Format

Send to

Choose Destination
Cleve Clin J Med. 2020 Mar;87(3):153-164. doi: 10.3949/ccjm.87a.19072.

Severe megaloblastic anemia: Vitamin deficiency and other causes.

Author information

1
Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic.
2
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic.
3
Department of Pediatric Hematology and Oncology, Yale School of Medicine, New Haven, CT.
4
Department of Hematology and Medical Oncology and Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic.
5
Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve, Cleveland, OH.
6
Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic rogersj5@ccf.org.
7
Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH rogersj5@ccf.org.

Abstract

Megaloblastic anemia causes macrocytic anemia from ineffective red blood cell production and intramedullary hemolysis. The most common causes are folate (vitamin B9) deficiency and cobalamin (vitamin B12) deficiency. Megaloblastic anemia can be diagnosed based on characteristic morphologic and laboratory findings. However, other benign and neoplastic diseases need to be considered, particularly in severe cases. Therapy involves treating the underlying cause-eg, with vitamin supplementation in cases of deficiency, or with discontinuation of a suspected medication.

PMID:
32127439
DOI:
10.3949/ccjm.87a.19072
Free full text

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center