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Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection.

Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL.

J Infect Dis. 2019 Oct 12. pii: jiz382. doi: 10.1093/infdis/jiz382. [Epub ahead of print]


Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques".

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

J Virol. 2019 Jan 17;93(3). pii: e01814-18. doi: 10.1128/JVI.01814-18. Print 2019 Feb 1. No abstract available.


Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques.

Mavigner M, Habib J, Deleage C, Rosen E, Mattingly C, Bricker K, Kashuba A, Amblard F, Schinazi RF, Lawson B, Vanderford TH, Jean S, Cohen J, McGary C, Paiardini M, Wood MP, Sodora DL, Silvestri G, Estes J, Chahroudi A.

J Virol. 2018 Aug 29;92(18). pii: e00562-18. doi: 10.1128/JVI.00562-18. Print 2018 Sep 15. Erratum in: J Virol. 2019 Jan 17;93(3):.


Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.

Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB.

Clin Infect Dis. 2018 Sep 28;67(8):1237-1246. doi: 10.1093/cid/ciy265.


Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

Fisher BS, Green RR, Brown RR, Wood MP, Hensley-McBain T, Fisher C, Chang J, Miller AD, Bosche WJ, Lifson JD, Mavigner M, Miller CJ, Gale M Jr, Silvestri G, Chahroudi A, Klatt NR, Sodora DL.

PLoS Pathog. 2018 Feb 21;14(2):e1006871. doi: 10.1371/journal.ppat.1006871. eCollection 2018 Feb.


T Cell Activation in South African HIV-Exposed Infants Correlates with Ochratoxin A Exposure.

Wood LF, Wood MP, Fisher BS, Jaspan HB, Sodora DL.

Front Immunol. 2017 Dec 22;8:1857. doi: 10.3389/fimmu.2017.01857. eCollection 2017.


Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host.

Palesch D, Bosinger SE, Tharp GK, Vanderford TH, Paiardini M, Chahroudi A, Johnson ZP, Kirchhoff F, Hahn BH, Norgren RB, Patel NB, Sodora DL, Dawoud RA, Stewart CB, Seepo SM, Harris RA, Liu Y, Raveendran M, Han Y, English A, Thomas GWC, Hahn MW, Pipes L, Mason CE, Muzny DM, Gibbs RA, Sauter D, Worley K, Rogers J, Silvestri G.

Nature. 2018 Jan 3;553(7686):77-81. doi: 10.1038/nature25140.


Increased soluble IL-7 receptor concentrations associate with improved IL-7 therapy outcomes in SIV-infected ART-treated Rhesus macaques.

Steele AK, Carrasco-Medina L, Sodora DL, Crawley AM.

PLoS One. 2017 Dec 19;12(12):e0188427. doi: 10.1371/journal.pone.0188427. eCollection 2017.


BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.

Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, Jaspan HB.

JCI Insight. 2017 Apr 6;2(7):e91963. doi: 10.1172/jci.insight.91963.


Nonpathogenic SIV and Pathogenic HIV Infections Associate with Disparate Innate Cytokine Signatures in Response to Mycobacterium bovis BCG.

Gasper MA, Biswas SP, Fisher BS, Ehnert SC, Sherman DR, Sodora DL.

PLoS One. 2016 Aug 9;11(8):e0158149. doi: 10.1371/journal.pone.0158149. eCollection 2016.


Delayed BCG vaccination results in minimal alterations in T cell immunogenicity of acellular pertussis and tetanus immunizations in HIV-exposed infants.

Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JA, Sodora DL, Gray CM, Jaspan HB.

Vaccine. 2015 Sep 11;33(38):4782-9. doi: 10.1016/j.vaccine.2015.07.096. Epub 2015 Aug 7.


Reduced Simian Immunodeficiency Virus Replication in Macrophages of Sooty Mangabeys Is Associated with Increased Expression of Host Restriction Factors.

Mir KD, Mavigner M, Wang C, Paiardini M, Sodora DL, Chahroudi AM, Bosinger SE, Silvestri G.

J Virol. 2015 Oct;89(20):10136-44. doi: 10.1128/JVI.00710-15. Epub 2015 Jul 22.


