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Items: 1 to 50 of 93

1.

Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP.

Abdul Azeez KR, Chatterjee S, Yu C, Golub TR, Sobott F, Elkins JM.

Nat Commun. 2019 Jul 18;10(1):3166. doi: 10.1038/s41467-019-11085-0.

2.

MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics.

Lermyte F, Dittwald P, Claesen J, Baggerman G, Sobott F, O'Connor PB, Laukens K, Hooyberghs J, Gambin A, Valkenborg D.

Anal Chem. 2019 Aug 6;91(15):10310-10319. doi: 10.1021/acs.analchem.9b02682. Epub 2019 Jul 23.

PMID:
31283196
3.

Native Ion Mobility-Mass Spectrometry Reveals the Formation of β-Barrel Shaped Amyloid-β Hexamers in a Membrane-Mimicking Environment.

Österlund N, Moons R, Ilag LL, Sobott F, Gräslund A.

J Am Chem Soc. 2019 Jul 3;141(26):10440-10450. doi: 10.1021/jacs.9b04596. Epub 2019 Jun 19.

4.

First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study.

Iacobucci C, Piotrowski C, Aebersold R, Amaral BC, Andrews P, Bernfur K, Borchers C, Brodie NI, Bruce JE, Cao Y, Chaignepain S, Chavez JD, Claverol S, Cox J, Davis T, Degliesposti G, Dong MQ, Edinger N, Emanuelsson C, Gay M, Götze M, Gomes-Neto F, Gozzo FC, Gutierrez C, Haupt C, Heck AJR, Herzog F, Huang L, Hoopmann MR, Kalisman N, Klykov O, Kukačka Z, Liu F, MacCoss MJ, Mechtler K, Mesika R, Moritz RL, Nagaraj N, Nesati V, Neves-Ferreira AGC, Ninnis R, Novák P, O'Reilly FJ, Pelzing M, Petrotchenko E, Piersimoni L, Plasencia M, Pukala T, Rand KD, Rappsilber J, Reichmann D, Sailer C, Sarnowski CP, Scheltema RA, Schmidt C, Schriemer DC, Shi Y, Skehel JM, Slavin M, Sobott F, Solis-Mezarino V, Stephanowitz H, Stengel F, Stieger CE, Trabjerg E, Trnka M, Vilaseca M, Viner R, Xiang Y, Yilmaz S, Zelter A, Ziemianowicz D, Leitner A, Sinz A.

Anal Chem. 2019 Jun 4;91(11):6953-6961. doi: 10.1021/acs.analchem.9b00658. Epub 2019 May 22.

5.

Thermodynamic Stability of the Transcription Regulator PaaR2 from Escherichia coli O157:H7.

De Bruyn P, Hadži S, Vandervelde A, Konijnenberg A, Prolič-Kalinšek M, Sterckx YG, Sobott F, Lah J, Van Melderen L, Loris R.

Biophys J. 2019 Apr 23;116(8):1420-1431. doi: 10.1016/j.bpj.2019.03.015. Epub 2019 Mar 28.

PMID:
30979547
6.

Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity.

Daniels MJ, Nourse JB Jr, Kim H, Sainati V, Schiavina M, Murrali MG, Pan B, Ferrie JJ, Haney CM, Moons R, Gould NS, Natalello A, Grandori R, Sobott F, Petersson EJ, Rhoades E, Pierattelli R, Felli I, Uversky VN, Caldwell KA, Caldwell GA, Krol ES, Ischiropoulos H.

Sci Rep. 2019 Feb 27;9(1):2937. doi: 10.1038/s41598-019-39480-z.

7.

A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT.

Talavera A, Tamman H, Ainelo A, Konijnenberg A, Hadži S, Sobott F, Garcia-Pino A, Hõrak R, Loris R.

Nat Commun. 2019 Feb 27;10(1):972. doi: 10.1038/s41467-019-08865-z.

8.

Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure.

Ponzini E, De Palma A, Cerboni L, Natalello A, Rossi R, Moons R, Konijnenberg A, Narkiewicz J, Legname G, Sobott F, Mauri P, Santambrogio C, Grandori R.

J Biol Chem. 2019 Apr 5;294(14):5657-5665. doi: 10.1074/jbc.RA118.001907. Epub 2019 Feb 12.

9.

Recommendations for reporting ion mobility Mass Spectrometry measurements.

Gabelica V, Shvartsburg AA, Afonso C, Barran P, Benesch JLP, Bleiholder C, Bowers MT, Bilbao A, Bush MF, Campbell JL, Campuzano IDG, Causon T, Clowers BH, Creaser CS, De Pauw E, Far J, Fernandez-Lima F, Fjeldsted JC, Giles K, Groessl M, Hogan CJ Jr, Hann S, Kim HI, Kurulugama RT, May JC, McLean JA, Pagel K, Richardson K, Ridgeway ME, Rosu F, Sobott F, Thalassinos K, Valentine SJ, Wyttenbach T.

