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Items: 1 to 50 of 190

1.

The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression.

Tassoni A, Farkhondeh V, Itoh Y, Itoh N, Sofroniew MV, Voskuhl RR.

Sci Rep. 2019 Jul 10;9(1):10010. doi: 10.1038/s41598-019-46232-6.

2.

Spinal cord repair: advances in biology and technology.

Courtine G, Sofroniew MV.

Nat Med. 2019 Jun;25(6):898-908. doi: 10.1038/s41591-019-0475-6. Epub 2019 Jun 3. Review.

PMID:
31160817
3.

Astrocytes usurp neurons as a disease focus.

Liddelow SA, Sofroniew MV.

Nat Neurosci. 2019 Apr;22(4):512-513. doi: 10.1038/s41593-019-0367-6. No abstract available.

PMID:
30858602
4.

Stem-Cell-Derived Astrocytes Divulge Secrets of Mutant GFAP.

Sofroniew MV.

Cell Stem Cell. 2018 Nov 1;23(5):630-631. doi: 10.1016/j.stem.2018.10.020.

PMID:
30388417
5.

Required growth facilitators propel axon regeneration across complete spinal cord injury.

Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, Kawaguchi R, Coppola G, Wang C, Deming TJ, He Z, Courtine G, Sofroniew MV.

Nature. 2018 Sep;561(7723):396-400. doi: 10.1038/s41586-018-0467-6. Epub 2018 Aug 29.

6.

Dissecting spinal cord regeneration.

Sofroniew MV.

Nature. 2018 May;557(7705):343-350. doi: 10.1038/s41586-018-0068-4. Epub 2018 May 16. Review.

PMID:
29769671
7.

Injectable polypeptide hydrogels via methionine modification for neural stem cell delivery.

Wollenberg AL, O'Shea TM, Kim JH, Czechanski A, Reinholdt LG, Sofroniew MV, Deming TJ.

Biomaterials. 2018 Sep;178:527-545. doi: 10.1016/j.biomaterials.2018.03.057. Epub 2018 Apr 5.

PMID:
29657091
8.

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes.

Itoh N, Itoh Y, Tassoni A, Ren E, Kaito M, Ohno A, Ao Y, Farkhondeh V, Johnsonbaugh H, Burda J, Sofroniew MV, Voskuhl RR.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E302-E309. doi: 10.1073/pnas.1716032115. Epub 2017 Dec 26.

9.

Conformation-Directed Formation of Self-Healing Diblock Copolypeptide Hydrogels via Polyion Complexation.

Sun Y, Wollenberg AL, O'Shea TM, Cui Y, Zhou ZH, Sofroniew MV, Deming TJ.

J Am Chem Soc. 2017 Oct 25;139(42):15114-15121. doi: 10.1021/jacs.7b08190. Epub 2017 Oct 12.

10.

Cell biology of spinal cord injury and repair.

O'Shea TM, Burda JE, Sofroniew MV.

J Clin Invest. 2017 Sep 1;127(9):3259-3270. doi: 10.1172/JCI90608. Epub 2017 Jul 24. Review.

11.

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.

Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR.

J Clin Invest. 2017 Aug 1;127(8):3136-3151. doi: 10.1172/JCI91301. Epub 2017 Jul 24.

12.

Seducing astrocytes to the dark side.

Burda JE, Sofroniew MV.

Cell Res. 2017 Jun;27(6):726-727. doi: 10.1038/cr.2017.37. Epub 2017 Mar 17.

13.

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury.

Ren Y, Ao Y, O'Shea TM, Burda JE, Bernstein AM, Brumm AJ, Muthusamy N, Ghashghaei HT, Carmichael ST, Cheng L, Sofroniew MV.

Sci Rep. 2017 Jan 24;7:41122. doi: 10.1038/srep41122.

14.

P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus.

Xu J, Bernstein AM, Wong A, Lu XH, Khoja S, Yang XW, Davies DL, Micevych P, Sofroniew MV, Khakh BS.

J Neurosci. 2016 Aug 24;36(34):8902-20. doi: 10.1523/JNEUROSCI.1496-16.2016.

15.

Thermoresponsive Copolypeptide Hydrogel Vehicles for Central Nervous System Cell Delivery.

Zhang S, Burda JE, Anderson MA, Zhao Z, Ao Y, Cheng Y, Sun Y, Deming TJ, Sofroniew MV.

ACS Biomater Sci Eng. 2015 Aug 10;1(8):705-717. Epub 2015 Jun 22.

16.

Astrocyte scar formation aids central nervous system axon regeneration.

Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV.

Nature. 2016 Apr 14;532(7598):195-200. doi: 10.1038/nature17623. Epub 2016 Mar 30.

17.

Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival.

Levine J, Kwon E, Paez P, Yan W, Czerwieniec G, Loo JA, Sofroniew MV, Wanner IB.

