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Items: 1 to 50 of 80

1.

A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice.

Sodhi CP, Nguyen J, Yamaguchi Y, Werts AD, Lu P, Ladd MR, Fulton WB, Kovler ML, Wang S, Prindle T Jr, Zhang Y, Lazartigues ED, Holtzman MJ, Alcorn JF, Hackam DJ, Jia H.

J Immunol. 2019 Dec 1;203(11):3000-3012. doi: 10.4049/jimmunol.1900579. Epub 2019 Oct 23.

PMID:
31645418
2.

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.

Chen L, Strohmeier V, He Z, Deshpande M, Catalan-Dibene J, Durum SK, Moran TM, Kraus T, Xiong H, Faith JJ, Sodhi CP, Hackam DJ, Lira SA, Furtado GC.

Nat Commun. 2019 Oct 4;10(1):4517. doi: 10.1038/s41467-019-12540-8.

3.

Development of Intestinal Scaffolds that Mimic Native Mammalian Intestinal Tissue.

Ladd MR, Costello CM, Gosztyla C, Werts AD, Johnson B, Fulton WB, Martin LY, Redfield EJ, Crawford B, Panaparambil R, Sodhi CP, March JC, Hackam DJ.

Tissue Eng Part A. 2019 Sep;25(17-18):1225-1241. doi: 10.1089/ten.TEA.2018.0239. Epub 2019 Sep 3.

PMID:
30652526
4.

The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model.

Sung J, Sodhi CP, Voltaggio L, Hou X, Jia H, Zhou Q, Čiháková D, Hackam DJ.

Mucosal Immunol. 2019 Mar;12(2):503-517. doi: 10.1038/s41385-018-0123-3. Epub 2019 Jan 7.

5.

Cognitive impairments induced by necrotizing enterocolitis can be prevented by inhibiting microglial activation in mouse brain.

Niño DF, Zhou Q, Yamaguchi Y, Martin LY, Wang S, Fulton WB, Jia H, Lu P, Prindle T Jr, Zhang F, Crawford J, Hou Z, Mori S, Chen LL, Guajardo A, Fatemi A, Pletnikov M, Kannan RM, Kannan S, Sodhi CP, Hackam DJ.

Sci Transl Med. 2018 Dec 12;10(471). pii: eaan0237. doi: 10.1126/scitranslmed.aan0237.

PMID:
30541786
6.

Fat composition in infant formula contributes to the severity of necrotising enterocolitis.

Sodhi CP, Fulton WB, Good M, Vurma M, Das T, Lai CS, Jia H, Yamaguchi Y, Lu P, Prindle T, Ozolek JA, Hackam DJ.

Br J Nutr. 2018 Sep;120(6):665-680. doi: 10.1017/S0007114518001836.

7.

Toll Like Receptor 4 Mediated Lymphocyte Imbalance Induces Nec-Induced Lung Injury.

Jia H, Sodhi CP, Yamaguchi Y, Lu P, Ladd MR, Werts A, Fulton WB, Wang S, Prindle T Jr, Hackam DJ.

Shock. 2019 Aug;52(2):215-223. doi: 10.1097/SHK.0000000000001255.

PMID:
30148762
8.

Toll-Like Receptor-Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis.

Hackam DJ, Sodhi CP.

Cell Mol Gastroenterol Hepatol. 2018 Apr 6;6(2):229-238.e1. doi: 10.1016/j.jcmgh.2018.04.001. eCollection 2018. Review.

9.

New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment.

Hackam DJ, Sodhi CP, Good M.

J Pediatr Surg. 2019 Mar;54(3):398-404. doi: 10.1016/j.jpedsurg.2018.06.012. Epub 2018 Jun 18. Review.

PMID:
29980346
10.

The Development of Newborn Porcine Models for Evaluation of Tissue-Engineered Small Intestine.

Ladd MR, Martin LY, Werts A, Costello C, Sodhi CP, Fulton WB, March JC, Hackam DJ.

Tissue Eng Part C Methods. 2018 Jun;24(6):331-345. doi: 10.1089/ten.TEC.2018.0040. Epub 2018 May 7.

11.

Early detection of necrotizing enterocolitis using broadband optical spectroscopy.

Goldstein SD, Beaulieu RJ, Niño DF, Chun Y, Banerjee A, Sodhi CP, Hackam DJ.

J Pediatr Surg. 2018 Jun;53(6):1192-1196. doi: 10.1016/j.jpedsurg.2018.02.083. Epub 2018 Mar 7.

