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Items: 1 to 50 of 189

1.

Evolution of genotoxicity test methods in Japan.

Sofuni T.

Genes Environ. 2017 Feb 21;39:15. doi: 10.1186/s41021-016-0063-7. eCollection 2017.

2.

Practical issues on the application of the GHS classification criteria for germ cell mutagens.

Morita T, Hayashi M, Nakajima M, Tanaka N, Tweats DJ, Morikawa K, Sofuni T.

Regul Toxicol Pharmacol. 2009 Oct;55(1):52-68. doi: 10.1016/j.yrtph.2009.06.001. Epub 2009 Jun 6.

PMID:
19505521
3.

Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards.

Tweats DJ, Blakey D, Heflich RH, Jacobs A, Jacobsen SD, Morita T, Nohmi T, O'Donovan MR, Sasaki YF, Sofuni T, Tice R; IWGT Working Group.

Mutat Res. 2007 Feb 3;627(1):78-91. Epub 2006 Nov 20.

PMID:
17116417
4.

Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test.

Tweats DJ, Blakey D, Heflich RH, Jacobs A, Jacobsen SD, Morita T, Nohmi T, O'Donovan MR, Sasaki YF, Sofuni T, Tice R; IWGT Working Group.

Mutat Res. 2007 Feb 3;627(1):92-105. Epub 2006 Nov 20. Review.

5.

Current status of chromosomal abnormalities in mouse embryonic stem cell lines used in Japan.

Sugawara A, Goto K, Sotomaru Y, Sofuni T, Ito T.

Comp Med. 2006 Feb;56(1):31-4.

PMID:
16521857
6.

Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells.

Satoh T, Yamamoto K, Miura KF, Sofuni T.

Cytogenet Genome Res. 2004;104(1-4):289-94.

PMID:
15162053
7.

Report from the in vitro micronucleus assay working group.

Kirsch-Volders M, Sofuni T, Aardema M, Albertini S, Eastmond D, Fenech M, Ishidate M Jr, Kirchner S, Lorge E, Morita T, Norppa H, Surrallés J, Vanhauwaert A, Wakata A.

Mutat Res. 2003 Oct 7;540(2):153-63. Erratum in: Mutat Res. 2004 Nov;564(1):97-100.

PMID:
14550499
8.

Summary of major conclusions.

Kirkland DJ, Hayashi M, MacGregor JT, Müller L, Schechtman LM, Sofuni T.

Mutat Res. 2003 Oct 7;540(2):123-5. No abstract available.

PMID:
14550496
9.

Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project.

Fenech M, Bonassi S, Turner J, Lando C, Ceppi M, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Bigatti MP, Bolognesi C, Cao J, De Luca G, Di Giorgio M, Ferguson LR, Fucic A, Lima OG, Hadjidekova VV, Hrelia P, Jaworska A, Joksic G, Krishnaja AP, Lee TK, Martelli A, McKay MJ, Migliore L, Mirkova E, Müller WU, Odagiri Y, Orsiere T, Scarfì MR, Silva MJ, Sofuni T, Surralles J, Trenta G, Vorobtsova I, Vral A, Zijno A; HUman MicroNucleus project.

Mutat Res. 2003 Jan 10;534(1-2):45-64. Erratum in: Mutat Res. 2003 Jul 8;538(1-2):185-6. Suralles, Jordi [corrected to Surralles, Jordi].

PMID:
12504754
10.

Chromosomal instability in B-lymphoblasotoid cell lines from Werner and Bloom syndrome patients.

Honma M, Tadokoro S, Sakamoto H, Tanabe H, Sugimoto M, Furuichi Y, Satoh T, Sofuni T, Goto M, Hayashi M.

Mutat Res. 2002 Sep 26;520(1-2):15-24.

PMID:
12297140
11.

Application of mFISH for the analysis of chemically-induced chromosomal aberrations: a model for the formation of triradial chromosomes.

Satoh T, Hatanaka M, Yamamoto K, Kuro-o M, Sofuni T.

Mutat Res. 2002 Jul 25;504(1-2):57-65.

PMID:
12106646
12.

Relevance of chemical structure and cytotoxicity to the induction of chromosome aberrations based on the testing results of 98 high production volume industrial chemicals.

Kusakabe H, Yamakage K, Wakuri S, Sasaki K, Nakagawa Y, Watanabe M, Hayashi M, Sofuni T, Ono H, Tanaka N.

Mutat Res. 2002 May 27;517(1-2):187-98.

PMID:
12034320
13.

In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse.

Noda Y, Suzuki T, Kohara A, Hasegawa A, Yotsuyanagi T, Hayashi M, Sofuni T, Yamanaka K, Okada S.

Mutat Res. 2002 Jan 15;513(1-2):205-12.

PMID:
11719106
14.

Spindle poisons induce allelic loss in mouse lymphoma cells through mitotic non-disjunction.

Honma M, Momose M, Sakamoto H, Sofuni T, Hayashi M.

Mutat Res. 2001 Jun 27;493(1-2):101-14.

PMID:
11516720
15.

