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Items: 1 to 50 of 60

1.

Directly Acting Oral Anticoagulants for the Prevention of Stroke in Atrial Fibrillation in England and Wales: Cost-Effectiveness Model and Value of Information Analysis.

Thom HHZ, Hollingworth W, Sofat R, Wang Z, Fang W, Bodalia PN, Bryden PA, Davies PA, Caldwell DM, Dias S, Eaton D, Higgins JPT, Hingorani AD, Lopez-Lopez JA, Okoli GN, Richards A, Salisbury C, Savović J, Stephens-Boal A, Sterne JAC, Welton NJ.

MDM Policy Pract. 2019 Aug 17;4(2):2381468319866828. doi: 10.1177/2381468319866828. eCollection 2019 Jul-Dec.

2.

Eligibility and subsequent burden of cardiovascular disease of four strategies for blood pressure-lowering treatment: a retrospective cohort study.

Herrett E, Gadd S, Jackson R, Bhaskaran K, Williamson E, van Staa T, Sofat R, Timmis A, Smeeth L.

Lancet. 2019 Aug 24;394(10199):663-671. doi: 10.1016/S0140-6736(19)31359-5. Epub 2019 Jul 25.

3.

24-hour vs Spot Urinary Sodium and Potassium Measurements in Adult Hypertensive patients; A Cohort Validation Study.

Wan ER, Cross J, Sofat R, Walsh SB.

Am J Hypertens. 2019 Jun 27. pii: hpz104. doi: 10.1093/ajh/hpz104. [Epub ahead of print]

PMID:
31247068
4.

Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.

Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K, Maclagan K, Quartly HL, Sofat R, Smit A, Schreiber BE, Coghlan GJ, MacAllister RJ.

Br J Pharmacol. 2019 May;176(9):1251-1267. doi: 10.1111/bph.14621. Epub 2019 Mar 31.

PMID:
30761523
5.

Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.

Kia DA, Noyce AJ, White J, Speed D, Nicolas A; IPDGC collaborators, Burgess S, Lawlor DA, Davey Smith G, Singleton A, Nalls MA, Sofat R, Wood NW.

Ann Neurol. 2018 Aug;84(2):191-199. doi: 10.1002/ana.25294.

6.

Resistant Hypertension: Trials and Tribulations.

George MJ, Marks DJB, Rezk T, Breckenridge R, Sofat R, Martin J, MacAllister R, Touyz RM, Staessen JA, Bursztyn M, Lappin D, Barigou M, Hingorani A.

Hypertension. 2018 May;71(5):772-780. doi: 10.1161/HYPERTENSIONAHA.118.10864. Epub 2018 Apr 2. Review. No abstract available.

PMID:
29610269
7.

Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis.

López-López JA, Sterne JAC, Thom HHZ, Higgins JPT, Hingorani AD, Okoli GN, Davies PA, Bodalia PN, Bryden PA, Welton NJ, Hollingworth W, Caldwell DM, Savović J, Dias S, Salisbury C, Eaton D, Stephens-Boal A, Sofat R.

BMJ. 2017 Nov 28;359:j5058. doi: 10.1136/bmj.j5058. Review. Erratum in: BMJ. 2017 Dec 4;359:j5631. BMJ. 2018 May 23;361:k2295.

8.

Cross-talk between iNKT cells and monocytes triggers an atheroprotective immune response in SLE patients with asymptomatic plaque.

Smith E, Croca S, Waddington KE, Sofat R, Griffin M, Nicolaides A, Isenberg DA, Torra IP, Rahman A, Jury EC.

Sci Immunol. 2016 Dec 2;1(6). pii: eaah4081. doi: 10.1126/sciimmunol.aah4081.

PMID:
28783690
9.

Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration.

Cipriani V, Hogg RE, Sofat R, Moore AT, Webster AR, Yates JRW, Fletcher AE; European Eye (EUREYE) Study Group.

JAMA Ophthalmol. 2017 Sep 1;135(9):909-916. doi: 10.1001/jamaophthalmol.2017.2191.

10.

Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis.

Welton NJ, McAleenan A, Thom HH, Davies P, Hollingworth W, Higgins JP, Okoli G, Sterne JA, Feder G, Eaton D, Hingorani A, Fawsitt C, Lobban T, Bryden P, Richards A, Sofat R.

