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A new family of small-molecule CD4-mimetic compounds contact the highly conserved aspartic acid 368 of HIV-1 gp120 and mediates ADCC.

Ding S, Grenier MC, Tolbert WD, Vézina D, Sherburn R, Richard J, Prévost J, Chapleau JP, Gendron-Lepage G, Medjahed H, Abrams C, Sodroski J, Pazgier M, Smith AB 3rd, Finzi A.

J Virol. 2019 Sep 25. pii: JVI.01325-19. doi: 10.1128/JVI.01325-19. [Epub ahead of print]


CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies.

Ding S, Gasser R, Gendron-Lepage G, Medjahed H, Tolbert WD, Sodroski J, Pazgier M, Finzi A.

J Virol. 2019 Oct 29;93(22). pii: e01403-19. doi: 10.1128/JVI.01403-19. Print 2019 Nov 15.


Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer.

Zhao C, Princiotto AM, Nguyen HT, Zou S, Zhao ML, Zhang S, Herschhorn A, Farrell M, Pahil K, Melillo B, Sambasivarao SV, Abrams C, Smith AB 3rd, Madani N, Sodroski J.

J Virol. 2019 Oct 15;93(21). pii: e01197-19. doi: 10.1128/JVI.01197-19. Print 2019 Nov 1.


An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.

Alsahafi N, Bakouche N, Kazemi M, Richard J, Ding S, Bhattacharyya S, Das D, Anand SP, Prévost J, Tolbert WD, Lu H, Medjahed H, Gendron-Lepage G, Ortega Delgado GG, Kirk S, Melillo B, Mothes W, Sodroski J, Smith AB 3rd, Kaufmann DE, Wu X, Pazgier M, Rouiller I, Finzi A, Munro JB.

Cell Host Microbe. 2019 Apr 10;25(4):578-587.e5. doi: 10.1016/j.chom.2019.03.002.


Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W.

Nature. 2019 Apr;568(7752):415-419. doi: 10.1038/s41586-019-1101-y. Epub 2019 Apr 10.


Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function.

Nguyen HT, Alsahafi N, Finzi A, Sodroski JG.

J Virol. 2019 May 29;93(12). pii: e00304-19. doi: 10.1128/JVI.00304-19. Print 2019 Jun 15.


Robustness of signal detection in cryo-electron microscopy via a bi-objective-function approach.

Wang WL, Yu Z, Castillo-Menendez LR, Sodroski J, Mao Y.

BMC Bioinformatics. 2019 Apr 3;20(1):169. doi: 10.1186/s12859-019-2714-8.


Blocking HIV-1 Infection by Chromosomal Integrative Expression of Human CD4 on the Surface of Lactobacillus acidophilus ATCC 4356.

Wei W, Wiggins J, Hu D, Vrbanac V, Bowder D, Mellon M, Tager A, Sodroski J, Xiang SH.

J Virol. 2019 Apr 3;93(8). pii: e01830-18. doi: 10.1128/JVI.01830-18. Print 2019 Apr 15.


Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry.

Lai YT, Wang T, O'Dell S, Louder MK, Schön A, Cheung CSF, Chuang GY, Druz A, Lin B, McKee K, Peng D, Yang Y, Zhang B, Herschhorn A, Sodroski J, Bailer RT, Doria-Rose NA, Mascola JR, Langley DR, Kwong PD.

Nat Commun. 2019 Jan 3;10(1):47. doi: 10.1038/s41467-018-07851-1.


Conformational Differences between Functional Human Immunodeficiency Virus Envelope Glycoprotein Trimers and Stabilized Soluble Trimers.

Castillo-Menendez LR, Nguyen HT, Sodroski J.

J Virol. 2019 Jan 17;93(3). pii: e01709-18. doi: 10.1128/JVI.01709-18. Print 2019 Feb 1.


Visualization of HIV-1 RNA Transcription from Integrated HIV-1 DNA in Reactivated Latently Infected Cells.

Ukah OB, Puray-Chavez M, Tedbury PR, Herschhorn A, Sodroski JG, Sarafianos SG.

Viruses. 2018 Sep 30;10(10). pii: E534. doi: 10.3390/v10100534.


SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement.

Alsahafi N, Anand SP, Castillo-Menendez L, Verly MM, Medjahed H, Prévost J, Herschhorn A, Richard J, Schön A, Melillo B, Freire E, Smith AB 3rd, Sodroski J, Finzi A.

J Virol. 2018 Sep 12;92(19). pii: e01080-18. doi: 10.1128/JVI.01080-18. Print 2018 Oct 1.


Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses.

Bowder D, Hollingsead H, Durst K, Hu D, Wei W, Wiggins J, Medjahed H, Finzi A, Sodroski J, Xiang SH.

Virology. 2018 Aug;521:158-168. doi: 10.1016/j.virol.2018.06.005. Epub 2018 Jun 21.


A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge.

Madani N, Princiotto AM, Mach L, Ding S, Prevost J, Richard J, Hora B, Sutherland L, Zhao CA, Conn BP, Bradley T, Moody MA, Melillo B, Finzi A, Haynes BF, Smith Iii AB, Santra S, Sodroski J.