12.

Intestinal epithelial Toll-like receptor 4 prevents metabolic syndrome by regulating interactions between microbes and intestinal epithelial cells in mice.

Lu P, Sodhi CP, Yamaguchi Y, Jia H, Prindle T Jr, Fulton WB, Vikram A, Bibby KJ, Morowitz MJ, Hackam DJ.

Mucosal Immunol. 2018 May;11(3):727-740. doi: 10.1038/mi.2017.114. Epub 2018 Jan 24.

13.

Tissue engineering for the treatment of short bowel syndrome in children.

Martin LY, Ladd MR, Werts A, Sodhi CP, March JC, Hackam DJ.

Pediatr Res. 2018 Jan;83(1-2):249-257. doi: 10.1038/pr.2017.234. Epub 2017 Nov 1. Review.

14.

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.

Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, Prindle T, Fulton WB, Wang S, McCray PB Jr, Chappell M, Hackam DJ, Jia H.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L17-L31. doi: 10.1152/ajplung.00498.2016. Epub 2017 Sep 21.

15.

TLR4 Inactivation in Myeloid Cells Accelerates Bone Healing of a Calvarial Defect Model in Mice.

Wang D, Gilbert JR, Taylor GM, Sodhi CP, Hackam DJ, Losee JE, Billiar TR, Cooper GM.

Plast Reconstr Surg. 2017 Aug;140(2):296e-306e. doi: 10.1097/PRS.0000000000003541.

16.

Myocardial oxidative stress correlates with left ventricular dysfunction on strain echocardiography in a rodent model of sepsis.

Haileselassie B, Su E, Pozios I, Niño DF, Liu H, Lu DY, Ventoulis I, Fulton WB, Sodhi CP, Hackam D, O'Rourke B, Abraham T.

Intensive Care Med Exp. 2017 Dec;5(1):21. doi: 10.1186/s40635-017-0134-5. Epub 2017 Apr 12.

17.

Enhanced Calvarial Bone Healing in CD11c-TLR4-/- and MyD88-/- Mice.

Wang D, Taylor GM, Gilbert JR, Losee JE, Sodhi CP, Hackam DJ, Billiar TR, Cooper GM.

Plast Reconstr Surg. 2017 Apr;139(4):933e-940e. doi: 10.1097/PRS.0000000000003206.

18.

The human milk oligosaccharide 2'-fucosyllactose attenuates the severity of experimental necrotising enterocolitis by enhancing mesenteric perfusion in the neonatal intestine.

Good M, Sodhi CP, Yamaguchi Y, Jia H, Lu P, Fulton WB, Martin LY, Prindle T, Nino DF, Zhou Q, Ma C, Ozolek JA, Buck RH, Goehring KC, Hackam DJ.

Br J Nutr. 2016 Oct;116(7):1175-1187. Epub 2016 Sep 9.

19.

Necrotizing enterocolitis: new insights into pathogenesis and mechanisms.

Niño DF, Sodhi CP, Hackam DJ.

Nat Rev Gastroenterol Hepatol. 2016 Oct;13(10):590-600. doi: 10.1038/nrgastro.2016.119. Epub 2016 Aug 18. Review.

20.

Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells.

Niño DF, Sodhi CP, Egan CE, Zhou Q, Lin J, Lu P, Yamaguchi Y, Jia H, Martin LY, Good M, Fulton WB, Prindle T Jr, Ozolek JA, Hackam DJ.

Shock. 2017 Jan;47(1):22-32.

21.

Pulmonary Epithelial TLR4 Activation Leads to Lung Injury in Neonatal Necrotizing Enterocolitis.

Jia H, Sodhi CP, Yamaguchi Y, Lu P, Martin LY, Good M, Zhou Q, Sung J, Fulton WB, Nino DF, Prindle T Jr, Ozolek JA, Hackam DJ.

J Immunol. 2016 Aug 1;197(3):859-71. doi: 10.4049/jimmunol.1600618. Epub 2016 Jun 15.

22.

Peroxisome Proliferator-activated Receptor-γ Coactivator 1-α (PGC1α) Protects against Experimental Murine Colitis.

Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP.

J Biol Chem. 2016 May 6;291(19):10184-200. doi: 10.1074/jbc.M115.688812. Epub 2016 Mar 11.

23.

Generation of an artificial intestine for the management of short bowel syndrome.

