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Items: 43

1.

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents.

Sijm M, Siciliano de Araújo J, Llorca AR, Orrling K, Stiny L, Matheeussen A, Maes L, de Esch IJP, Soeiro MNC, Sterk GJ, Leurs R.

ChemMedChem. 2019 Jul 18. doi: 10.1002/cmdc.201900370. [Epub ahead of print]

PMID:
31319019
2.

New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors.

Feitosa LM, da Silva ER, Hoelz LVB, Souza DL, Come JAASS, Cardoso-Santos C, Batista MM, Soeiro MNC, Boechat N, Pinheiro LCS.

Bioorg Med Chem. 2019 Jul 15;27(14):3061-3069. doi: 10.1016/j.bmc.2019.05.026. Epub 2019 May 17.

PMID:
31176565
3.

Repurposing strategies for Chagas disease therapy: the effect of imatinib and derivatives against Trypanosoma cruzi.

Simões-Silva MR, De Araújo JS, Peres RB, Da Silva PB, Batista MM, De Azevedo LD, Bastos MM, Bahia MT, Boechat N, Soeiro MNC.

Parasitology. 2019 Jul;146(8):1006-1012. doi: 10.1017/S0031182019000234. Epub 2019 Mar 12.

PMID:
30859917
4.

Imidazole Derivatives as Promising Agents for the Treatment of Chagas Disease.

de Araújo JS, García-Rubia A, Sebastián-Pérez V, Kalejaiye TD, Bernardino da Silva P, Fonseca-Berzal CR, Maes L, De Koning HP, Soeiro MNC, Gil C.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02156-18. doi: 10.1128/AAC.02156-18. Print 2019 Apr.

PMID:
30670432
5.

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi.

Guedes-da-Silva FH, Batista DDGJ, Da Silva CF, Pavão BP, Batista MM, Moreira OC, Souza LRQ, Britto C, Rachakonda G, Villalta F, Lepesheva GI, Soeiro MNC.

ACS Infect Dis. 2019 Mar 8;5(3):365-371. doi: 10.1021/acsinfecdis.8b00253. Epub 2019 Jan 23.

PMID:
30625275
6.

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae.

Friggeri L, Hargrove TY, Rachakonda G, Blobaum AL, Fisher P, de Oliveira GM, da Silva CF, Soeiro MNC, Nes WD, Lindsley CW, Villalta F, Guengerich FP, Lepesheva GI.

J Med Chem. 2018 Dec 13;61(23):10910-10921. doi: 10.1021/acs.jmedchem.8b01671. Epub 2018 Nov 30.

PMID:
30451500
7.

Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: In Vitro Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity.

Araujo-Lima CF, Peres RB, Silva PB, Batista MM, Aiub CAF, Felzenszwalb I, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00979-18. doi: 10.1128/AAC.00979-18. Print 2018 Sep.

8.

Atorvastatin Downregulates In Vitro Methyl Methanesulfonate and Cyclophosphamide Alkylation-Mediated Cellular and DNA Injuries.

Araujo-Lima CF, Christoni LSA, Justo G, Soeiro MNC, Aiub CAF, Felzenszwalb I.

Oxid Med Cell Longev. 2018 Apr 3;2018:7820890. doi: 10.1155/2018/7820890. eCollection 2018.

9.

New 1,2,3-triazole-based analogues of benznidazole for use against Trypanosoma cruzi infection: In vitro and in vivo evaluations.

Leite DI, Fontes FV, Bastos MM, Hoelz LVB, Bianco MDCAD, de Oliveira AP, da Silva PB, da Silva CF, Batista DDGJ, da Gama ANS, Peres RB, Villar JDF, Soeiro MNC, Boechat N.

Chem Biol Drug Des. 2018 Sep;92(3):1670-1682. doi: 10.1111/cbdd.13333. Epub 2018 Jun 13.

PMID:
29745048
10.

Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2-Benzyl-5-nitroindazole-Derived Amines.

Fonseca-Berzal C, Ibáñez-Escribano A, Vela N, Cumella J, Nogal-Ruiz JJ, Escario JA, da Silva PB, Batista MM, Soeiro MNC, Sifontes-Rodríguez S, Meneses-Marcel A, Gómez-Barrio A, Arán VJ.