Hepatocarcinogen quinoline induces G:C to C:G transversions in the cII gene in the liver of lambda/lacZ transgenic mice (MutaMouse).

Suzuki T, Wang X, Miyata Y, Saeki K, Kohara A, Kawazoe Y, Hayashi M, Sofuni T.

Mutat Res. 2000 Nov 30;456(1-2):73-81.

PMID:
11087898
16.

Requirement of wild-type p53 protein for maintenance of chromosomal integrity.

Honma M, Momose M, Tanabe H, Sakamoto H, Yu Y, Little JB, Sofuni T, Hayashi M.

Mol Carcinog. 2000 Aug;28(4):203-14.

PMID:
10972990
17.

Human monochromosome hybrid cell panel characterized by FISH in the JCRB/HSRRB.

Tanabe H, Nakagawa Y, Minegishi D, Hashimoto K, Tanaka N, Oshimura M, Sofuni T, Mizusawa H.

Chromosome Res. 2000;8(4):319-34.

PMID:
10919723
18.

In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.

Itoh T, Suzuki T, Nishikawa A, Furukawa F, Takahashi M, Xue W, Sofuni T, Hayashi M.

Mutat Res. 2000 Jun 22;468(1):19-25.

PMID:
10863154
19.

Appropriate levels of cytotoxicity for genotoxicity tests using mammalian cells in vitro.

Müller L, Sofuni T.

Environ Mol Mutagen. 2000;35(3):202-5.

PMID:
10737955
20.

Report from the In Vitro Micronucleus Assay Working Group.

Kirsch-Volders M, Sofuni T, Aardema M, Albertini S, Eastmond D, Fenech M, Ishidate M Jr, Lorge E, Norppa H, Surrallés J, von der Hude W, Wakata A.

Environ Mol Mutagen. 2000;35(3):167-72.

PMID:
10737951
21.

Summary of major conclusions from the International Workshop on Genotoxicity Test Procedures.

Kirkland DJ, Hayashi M, MacGregor JT, Müller L, Schechtman L, Sofuni T.

Environ Mol Mutagen. 2000;35(3):162-6. No abstract available.

PMID:
10737950
22.

Semi-quantitative evaluation of genotoxic activity of chemical substances and evidence for a biological threshold of genotoxic activity.

Sofuni T, Hayashi M, Nohmi T, Matsuoka A, Yamada M, Kamata E.

Mutat Res. 2000 Jan 3;464(1):97-104. Review.

PMID:
10633181
23.

A micronucleus assay in sea urchin embryos.

Saotome K, Sofuni T, Hayashi M.

Mutat Res. 1999 Oct 29;446(1):121-7.

PMID:
10613192
24.

Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU).

Matsushima T, Hayashi M, Matsuoka A, Ishidate M Jr, Miura KF, Shimizu H, Suzuki Y, Morimoto K, Ogura H, Mure K, Koshi K, Sofuni T.

Mutagenesis. 1999 Nov;14(6):569-80.

PMID:
10567032
25.

Effects of O (6)-alkylguanine-DNA alkyltransferase deficiency in Escherichia coli as the host for the detection of mutations in lacI transgenic mice.

Sui H, Suzuki M, Yamada M, Hara T, Kawakami K, Shibuya T, Nohmi T, Sofuni T.

Environ Mol Mutagen. 1999;34(2-3):221-6.

PMID:
10529748
26.

UVB-induced gpt mutations in the skin of gpt delta transgenic mice.

Horiguchi M, Masumura K, Ikehata H, Ono T, Kanke Y, Sofuni T, Nohmi T.

Environ Mol Mutagen. 1999;34(2-3):72-9.

PMID:
10529728
27.

Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations.

Suzuki T, Uno Y, Idehara K, Baba T, Maniwa J, Ohkouchi A, Wang X, Hayashi M, Sofuni T, Tsuruoka M, Miyajima H, Kondo K.

Mutat Res. 1999 Aug 18;444(2):269-81.

PMID:
10521668
28.

Mutagenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the new gpt delta transgenic mouse.

Masumura K, Matsui K, Yamada M, Horiguchi M, Ishida K, Watanabe M, Ueda O, Suzuki H, Kanke Y, Tindall KR, Wakabayashi K, Sofuni T, Nohmi T.

Cancer Lett. 1999 Sep 1;143(2):241-4.

PMID:
10503911
29.

Toxicity study of a rubber antioxidant, mixture of 2-mercaptomethylbenzimidazoles, by repeated oral administration to rats.

Saitoh M, Umemura T, Kawasaki Y, Momma J, Matsushima Y, Sakemi K, Isama K, Kitajima S, Ogawa Y, Hasegawa R, Suzuki T, Hayashi M, Inoue T, Ohno Y, Sofuni T, Kurokawa Y, Tsuda M.

Food Chem Toxicol. 1999 Jul;37(7):777-87.

PMID:
10496380
30.

The need for long-term treatment in the mouse lymphoma assay.

Honma M, Zhang LZ, Sakamoto H, Ozaki M, Takeshita K, Momose M, Hayashi M, Sofuni T.

