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Items: 1 to 50 of 110

1.

DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity.

Li J, Svilar D, McClellan S, Kim JH, Ahn EE, Vens C, Wilson DM 3rd, Sobol RW.

Oncotarget. 2018 Aug 3;9(60):31719-31743. doi: 10.18632/oncotarget.25859. eCollection 2018 Aug 3.

2.

Immunoregulatory protein B7-H3 regulates cancer stem cell enrichment and drug resistance through MVP-mediated MEK activation.

Liu Z, Zhang W, Phillips JB, Arora R, McClellan S, Li J, Kim JH, Sobol RW, Tan M.

Oncogene. 2018 Aug 6. doi: 10.1038/s41388-018-0407-9. [Epub ahead of print]

PMID:
30082909
3.

Camptothecin Efficacy to Poison Top1 Is Altered by Bisphenol A in Mouse Embryonic Fibroblasts.

Sonavane M, Sykora P, Andrews JF, Sobol RW, Gassman NR.

Chem Res Toxicol. 2018 Jun 18;31(6):510-519. doi: 10.1021/acs.chemrestox.8b00050. Epub 2018 Jun 5.

PMID:
29799191
4.

Application of the CometChip platform to assess DNA damage in field-collected blood samples from turtles.

Sykora P, Chiari Y, Heaton A, Moreno N, Glaberman S, Sobol RW.

Environ Mol Mutagen. 2018 May;59(4):322-333. doi: 10.1002/em.22183. Epub 2018 Mar 14.

PMID:
29536573
5.

Next generation high throughput DNA damage detection platform for genotoxic compound screening.

Sykora P, Witt KL, Revanna P, Smith-Roe SL, Dismukes J, Lloyd DG, Engelward BP, Sobol RW.

Sci Rep. 2018 Feb 9;8(1):2771. doi: 10.1038/s41598-018-20995-w.

6.

Development of a Cell-Based Assay for Measuring Base Excision Repair Responses.

Golato T, Brenerman B, McNeill DR, Li J, Sobol RW, Wilson DM 3rd.

Sci Rep. 2017 Oct 11;7(1):13007. doi: 10.1038/s41598-017-12963-7.

7.

DNA polymerase beta participates in mitochondrial DNA repair.

Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA.

Mol Cell Biol. 2017 May 30. pii: MCB.00237-17. doi: 10.1128/MCB.00237-17. [Epub ahead of print]

8.

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.

Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT.

Mutat Res. 2017 Aug;800-802:14-28. doi: 10.1016/j.mrfmmm.2017.03.007. Epub 2017 Apr 6. Review.

9.

Constrained Inversion and Spectral Unmixing in Multispectral Optoacoustic Tomography.

Ding L, Dean-Ben XL, Burton NC, Sobol RW, Ntziachristos V, Razansky D.

IEEE Trans Med Imaging. 2017 Aug;36(8):1676-1685. doi: 10.1109/TMI.2017.2686006. Epub 2017 Mar 22.

10.

Differential role of base excision repair proteins in mediating cisplatin cytotoxicity.

Sawant A, Floyd AM, Dangeti M, Lei W, Sobol RW, Patrick SM.

DNA Repair (Amst). 2017 Mar;51:46-59. doi: 10.1016/j.dnarep.2017.01.002. Epub 2017 Jan 11.

11.

UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase.

Braganza A, Li J, Zeng X, Yates NA, Dey NB, Andrews J, Clark J, Zamani L, Wang XH, St Croix C, O'Sullivan R, Garcia-Exposito L, Brodsky JL, Sobol RW.

J Biol Chem. 2017 Feb 10;292(6):2470-2484. doi: 10.1074/jbc.M116.766824. Epub 2016 Dec 21.

12.

FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage.

Bigarella CL, Li J, Rimmelé P, Liang R, Sobol RW, Ghaffari S.

J Biol Chem. 2017 Feb 17;292(7):3005-3015. doi: 10.1074/jbc.M116.769455. Epub 2016 Dec 19.

13.

Oxidative guanine base damage regulates human telomerase activity.

Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL.

Nat Struct Mol Biol. 2016 Dec;23(12):1092-1100. doi: 10.1038/nsmb.3319. Epub 2016 Nov 7.

14.

Regulation of DNA Alkylation Damage Repair: Lessons and Therapeutic Opportunities.

Soll JM, Sobol RW, Mosammaparast N.

Trends Biochem Sci. 2017 Mar;42(3):206-218. doi: 10.1016/j.tibs.2016.10.001. Epub 2016 Nov 2. Review.

15.

Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD+ and retinoic acid.

Moretti A, Li J, Donini S, Sobol RW, Rizzi M, Garavaglia S.

Sci Rep. 2016 Oct 19;6:35710. doi: 10.1038/srep35710.

16.

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

Srivas R, Shen JP, Yang CC, Sun SM, Li J, Gross AM, Jensen J, Licon K, Bojorquez-Gomez A, Klepper K, Huang J, Pekin D, Xu JL, Yeerna H, Sivaganesh V, Kollenstart L, van Attikum H, Aza-Blanc P, Sobol RW, Ideker T.