ChemMedChem. 2018 Jun 20;13(12):1246-1259. doi: 10.1002/cmdc.201800084. Epub 2018 May 22.

PMID:
29624912
11.

Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.

Ferreira de Almeida Fiuza L, Peres RB, Simões-Silva MR, da Silva PB, Batista DDGJ, da Silva CF, Nefertiti Silva da Gama A, Krishna Reddy TR, Soeiro MNC.

Eur J Med Chem. 2018 Apr 10;149:257-268. doi: 10.1016/j.ejmech.2018.02.020. Epub 2018 Feb 23.

PMID:
29501946
12.

In Vitro, In Silico, and In Vivo Analyses of Novel Aromatic Amidines against Trypanosoma cruzi.

Santos CC, Lionel JR, Peres RB, Batista MM, da Silva PB, de Oliveira GM, da Silva CF, Batista DGJ, Souza SMO, Andrade CH, Neves BJ, Braga RC, Patrick DA, Bakunova SM, Tidwell RR, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02205-17. doi: 10.1128/AAC.02205-17. Print 2018 Feb.

13.

In Vitro and In Vivo Studies of the Trypanocidal Effect of Novel Quinolines.

Nefertiti ASG, Batista MM, Da Silva PB, Batista DGJ, Da Silva CF, Peres RB, Torres-Santos EC, Cunha-Junior EF, Holt E, Boykin DW, Brun R, Wenzler T, Soeiro MNC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01936-17. doi: 10.1128/AAC.01936-17. Print 2018 Feb.

14.

Drug repurposing strategy against Trypanosoma cruzi infection: In vitro and in vivo assessment of the activity of metronidazole in mono- and combined therapy.

Simões-Silva MR, De Araújo JS, Oliveira GM, Demarque KC, Peres RB, D'Almeida-Melo I, Batista DGJ, Da Silva CF, Cardoso-Santos C, Da Silva PB, Batista MM, Bahia MT, Soeiro MNC.

Biochem Pharmacol. 2017 Dec 1;145:46-53. doi: 10.1016/j.bcp.2017.08.025. Epub 2017 Sep 7.

PMID:
28870526
15.

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.

da Silva CF, Batista DDGJ, de Araújo JS, Cunha-Junior EF, Stephens CE, Banerjee M, Farahat AA, Akay S, Fisher MK, Boykin DW, Soeiro MNC.

Drug Des Devel Ther. 2017 Apr 3;11:1095-1105. doi: 10.2147/DDDT.S120618. eCollection 2017.

16.

Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.

Guedes-da-Silva FH, Batista DG, Da Silva CF, De Araújo JS, Pavão BP, Simões-Silva MR, Batista MM, Demarque KC, Moreira OC, Britto C, Lepesheva GI, Soeiro MN.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02098-16. doi: 10.1128/AAC.02098-16. Print 2017 Apr.

17.

Phenotypic Screening In Vitro of Novel Aromatic Amidines against Trypanosoma cruzi.

Simões-Silva MR, Nefertiti AS, De Araújo JS, Batista MM, Da Silva PB, Bahia MT, Menna-Barreto RS, Pavão BP, Green J, Farahat AA, Kumar A, Boykin DW, Soeiro MN.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4701-7. doi: 10.1128/AAC.01788-15. Print 2016 Aug.

18.

In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi.

Guedes-da-Silva FH, Batista DG, Meuser MB, Demarque KC, Fulco TO, Araújo JS, Da Silva PB, Da Silva CF, Patrick DA, Bakunova SM, Bakunov SA, Tidwell RR, Oliveira GM, Britto C, Moreira OC, Soeiro MN.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2425-34. doi: 10.1128/AAC.01667-15. Print 2016 Apr.

19.

Nucleoside triphosphate diphosphohydrolase1 (TcNTPDase-1) gene expression is increased due to heat shock and in infective forms of Trypanosoma cruzi.

