Pellegrino PM, de Fusco A, Soh HT, Stagliano NE.

PLoS One. 2011;6(11):e26925. doi: 10.1371/journal.pone.0026925. Epub 2011 Nov 28.


Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling.

Zuo X, Xia F, Patterson A, Soh HT, Xiao Y, Plaxco KW.

Chembiochem. 2011 Dec 16;12(18):2745-7. doi: 10.1002/cbic.201100592. Epub 2011 Nov 28.


Probing the limits of aptamer affinity with a microfluidic SELEX platform.

Ahmad KM, Oh SS, Kim S, McClellen FM, Xiao Y, Soh HT.

PLoS One. 2011;6(11):e27051. doi: 10.1371/journal.pone.0027051. Epub 2011 Nov 14.


Measurement of aptamer-protein interactions with back-scattering interferometry.

Olmsted IR, Xiao Y, Cho M, Csordas AT, Sheehan JH, Meiler J, Soh HT, Bornhop DJ.

Anal Chem. 2011 Dec 1;83(23):8867-70. doi: 10.1021/ac202823m. Epub 2011 Nov 8.


Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches.

Hsieh K, White RJ, Ferguson BS, Plaxco KW, Xiao Y, Soh HT.

Angew Chem Int Ed Engl. 2011 Nov 18;50(47):11176-80. doi: 10.1002/anie.201103482. Epub 2011 Oct 4. No abstract available.


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