Nat Commun. 2018 Jun 18;9(1):2363. doi: 10.1038/s41467-018-04758-9.


Comparison of Uncleaved and Mature Human Immunodeficiency Virus Membrane Envelope Glycoprotein Trimers.

Castillo-Menendez LR, Witt K, Espy N, Princiotto A, Madani N, Pacheco B, Finzi A, Sodroski J.

J Virol. 2018 May 29;92(12). pii: e00277-18. doi: 10.1128/JVI.00277-18. Print 2018 Jun 15.


A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow-Liver-Thymus Humanized Mice From HIV-1 Infection.

Princiotto AM, Vrbanac VD, Melillo B, Park J, Tager AM, Smith AB 3rd, Sodroski J, Madani N.

J Infect Dis. 2018 Jul 2;218(3):471-475. doi: 10.1093/infdis/jiy174.


Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2018 Jan 8;9(1):158. doi: 10.1038/s41467-017-02463-7.


Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.

Schulte B, Selyutina A, Opp S, Herschhorn A, Sodroski JG, Pizzato M, Diaz-Griffero F.

Virology. 2018 Feb;515:52-65. doi: 10.1016/j.virol.2017.12.005. Epub 2017 Dec 18.


Folding DNA into a Lipid-Conjugated Nanobarrel for Controlled Reconstitution of Membrane Proteins.

Dong Y, Chen S, Zhang S, Sodroski J, Yang Z, Liu D, Mao Y.

Angew Chem Int Ed Engl. 2018 Feb 19;57(8):2072-2076. doi: 10.1002/anie.201710147. Epub 2018 Jan 9.


The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2017 Oct 19;8(1):1049. doi: 10.1038/s41467-017-01119-w. Erratum in: Nat Commun. 2018 Jan 8;9(1):158.


Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PD.

Nat Chem Biol. 2017 Oct;13(10):1115-1122. doi: 10.1038/nchembio.2460. Epub 2017 Aug 21.


An entry-competent intermediate state of the HIV-1 envelope glycoproteins.

Herschhorn A, Sodroski J.

Receptors Clin Investig. 2017;4(1). pii: e1544. doi: 10.14800/rci.1544. Epub 2017 May 24.


Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor.

Espy N, Pacheco B, Sodroski J.

Virology. 2017 Aug;508:90-107. doi: 10.1016/j.virol.2017.04.033. Epub 2017 May 15.


Induction of a Tier-1-Like Phenotype in Diverse Tier-2 Isolates by Agents That Guide HIV-1 Env to Perturbation-Sensitive, Nonnative States.

Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith AB 3rd, Madani N, Sodroski J, Haim H.

J Virol. 2017 Jul 12;91(15). pii: e00174-17. doi: 10.1128/JVI.00174-17. Print 2017 Aug 1.


BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity.

Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB 3rd, Sodroski J, Sauter D, Kirchhoff F, Gee K, Neil SJ, Evans DT, Finzi A.

J Virol. 2017 May 12;91(11). pii: e00219-17. doi: 10.1128/JVI.00219-17. Print 2017 Jun 1.


Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

Alam SM, Aussedat B, Vohra Y, Meyerhoff RR, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF.

Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7521. doi: 10.1126/scitranslmed.aai7521.


Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.

Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG.

Virol J. 2017 Feb 16;14(1):33. doi: 10.1186/s12985-017-0704-x.


Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers.

Go EP, Ding H, Zhang S, Ringe RP, Nicely N, Hua D, Steinbock RT, Golabek M, Alin J, Alam SM, Cupo A, Haynes BF, Kappes JC, Moore JP, Sodroski JG, Desaire H.

J Virol. 2017 Apr 13;91(9). pii: e02428-16. doi: 10.1128/JVI.02428-16. Print 2017 May 1.


Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs.

Witt KC, Castillo-Menendez L, Ding H, Espy N, Zhang S, Kappes JC, Sodroski J.

PLoS One. 2017 Feb 2;12(2):e0170672. doi: 10.1371/journal.pone.0170672. eCollection 2017.


Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses.

Prévost J, Zoubchenok D, Richard J, Veillette M, Pacheco B, Coutu M, Brassard N, Parsons MS, Ruxrungtham K, Bunupuradah T, Tovanabutra S, Hwang KK, Moody MA, Haynes BF, Bonsignori M, Sodroski J, Kaufmann DE, Shaw GM, Chenine AL, Finzi A.

J Virol. 2017 Mar 13;91(7). pii: e02452-16. doi: 10.1128/JVI.02452-16. Print 2017 Apr 1.


Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.

Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A.

J Virol. 2017 Feb 14;91(5). pii: e02219-16. doi: 10.1128/JVI.02219-16. Print 2017 Mar 1.


Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.

Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB 3rd, Sodroski J.

J Virol. 2017 Jan 18;91(3). pii: e01880-16. doi: 10.1128/JVI.01880-16. Print 2017 Feb 1.


Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes.

Pacheco B, Menéndez-Arias L, Sodroski J.