Ladd MR, Niño DF, March JC, Sodhi CP, Hackam DJ.

Curr Opin Organ Transplant. 2016 Apr;21(2):178-85. doi: 10.1097/MOT.0000000000000284. Review.

24.

Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis.

Egan CE, Sodhi CP, Good M, Lin J, Jia H, Yamaguchi Y, Lu P, Ma C, Branca MF, Weyandt S, Fulton WB, Niño DF, Prindle T Jr, Ozolek JA, Hackam DJ.

J Clin Invest. 2016 Feb;126(2):495-508.

25.

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D.

J Clin Invest. 2016 Feb;126(2):695-705.

26.

Toll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis.

Deng M, Ma T, Yan Z, Zettel KR, Scott MJ, Liao H, Frank A, Morelli AE, Sodhi CP, Hackam DJ, Billiar TR.

J Infect Dis. 2016 Apr 15;213(8):1280-8. doi: 10.1093/infdis/jiv562. Epub 2015 Nov 24.

27.

Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals.

Shaffiey SA, Jia H, Keane T, Costello C, Wasserman D, Quidgley M, Dziki J, Badylak S, Sodhi CP, March JC, Hackam DJ.

Regen Med. 2016 Jan;11(1):45-61. doi: 10.2217/rme.15.70. Epub 2015 Sep 23.

28.

Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4).

Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T Jr, Lu P, Brodsky JL, Hackam DJ.

Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.

29.

Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll-like receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor.

Good M, Sodhi CP, Egan CE, Afrazi A, Jia H, Yamaguchi Y, Lu P, Branca MF, Ma C, Prindle T Jr, Mielo S, Pompa A, Hodzic Z, Ozolek JA, Hackam DJ.

Mucosal Immunol. 2015 Sep;8(5):1166-79. doi: 10.1038/mi.2015.30. Epub 2015 Apr 22.

30.

Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut.

Sodhi CP, Jia H, Yamaguchi Y, Lu P, Good M, Egan C, Ozolek J, Zhu X, Billiar TR, Hackam DJ.

J Immunol. 2015 May 15;194(10):4931-9. doi: 10.4049/jimmunol.1402490. Epub 2015 Apr 10.

31.

Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus.

Buchholz BM, Shapiro RA, Vodovotz Y, Billiar TR, Sodhi CP, Hackam DJ, Bauer AJ.

Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G852-62. doi: 10.1152/ajpgi.00211.2014. Epub 2015 Mar 6.

32.

Mucosa-associated bacterial diversity in necrotizing enterocolitis.

Brower-Sinning R, Zhong D, Good M, Firek B, Baker R, Sodhi CP, Hackam DJ, Morowitz MJ.

PLoS One. 2014 Sep 9;9(9):e105046. doi: 10.1371/journal.pone.0105046. eCollection 2014.

33.

Toll-like receptor 4 regulates platelet function and contributes to coagulation abnormality and organ injury in hemorrhagic shock and resuscitation.

Ding N, Chen G, Hoffman R, Loughran PA, Sodhi CP, Hackam DJ, Billiar TR, Neal MD.

Circ Cardiovasc Genet. 2014 Oct;7(5):615-24. doi: 10.1161/CIRCGENETICS.113.000398. Epub 2014 Jul 21.

34.

Evidence-based feeding strategies before and after the development of necrotizing enterocolitis.

Good M, Sodhi CP, Hackam DJ.

Expert Rev Clin Immunol. 2014 Jul;10(7):875-84. doi: 10.1586/1744666X.2014.913481. Epub 2014 Jun 5. Review.

35.

Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges.

Lu P, Sodhi CP, Jia H, Shaffiey S, Good M, Branca MF, Hackam DJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G917-28. doi: 10.1152/ajpgi.00422.2013. Epub 2014 Apr 24.

36.

Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9.

Good M, Sodhi CP, Ozolek JA, Buck RH, Goehring KC, Thomas DL, Vikram A, Bibby K, Morowitz MJ, Firek B, Lu P, Hackam DJ.

Am J Physiol Gastrointest Liver Physiol. 2014 Jun 1;306(11):G1021-32. doi: 10.1152/ajpgi.00452.2013. Epub 2014 Apr 17.

37.

Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension.

Bauer EM, Chanthaphavong RS, Sodhi CP, Hackam DJ, Billiar TR, Bauer PM.

Circ Res. 2014 May 9;114(10):1596-600. doi: 10.1161/CIRCRESAHA.114.303662. Epub 2014 Mar 17.