Health Technol Assess. 2017 May;21(29):1-236. doi: 10.3310/hta21290. Review.

11.

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A; UCLEB Consortium; METASTROKE Consortium, Mutsert R, Noordam R, Caulfield MJ, Jukema JW, Worrall BB, Munroe PB, Menon U, Power C, Kuh D, Lawlor DA, Humphries SE, Mook-Kanamori DO, Sattar N, Kivimaki M, Price JF, Davey Smith G, Dudbridge F, Hingorani AD, Holmes MV, Casas JP.

Circulation. 2017 Jun 13;135(24):2373-2388. doi: 10.1161/CIRCULATIONAHA.116.026560. Epub 2017 May 12.

12.

Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis.

Sterne JA, Bodalia PN, Bryden PA, Davies PA, López-López JA, Okoli GN, Thom HH, Caldwell DM, Dias S, Eaton D, Higgins JP, Hollingworth W, Salisbury C, Savović J, Sofat R, Stephens-Boal A, Welton NJ, Hingorani AD.

Health Technol Assess. 2017 Mar;21(9):1-386. doi: 10.3310/hta21090. Review.

13.

Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies.

Sofat R, Cooper JA, Kumari M, Casas JP, Mitchell JP, Acharya J, Thom S, Hughes AD, Humphries SE, Hingorani AD.

PLoS Med. 2016 Oct 18;13(10):e1002146. doi: 10.1371/journal.pmed.1002146. eCollection 2016 Oct.

14.

Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.

Swerdlow DI, Kuchenbaecker KB, Shah S, Sofat R, Holmes MV, White J, Mindell JS, Kivimaki M, Brunner EJ, Whittaker JC, Casas JP, Hingorani AD.

Int J Epidemiol. 2016 Oct;45(5):1600-1616. Epub 2016 Jun 24. Review.

15.

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, Shah S, Kruger FA, Giambartolomei C, Swerdlow DI, Palmer T, McLachlan S, Langenberg C, Zabaneh D, Lovering R, Cavadino A, Jefferis B, Finan C, Wong A, Amuzu A, Ong K, Gaunt TR, Warren H, Davies TL, Drenos F, Cooper J, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hypponen E, Richards M, Hardy R, Kuh D, Wareham N, Ben-Shlomo Y, Day IN, Whincup P, Morris R, Strachan MW, Price J, Kumari M, Kivimaki M, Plagnol V, Whittaker JC; International Consortium for Blood Pressure (ICBP), Smith GD, Dudbridge F, Casas JP, Holmes MV, Hingorani AD; UCLEB (University College London-London School of Hygiene & Tropical Medicine-Edinburgh-Bristol Consortium.

Lancet Diabetes Endocrinol. 2016 Apr;4(4):327-36. doi: 10.1016/S2213-8587(15)00386-1. Epub 2016 Jan 16.

16.

Osteoarticular tuberculosis: The great mimicker still catches us out--a case report.

Magnussen A, Amirthanayagam T, Sofat R.

Acta Orthop. 2016 Feb;87(1):83-4. doi: 10.3109/17453674.2015.1103115. Epub 2015 Oct 16. No abstract available.

17.

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.

Nüesch E, Dale C, Palmer TM, White J, Keating BJ, van Iperen EP, Goel A, Padmanabhan S, Asselbergs FW; EPIC-Netherland Investigators, Verschuren WM, Wijmenga C, Van der Schouw YT, Onland-Moret NC, Lange LA, Hovingh GK, Sivapalaratnam S, Morris RW, Whincup PH, Wannamethe GS, Gaunt TR, Ebrahim S, Steel L, Nair N, Reiner AP, Kooperberg C, Wilson JF, Bolton JL, McLachlan S, Price JF, Strachan MW, Robertson CM, Kleber ME, Delgado G, März W, Melander O, Dominiczak AF, Farrall M, Watkins H, Leusink M, Maitland-van der Zee AH, de Groot MC, Dudbridge F, Hingorani A, Ben-Shlomo Y, Lawlor DA; UCLEB Investigators, Amuzu A, Caufield M, Cavadino A, Cooper J, Davies TL; IN Day, Drenos F, Engmann J, Finan C, Giambartolomei C, Hardy R, Humphries SE, Hypponen E, Kivimaki M, Kuh D, Kumari M, Ong K, Plagnol V, Power C, Richards M, Shah S, Shah T, Sofat R, Talmud PJ, Wareham N, Warren H, Whittaker JC, Wong A, Zabaneh D, Davey Smith G, Wells JC, Leon DA, Holmes MV, Casas JP.