Characterization and Implementation of a Diverse Simian Immunodeficiency Virus SIVsm Envelope Panel in the Assessment of Neutralizing Antibody Breadth Elicited in Rhesus Macaques by Multimodal Vaccines Expressing the SIVmac239 Envelope.

Kilgore KM, Murphy MK, Burton SL, Wetzel KS, Smith SA, Xiao P, Reddy S, Francella N, Sodora DL, Silvestri G, Cole KS, Villinger F, Robinson JE, Pulendran B, Hunter E, Collman RG, Amara RR, Derdeyn CA.

J Virol. 2015 Aug;89(16):8130-51. doi: 10.1128/JVI.01221-14. Epub 2015 May 27.


Delaying BCG vaccination until 8 weeks of age results in robust BCG-specific T-cell responses in HIV-exposed infants.

Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB.

J Infect Dis. 2015 Feb 1;211(3):338-46. doi: 10.1093/infdis/jiu434. Epub 2014 Aug 8.


In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants.

Kidzeru EB, Hesseling AC, Passmore JA, Myer L, Gamieldien H, Tchakoute CT, Gray CM, Sodora DL, Jaspan HB.

AIDS. 2014 Jun 19;28(10):1421-30. doi: 10.1097/QAD.0000000000000292.


Natural killer cell and T-cell subset distributions and activation influence susceptibility to perinatal HIV-1 infection.

Gasper MA, Kunwar P, Itaya G, Lejarcegui N, Bosire R, Maleche-Obimbo E, Wamalwa D, Slyker J, Overbaugh J, Horton H, Sodora DL, John-Stewart G, Lohman-Payne B.

AIDS. 2014 May 15;28(8):1115-24. doi: 10.1097/QAD.0000000000000263.


Link between primate lentiviral coreceptor usage and Nef function.

Schmökel J, Li H, Shabir A, Yu H, Geyer M, Silvestri G, Sodora DL, Hahn BH, Kirchhoff F.

Cell Rep. 2013 Nov 27;5(4):997-1009. doi: 10.1016/j.celrep.2013.10.028. Epub 2013 Nov 21.


Early detection of simian immunodeficiency virus in the central nervous system following oral administration to rhesus macaques.

Milush JM, Chen HL, Atteberry G, Sodora DL.

Front Immunol. 2013 Aug 14;4:236. doi: 10.3389/fimmu.2013.00236. eCollection 2013.


Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.

Sundaravaradan V, Saleem R, Micci L, Gasper MA, Ortiz AM, Else J, Silvestri G, Paiardini M, Aitchison JD, Sodora DL.

PLoS Pathog. 2013;9(6):e1003441. doi: 10.1371/journal.ppat.1003441. Epub 2013 Jun 27.


The oral mucosa immune environment and oral transmission of HIV/SIV.

Wood LF, Chahroudi A, Chen HL, Jaspan HB, Sodora DL.

Immunol Rev. 2013 Jul;254(1):34-53. doi: 10.1111/imr.12078. Review.


Impact of mucosal inflammation on oral simian immunodeficiency virus transmission.

Giavedoni LD, Chen HL, Hodara VL, Chu L, Parodi LM, Smith LM, Sexton V, Cappelli D, Sodora DL.

J Virol. 2013 Feb;87(3):1750-8. doi: 10.1128/JVI.02079-12. Epub 2012 Nov 21.


Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.

Mir KD, Bosinger SE, Gasper M, Ho O, Else JG, Brenchley JM, Kelvin DJ, Silvestri G, Hu SL, Sodora DL.

J Virol. 2012 Jul;86(14):7605-15. doi: 10.1128/JVI.06813-11. Epub 2012 May 2.


Double-negative T cells during HIV/SIV infections: potential pinch hitters in the T-cell lineup.

Sundaravaradan V, Mir KD, Sodora DL.

Curr Opin HIV AIDS. 2012 Mar;7(2):164-71. doi: 10.1097/COH.0b013e3283504a66. Review.


Cloning and analysis of sooty mangabey alternative coreceptors that support simian immunodeficiency virus SIVsmm entry independently of CCR5.

Elliott ST, Riddick NE, Francella N, Paiardini M, Vanderford TH, Li B, Apetrei C, Sodora DL, Derdeyn CA, Silvestri G, Collman RG.

