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Items: 1 to 50 of 124

1.

Involvement of central nervous system in adult patients with acute myeloid leukemia: Incidence and impact on outcome.

Del Principe MI, Buccisano F, Soddu S, Maurillo L, Cefalo M, Piciocchi A, Consalvo MI, Paterno G, Sarlo C, De Bellis E, Zizzari A, De Angelis G, Fraboni D, Divona M, Voso MT, Sconocchia G, Del Poeta G, Lo-Coco F, Arcese W, Amadori S, Venditti A.

Semin Hematol. 2018 Oct;55(4):209-214. doi: 10.1053/j.seminhematol.2018.02.006. Epub 2018 Feb 21. Review.

PMID:
30502849
2.

Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia.

Fedullo AL, Messina M, Elia L, Piciocchi A, Gianfelici V, Lauretti A, Soddu S, Puzzolo MC, Minotti C, Ferrara F, Martino B, Chiusolo P, Calafiore V, Paolini S, Vignetti M, Vitale A, Guarini A, Foà R, Chiaretti S.

Haematologica. 2019 Feb;104(2):312-318. doi: 10.3324/haematol.2018.196055. Epub 2018 Sep 6.

3.

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.

Petroni M, Sardina F, Infante P, Bartolazzi A, Locatelli E, Fabretti F, Di Giulio S, Capalbo C, Cardinali B, Coppa A, Tessitore A, Colicchia V, Sahùn Roncero M, Belardinilli F, Di Marcotullio L, Soddu S, Comes Franchini M, Petricci E, Gulino A, Giannini G.

Cell Death Dis. 2018 Aug 30;9(9):895. doi: 10.1038/s41419-018-0924-z.

4.

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.

La Torre M, Merigliano C, Burla R, Mottini C, Zanetti G, Del Giudice S, Carcuro M, Virdia I, Bucciarelli E, Manni I, Vinciguerra GR, Piaggio G, Riminucci M, Cumano A, Bartolazzi A, Vernì F, Soddu S, Gatti M, Saggio I.

Aging Cell. 2018 Apr 10:e12730. doi: 10.1111/acel.12730. [Epub ahead of print]

5.

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis.

Monteonofrio L, Valente D, Ferrara M, Camerini S, Miscione R, Crescenzi M, Rinaldo C, Soddu S.

Oncogene. 2018 Jun;37(26):3562-3574. doi: 10.1038/s41388-018-0191-6. Epub 2018 Mar 22.

6.

Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.

Scaglione A, Monteonofrio L, Parisi G, Cecchetti C, Siepi F, Rinaldo C, Giorgi A, Verzili D, Zamparelli C, Savino C, Soddu S, Vallone B, Montemiglio LC.

Protein Sci. 2018 Mar;27(3):725-737. doi: 10.1002/pro.3367. Epub 2017 Dec 28.

PMID:
29277937
7.

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.

Barbiero I, Valente D, Chandola C, Magi F, Bergo A, Monteonofrio L, Tramarin M, Fazzari M, Soddu S, Landsberger N, Rinaldo C, Kilstrup-Nielsen C.

Sci Rep. 2017 Jul 24;7(1):6228. doi: 10.1038/s41598-017-05875-z.

8.

HIPK2-T566 autophosphorylation diversely contributes to UV- and doxorubicin-induced HIPK2 activation.

Verdina A, Di Rocco G, Virdia I, Monteonofrio L, Gatti V, Policicchio E, Bruselles A, Tartaglia M, Soddu S.

Oncotarget. 2017 Mar 7;8(10):16744-16754. doi: 10.18632/oncotarget.14421.

9.

Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer.

Prodosmo A, Buffone A, Mattioni M, Barnabei A, Persichetti A, De Leo A, Appetecchia M, Nicolussi A, Coppa A, Sciacchitano S, Giordano C, Pinnarò P, Sanguineti G, Strigari L, Alessandrini G, Facciolo F, Cosimelli M, Grazi GL, Corrado G, Vizza E, Giannini G, Soddu S.

J Exp Clin Cancer Res. 2016 Nov 28;35(1):185. No abstract available.

10.

Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer.

Prodosmo A, Buffone A, Mattioni M, Barnabei A, Persichetti A, De Leo A, Appetecchia M, Nicolussi A, Coppa A, Sciacchitano S, Giordano C, Pinnarò P, Sanguineti G, Strigari L, Alessandrini G, Facciolo F, Cosimelli M, Grazi GL, Corrado G, Vizza E, Giannini G, Soddu S.

J Exp Clin Cancer Res. 2016 Sep 6;35(1):135. doi: 10.1186/s13046-016-0410-3. Erratum in: J Exp Clin Cancer Res. 2016 Nov 28;35(1):185.