Int J Epidemiol. 2016 Dec 1;45(6):1927-1937. doi: 10.1093/ije/dyv074.

18.

Intravenous Furosemide for Acute Decompensated Congestive Heart Failure: What Is the Evidence?

Owen DR, MacAllister R, Sofat R.

Clin Pharmacol Ther. 2015 Aug;98(2):119-21. doi: 10.1002/cpt.120. Epub 2015 Jun 30. Review.

19.

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.

Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G, Gallacher J, Stewart MC, Tzoulaki I, Buxbaum SG, van der A DL, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Stepaniak U, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Veglia F, Ford I, Jukema JW, Westendorp RG, de Borst GJ, de Jong PA, Algra A, Spiering W, Maitland-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Eaton CB, Robinson JG, Duggan D; DIAGRAM Consortium; MAGIC Consortium; InterAct Consortium, Kjekshus J, Downs JR, Gotto AM, Keech AC, Marchioli R, Tognoni G, Sever PS, Poulter NR, Waters DD, Pedersen TR, Amarenco P, Nakamura H, McMurray JJ, Lewsey JD, Chasman DI, Ridker PM, Maggioni AP, Tavazzi L, Ray KK, Seshasai SR, Manson JE, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Schreiner PJ, Fornage M, Siscovick DS, Cushman M, Kumari M, Wareham NJ, Verschuren WM, Redline S, Patel SR, Whittaker JC, Hamsten A, Delaney JA, Dale C, Gaunt TR, Wong A, Kuh D, Hardy R, Kathiresan S, Castillo BA, van der Harst P, Brunner EJ, Tybjaerg-Hansen A, Marmot MG, Krauss RM, Tsai M, Coresh J, Hoogeveen RC, Psaty BM, Lange LA, Hakonarson H, Dudbridge F, Humphries SE, Talmud PJ, Kivimäki M, Timpson NJ, Langenberg C, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Reiner AP, Keating BJ, Hingorani AD, Sattar N.

Lancet. 2015 Jan 24;385(9965):351-61. doi: 10.1016/S0140-6736(14)61183-1. Epub 2014 Sep 24.

20.

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.

Holmes MV, Exeter HJ, Folkersen L, Nelson CP, Guardiola M, Cooper JA, Sofat R, Boekholdt SM, Khaw KT, Li KW, Smith AJ, Van't Hooft F, Eriksson P, Franco-Cereceda A, Asselbergs FW, Boer JM, Onland-Moret NC, Hofker M, Erdmann J, Kivimaki M, Kumari M, Reiner AP, Keating BJ, Humphries SE, Hingorani AD, Mallat Z, Samani NJ, Talmud PJ; CARDIoGRAM Consortium.

Circ Cardiovasc Genet. 2014 Apr;7(2):144-50. doi: 10.1161/CIRCGENETICS.113.000271. Epub 2014 Feb 21.

21.

Mendelian randomization of blood lipids for coronary heart disease.

Holmes MV, Asselbergs FW, Palmer TM, Drenos F, Lanktree MB, Nelson CP, Dale CE, Padmanabhan S, Finan C, Swerdlow DI, Tragante V, van Iperen EP, Sivapalaratnam S, Shah S, Elbers CC, Shah T, Engmann J, Giambartolomei C, White J, Zabaneh D, Sofat R, McLachlan S; UCLEB consortium, Doevendans PA, Balmforth AJ, Hall AS, North KE, Almoguera B, Hoogeveen RC, Cushman M, Fornage M, Patel SR, Redline S, Siscovick DS, Tsai MY, Karczewski KJ, Hofker MH, Verschuren WM, Bots ML, van der Schouw YT, Melander O, Dominiczak AF, Morris R, Ben-Shlomo Y, Price J, Kumari M, Baumert J, Peters A, Thorand B, Koenig W, Gaunt TR, Humphries SE, Clarke R, Watkins H, Farrall M, Wilson JG, Rich SS, de Bakker PI, Lange LA, Davey Smith G, Reiner AP, Talmud PJ, Kivimäki M, Lawlor DA, Dudbridge F, Samani NJ, Keating BJ, Hingorani AD, Casas JP.