J Virol. 2012 Jan;86(2):898-908. doi: 10.1128/JVI.06415-11. Epub 2011 Nov 16.


Differential innate immune responses to low or high dose oral SIV challenge in Rhesus macaques.

Durudas A, Chen HL, Gasper MA, Sundaravaradan V, Milush JM, Silvestri G, Johnson W, Giavedoni LD, Sodora DL.

Curr HIV Res. 2011 Jul;9(5):276-88.


Generalized immune activation and innate immune responses in simian immunodeficiency virus infection.

Bosinger SE, Sodora DL, Silvestri G.

Curr Opin HIV AIDS. 2011 Sep;6(5):411-8. doi: 10.1097/COH.0b013e3283499cf6. Review.


Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4+ T cell loss is associated with double-negative T cells.

Milush JM, Mir KD, Sundaravaradan V, Gordon SN, Engram J, Cano CA, Reeves JD, Anton E, O'Neill E, Butler E, Hancock K, Cole KS, Brenchley JM, Else JG, Silvestri G, Sodora DL.

J Clin Invest. 2011 Mar;121(3):1102-10. doi: 10.1172/JCI44876. Epub 2011 Feb 7.


SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase.

Mir KD, Gasper MA, Sundaravaradan V, Sodora DL.

Microbes Infect. 2011 Jan;13(1):14-24. doi: 10.1016/j.micinf.2010.09.011. Epub 2010 Oct 15. Review.


A novel CCR5 mutation common in sooty mangabeys reveals SIVsmm infection of CCR5-null natural hosts and efficient alternative coreceptor use in vivo.

Riddick NE, Hermann EA, Loftin LM, Elliott ST, Wey WC, Cervasi B, Taaffe J, Engram JC, Li B, Else JG, Li Y, Hahn BH, Derdeyn CA, Sodora DL, Apetrei C, Paiardini M, Silvestri G, Collman RG.

PLoS Pathog. 2010 Aug 26;6(8):e1001064. doi: 10.1371/journal.ppat.1001064.


Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.

Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL.

J Immunol. 2010 Aug 1;185(3):1650-9. doi: 10.4049/jimmunol.0902626. Epub 2010 Jul 9.


HIV, mucosal tissues, and T helper 17 cells: where we come from, where we are, and where we go from here.

Sodora DL, Silvestri G.

Curr Opin HIV AIDS. 2010 Mar;5(2):111-3. doi: 10.1097/COH.0b013e328335c18f. No abstract available.


Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques.

Harris LD, Tabb B, Sodora DL, Paiardini M, Klatt NR, Douek DC, Silvestri G, Müller-Trutwin M, Vasile-Pandrea I, Apetrei C, Hirsch V, Lifson J, Brenchley JM, Estes JD.

J Virol. 2010 Aug;84(15):7886-91. doi: 10.1128/JVI.02612-09. Epub 2010 May 19.


Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates.

Engram JC, Cervasi B, Borghans JA, Klatt NR, Gordon SN, Chahroudi A, Else JG, Mittler RS, Sodora DL, de Boer RJ, Brenchley JM, Silvestri G, Paiardini M.

Blood. 2010 Aug 5;116(5):748-58. doi: 10.1182/blood-2010-01-263814. Epub 2010 May 18.


Nonpathogenic simian immunodeficiency virus infection of sooty mangabeys is not associated with high levels of autologous neutralizing antibodies.

Li B, Stefano-Cole K, Kuhrt DM, Gordon SN, Else JG, Mulenga J, Allen S, Sodora DL, Silvestri G, Derdeyn CA.

J Virol. 2010 Jun;84(12):6248-53. doi: 10.1128/JVI.00295-10. Epub 2010 Apr 7.


Evidence of early B-cell dysregulation in simian immunodeficiency virus infection: rapid depletion of naïve and memory B-cell subsets with delayed reconstitution of the naïve B-cell population.

Kuhrt D, Faith SA, Leone A, Rohankedkar M, Sodora DL, Picker LJ, Cole KS.

J Virol. 2010 Mar;84(5):2466-76. doi: 10.1128/JVI.01966-09. Epub 2009 Dec 23.


Elevated levels of innate immune modulators in lymph nodes and blood are associated with more-rapid disease progression in simian immunodeficiency virus-infected monkeys.