11.

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers.

Bon G, Loria R, Amoreo CA, Verdina A, Sperduti I, Mastrofrancesco A, Soddu S, Diodoro MG, Mottolese M, Todaro M, Stassi G, Milella M, De Maria R, Falcioni R.

Oncotarget. 2016 Aug 19;8(65):108463-108479. doi: 10.18632/oncotarget.11400. eCollection 2017 Dec 12.

12.

Epitelial-to-mesenchimal transition and invasion are upmodulated by tumor-expressed granzyme B and inhibited by docosahexaenoic acid in human colorectal cancer cells.

D'Eliseo D, Di Rocco G, Loria R, Soddu S, Santoni A, Velotti F.

J Exp Clin Cancer Res. 2016 Feb 2;35:24. doi: 10.1186/s13046-016-0302-6.

13.

Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.

Di Rocco G, Verdina A, Gatti V, Virdia I, Toietta G, Todaro M, Stassi G, Soddu S.

Oncotarget. 2016 Jan 12;7(2):1675-86. doi: 10.18632/oncotarget.6423.

14.

hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.

Trono P, Di Modugno F, Circo R, Spada S, Di Benedetto A, Melchionna R, Palermo B, Matteoni S, Soddu S, Mottolese M, De Maria R, Nisticò P.

Oncogene. 2016 Feb 18;35(7):887-96. doi: 10.1038/onc.2015.143. Epub 2015 May 11.

PMID:
25961924
15.

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response.

Mancini F, Pieroni L, Monteleone V, Lucà R, Fici L, Luca E, Urbani A, Xiong S, Soddu S, Masetti R, Lozano G, Pontecorvi A, Moretti F.

Oncogene. 2016 Jan 14;35(2):228-40. doi: 10.1038/onc.2015.76. Epub 2015 May 11.

16.

Prognostic role of serum p53 antibodies in lung cancer.

Mattioni M, Soddu S, Prodosmo A, Visca P, Conti S, Alessandrini G, Facciolo F, Strigari L.

BMC Cancer. 2015 Mar 18;15:148. doi: 10.1186/s12885-015-1174-4.

17.

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity.

Valente D, Bossi G, Moncada A, Tornincasa M, Indelicato S, Piscuoglio S, Karamitopoulou ED, Bartolazzi A, Pierantoni GM, Fusco A, Soddu S, Rinaldo C.

Oncotarget. 2015 Apr 30;6(12):10320-34.

18.

Abscopal effect of radiation therapy: interplay between radiation dose and p53 status.

Strigari L, Mancuso M, Ubertini V, Soriani A, Giardullo P, Benassi M, D'Alessio D, Leonardi S, Soddu S, Bossi G.

Int J Radiat Biol. 2015 Mar;91(3):294. doi: 10.3109/09553002.2014.997514. Epub 2015 Feb 4. No abstract available.

PMID:
25650895
19.

HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation.

De Nicola F, Catena V, Rinaldo C, Bruno T, Iezzi S, Sorino C, Desantis A, Camerini S, Crescenzi M, Floridi A, Passananti C, Soddu S, Fanciulli M.

Cell Death Dis. 2014 Sep 11;5:e1414. doi: 10.1038/cddis.2014.381.

20.

Mutant cohesin drives chromosomal instability in early colorectal adenomas.

Cucco F, Servadio A, Gatti V, Bianchi P, Mannini L, Prodosmo A, De Vitis E, Basso G, Friuli A, Laghi L, Soddu S, Fontanini G, Musio A.

Hum Mol Genet. 2014 Dec 20;23(25):6773-8. doi: 10.1093/hmg/ddu394. Epub 2014 Jul 30.

PMID:
25080505
21.

Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist.

Ubertini V, Norelli G, D'Arcangelo D, Gurtner A, Cesareo E, Baldari S, Gentileschi MP, Piaggio G, Nisticò P, Soddu S, Facchiano A, Bossi G.

Oncogene. 2015 May 7;34(19):2493-504. doi: 10.1038/onc.2014.191. Epub 2014 Jul 7.

PMID:
24998848
22.

Homeodomain-interacting protein kinase-2 stabilizes p27kip1 by its phosphorylation at serine 10 and contributes to cell motility.

Pierantoni GM, Esposito F, Tornincasa M, Rinaldo C, Viglietto G, Soddu S, Fusco A.

J Biol Chem. 2014 Jun 20;289(25):17426. doi: 10.1074/jbc.A111.230854. No abstract available.

23.

Abscopal effect of radiation therapy: Interplay between radiation dose and p53 status.