38.

Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis.

Afrazi A, Branca MF, Sodhi CP, Good M, Yamaguchi Y, Egan CE, Lu P, Jia H, Shaffiey S, Lin J, Ma C, Vincent G, Prindle T Jr, Weyandt S, Neal MD, Ozolek JA, Wiersch J, Tschurtschenthaler M, Shiota C, Gittes GK, Billiar TR, Mollen K, Kaser A, Blumberg R, Hackam DJ.

J Biol Chem. 2014 Apr 4;289(14):9584-99. doi: 10.1074/jbc.M113.526517. Epub 2014 Feb 11.

39.

Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis.

Lu P, Sodhi CP, Hackam DJ.

Pathophysiology. 2014 Feb;21(1):81-93. doi: 10.1016/j.pathophys.2013.11.007. Epub 2013 Dec 22.

40.

Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors.

Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T Jr, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ.

PLoS One. 2013 Jun 12;8(6):e65779. doi: 10.1371/journal.pone.0065779. Print 2013.

41.

Innate immune signaling in the pathogenesis of necrotizing enterocolitis.

Hackam DJ, Afrazi A, Good M, Sodhi CP.

Clin Dev Immunol. 2013;2013:475415. doi: 10.1155/2013/475415. Epub 2013 May 23. Review.

42.

Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS-NO-nitrite signaling.

Yazji I, Sodhi CP, Lee EK, Good M, Egan CE, Afrazi A, Neal MD, Jia H, Lin J, Ma C, Branca MF, Prindle T, Richardson WM, Ozolek J, Billiar TR, Binion DG, Gladwin MT, Hackam DJ.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9451-6. doi: 10.1073/pnas.1219997110. Epub 2013 May 6.

43.

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch.

Hackam DJ, Good M, Sodhi CP.

Semin Pediatr Surg. 2013 May;22(2):76-82. doi: 10.1053/j.sempedsurg.2013.01.003. Review.

44.

Cellular-specific role of toll-like receptor 4 in hepatic ischemia-reperfusion injury in mice.

Nace GW, Huang H, Klune JR, Eid RE, Rosborough BR, Korff S, Li S, Shapiro RA, Stolz DB, Sodhi CP, Hackam DJ, Geller DA, Billiar TR, Tsung A.

Hepatology. 2013 Jul;58(1):374-87. doi: 10.1002/hep.26346. Epub 2013 May 27.

45.

A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis.

Neal MD, Sodhi CP, Dyer M, Craig BT, Good M, Jia H, Yazji I, Afrazi A, Richardson WM, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca MF, Ozolek J, Hackam DJ.

J Immunol. 2013 Apr 1;190(7):3541-51. doi: 10.4049/jimmunol.1202264. Epub 2013 Mar 1.

46.

Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.

Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ.

J Biol Chem. 2012 Oct 26;287(44):37296-308. doi: 10.1074/jbc.M112.375881. Epub 2012 Sep 6.

47.

Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice.

Sodhi CP, Neal MD, Siggers R, Sho S, Ma C, Branca MF, Prindle T Jr, Russo AM, Afrazi A, Good M, Brower-Sinning R, Firek B, Morowitz MJ, Ozolek JA, Gittes GK, Billiar TR, Hackam DJ.

Gastroenterology. 2012 Sep;143(3):708-718.e5. doi: 10.1053/j.gastro.2012.05.053. Epub 2012 Jul 13.

48.

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium.

Good M, Siggers RH, Sodhi CP, Afrazi A, Alkhudari F, Egan CE, Neal MD, Yazji I, Jia H, Lin J, Branca MF, Ma C, Prindle T, Grant Z, Shah S, Slagle D 2nd, Paredes J, Ozolek J, Gittes GK, Hackam DJ.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11330-5. doi: 10.1073/pnas.1200856109. Epub 2012 Jun 25.

49.

Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis.

Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS.

PLoS One. 2012;7(5):e36560. doi: 10.1371/journal.pone.0036560. Epub 2012 May 17.

50.

Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium.

Afrazi A, Sodhi CP, Good M, Jia H, Siggers R, Yazji I, Ma C, Neal MD, Prindle T, Grant ZS, Branca MF, Ozolek J, Chang EB, Hackam DJ.

J Immunol. 2012 May 1;188(9):4543-57. doi: 10.4049/jimmunol.1103114. Epub 2012 Mar 28.

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