Eur Heart J. 2015 Mar 1;36(9):539-50. doi: 10.1093/eurheartj/eht571. Epub 2014 Jan 27.

22.

Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D, Cavadino A, Finan C, Wong A, Amuzu A, Ong K, Gaunt T, Holmes MV, Warren H, Swerdlow DI, Davies TL, Drenos F, Cooper J, Sofat R, Caulfield M, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hypponen E, Richards M, Hardy R, Kuh D, Wareham N, Langenberg C, Ben-Shlomo Y, Day IN, Whincup P, Morris R, Strachan MW, Price J, Kumari M, Kivimaki M, Plagnol V, Dudbridge F, Whittaker JC, Casas JP, Hingorani AD; UCLEB Consortium.

PLoS One. 2013 Aug 20;8(8):e71345. doi: 10.1371/journal.pone.0071345. eCollection 2013. Erratum in: PLoS One. 2014;8(9): doi/10.1371/annotation/89b51e89-a415-49c7-9caa-8dfcf6fde855. Swerdlow, Daniel I [added]; Langenberg, Claudia [added].

23.

Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.

Alg VS, Sofat R, Houlden H, Werring DJ.

Neurology. 2013 Jun 4;80(23):2154-65. doi: 10.1212/WNL.0b013e318295d751. Review.

24.

Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.

Shah T, Zabaneh D, Gaunt T, Swerdlow DI, Shah S, Talmud PJ, Day IN, Whittaker J, Holmes MV, Sofat R, Humphries SE, Kivimaki M, Kumari M, Hingorani AD, Casas JP.

Circ Cardiovasc Genet. 2013 Apr;6(2):163-70. doi: 10.1161/CIRCGENETICS.112.964254. Epub 2013 Mar 16.

PMID:
23505291
25.

Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay.

Sofat R, Mangione PP, Gallimore JR, Hakobyan S, Hughes TR, Shah T, Goodship T, D'Aiuto F, Langenberg C, Wareham N, Morgan BP, Pepys MB, Hingorani AD.

J Immunol Methods. 2013 Apr 30;390(1-2):63-73. doi: 10.1016/j.jim.2013.01.009. Epub 2013 Jan 30.

PMID:
23376722
26.

Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trials.

Bodalia PN, Grosso AM, Sofat R, Macallister RJ, Smeeth L, Dhillon S, Casas JP, Wonderling D, Hingorani AD.

Br J Clin Pharmacol. 2013 Nov;76(5):649-67. doi: 10.1111/bcp.12083. Review.

27.

ARMS2 increases the risk of early and late age-related macular degeneration in the European Eye Study.

Chakravarthy U, McKay GJ, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J, Young IS, Sofat R, Hingorani AD, Fletcher AE.

Ophthalmology. 2013 Feb;120(2):342-8. doi: 10.1016/j.ophtha.2012.08.004. Epub 2012 Oct 23.

PMID:
23098369
28.

Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.

Shah S, Casas JP, Gaunt TR, Cooper J, Drenos F, Zabaneh D, Swerdlow DI, Shah T, Sofat R, Palmen J, Kumari M, Kivimaki M, Ebrahim S, Smith GD, Lawlor DA, Talmud PJ, Whittaker J, Day IN, Hingorani AD, Humphries SE.

Eur Heart J. 2013 Apr;34(13):972-81. doi: 10.1093/eurheartj/ehs243. Epub 2012 Sep 13.

29.

Is it important to measure or reduce C-reactive protein in people at risk of cardiovascular disease?

Hingorani AD, Sofat R, Morris RW, Whincup P, Lowe GD, Mindell J, Sattar N, Casas JP, Shah T.

Eur Heart J. 2012 Sep;33(18):2258-64. doi: 10.1093/eurheartj/ehs168. Epub 2012 Jul 5. No abstract available.

PMID:
22766581
30.