Sci Rep. 2016 Nov 23;6:37489. doi: 10.1038/srep37489.


Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates.

Ding S, Verly MM, Princiotto A, Melillo B, Moody AM, Bradley T, Easterhoff D, Roger M, Hahn BH, Madani N, Smith AB 3rd, Haynes BF, Sodroski J, Finzi A.

AIDS Res Hum Retroviruses. 2017 May;33(5):428-431. doi: 10.1089/AID.2016.0246. Epub 2016 Dec 19.


Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.

Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.

MBio. 2016 Oct 25;7(5). pii: e01598-16. doi: 10.1128/mBio.01598-16.


Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.

Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.

EBioMedicine. 2016 Oct;12:208-218. doi: 10.1016/j.ebiom.2016.09.004. Epub 2016 Sep 9.


Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity.

Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB 3rd, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF.

EBioMedicine. 2016 Oct;12:196-207. doi: 10.1016/j.ebiom.2016.08.045. Epub 2016 Aug 31.


Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.

Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM.

Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3413-22. doi: 10.1073/pnas.1606636113. Epub 2016 May 31.


Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.

Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB 3rd.

ACS Med Chem Lett. 2016 Jan 19;7(3):330-4. doi: 10.1021/acsmedchemlett.5b00471. eCollection 2016 Mar 10.


Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.

Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB 3rd, Karlsson Hedestam GB, Haynes B, Sodroski J.

J Virol. 2016 Apr 29;90(10):5031-5046. doi: 10.1128/JVI.03211-15. Print 2016 May 15.


HIV-Host Interactions: Implications for Vaccine Design.

Haynes BF, Shaw GM, Korber B, Kelsoe G, Sodroski J, Hahn BH, Borrow P, McMichael AJ.

Cell Host Microbe. 2016 Mar 9;19(3):292-303. doi: 10.1016/j.chom.2016.02.002. Epub 2016 Feb 25. Review.


Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity.

Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, Brassard N, Park J, Courter JR, Melillo B, Smith AB 3rd, Shaw GM, Hahn BH, Sodroski J, Kaufmann DE, Finzi A.

EBioMedicine. 2015 Dec 9;3:122-134. doi: 10.1016/j.ebiom.2015.12.004. eCollection 2016 Jan.


Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.

Lee WS, Richard J, Lichtfuss M, Smith AB 3rd, Park J, Courter JR, Melillo BN, Sodroski JG, Kaufmann DE, Finzi A, Parsons MS, Kent SJ.

J Virol. 2015 Dec 9;90(4):2021-30. doi: 10.1128/JVI.02717-15. Print 2016 Feb 15.


HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2.

Fernández-Oliva A, Finzi A, Haim H, Menéndez-Arias L, Sodroski J, Pacheco B.

J Virol. 2015 Oct 28;90(2):725-40. doi: 10.1128/JVI.02431-15. Print 2016 Jan 15.


Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses.

Moody MA, Gao F, Gurley TC, Amos JD, Kumar A, Hora B, Marshall DJ, Whitesides JF, Xia SM, Parks R, Lloyd KE, Hwang KK, Lu X, Bonsignori M, Finzi A, Vandergrift NA, Alam SM, Ferrari G, Shen X, Tomaras GD, Kamanga G, Cohen MS, Sam NE, Kapiga S, Gray ES, Tumba NL, Morris L, Zolla-Pazner S, Gorny MK, Mascola JR, Hahn BH, Shaw GM, Sodroski JG, Liao HX, Montefiori DC, Hraber PT, Korber BT, Haynes BF.

Cell Host Microbe. 2015 Sep 9;18(3):354-62. doi: 10.1016/j.chom.2015.08.006.


Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140.

Go EP, Herschhorn A, Gu C, Castillo-Menendez L, Zhang S, Mao Y, Chen H, Ding H, Wakefield JK, Hua D, Liao HX, Kappes JC, Sodroski J, Desaire H.

J Virol. 2015 Aug;89(16):8245-57. doi: 10.1128/JVI.00628-15. Epub 2015 May 27.


CD4 mimetics sensitize HIV-1-infected cells to ADCC.

Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A.

Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2687-94. doi: 10.1073/pnas.1506755112. Epub 2015 May 4.


Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer.

Alsahafi N, Debbeche O, Sodroski J, Finzi A.

PLoS One. 2015 Apr 7;10(4):e0122111. doi: 10.1371/journal.pone.0122111. eCollection 2015. Erratum in: PLoS One. 2015;10(5):e0129405.


Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8.

Zhang S, Sodroski J.

Virology. 2015 Jul;481:73-8. doi: 10.1016/j.virol.2015.01.034. Epub 2015 Mar 11.


Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.

Asmal M, Luedemann C, Lavine CL, Mach LV, Balachandran H, Brinkley C, Denny TN, Lewis MG, Anderson H, Pal R, Sok D, Le K, Pauthner M, Hahn BH, Shaw GM, Seaman MS, Letvin NL, Burton DR, Sodroski JG, Haynes BF, Santra S.

Virology. 2015 Jan 15;475:37-45. doi: 10.1016/j.virol.2014.10.032. Epub 2014 Nov 22.

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