Silva-Gomes NL, Ennes-Vidal V, Carolo JC, Batista MM, Soeiro MN, Menna-Barreto R, Moreira OC.

Parasit Vectors. 2014 Oct 5;7:463. doi: 10.1186/s13071-014-0463-0.

20.

In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.

Timm BL, Da Silva PB, Batista MM, Farahat AA, Kumar A, Boykin DW, Soeiro MN.

Parasitology. 2014 Sep;141(10):1272-6. doi: 10.1017/S0031182014000407. Epub 2014 Apr 15.

PMID:
24735493
21.

In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi.

De Araújo JS, Da Silva CF, Batista DG, Da Silva PB, Meuser MB, Aiub CA, da Silva MF, Araújo-Lima CF, Banerjee M, Farahat AA, Stephens CE, Kumar A, Boykin DW, Soeiro MN.

Antimicrob Agents Chemother. 2014 Jul;58(7):4191-5. doi: 10.1128/AAC.01403-13. Epub 2014 Mar 3.

22.

Novel amidines and analogues as promising agents against intracellular parasites: a systematic review.

Soeiro MN, Werbovetz K, Boykin DW, Wilson WD, Wang MZ, Hemphill A.

Parasitology. 2013 Jul;140(8):929-51. doi: 10.1017/S0031182013000292. Epub 2013 Apr 8. Review.

23.

The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.

Daliry A, Pires MQ, Silva CF, Pacheco RS, Munde M, Stephens CE, Kumar A, Ismail MA, Liu Z, Farahat AA, Akay S, Som P, Hu Q, Boykin DW, Wilson WD, De Castro SL, Soeiro MN.

Antimicrob Agents Chemother. 2011 Oct;55(10):4765-73. doi: 10.1128/AAC.00229-11. Epub 2011 Aug 1.

24.

Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi.

De Souza EM, da Silva PB, Nefertiti AS, Ismail MA, Arafa RK, Tao B, Nixon-Smith CK, Boykin DW, Soeiro MN.

Exp Parasitol. 2011 Feb;127(2):429-35. doi: 10.1016/j.exppara.2010.10.010. Epub 2010 Nov 11.

PMID:
20971106
25.

Differential apoptosis-like cell death in amastigote and trypomastigote forms from Trypanosoma cruzi-infected heart cells in vitro.

De Souza EM, Nefertiti AS, Bailly C, Lansiaux A, Soeiro MN.

Cell Tissue Res. 2010 Jul;341(1):173-80. doi: 10.1007/s00441-010-0985-5. Epub 2010 May 22.

PMID:
20495825
26.

Glycosylation patterns of human alpha2-macroglobulin: analysis of lectin binding by electron microscopy.

Paiva MM, Soeiro MN, Barbosa HS, Meirelles MN, Delain E, Araújo-Jorge TC.

Micron. 2010 Aug;41(6):666-73. doi: 10.1016/j.micron.2010.02.015. Epub 2010 Mar 6.

PMID:
20399104
27.

Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi.

Batista DG, Pacheco MG, Kumar A, Branowska D, Ismail MA, Hu L, Boykin DW, Soeiro MN.

Parasitology. 2010 Feb;137(2):251-9. doi: 10.1017/S0031182009991223. Epub 2009 Sep 21.

PMID:
19765349
28.

Trypanosoma cruzi targets for new chemotherapeutic approaches.

Soeiro MN, de Castro SL.

Expert Opin Ther Targets. 2009 Jan;13(1):105-21. doi: 10.1517/14728220802623881 . Review.

PMID:
19063710
29.

Diamidine activity against trypanosomes: the state of the art.

Soeiro MN, de Castro SL, de Souza EM, Batista DG, Silva CF, Boykin DW.

Curr Mol Pharmacol. 2008 Jun;1(2):151-61. Review.

PMID:
20021429
30.

Trypanosoma cruzi: alpha-2-macroglobulin regulates host cell apoptosis induced by the parasite infection in vitro.

De Souza EM, Meuser-Batista M, Batista DG, Duarte BB, Araújo-Jorge TC, Soeiro MN.

Exp Parasitol. 2008 Mar;118(3):331-7. Epub 2007 Sep 14.