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JE, Shah T, Sofat R, Guo Y, Chung C, Peasey A, Pfister R, Mooijaart SP, Ireland HA, Leusink M, Langenberg C, Li KW, Palmen J, Howard P, Cooper JA, Drenos F, Hardy J, Nalls MA, Li YR, Lowe G, Stewart M, Bielinski SJ, Peto J, Timpson NJ, Gallacher J, Dunlop M, Houlston R, Tomlinson I, Tzoulaki I, Luan J, Boer JM, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Ferrucci L, Bandenelli S, Tanaka T, Meschia JF, Singleton A, Navis G, Mateo Leach I, Bakker SJ, Gansevoort RT, Ford I, Epstein SE, Burnett MS, Devaney JM, Jukema JW, Westendorp RG, Jan de Borst G, van der Graaf Y, de Jong PA, Mailand-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Stephens JW, Eaton CB, Robinson JG, Manson JE, Fowkes FG, Frayling TM, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Redline S, Lange LA, Kumari M, Wareham NJ, Verschuren WM, Benjamin EJ, Whittaker JC, Hamsten A, Dudbridge F, Delaney JA, Wong A, Kuh D, Hardy R, Castillo BA, Connolly JJ, van der Harst P, Brunner EJ, Marmot MG, Wassel CL, Humphries SE, Talmud PJ, Kivimaki M, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Hakonarson H, Reiner AP, Keating BJ, Sattar N, Hingorani AD, Casas JP.

Lancet. 2012 Mar 31;379(9822):1214-24. doi: 10.1016/S0140-6736(12)60110-X. Epub 2012 Mar 14.

31.

Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.

Sofat R, Casas JP, Webster AR, Bird AC, Mann SS, Yates JR, Moore AT, Sepp T, Cipriani V, Bunce C, Khan JC, Shahid H, Swaroop A, Abecasis G, Branham KE, Zareparsi S, Bergen AA, Klaver CC, Baas DC, Zhang K, Chen Y, Gibbs D, Weber BH, Keilhauer CN, Fritsche LG, Lotery A, Cree AJ, Griffiths HL, Bhattacharya SS, Chen LL, Jenkins SA, Peto T, Lathrop M, Leveillard T, Gorin MB, Weeks DE, Ortube MC, Ferrell RE, Jakobsdottir J, Conley YP, Rahu M, Seland JH, Soubrane G, Topouzis F, Vioque J, Tomazzoli L, Young I, Whittaker J, Chakravarthy U, de Jong PT, Smeeth L, Fletcher A, Hingorani AD.

Int J Epidemiol. 2012 Feb;41(1):250-62. doi: 10.1093/ije/dyr204. Epub 2012 Jan 13.

32.

Could NICE guidance on the choice of blood pressure lowering drugs be simplified?

Sofat R, Casas JP, Grosso AM, Prichard BN, Smeeth L, MacAllister R, Hingorani AD.

BMJ. 2012 Jan 13;344:d8078. doi: 10.1136/bmj.d8078. No abstract available.

33.

Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies.

McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, Ho L, de Jong PT, Fletcher AE, Young IS, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Hingorani AD, Sofat R, Dean M, Sawitzke J, Seddon JM, Peter I, Webster AR, Moore AT, Yates JR, Cipriani V, Fritsche LG, Weber BH, Keilhauer CN, Lotery AJ, Ennis S, Klein ML, Francis PJ, Stambolian D, Orlin A, Gorin MB, Weeks DE, Kuo CL, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Wright AF, Hayward C, Baird PN, Guymer RH, Attia J, Thakkinstian A, Silvestri G.

Hum Mutat. 2011 Dec;32(12):1407-16. doi: 10.1002/humu.21577. Epub 2011 Sep 12.

34.

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, Palmen J, Tzoulaki I, Wong A, Jefferis BJ, Maniatis N, Drenos F, Gigante B, Hardy R, Laxton RC, Leander K, Motterle A, Simpson IA, Smeeth L, Thomson A, Verzilli C, Kuh D, Ireland H, Deanfield J, Caulfield M, Wallace C, Samani N, Munroe PB, Lathrop M, Fowkes FG, Marmot M, Whincup PH, Whittaker JC, de Faire U, Kivimaki M, Kumari M, Hypponen E, Power C, Humphries SE, Talmud PJ, Price J, Morris RW, Ye S, Casas JP, Hingorani AD.