Mol Cell. 2016 Aug 4;63(3):514-25. doi: 10.1016/j.molcel.2016.06.022. Epub 2016 Jul 21.

17.

Administration of polysaccharide from Panax notoginseng prolonged the survival of H22 tumor-bearing mice.

Li H, Gu L, Zhong Y, Chen Y, Zhang L, Zhang AR, Sobol RW, Chen T, Li J.

Onco Targets Ther. 2016 Jun 8;9:3433-41. doi: 10.2147/OTT.S79427. eCollection 2016.

18.

Crosstalk between mismatch repair and base excision repair in human gastric cancer.

Simonelli V, Leuzzi G, Basile G, D'Errico M, Fortini P, Franchitto A, Viti V, Brown AR, Parlanti E, Pascucci B, Palli D, Giuliani A, Palombo F, Sobol RW, Dogliotti E.

Oncotarget. 2016 Jun 20;8(49):84827-84840. doi: 10.18632/oncotarget.10185. eCollection 2017 Oct 17.

19.

The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products.

Godin SK, Zhang Z, Herken BW, Westmoreland JW, Lee AG, Mihalevic MJ, Yu Z, Sobol RW, Resnick MA, Bernstein KA.

Nucleic Acids Res. 2016 Sep 30;44(17):8199-215. doi: 10.1093/nar/gkw535. Epub 2016 Jun 13.

20.

Role of mismatch repair proteins in the processing of cisplatin interstrand cross-links.

Sawant A, Kothandapani A, Zhitkovich A, Sobol RW, Patrick SM.

DNA Repair (Amst). 2015 Nov;35:126-36. doi: 10.1016/j.dnarep.2015.10.003. Epub 2015 Oct 23.

21.

Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.

Shen JP, Srivas R, Gross A, Li J, Jaehnig EJ, Sun SM, Bojorquez-Gomez A, Licon K, Sivaganesh V, Xu JL, Klepper K, Yeerna H, Pekin D, Qiu CP, van Attikum H, Sobol RW, Ideker T.

Oncotarget. 2015 Nov 3;6(34):35755-69. doi: 10.18632/oncotarget.5928.

22.

Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells.

Chandran UR, Luthra S, Santana-Santos L, Mao P, Kim SH, Minata M, Li J, Benos PV, DeWang M, Hu B, Cheng SY, Nakano I, Sobol RW.

Genom Data. 2015 Sep 1;5:333-336.

23.

Enzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivo.

Quiñones JL, Thapar U, Yu K, Fang Q, Sobol RW, Demple B.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8602-7. doi: 10.1073/pnas.1501101112. Epub 2015 Jun 29.

24.

Loss of caspase-3 sensitizes colon cancer cells to genotoxic stress via RIP1-dependent necrosis.

Brown MF, Leibowitz BJ, Chen D, He K, Zou F, Sobol RW, Beer-Stolz D, Zhang L, Yu J.

Cell Death Dis. 2015 Apr 23;6:e1729. doi: 10.1038/cddis.2015.104.

25.

15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids.

Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA.

J Biol Chem. 2015 Feb 27;290(9):5868-80. doi: 10.1074/jbc.M114.635151. Epub 2015 Jan 12.

26.

A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1.

Wang J, Li J, Santana-Santos L, Shuda M, Sobol RW, Van Houten B, Qian W.

Mol Oncol. 2015 Feb;9(2):488-502. doi: 10.1016/j.molonc.2014.10.002. Epub 2014 Oct 17.

27.

Preface. NAD metabolism and signaling: Critical pathways in bacteria, yeast and mammals influencing genome stability, cell survival and disease.

Sobol RW.

DNA Repair (Amst). 2014 Nov;23:1-3. doi: 10.1016/j.dnarep.2014.10.007. Epub 2014 Nov 15. No abstract available.

PMID:
25454703
28.

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.

Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW.

Nat Commun. 2014 Nov 26;5:5513. doi: 10.1038/ncomms6513.

29.

ARTD1 (PARP1) activation and NAD(+) in DNA repair and cell death.

Fouquerel E, Sobol RW.

DNA Repair (Amst). 2014 Nov;23:27-32. doi: 10.1016/j.dnarep.2014.09.004. Epub 2014 Oct 3. Review.

30.

ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion.

Fouquerel E, Goellner EM, Yu Z, Gagné JP, Barbi de Moura M, Feinstein T, Wheeler D, Redpath P, Li J, Romero G, Migaud M, Van Houten B, Poirier GG, Sobol RW.

Cell Rep. 2014 Sep 25;8(6):1819-1831. doi: 10.1016/j.celrep.2014.08.036. Epub 2014 Sep 15.

31.

Mitochondria, energetics, epigenetics, and cellular responses to stress.

Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL.

Environ Health Perspect. 2014 Dec;122(12):1271-8. doi: 10.1289/ehp.1408418. Epub 2014 Aug 15. Review.