Strigari L, Mancuso M, Ubertini V, Soriani A, Giardullo P, Benassi M, D'Alessio D, Leonardi S, Soddu S, Bossi G.

Int J Radiat Biol. 2014 Mar;90(3):248-55. doi: 10.3109/09553002.2014.874608. Epub 2014 Feb 6. Erratum in: Int J Radiat Biol. 2015 Mar;91(3):294.

PMID:
24350918
24.

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition.

Gilardini Montani MS, Prodosmo A, Stagni V, Merli D, Monteonofrio L, Gatti V, Gentileschi MP, Barilà D, Soddu S.

J Exp Clin Cancer Res. 2013 Nov 19;32:95. doi: 10.1186/1756-9966-32-95.

25.

Pax8 has a critical role in epithelial cell survival and proliferation.

Di Palma T, Filippone MG, Pierantoni GM, Fusco A, Soddu S, Zannini M.

Cell Death Dis. 2013 Jul 18;4:e729. doi: 10.1038/cddis.2013.262.

26.

IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study.

Soddu S, Di Felice E, Cabras S, Castellanos ME, Atzori L, Faa G, Pilloni L.

Eur J Histochem. 2013 Feb 14;57(1):e6. doi: 10.4081/ejh.2013.e6.

27.

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

Siepi F, Gatti V, Camerini S, Crescenzi M, Soddu S.

Biochim Biophys Acta. 2013 Jun;1833(6):1443-53. doi: 10.1016/j.bbamcr.2013.02.018. Epub 2013 Feb 26.

28.

p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes.

Prodosmo A, De Amicis A, Nisticò C, Gabriele M, Di Rocco G, Monteonofrio L, Piane M, Cundari E, Chessa L, Soddu S.

J Clin Invest. 2013 Mar;123(3):1335-42. doi: 10.1172/JCI67289. Epub 2013 Feb 1.

29.

Serum p53 antibody detection in patients with impaired lung function.

Mattioni M, Chinzari P, Soddu S, Strigari L, Cilenti V, Mastropasqua E.

BMC Cancer. 2013 Feb 6;13:62. doi: 10.1186/1471-2407-13-62.

30.

Updates on HIPK2: a resourceful oncosuppressor for clearing cancer.

D'Orazi G, Rinaldo C, Soddu S.

J Exp Clin Cancer Res. 2012 Aug 13;31:63. doi: 10.1186/1756-9966-31-63. Review.

31.

HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.

Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S.

Mol Cell. 2012 Jul 13;47(1):87-98. doi: 10.1016/j.molcel.2012.04.029. Epub 2012 May 31.

32.

PKC theta ablation improves healing in a mouse model of muscular dystrophy.

Madaro L, Pelle A, Nicoletti C, Crupi A, Marrocco V, Bossi G, Soddu S, Bouché M.

PLoS One. 2012;7(2):e31515. doi: 10.1371/journal.pone.0031515. Epub 2012 Feb 14.

33.

Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.

Pierantoni GM, Esposito F, Tornincasa M, Rinaldo C, Viglietto G, Soddu S, Fusco A.

J Biol Chem. 2011 Aug 19;286(33):29005-13. doi: 10.1074/jbc.M111.230854. Epub 2011 Jun 29. Retraction in: J Biol Chem. 2014 Jun 20;289(25):17426.

34.

The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas.

Lavra L, Rinaldo C, Ulivieri A, Luciani E, Fidanza P, Giacomelli L, Bellotti C, Ricci A, Trovato M, Soddu S, Bartolazzi A, Sciacchitano S.

PLoS One. 2011;6(6):e20665. doi: 10.1371/journal.pone.0020665. Epub 2011 Jun 17.

35.

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

Lazzari C, Prodosmo A, Siepi F, Rinaldo C, Galli F, Gentileschi M, Bartolazzi A, Costanzo A, Sacchi A, Guerrini L, Soddu S.

Oncogene. 2011 Dec 1;30(48):4802-13. doi: 10.1038/onc.2011.182. Epub 2011 May 23.

PMID:
21602882
36.

MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.

Petroni M, Veschi V, Prodosmo A, Rinaldo C, Massimi I, Carbonari M, Dominici C, McDowell HP, Rinaldi C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Soddu S, Giannini G.

Mol Cancer Res. 2011 Jan;9(1):67-77. doi: 10.1158/1541-7786.MCR-10-0227. Epub 2010 Dec 20.

37.

P53 detection by fluorescence lifetime on a hybrid fluorescein isothiocyanate gold nanosensor.

Sironi L, Freddi S, D'Alfonso L, Collini M, Gorletta T, Soddu S, Chirico G.

