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Items: 20


An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions.

Lim YT, Prabhu N, Dai L, Go KD, Chen D, Sreekumar L, Egeblad L, Eriksson S, Chen L, Veerappan S, Teo HL, Tan CSH, Lengqvist J, Larsson A, Sobota RM, Nordlund P.

PLoS One. 2018 Dec 6;13(12):e0208273. doi: 10.1371/journal.pone.0208273. eCollection 2018.


2C-BioID: An Advanced Two Component BioID System for Precision Mapping of Protein Interactomes.

Chojnowski A, Sobota RM, Ong PF, Xie W, Wong X, Dreesen O, Burke B, Stewart CL.

iScience. 2018 Nov 15;10:40-52. doi: 10.1016/j.isci.2018.11.023. [Epub ahead of print]


Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding.

Zhong FL, Robinson K, Teo DET, Tan KY, Lim C, Harapas CR, Yu CH, Xie WH, Sobota RM, Au VB, Hopkins R, D'Osualdo A, Reed JC, Connolly JE, Masters SL, Reversade B.

J Biol Chem. 2018 Dec 7;293(49):18864-18878. doi: 10.1074/jbc.RA118.004350. Epub 2018 Oct 5.


Synthetic 10FN3-based mono- and bivalent inhibitors of MDM2/X function.

Lau SY, Siau JW, Sobota RM, Wang CI, Zhong P, Lane DP, Ghadessy FJ.

Protein Eng Des Sel. 2018 Jul 1;31(7-8):301-312. doi: 10.1093/protein/gzy018.


Modulation of Protein-Interaction States through the Cell Cycle.

Dai L, Zhao T, Bisteau X, Sun W, Prabhu N, Lim YT, Sobota RM, Kaldis P, Nordlund P.

Cell. 2018 May 31;173(6):1481-1494.e13. doi: 10.1016/j.cell.2018.03.065. Epub 2018 Apr 26.


Thermal proximity coaggregation for system-wide profiling of protein complex dynamics in cells.

Tan CSH, Go KD, Bisteau X, Dai L, Yong CH, Prabhu N, Ozturk MB, Lim YT, Sreekumar L, Lengqvist J, Tergaonkar V, Kaldis P, Sobota RM, Nordlund P.

Science. 2018 Mar 9;359(6380):1170-1177. doi: 10.1126/science.aan0346. Epub 2018 Feb 8.


Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.

Gimpel P, Lee YL, Sobota RM, Calvi A, Koullourou V, Patel R, Mamchaoui K, Nédélec F, Shackleton S, Schmoranzer J, Burke B, Cadot B, Gomes ER.

Curr Biol. 2017 Oct 9;27(19):2999-3009.e9. doi: 10.1016/j.cub.2017.08.031. Epub 2017 Sep 28.


Going native: Complete removal of protein purification affinity tags by simple modification of existing tags and proteases.

Goh HC, Sobota RM, Ghadessy FJ, Nirantar S.

Protein Expr Purif. 2017 Jan;129:18-24. doi: 10.1016/j.pep.2016.09.001. Epub 2016 Sep 8.


Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.

Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A.

Nat Commun. 2015 Oct 28;6:8761. doi: 10.1038/ncomms9761.


Dendritic cell derived IL-2 inhibits survival of terminally mature cells via an autocrine signaling pathway.

Balachander A, Nabti S, Sobota RM, Foo S, Zolezzi F, Lee BT, Poidinger M, Ricciardi-Castagnoli P.

Eur J Immunol. 2015 May;45(5):1494-9. doi: 10.1002/eji.201445050. Epub 2015 Mar 18.


Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia.

Müller PJ, Rigbolt KT, Paterok D, Piehler J, Vanselow J, Lasonder E, Andersen JS, Schaper F, Sobota RM.

J Proteomics. 2013 Jun 12;84:132-47. doi: 10.1016/j.jprot.2013.04.005. Epub 2013 Apr 11.


Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model.

Schuh A, Kroh A, Konschalla S, Liehn EA, Sobota RM, Biessen EA, Bot I, Sönmez TT, Schober A, Marx N, Weber C, Sasse A.

J Cell Mol Med. 2012 Oct;16(10):2311-20. doi: 10.1111/j.1582-4934.2012.01539.x. Erratum in: J Cell Mol Med. 2013 Nov;17(11):1513. Tolga Taha, Sönmez [corrected to Sönmez, Tolga Taha].


SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling.

Stendel C, Roos A, Kleine H, Arnaud E, Ozçelik M, Sidiropoulos PN, Zenker J, Schüpfer F, Lehmann U, Sobota RM, Litchfield DW, Lüscher B, Chrast R, Suter U, Senderek J.

Brain. 2010 Aug;133(Pt 8):2462-74. doi: 10.1093/brain/awq168.


SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.

Sobota RM, Müller PJ, Khouri C, Ullrich A, Poli V, Noguchi T, Heinrich PC, Schaper F.

Cell Signal. 2008 Jul;20(7):1385-91. doi: 10.1016/j.cellsig.2008.03.005. Epub 2008 Mar 21.


Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation.

Sobota RM, Müller PJ, Heinrich PC, Schaper F.

Biochem J. 2008 May 15;412(1):65-72. doi: 10.1042/BJ20071572.


Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.

Sommer U, Schmid C, Sobota RM, Lehmann U, Stevenson NJ, Johnston JA, Schaper F, Heinrich PC, Haan S.

J Biol Chem. 2005 Sep 9;280(36):31478-88. Epub 2005 Jul 6.


Dual function of interleukin-1beta for the regulation of interleukin-6-induced suppressor of cytokine signaling 3 expression.

Yang XP, Albrecht U, Zakowski V, Sobota RM, Häussinger D, Heinrich PC, Ludwig S, Bode JG, Schaper F.

J Biol Chem. 2004 Oct 22;279(43):45279-89. Epub 2004 Aug 11.


The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling.

Fischer P, Lehmann U, Sobota RM, Schmitz J, Niemand C, Linnemann S, Haan S, Behrmann I, Yoshimura A, Johnston JA, Müller-Newen G, Heinrich PC, Schaper F.

Biochem J. 2004 Mar 1;378(Pt 2):449-60.


SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130.

Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F.

J Biol Chem. 2003 Jan 3;278(1):661-71. Epub 2002 Oct 27.

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