32.

ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents.

Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, Gajadhar A, Fernandez NA, Clarke ID, Barszczyk MS, Pajovic S, Ternamian C, Head R, Sabha N, Sobol RW, Taylor MD, Rutka JT, Jones C, Dirks PB, Zadeh G, Hawkins C.

Cancer Discov. 2014 Oct;4(10):1198-213. doi: 10.1158/2159-8290.CD-14-0157. Epub 2014 Aug 6.

33.

Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.

Bennett GR, Peters R, Wang XH, Hanne J, Sobol RW, Bundschuh R, Fishel R, Yoder KE.

PLoS One. 2014 Jul 22;9(7):e103164. doi: 10.1371/journal.pone.0103164. eCollection 2014.

34.

Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P.

PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014.

35.

Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin.

Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS.

Nucleic Acids Res. 2014 Feb;42(4):2330-45. doi: 10.1093/nar/gkt1233. Epub 2013 Nov 29.

36.

Epistatic role of base excision repair and mismatch repair pathways in mediating cisplatin cytotoxicity.

Kothandapani A, Sawant A, Dangeti VS, Sobol RW, Patrick SM.

Nucleic Acids Res. 2013 Aug;41(15):7332-43. doi: 10.1093/nar/gkt479. Epub 2013 Jun 12.

37.

Mutation research/fundamental and molecular mechanisms of mutagenesis: special issue: DNA repair and genetic instability.

Williams K, Sobol RW.

Mutat Res. 2013 Mar-Apr;743-744:1-3. doi: 10.1016/j.mrfmmm.2013.04.009. No abstract available.

38.

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3.

Mao P, Joshi K, Li J, Kim SH, Li P, Santana-Santos L, Luthra S, Chandran UR, Benos PV, Smith L, Wang M, Hu B, Cheng SY, Sobol RW, Nakano I.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8644-9. doi: 10.1073/pnas.1221478110. Epub 2013 May 6.

39.

MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells.

Joshi K, Banasavadi-Siddegowda Y, Mo X, Kim SH, Mao P, Kig C, Nardini D, Sobol RW, Chow LM, Kornblum HI, Waclaw R, Beullens M, Nakano I.

Stem Cells. 2013 Jun;31(6):1051-63. doi: 10.1002/stem.1358.

40.

Base excision repair facilitates a functional relationship between Guanine oxidation and histone demethylation.

Li J, Braganza A, Sobol RW.

Antioxid Redox Signal. 2013 Jun 20;18(18):2429-43. doi: 10.1089/ars.2012.5107. Epub 2013 Feb 28. Review.

41.

SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress.

Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD.

Mutat Res. 2013 Mar-Apr;743-744:26-32. doi: 10.1016/j.mrfmmm.2012.12.001. Epub 2012 Dec 17.

42.

Synthesis and characterization of DNA minor groove binding alkylating agents.

Iyer P, Srinivasan A, Singh SK, Mascara GP, Zayitova S, Sidone B, Fouquerel E, Svilar D, Sobol RW, Bobola MS, Silber JR, Gold B.

Chem Res Toxicol. 2013 Jan 18;26(1):156-68. doi: 10.1021/tx300437x. Epub 2012 Dec 26.

43.

Transcriptional profiling reveals elevated Sox2 in DNA polymerase ß null mouse embryonic fibroblasts.

Li J, Luthra S, Wang XH, Chandran UR, Sobol RW.

Am J Cancer Res. 2012;2(6):699-713. Epub 2012 Nov 20.

44.

Genome instability caused by a germline mutation in the human DNA repair gene POLB.

Sobol RW.

PLoS Genet. 2012;8(11):e1003086. doi: 10.1371/journal.pgen.1003086. Epub 2012 Nov 8. No abstract available.

45.

Alkylation sensitivity screens reveal a conserved cross-species functionome.

Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW.

Mol Cancer Res. 2012 Dec;10(12):1580-96. doi: 10.1158/1541-7786.MCR-12-0168. Epub 2012 Oct 4.

46.
47.

Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors.

Srinivasan A, Wang L, Cline CJ, Xie Z, Sobol RW, Xie XQ, Gold B.

Biochemistry. 2012 Aug 7;51(31):6246-59. Epub 2012 Jul 24.

48.

For MutY, it's all about the OG.

Sobol RW.

Chem Biol. 2012 Mar 23;19(3):313-4. doi: 10.1016/j.chembiol.2012.03.002.

49.

Targeting DNA polymerase ß for therapeutic intervention.

Goellner EM, Svilar D, Almeida KH, Sobol RW.

Curr Mol Pharmacol. 2012 Jan;5(1):68-87. Review.

50.

XRCC1 and base excision repair balance in response to nitric oxide.

Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, Sobol RW, Engelward BP.

DNA Repair (Amst). 2011 Dec 10;10(12):1282-93. doi: 10.1016/j.dnarep.2011.10.008. Epub 2011 Oct 29.

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