Glia. 2016 May;64(5):668-94. doi: 10.1002/glia.22953. Epub 2015 Dec 19.

18.

Astrocytes: a central element in neurological diseases.

Pekny M, Pekna M, Messing A, Steinhäuser C, Lee JM, Parpura V, Hol EM, Sofroniew MV, Verkhratsky A.

Acta Neuropathol. 2016 Mar;131(3):323-45. doi: 10.1007/s00401-015-1513-1. Epub 2015 Dec 15. Review.

PMID:
26671410
19.

Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury.

Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng L, Yang Z, Sun YE, Li X.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13360-5. doi: 10.1073/pnas.1510176112. Epub 2015 Oct 12.

20.

Diversity of astrocyte functions and phenotypes in neural circuits.

Khakh BS, Sofroniew MV.

Nat Neurosci. 2015 Jul;18(7):942-52. doi: 10.1038/nn.4043. Review.

21.

Astrocyte barriers to neurotoxic inflammation.

Sofroniew MV.

Nat Rev Neurosci. 2015 May;16(5):249-63. doi: 10.1038/nrn3898. Review. Erratum in: Nat Rev Neurosci. 2015 Jun;16(6):372.

22.

Astrocyte roles in traumatic brain injury.

Burda JE, Bernstein AM, Sofroniew MV.

Exp Neurol. 2016 Jan;275 Pt 3:305-315. doi: 10.1016/j.expneurol.2015.03.020. Epub 2015 Mar 28. Review.

23.

Design and synthesis of nonionic copolypeptide hydrogels with reversible thermoresponsive and tunable physical properties.

Zhang S, Alvarez DJ, Sofroniew MV, Deming TJ.

Biomacromolecules. 2015 Apr 13;16(4):1331-40. doi: 10.1021/acs.biomac.5b00124. Epub 2015 Mar 19.

24.

Imaging intracellular Ca²⁺ signals in striatal astrocytes from adult mice using genetically-encoded calcium indicators.

Jiang R, Haustein MD, Sofroniew MV, Khakh BS.

J Vis Exp. 2014 Nov 19;(93):e51972. doi: 10.3791/51972.

25.

Astrogliosis.

Sofroniew MV.

Cold Spring Harb Perspect Biol. 2014 Nov 7;7(2):a020420. doi: 10.1101/cshperspect.a020420. Review.

26.

Glia in the pathogenesis of neurodegenerative diseases.

Verkhratsky A, Parpura V, Pekna M, Pekny M, Sofroniew M.

Biochem Soc Trans. 2014 Oct;42(5):1291-301. doi: 10.1042/BST20140107. Review.

PMID:
25233406
27.

Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity.

O'Callaghan JP, Kelly KA, VanGilder RL, Sofroniew MV, Miller DB.

PLoS One. 2014 Jul 15;9(7):e102003. doi: 10.1371/journal.pone.0102003. eCollection 2014.

28.

Astrocyte CCL2 sustains immune cell infiltration in chronic experimental autoimmune encephalomyelitis.

Kim RY, Hoffman AS, Itoh N, Ao Y, Spence R, Sofroniew MV, Voskuhl RR.

J Neuroimmunol. 2014 Sep 15;274(1-2):53-61. doi: 10.1016/j.jneuroim.2014.06.009. Epub 2014 Jun 24.

29.

Memantine enhances recovery from stroke.

López-Valdés HE, Clarkson AN, Ao Y, Charles AC, Carmichael ST, Sofroniew MV, Brennan KC.

Stroke. 2014 Jul;45(7):2093-2100. doi: 10.1161/STROKEAHA.113.004476. Epub 2014 Jun 17. Erratum in: Stroke. 2014 Nov;45(11):e238.

30.

Astrocytes and Huntington's disease.

Khakh BS, Sofroniew MV.

ACS Chem Neurosci. 2014 Jul 16;5(7):494-6. doi: 10.1021/cn500100r. Epub 2014 May 20.

31.

Traumatic brain injury reveals novel cell lineage relationships within the subventricular zone.

Thomsen GM, Le Belle JE, Harnisch JA, Mc Donald WS, Hovda DA, Sofroniew MV, Kornblum HI, Harris NG.

Stem Cell Res. 2014 Jul;13(1):48-60. doi: 10.1016/j.scr.2014.04.013. Epub 2014 Apr 28.

32.

Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.

Assi H, Espinosa J, Suprise S, Sofroniew M, Doherty R, Zamler D, Lowenstein PR, Castro MG.

PLoS One. 2014 May 7;9(5):e96318. doi: 10.1371/journal.pone.0096318. eCollection 2014.

33.

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.

Tong X, Ao Y, Faas GC, Nwaobi SE, Xu J, Haustein MD, Anderson MA, Mody I, Olsen ML, Sofroniew MV, Khakh BS.