Durudas A, Milush JM, Chen HL, Engram JC, Silvestri G, Sodora DL.

J Virol. 2009 Dec;83(23):12229-40. doi: 10.1128/JVI.01311-09. Epub 2009 Sep 16.


Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts.

Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, Else JG, Estes JD, Hahn BH, Hirsch VM, Kaur A, Kirchhoff F, Muller-Trutwin M, Pandrea I, Schmitz JE, Silvestri G.

Nat Med. 2009 Aug;15(8):861-5. doi: 10.1038/nm.2013. Review.


Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.

Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ.

J Exp Med. 2009 Jul 6;206(7):1575-88. doi: 10.1084/jem.20090356. Epub 2009 Jun 22.


IL-2, IL-7 and IL-15 as immuno-modulators during SIV/HIV vaccination and treatment.

Leone A, Picker LJ, Sodora DL.

Curr HIV Res. 2009 Jan;7(1):83-90. Review.


Simian immunodeficiency virus pathogenesis.

Sodora DL, Ross TM.

Curr HIV Res. 2009 Jan;7(1):1. No abstract available.


Gamma/Delta T cell mRNA levels decrease at mucosal sites and increase at lymphoid sites following an oral SIV infection of macaques.

Kosub DA, Durudas A, Lehrman G, Milush JM, Cano CA, Jain MK, Sodora DL.

Curr HIV Res. 2008 Nov;6(6):520-30.


Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.

Paiardini M, Cervasi B, Engram JC, Gordon SN, Klatt NR, Muthukumar A, Else J, Mittler RS, Staprans SI, Sodora DL, Silvestri G.

Blood. 2009 Jan 15;113(3):612-21. doi: 10.1182/blood-2008-06-159442. Epub 2008 Oct 1.


Into the wild: simian immunodeficiency virus (SIV) infection in natural hosts.

Pandrea I, Sodora DL, Silvestri G, Apetrei C.

Trends Immunol. 2008 Sep;29(9):419-28. doi: 10.1016/ Review.


Inefficient Nef-mediated downmodulation of CD3 and MHC-I correlates with loss of CD4+T cells in natural SIV infection.

Schindler M, Schmökel J, Specht A, Li H, Münch J, Khalid M, Sodora DL, Hahn BH, Silvestri G, Kirchhoff F.

PLoS Pathog. 2008 Jul 18;4(7):e1000107. doi: 10.1371/journal.ppat.1000107.


Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.

Klatt NR, Villinger F, Bostik P, Gordon SN, Pereira L, Engram JC, Mayne A, Dunham RM, Lawson B, Ratcliffe SJ, Sodora DL, Else J, Reimann K, Staprans SI, Haase AT, Estes JD, Silvestri G, Ansari AA.

J Clin Invest. 2008 Jun;118(6):2039-49. doi: 10.1172/JCI33814.


CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.

Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G.

J Immunol. 2008 Apr 15;180(8):5582-92.


Immune activation and AIDS pathogenesis.

Sodora DL, Silvestri G.

AIDS. 2008 Feb 19;22(4):439-46. doi: 10.1097/QAD.0b013e3282f2dbe7. No abstract available.


Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis.

Gordon SN, Dunham RM, Engram JC, Estes J, Wang Z, Klatt NR, Paiardini M, Pandrea IV, Apetrei C, Sodora DL, Lee HY, Haase AT, Miller MD, Kaur A, Staprans SI, Perelson AS, Feinberg MB, Silvestri G.

J Virol. 2008 Apr;82(7):3725-35. doi: 10.1128/JVI.02408-07. Epub 2008 Jan 23.


Gamma/Delta T-cell functional responses differ after pathogenic human immunodeficiency virus and nonpathogenic simian immunodeficiency virus infections.

Kosub DA, Lehrman G, Milush JM, Zhou D, Chacko E, Leone A, Gordon S, Silvestri G, Else JG, Keiser P, Jain MK, Sodora DL.

J Virol. 2008 Feb;82(3):1155-65. Epub 2007 Nov 28.


Understanding the benign nature of SIV infection in natural hosts.

Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL.

J Clin Invest. 2007 Nov;117(11):3148-54. Review.

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