Mutagenesis. 1999 Jan;14(1):23-9.

PMID:
10474817
31.

Evaluation of the mouse lymphoma tk assay (microwell method) as an alternative to the in vitro chromosomal aberration test.

Honma M, Hayashi M, Shimada H, Tanaka N, Wakuri S, Awogi T, Yamamoto KI, Kodani N, Nishi Y, Nakadate M, Sofuni T.

Mutagenesis. 1999 Jan;14(1):5-22.

PMID:
10474816
32.

Spi(-) selection: An efficient method to detect gamma-ray-induced deletions in transgenic mice.

Nohmi T, Suzuki M, Masumura K, Yamada M, Matsui K, Ueda O, Suzuki H, Katoh M, Ikeda H, Sofuni T.

Environ Mol Mutagen. 1999;34(1):9-15.

PMID:
10462718
33.

Spectra of gpt mutations in ethylnitrosourea-treated and untreated transgenic mice.

Masumura K, Matsui M, Katoh M, Horiya N, Ueda O, Tanabe H, Yamada M, Suzuki H, Sofuni T, Nohmi T.

Environ Mol Mutagen. 1999;34(1):1-8.

PMID:
10462717
34.

A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test.

Matsuoka A, Matsuura K, Sakamoto H, Hayashi M, Sofuni T.

Mutagenesis. 1999 Jul;14(4):385-9.

PMID:
10390505
35.

ICH-harmonised guidances on genotoxicity testing of pharmaceuticals: evolution, reasoning and impact.

Müller L, Kikuchi Y, Probst G, Schechtman L, Shimada H, Sofuni T, Tweats D.

Mutat Res. 1999 May;436(3):195-225. Review.

PMID:
10354523
36.

[Studies on development and improvement of toxicity guidelines conducted at the Biological Safety Research Center].

Inoue T, Ohno Y, Takahshi M, Sofuni T, Nakadate M, Korokawa Y.

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku. 1998;(116):149-52. Review. Japanese.

PMID:
10097526
37.

New O-acetyltransferase-deficient Ames Salmonella strains generated by specific gene disruption.

Espinosa-Aguirre JJ, Yamada M, Matsui K, Watanabe M, Sofuni T, Nohmi T.

Mutat Res. 1999 Feb 19;439(2):159-69.

PMID:
10023048
38.

Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice.

Wang X, Suzuki T, Itoh T, Honma M, Nishikawa A, Furukawa F, Takahashi M, Hayashi M, Kato T, Sofuni T.

Mutagenesis. 1998 Nov;13(6):625-30.

PMID:
9862195
40.

Harmonization of genotoxicity testing requirements for pharmaceuticals.

Sofuni T.

J Toxicol Sci. 1998 Jul;23 Suppl 2:262-4. No abstract available.

PMID:
9760479
41.

Chromosome aberration assays in genetic toxicology testing in vitro.

Ishidate M Jr, Miura KF, Sofuni T.

Mutat Res. 1998 Aug 3;404(1-2):167-72.

PMID:
9729363
43.

DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity.

Ochiai M, Ishida K, Ushijima T, Suzuki T, Sofuni T, Sugimura T, Nagao M.

Mutagenesis. 1998 Jul;13(4):381-4.

PMID:
9717175
44.

Dilution series for test chemicals in the mouse lymphoma mutation assay.

Hayashi M, Honma M, Sofuni T.

Mutat Res. 1998 Jul 8;415(1-2):165-6. No abstract available.

PMID:
9711273
45.

No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice.

Nagao M, Fujita H, Ochiai M, Wakabayashi K, Sofuni T, Matsushima T, Sugimura T, Ushijima T.

Mutat Res. 1998 May 25;400(1-2):251-7.

PMID:
9685668
46.

Development of genotoxicity assay systems that use aquatic organisms.

Hayashi M, Ueda T, Uyeno K, Wada K, Kinae N, Saotome K, Tanaka N, Takai A, Sasaki YF, Asano N, Sofuni T, Ojima Y.

Mutat Res. 1998 Mar 20;399(2):125-33.

PMID:
9672655
47.

Antimutagenic structural modification of quinoline assessed by an in vivo mutagenesis assay using lacZ-transgenic mice.

Miyata Y, Saeki K, Kawazoe Y, Hayashi M, Sofuni T, Suzuki T.

Mutat Res. 1998 May 11;414(1-3):165-9.

PMID:
9630605
48.
49.

In vivo mutagenesis by the hepatocarcinogen quinoline in the lacZ transgenic mouse: evidence for its in vivo genotoxicity.

Suzuki T, Miyata Y, Saeki K, Kawazoe Y, Hayashi M, Sofuni T.

Mutat Res. 1998 Jan 30;412(2):161-6.

PMID:
9539970
50.

A comparison of the genotoxicity of ethylnitrosourea and ethyl methanesulfonate in lacZ transgenic mice (Muta Mouse).

Suzuki T, Hayashi M, Wang X, Yamamoto K, Ono T, Myhr BC, Sofuni T.

Mutat Res. 1997 Dec 5;395(1):75-82.

PMID:
9465915

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