Mass Spectrom Rev. 2019 May;38(3):291-320. doi: 10.1002/mas.21585. Epub 2019 Feb 1. Review.

10.

masstodon: A Tool for Assigning Peaks and Modeling Electron Transfer Reactions in Top-Down Mass Spectrometry.

Łącki MK, Lermyte F, Miasojedow B, Startek MP, Sobott F, Valkenborg D, Gambin A.

Anal Chem. 2019 Feb 5;91(3):1801-1807. doi: 10.1021/acs.analchem.8b01479. Epub 2019 Jan 28.

PMID:
30608646
11.

Editorial and Review: 30th ASMS Sanibel Conference on Mass Spectrometry-Computational Modelling in Mass Spectrometry and Ion Mobility: Methods for Ion Structure and Reactivity Determination.

Campuzano IDG, Sobott F, van Stipdonk MJ.

J Am Soc Mass Spectrom. 2018 Dec;29(12):2283-2286. doi: 10.1007/s13361-018-2083-y. No abstract available.

PMID:
30397862
12.

The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor.

De Backer J, Razzokov J, Hammerschmid D, Mensch C, Hafideddine Z, Kumar N, van Raemdonck G, Yusupov M, Van Doorslaer S, Johannessen C, Sobott F, Bogaerts A, Dewilde S.

Redox Biol. 2018 Oct;19:1-10. doi: 10.1016/j.redox.2018.07.019. Epub 2018 Jul 24.

13.

Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.

Talavera A, Hendrix J, Versées W, Jurėnas D, Van Nerom K, Vandenberk N, Singh RK, Konijnenberg A, De Gieter S, Castro-Roa D, Barth A, De Greve H, Sobott F, Hofkens J, Zenkin N, Loris R, Garcia-Pino A.

Sci Adv. 2018 Mar 14;4(3):eaap9714. doi: 10.1126/sciadv.aap9714. eCollection 2018 Mar.

14.

Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure.

Lermyte F, Valkenborg D, Loo JA, Sobott F.

Mass Spectrom Rev. 2018 Nov;37(6):750-771. doi: 10.1002/mas.21560. Epub 2018 Feb 9. Review.

15.

Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes.

Polasky DA, Lermyte F, Nshanian M, Sobott F, Andrews PC, Loo JA, Ruotolo BT.

Anal Chem. 2018 Feb 20;90(4):2756-2764. doi: 10.1021/acs.analchem.7b04806. Epub 2018 Feb 2.

16.

The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere.

Fisher GL, Pastrana CL, Higman VA, Koh A, Taylor JA, Butterer A, Craggs T, Sobott F, Murray H, Crump MP, Moreno-Herrero F, Dillingham MS.

Elife. 2017 Dec 15;6. pii: e28086. doi: 10.7554/eLife.28086.

17.

Evaluation of ion mobility for the separation of glycoconjugate isomers due to different types of sialic acid linkage, at the intact glycoprotein, glycopeptide and glycan level.

Barroso A, Giménez E, Konijnenberg A, Sancho J, Sanz-Nebot V, Sobott F.

J Proteomics. 2018 Feb 20;173:22-31. doi: 10.1016/j.jprot.2017.11.020. Epub 2017 Nov 29.

18.

Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes.

Bruce HA, Du D, Matak-Vinkovic D, Bandyra KJ, Broadhurst RW, Martin E, Sobott F, Shkumatov AV, Luisi BF.

Nucleic Acids Res. 2018 Jan 9;46(1):387-402. doi: 10.1093/nar/gkx1083.

19.

A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.

Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W.

Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4.

20.

Advances in native high-performance liquid chromatography and intact mass spectrometry for the characterization of biopharmaceutical products.

Tassi M, De Vos J, Chatterjee S, Sobott F, Bones J, Eeltink S.

J Sep Sci. 2018 Jan;41(1):125-144. doi: 10.1002/jssc.201700988. Epub 2017 Nov 2. Review.

21.

Estimation of Rates of Reactions Triggered by Electron Transfer in Top-Down Mass Spectrometry.

Ciach MA, Łącki MK, Miasojedow B, Lermyte F, Valkenborg D, Sobott F, Gambin A.

J Comput Biol. 2018 Mar;25(3):282-301. doi: 10.1089/cmb.2017.0156. Epub 2017 Sep 25.

22.

Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry.

Yefremova Y, Melder FTI, Danquah BD, Opuni KFM, Koy C, Ehrens A, Frommholz D, Illges H, Koelbel K, Sobott F, Glocker MO.