Eur Heart J. 2012 Feb;33(3):393-407. doi: 10.1093/eurheartj/ehr225. Epub 2011 Jul 30.

35.

Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials.

Holmes MV, Newcombe P, Hubacek JA, Sofat R, Ricketts SL, Cooper J, Breteler MM, Bautista LE, Sharma P, Whittaker JC, Smeeth L, Fowkes FG, Algra A, Shmeleva V, Szolnoki Z, Roest M, Linnebank M, Zacho J, Nalls MA, Singleton AB, Ferrucci L, Hardy J, Worrall BB, Rich SS, Matarin M, Norman PE, Flicker L, Almeida OP, van Bockxmeer FM, Shimokata H, Khaw KT, Wareham NJ, Bobak M, Sterne JA, Smith GD, Talmud PJ, van Duijn C, Humphries SE, Price JF, Ebrahim S, Lawlor DA, Hankey GJ, Meschia JF, Sandhu MS, Hingorani AD, Casas JP.

Lancet. 2011 Aug 13;378(9791):584-94. doi: 10.1016/S0140-6736(11)60872-6. Epub 2011 Jul 29.

36.

Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.

Zabaneh D, Gaunt TR, Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN, Humphries SE.

Ann Hum Genet. 2011 Jul;75(4):456-67. doi: 10.1111/j.1469-1809.2011.00654.x. Epub 2011 Apr 28.

37.

Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people.

McKay GJ, Silvestri G, Chakravarthy U, Dasari S, Fritsche LG, Weber BH, Keilhauer CN, Klein ML, Francis PJ, Klaver CC, Vingerling JR, Ho L, De Jong PT, Dean M, Sawitzke J, Baird PN, Guymer RH, Stambolian D, Orlin A, Seddon JM, Peter I, Wright AF, Hayward C, Lotery AJ, Ennis S, Gorin MB, Weeks DE, Kuo CL, Hingorani AD, Sofat R, Cipriani V, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Yates JR, Webster AR, Moore AT, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Young IS, Fletcher AE, Patterson CC.

Am J Epidemiol. 2011 Jun 15;173(12):1357-64. doi: 10.1093/aje/kwr015. Epub 2011 Apr 15. Review.

38.

Association of a sequence variant in DAB2IP with coronary heart disease.

Harrison SC, Cooper JA, Li K, Talmud PJ, Sofat R, Stephens JW, Hamsten A; HIFMECH Consortium, Sanders J, Montgomery H, Neil A; Simon Broome Research Consortium, Humphries SE.

Eur Heart J. 2012 Apr;33(7):881-8. doi: 10.1093/eurheartj/ehr075. Epub 2011 Mar 28.

39.

Translating genomics into improved healthcare.

Hingorani AD, Shah T, Kumari M, Sofat R, Smeeth L.

BMJ. 2010 Nov 5;341:c5945. doi: 10.1136/bmj.c5945. Review. No abstract available.

40.

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.

Sofat R, Casas JP, Kumari M, Talmud PJ, Ireland H, Kivimaki M, Marmot M, Hughes AD, Thom S, Ebrahim S, Whittaker JC, Smeeth L, Lawlor DA, Humphries SE, Hingorani AD.

Atherosclerosis. 2010 Nov;213(1):184-90. doi: 10.1016/j.atherosclerosis.2010.07.021. Epub 2010 Jul 29.

PMID:
20708732
41.

Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans.

Loukogeorgakis SP, van den Berg MJ, Sofat R, Nitsch D, Charakida M, Haiyee B, de Groot E, MacAllister RJ, Kuijpers TW, Deanfield JE.

Circulation. 2010 Jun 1;121(21):2310-6. doi: 10.1161/CIRCULATIONAHA.108.814731. Epub 2010 May 17.

PMID:
20479156
42.

PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.

Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN, Corsetti JP, Fowkes FG, Tzoulaki I, Kumari M, Brunner EJ, Kivimaki M, Marmot MG, Hoffmann MM, Winkler K, März W, Ye S, Stirnadel HA, Boekholdt SM, Khaw KT, Humphries SE, Sandhu MS, Hingorani AD, Talmud PJ.