PMID:
18028912
31.

Cellular effects of reversed amidines on Trypanosoma cruzi.

Silva CF, Meuser MB, De Souza EM, Meirelles MN, Stephens CE, Som P, Boykin DW, Soeiro MN.

Antimicrob Agents Chemother. 2007 Nov;51(11):3803-9. Epub 2007 Aug 13.

32.

Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi.

De Souza EM, Menna-Barreto R, Araújo-Jorge TC, Kumar A, Hu Q, Boykin DW, Soeiro MN.

Parasitology. 2006 Jul;133(Pt 1):75-9. Epub 2006 Mar 27.

PMID:
16563202
33.

Aromatic diamidines as antiparasitic agents.

Soeiro MN, De Souza EM, Stephens CE, Boykin DW.

Expert Opin Investig Drugs. 2005 Aug;14(8):957-72. Review.

PMID:
16050790
34.

Trypanosoma cruzi modulates the expression of Rabs and alters the endocytosis in mouse cardiomyocytes in vitro.

Batista DG, Silva CF, Mota RA, Costa LC, Meirelles MN, Meuser-Batista M, Soeiro MN.

J Histochem Cytochem. 2006 Jun;54(6):605-14. Epub 2005 Jul 11.

PMID:
16009966
35.

Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.

De Souza EM, Lansiaux A, Bailly C, Wilson WD, Hu Q, Boykin DW, Batista MM, Araújo-Jorge TC, Soeiro MN.

Biochem Pharmacol. 2004 Aug 15;68(4):593-600.

PMID:
15276066
36.

Host and parasite apoptosis following Trypanosoma cruzi infection in in vitro and in vivo models.

de Souza EM, Araújo-Jorge TC, Bailly C, Lansiaux A, Batista MM, Oliveira GM, Soeiro MN.

Cell Tissue Res. 2003 Nov;314(2):223-35. Epub 2003 Aug 20.

PMID:
12928860
37.

Trypanosoma cruzi Infection Impairs the Endocytosis of Zymosan A by Cardiomyocytes.

Soeiro MN, Mota RA, Batista DG, Pereira MC, Meirelles MN.

Pathobiology. 2002-2003;70(2):69-75.

PMID:
12476031
38.

Increased Trypanosoma cruzi invasion and heart fibrosis associated with high transforming growth factor beta levels in mice deficient in alpha(2)-macroglobulin.

Waghabi MC, Coutinho CM, Soeiro MN, Pereira MC, Feige JJ, Keramidas M, Cosson A, Minoprio P, Van Leuven F, Araújo-Jorge TC.

Infect Immun. 2002 Sep;70(9):5115-23.

39.

Trypanosoma cruzi-cardiomyocytes: new contributions regarding a better understanding of this interaction.

Meirelles MN, Pereira MC, Singer RH, Soeiro MN, Garzoni LR, Silva DT, Barbosa HS, Araujo-Jorge TC, Masuda MO, Capella MA, Lopes AG, Vermelho AB.

Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:149-52. Review.

40.

Alpha 2-macroglobulin in experimental and human Chagas' disease.

Araújo-Jorge TC, Luz MR, Coutinho CM, Medrano N, Soeiro MN, Meirelles MN, Isaac L, Van Leuven F.

Ann N Y Acad Sci. 1994 Sep 10;737:453-5. No abstract available.

PMID:
7524420
41.

The nature of anionic sites and the endocytic pathway in heart muscle cells.

Soeiro MN, Silva-Filho FC, Meirelles MN.

J Submicrosc Cytol Pathol. 1994 Jan;26(1):121-30.

PMID:
8149329
42.

Differential effect of amphotericin B on the three evolutive stages of Trypanosoma cruzi and on the host cell-parasite interaction.

de-Castro SL, Soeiro MN, Higashi KO, Meirelles MN.

Braz J Med Biol Res. 1993 Nov;26(11):1219-29.

PMID:
8136722
43.

Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells.

De Castro SL, Soeiro MN, De Meirelles Mde N.

Mem Inst Oswaldo Cruz. 1992 Apr-Jun;87(2):209-15.

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