Anal Bioanal Chem. 2017 Nov;409(28):6549-6558. doi: 10.1007/s00216-017-0603-4. Epub 2017 Sep 12.

23.
24.

Native Mass Spectrometry for the Characterization of Structure and Interactions of Membrane Proteins.

van Dyck JF, Konijnenberg A, Sobott F.

Methods Mol Biol. 2017;1635:205-232. doi: 10.1007/978-1-4939-7151-0_11.

PMID:
28755371
25.

Antarctic fish versus human cytoglobins - The same but yet so different.

Cuypers B, Vermeylen S, Hammerschmid D, Trashin S, Rahemi V, Konijnenberg A, De Schutter A, Cheng CC, Giordano D, Verde C, De Wael K, Sobott F, Dewilde S, Van Doorslaer S.

J Inorg Biochem. 2017 Aug;173:66-78. doi: 10.1016/j.jinorgbio.2017.04.025. Epub 2017 Apr 28.

26.

Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1.

Heirbaut M, Lermyte F, Martin EM, Beelen S, Sobott F, Strelkov SV, Weeks SD.

J Biol Chem. 2017 Jun 16;292(24):9944-9957. doi: 10.1074/jbc.M116.773515. Epub 2017 May 9.

27.

Preprotein mature domains contain translocase targeting signals that are essential for secretion.

Chatzi KE, Sardis MF, Tsirigotaki A, Koukaki M, Šoštarić N, Konijnenberg A, Sobott F, Kalodimos CG, Karamanou S, Economou A.

J Cell Biol. 2017 May 1;216(5):1357-1369. doi: 10.1083/jcb.201609022. Epub 2017 Apr 12.

28.

AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet.

Jurėnas D, Chatterjee S, Konijnenberg A, Sobott F, Droogmans L, Garcia-Pino A, Van Melderen L.

Nat Chem Biol. 2017 Jun;13(6):640-646. doi: 10.1038/nchembio.2346. Epub 2017 Apr 3.

29.

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L.

Mol Cell. 2017 Mar 16;65(6):1044-1055.e5. doi: 10.1016/j.molcel.2017.02.013.

30.

Analyzing complex mixtures of drug-like molecules: Ion mobility as an adjunct to existing liquid chromatography-(tandem) mass spectrometry methods.

Boschmans J, Lemière F, Sobott F.

J Chromatogr A. 2017 Mar 24;1490:80-88. doi: 10.1016/j.chroma.2017.02.015. Epub 2017 Feb 14.

31.

Proton Dynamics in Protein Mass Spectrometry.

Li J, Lyu W, Rossetti G, Konijnenberg A, Natalello A, Ippoliti E, Orozco M, Sobott F, Grandori R, Carloni P.

J Phys Chem Lett. 2017 Mar 16;8(6):1105-1112. doi: 10.1021/acs.jpclett.7b00127. Epub 2017 Feb 22.

32.

Hidden States within Disordered Regions of the CcdA Antitoxin Protein.

Burger VM, Vandervelde A, Hendrix J, Konijnenberg A, Sobott F, Loris R, Stultz CM.

J Am Chem Soc. 2017 Feb 22;139(7):2693-2701. doi: 10.1021/jacs.6b11450. Epub 2017 Feb 8.

33.

The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain.

Heirbaut M, Lermyte F, Martin EM, Beelen S, Verschueren T, Sobott F, Strelkov SV, Weeks SD.

Arch Biochem Biophys. 2016 Nov 15;610:41-50. doi: 10.1016/j.abb.2016.10.002. Epub 2016 Oct 4.

34.

Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin.

Lermyte F, Łącki MK, Valkenborg D, Gambin A, Sobott F.

J Am Soc Mass Spectrom. 2017 Jan;28(1):69-76. doi: 10.1007/s13361-016-1444-7. Epub 2016 Aug 5.

35.

Gas-phase microsolvation of ubiquitin: investigation of crown ether complexation sites using ion mobility-mass spectrometry.

Göth M, Lermyte F, Schmitt XJ, Warnke S, von Helden G, Sobott F, Pagel K.

Analyst. 2016 Oct 7;141(19):5502-10. doi: 10.1039/c6an01377e. Epub 2016 Aug 5.

36.

Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein.

Konijnenberg A, Ranica S, Narkiewicz J, Legname G, Grandori R, Sobott F, Natalello A.

Anal Chem. 2016 Sep 6;88(17):8468-75. doi: 10.1021/acs.analchem.6b00731. Epub 2016 Aug 12.

37.

Development of a novel antibody-tetrazine conjugate for bioorthogonal pretargeting.

Maggi A, Ruivo E, Fissers J, Vangestel C, Chatterjee S, Joossens J, Sobott F, Staelens S, Stroobants S, Van Der Veken P, Wyffels L, Augustyns K.