Circulation. 2010 Jun 1;121(21):2284-93. doi: 10.1161/CIRCULATIONAHA.109.923383. Epub 2010 May 17. Erratum in: Circulation. 2010 Jul 20;122(3):e400. Boekholdt, S Matthijs [added].

43.

An ecological correlation study of late age-related macular degeneration and the complement factor H Y402H polymorphism.

Nonyane BA, Nitsch D, Whittaker JC, Sofat R, Smeeth L, Chakravarthy U, Fletcher AE.

Invest Ophthalmol Vis Sci. 2010 May;51(5):2393-402. doi: 10.1167/iovs.09-4228. Epub 2009 Dec 30.

44.

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.

Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu MS, Ricketts SL, Boekholdt SM, Wareham N, Khaw KT, Kumari M, Kivimaki M, Marmot M, Asselbergs FW, van der Harst P, Dullaart RP, Navis G, van Veldhuisen DJ, Van Gilst WH, Thompson JF, McCaskie P, Palmer LJ, Arca M, Quagliarini F, Gaudio C, Cambien F, Nicaud V, Poirer O, Gudnason V, Isaacs A, Witteman JC, van Duijn CM, Pencina M, Vasan RS, D'Agostino RB Sr, Ordovas J, Li TY, Kakko S, Kauma H, Savolainen MJ, Kesäniemi YA, Sandhofer A, Paulweber B, Sorli JV, Goto A, Yokoyama S, Okumura K, Horne BD, Packard C, Freeman D, Ford I, Sattar N, McCormack V, Lawlor DA, Ebrahim S, Smith GD, Kastelein JJ, Deanfield J, Casas JP.

Circulation. 2010 Jan 5;121(1):52-62. doi: 10.1161/CIRCULATIONAHA.109.865444. Epub 2009 Dec 21. Erratum in: Circulation. 2010 Feb 23;121(7):e216.

45.

A report on the Genetics of Complex Diseases meeting of the British Atherosclerosis Society, Cambridge, UK, 17-18 September 2009.

Holmes MV, Shah SH, Angelakopoulou A, Khan T, Swerdlow D, Kuchenbaecker K, Sofat R, Shah T.

Atherosclerosis. 2010 Feb;208(2):599-602. doi: 10.1016/j.atherosclerosis.2009.11.034. Epub 2009 Nov 26. No abstract available.

PMID:
20022008
46.

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium.

Am J Hum Genet. 2009 Nov;85(5):628-42. doi: 10.1016/j.ajhg.2009.10.014.

47.

Complex disease genetics: present and future translational applications.

Holmes MV, Shah SH, Angelakopoulou A, Khan T, Swerdlow D, Kuchenbaecker K, Sofat R, Shah T.

Genome Med. 2009;1(11):104. doi: 10.1186/gm104. Epub 2009 Nov 5.

48.

Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.

Shah T, Casas JP, Cooper JA, Tzoulaki I, Sofat R, McCormack V, Smeeth L, Deanfield JE, Lowe GD, Rumley A, Fowkes FG, Humphries SE, Hingorani AD.

Int J Epidemiol. 2009 Feb;38(1):217-31. doi: 10.1093/ije/dyn217. Epub 2008 Oct 17. Review. Erratum in: Int J Epidemiol. 2009 Jun;38(3):890.

49.

Bayesian meta-analysis of genetic association studies with different sets of markers.

Verzilli C, Shah T, Casas JP, Chapman J, Sandhu M, Debenham SL, Boekholdt MS, Khaw KT, Wareham NJ, Judson R, Benjamin EJ, Kathiresan S, Larson MG, Rong J, Sofat R, Humphries SE, Smeeth L, Cavalleri G, Whittaker JC, Hingorani AD.

Am J Hum Genet. 2008 Apr;82(4):859-72. doi: 10.1016/j.ajhg.2008.01.016.

50.

Is there a difference between the ability to kneel after unilateral and bilateral total knee replacement?

Sofat R, Ramkumar U, Wellsted D, Parmar H.

Acta Orthop Belg. 2006 Oct;72(5):578-82.

PMID:
17152421

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