Nat Neurosci. 2014 May;17(5):694-703. doi: 10.1038/nn.3691. Epub 2014 Mar 30.

34.

Reactive gliosis and the multicellular response to CNS damage and disease.

Burda JE, Sofroniew MV.

Neuron. 2014 Jan 22;81(2):229-48. doi: 10.1016/j.neuron.2013.12.034. Review.

35.

Heterogeneity of reactive astrocytes.

Anderson MA, Ao Y, Sofroniew MV.

Neurosci Lett. 2014 Apr 17;565:23-9. doi: 10.1016/j.neulet.2013.12.030. Epub 2013 Dec 19. Review.

36.

Tunable diblock copolypeptide hydrogel depots for local delivery of hydrophobic molecules in healthy and injured central nervous system.

Zhang S, Anderson MA, Ao Y, Khakh BS, Fan J, Deming TJ, Sofroniew MV.

Biomaterials. 2014 Feb;35(6):1989-2000. doi: 10.1016/j.biomaterials.2013.11.005. Epub 2013 Dec 4.

37.

Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators.

Sofroniew MV.

Neuroscientist. 2014 Apr;20(2):160-72. doi: 10.1177/1073858413504466. Epub 2013 Oct 8. Review.

PMID:
24106265
38.

Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury.

Wanner IB, Anderson MA, Song B, Levine J, Fernandez A, Gray-Thompson Z, Ao Y, Sofroniew MV.

J Neurosci. 2013 Jul 31;33(31):12870-86. doi: 10.1523/JNEUROSCI.2121-13.2013.

39.

Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons.

Spence RD, Wisdom AJ, Cao Y, Hill HM, Mongerson CR, Stapornkul B, Itoh N, Sofroniew MV, Voskuhl RR.

J Neurosci. 2013 Jun 26;33(26):10924-33. doi: 10.1523/JNEUROSCI.0886-13.2013.

40.

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.

Shigetomi E, Bushong EA, Haustein MD, Tong X, Jackson-Weaver O, Kracun S, Xu J, Sofroniew MV, Ellisman MH, Khakh BS.

J Gen Physiol. 2013 May;141(5):633-47. doi: 10.1085/jgp.201210949. Epub 2013 Apr 15.

41.

Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.

Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV.

J Neurosci. 2012 Oct 17;32(42):14489-510. doi: 10.1523/JNEUROSCI.1256-12.2012.

42.

Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots.

Song B, Song J, Zhang S, Anderson MA, Ao Y, Yang CY, Deming TJ, Sofroniew MV.

Biomaterials. 2012 Dec;33(35):9105-16. doi: 10.1016/j.biomaterials.2012.08.060. Epub 2012 Sep 15.

PMID:
22985994
43.

STAT3-mediated astrogliosis protects myelin development in neonatal brain injury.

Nobuta H, Ghiani CA, Paez PM, Spreuer V, Dong H, Korsak RA, Manukyan A, Li J, Vinters HV, Huang EJ, Rowitch DH, Sofroniew MV, Campagnoni AT, de Vellis J, Waschek JA.

Ann Neurol. 2012 Nov;72(5):750-65. doi: 10.1002/ana.23670. Epub 2012 Aug 31.

44.

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR.

J Clin Invest. 2012 Jul;122(7):2454-68. doi: 10.1172/JCI60842. Epub 2012 Jun 1.

45.

Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories.

Cushman JD, Maldonado J, Kwon EE, Garcia AD, Fan G, Imura T, Sofroniew MV, Fanselow MS.

Front Behav Neurosci. 2012 Feb 2;6:3. doi: 10.3389/fnbeh.2012.00003. eCollection 2012.

46.

Neurological diseases as primary gliopathies: a reassessment of neurocentrism.

Verkhratsky A, Sofroniew MV, Messing A, deLanerolle NC, Rempe D, Rodríguez JJ, Nedergaard M.

ASN Neuro. 2012 Apr 5;4(3). pii: e00082. doi: 10.1042/AN20120010. Review.

47.
48.

Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration.

Tao J, Wu H, Lin Q, Wei W, Lu XH, Cantle JP, Ao Y, Olsen RW, Yang XW, Mody I, Sofroniew MV, Sun YE.

J Neurosci. 2011 Jun 1;31(22):8306-19. doi: 10.1523/JNEUROSCI.0567-11.2011.

49.

Neuroprotection mediated through estrogen receptor-alpha in astrocytes.

Spence RD, Hamby ME, Umeda E, Itoh N, Du S, Wisdom AJ, Cao Y, Bondar G, Lam J, Ao Y, Sandoval F, Suriany S, Sofroniew MV, Voskuhl RR.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8867-72. doi: 10.1073/pnas.1103833108. Epub 2011 May 9.

50.

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