Org Biomol Chem. 2016 Aug 21;14(31):7544-51. doi: 10.1039/c6ob01411a. Epub 2016 Jul 19.

PMID:
27431745
38.

Lipids modulate the conformational dynamics of a secondary multidrug transporter.

Martens C, Stein RA, Masureel M, Roth A, Mishra S, Dawaliby R, Konijnenberg A, Sobott F, Govaerts C, Mchaourab HS.

Nat Struct Mol Biol. 2016 Aug;23(8):744-51. doi: 10.1038/nsmb.3262. Epub 2016 Jul 11.

39.

ATP and autophosphorylation driven conformational changes of HipA kinase revealed by ion mobility and crosslinking mass spectrometry.

Wen Y, Sobott F, Devreese B.

Anal Bioanal Chem. 2016 Aug;408(21):5925-5933. doi: 10.1007/s00216-016-9709-3. Epub 2016 Jun 20.

40.

Combining density functional theory (DFT) and collision cross-section (CCS) calculations to analyze the gas-phase behaviour of small molecules and their protonation site isomers.

Boschmans J, Jacobs S, Williams JP, Palmer M, Richardson K, Giles K, Lapthorn C, Herrebout WA, Lemière F, Sobott F.

Analyst. 2016 Jun 20;141(13):4044-54. doi: 10.1039/c5an02456k.

41.

Covalent adducts of melphalan with free amino acids and a model peptide studied by liquid chromatography/tandem mass spectrometry.

Dewaele D, Sobott F, Lemière F.

Rapid Commun Mass Spectrom. 2016 Mar 30;30(6):719-30. doi: 10.1002/rcm.7489.

PMID:
26864525
42.

Differences in the Elemental Isotope Definition May Lead to Errors in Modern Mass-Spectrometry-Based Proteomics.

Claesen J, Lermyte F, Sobott F, Burzykowski T, Valkenborg D.

Anal Chem. 2015 Nov 3;87(21):10747-54. doi: 10.1021/acs.analchem.5b01165. Epub 2015 Oct 22.

PMID:
26457653
43.

Extending native mass spectrometry approaches to integral membrane proteins.

Konijnenberg A, van Dyck JF, Kailing LL, Sobott F.

Biol Chem. 2015 Sep;396(9-10):991-1002. doi: 10.1515/hsz-2015-0136. Review.

PMID:
26352204
44.

Signal loss due to oligomerization in ELISA analysis of amyloid-beta can be recovered by a novel sample pre-treatment method.

Janssen L, Sobott F, De Deyn PP, Van Dam D.

MethodsX. 2015 Feb 27;2:112-23. doi: 10.1016/j.mex.2015.02.011. eCollection 2015.

45.

Electron transfer dissociation provides higher-order structural information of native and partially unfolded protein complexes.

Lermyte F, Sobott F.

Proteomics. 2015 Aug;15(16):2813-22. doi: 10.1002/pmic.201400516. Epub 2015 Jul 22.

PMID:
26081219
46.

Characterization of top-down ETD in a travelling-wave ion guide.

Lermyte F, Verschueren T, Brown JM, Williams JP, Valkenborg D, Sobott F.

Methods. 2015 Nov 1;89:22-9. doi: 10.1016/j.ymeth.2015.05.019. Epub 2015 May 23.

PMID:
26014039
47.

Bouncing off the Walls: Excited Protein Complexes Tell Their Story.

Konijnenberg A, Sobott F.

Chem Biol. 2015 May 21;22(5):563-4. doi: 10.1016/j.chembiol.2015.05.004.

48.

Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment.

Konijnenberg A, Bannwarth L, Yilmaz D, Koçer A, Venien-Bryan C, Sobott F.

Protein Sci. 2015 Aug;24(8):1292-300. doi: 10.1002/pro.2703. Epub 2015 May 29.

49.

Extensive Charge Reduction and Dissociation of Intact Protein Complexes Following Electron Transfer on a Quadrupole-Ion Mobility-Time-of-Flight MS.

Lermyte F, Williams JP, Brown JM, Martin EM, Sobott F.

J Am Soc Mass Spectrom. 2015 Jul;26(7):1068-76. doi: 10.1007/s13361-015-1124-z. Epub 2015 Apr 11.

PMID:
25862188
50.

Protomers of benzocaine: solvent and permittivity dependence.

Warnke S, Seo J, Boschmans J, Sobott F, Scrivens JH, Bleiholder C, Bowers MT, Gewinner S, Schöllkopf W, Pagel K, von Helden G.

J Am Chem Soc. 2015 Apr 1;137(12):4236-42. doi: 10.1021/jacs.5b01338. Epub 2015 Mar 17.

PMID:
25760934

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