J Biomed Nanotechnol. 2009 Dec;5(6):683-91.

PMID:
20201230
38.

Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.

Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C.

EMBO Rep. 2009 Dec;10(12):1327-33. doi: 10.1038/embor.2009.217. Epub 2009 Oct 9.

39.

Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

Amato R, D'Antona L, Porciatti G, Agosti V, Menniti M, Rinaldo C, Costa N, Bellacchio E, Mattarocci S, Fuiano G, Soddu S, Paggi MG, Lang F, Perrotti N.

J Mol Med (Berl). 2009 Dec;87(12):1221-39. doi: 10.1007/s00109-009-0525-5. Epub 2009 Sep 11.

PMID:
19756449
40.

Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1).

Mattiussi S, Lazzari C, Truffa S, Antonini A, Soddu S, Capogrossi MC, Gaetano C.

PLoS One. 2009 Aug 11;4(8):e6603. doi: 10.1371/journal.pone.0006603.

41.

HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA.

Rinaldo C, Prodosmo A, Siepi F, Moncada A, Sacchi A, Selivanova G, Soddu S.

Cancer Res. 2009 Aug 1;69(15):6241-8. doi: 10.1158/0008-5472.CAN-09-0337. Epub 2009 Jul 28.

42.

Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.

Bon G, Di Carlo SE, Folgiero V, Avetrani P, Lazzari C, D'Orazi G, Brizzi MF, Sacchi A, Soddu S, Blandino G, Mottolese M, Falcioni R.

Cancer Res. 2009 Jul 15;69(14):5978-86. doi: 10.1158/0008-5472.CAN-09-0244. Epub 2009 Jun 30.

43.

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway.

Mancini F, Di Conza G, Pellegrino M, Rinaldo C, Prodosmo A, Giglio S, D'Agnano I, Florenzano F, Felicioni L, Buttitta F, Marchetti A, Sacchi A, Pontecorvi A, Soddu S, Moretti F.

EMBO J. 2009 Jul 8;28(13):1926-39. doi: 10.1038/emboj.2009.154. Epub 2009 Jun 11.

44.

HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.

Iacovelli S, Ciuffini L, Lazzari C, Bracaglia G, Rinaldo C, Prodosmo A, Bartolazzi A, Sacchi A, Soddu S.

Cell Prolif. 2009 Jun;42(3):373-84. doi: 10.1111/j.1365-2184.2009.00601.x. Epub 2009 Mar 31.

PMID:
19438900
45.

Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.

Trapasso F, Aqeilan RI, Iuliano R, Visone R, Gaudio E, Ciuffini L, Alder H, Paduano F, Pierantoni GM, Soddu S, Croce CM, Fusco A.

DNA Cell Biol. 2009 Apr;28(4):161-7. doi: 10.1089/dna.2008.0778. Retraction in: DNA Cell Biol. 2014 Mar;33(3):189.

PMID:
19364276
46.

Gal-3 is stimulated by gain-of-function p53 mutations and modulates chemoresistance in anaplastic thyroid carcinomas.

Lavra L, Ulivieri A, Rinaldo C, Dominici R, Volante M, Luciani E, Bartolazzi A, Frasca F, Soddu S, Sciacchitano S.

J Pathol. 2009 May;218(1):66-75. doi: 10.1002/path.2510.

PMID:
19199318
47.

HIPKs: Jack of all trades in basic nuclear activities.

Rinaldo C, Siepi F, Prodosmo A, Soddu S.

Biochim Biophys Acta. 2008 Nov;1783(11):2124-9. doi: 10.1016/j.bbamcr.2008.06.006. Epub 2008 Jun 18. Review.

48.

Serum anti-p53 antibodies as a useful marker for prognosis of gastric carcinoma.

Mattioni M, Soddu S, Porrello A, D'Alessandro R, Spila A, Guadagni F.

Int J Biol Markers. 2007 Oct-Dec;22(4):302-6.

PMID:
18161662
49.

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

Rinaldo C, Prodosmo A, Siepi F, Soddu S.

Biochem Cell Biol. 2007 Aug;85(4):411-8. Review.

PMID:
17713576
50.

Investigation into the reactivity of the coordinatively unsaturated phosphonodithioato [Ni(MeOpdt)2] towards 2,4,6-tris(2-pyridyl)-1,3,5-triazine: goals and achievements.

Aragoni MC, Arca M, Devillanova FA, Hursthouse MB, Huth SL, Isaia F, Lippolis V, Mancini A, Soddu S, Verani G.

Dalton Trans. 2007 Jun 7;(21):2127-34. Epub 2007 Apr 2.

PMID:
17514333

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