Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 95

1.

Slow Delayed Rectifier Current Protects Ventricular Myocytes From Arrhythmic Dynamics Across Multiple Species.

Varshneya M, Devenyi RA, Sobie EA.

Circ Arrhythm Electrophysiol. 2018 Oct;11(10):e006558. doi: 10.1161/CIRCEP.118.006558.

PMID:
30354408
2.

Ca2+ Cycling Impairment in Heart Failure Is Exacerbated by Fibrosis: Insights Gained From Mechanistic Simulations.

Mora MT, Ferrero JM, Gomez JF, Sobie EA, Trenor B.

Front Physiol. 2018 Aug 23;9:1194. doi: 10.3389/fphys.2018.01194. eCollection 2018.

3.

An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity.

Mayourian J, Sobie EA, Costa KD.

Methods Mol Biol. 2018;1816:17-35. doi: 10.1007/978-1-4939-8597-5_2.

4.

A privileged role for neuronal Na+ channels in regulating ventricular [Ca2+] and arrhythmias.

Jones DC, Gong JQX, Sobie EA.

J Gen Physiol. 2018 Jul 2;150(7):901-905. doi: 10.1085/jgp.201812120. Epub 2018 Jun 13. No abstract available.

5.

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types.

Gong JQX, Sobie EA.

NPJ Syst Biol Appl. 2018 Feb 24;4:11. doi: 10.1038/s41540-018-0047-2. eCollection 2018.

6.

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A.

Cell Syst. 2018 Jan 24;6(1):13-24. doi: 10.1016/j.cels.2017.11.001. Epub 2017 Nov 29. Review.

7.

A Comparison of mRNA Sequencing with Random Primed and 3'-Directed Libraries.

Xiong Y, Soumillon M, Wu J, Hansen J, Hu B, van Hasselt JGC, Jayaraman G, Lim R, Bouhaddou M, Ornelas L, Bochicchio J, Lenaeus L, Stocksdale J, Shim J, Gomez E, Sareen D, Svendsen C, Thompson LM, Mahajan M, Iyengar R, Sobie EA, Azeloglu EU, Birtwistle MR.

Sci Rep. 2017 Nov 7;7(1):14626. doi: 10.1038/s41598-017-14892-x.

8.

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

Shim JV, Chun B, van Hasselt JGC, Birtwistle MR, Saucerman JJ, Sobie EA.

Front Physiol. 2017 Sep 8;8:651. doi: 10.3389/fphys.2017.00651. eCollection 2017.

9.

Ambiguous interactions between diastolic and SR Ca2+ in the regulation of cardiac Ca2+ release.

Sobie EA, Williams GSB, Lederer WJ.

J Gen Physiol. 2017 Sep 4;149(9):847-855. doi: 10.1085/jgp.201711814. Epub 2017 Aug 10. Review. No abstract available.

10.

Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity.

Mayourian J, Cashman TJ, Ceholski DK, Johnson BV, Sachs D, Kaji DA, Sahoo S, Hare JM, Hajjar RJ, Sobie EA, Costa KD.

Circ Res. 2017 Aug 4;121(4):411-423. doi: 10.1161/CIRCRESAHA.117.310796. Epub 2017 Jun 22.

11.

I love it when a plan comes together: Insight gained through convergence of competing mathematical models.

Gong JQ, Shim JV, Núñez-Acosta E, Sobie EA.

J Mol Cell Cardiol. 2017 Jan;102:31-33. doi: 10.1016/j.yjmcc.2016.10.015. Epub 2016 Nov 30. No abstract available.

PMID:
27913283
13.

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

Devenyi RA, Ortega FA, Groenendaal W, Krogh-Madsen T, Christini DJ, Sobie EA.

J Physiol. 2017 Apr 1;595(7):2301-2317. doi: 10.1113/JP273191. Epub 2016 Dec 28.

14.

Identification of novel prognostic indicators for triple-negative breast cancer patients through integrative analysis of cancer genomics data and protein interactome data.

Zhang F, Ren C, Zhao H, Yang L, Su F, Zhou MM, Han J, Sobie EA, Walsh MJ.

Oncotarget. 2016 Nov 1;7(44):71620-71634. doi: 10.18632/oncotarget.12287.

15.

Response to "Complexity vs. Simplicity: The Winner Is?" Mechanism-Based Classifiers Provide More Than Just Classification.

Lancaster MC, Sobie EA.

Clin Pharmacol Ther. 2017 Mar;101(3):327. doi: 10.1002/cpt.500. Epub 2016 Nov 15. No abstract available.

PMID:
27618710
16.

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes.

Josowitz R, Mulero-Navarro S, Rodriguez NA, Falce C, Cohen N, Ullian EM, Weiss LA, Rauen KA, Sobie EA, Gelb BD.

Stem Cell Reports. 2016 Sep 13;7(3):355-369. doi: 10.1016/j.stemcr.2016.07.018. Epub 2016 Aug 25.

17.

A network medicine approach to build a comprehensive atlas for the prognosis of human cancer.

Zhang F, Ren C, Lau KK, Zheng Z, Lu G, Yi Z, Zhao Y, Su F, Zhang S, Zhang B, Sobie EA, Zhang W, Walsh MJ.

Brief Bioinform. 2016 Nov;17(6):1044-1059. Epub 2016 Aug 24.

18.

Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes.

Mayourian J, Savizky RM, Sobie EA, Costa KD.

PLoS Comput Biol. 2016 Jul 25;12(7):e1005014. doi: 10.1371/journal.pcbi.1005014. eCollection 2016 Jul.

19.

The Contribution of Ionic Currents to Rate-Dependent Action Potential Duration and Pattern of Reentry in a Mathematical Model of Human Atrial Fibrillation.

Lee YS, Hwang M, Song JS, Li C, Joung B, Sobie EA, Pak HN.

PLoS One. 2016 Mar 10;11(3):e0150779. doi: 10.1371/journal.pone.0150779. eCollection 2016.

20.

Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms.

Lancaster MC, Sobie EA.

Clin Pharmacol Ther. 2016 Oct;100(4):371-9. doi: 10.1002/cpt.367. Epub 2016 May 20.

21.

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms.

Krogh-Madsen T, Sobie EA, Christini DJ.

J Physiol. 2016 May 1;594(9):2525-36. doi: 10.1113/JP270618. Epub 2016 Feb 4. Review.

22.

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes.

Devenyi RA, Sobie EA.

J Mol Cell Cardiol. 2016 Jul;96:38-48. doi: 10.1016/j.yjmcc.2015.07.016. Epub 2015 Jul 30.

23.

Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome.

Yue Y, Castrichini M, Srivastava U, Fabris F, Shah K, Li Z, Qu Y, El-Sherif N, Zhou Z, January C, Hussain MM, Jiang XC, Sobie EA, Wahren-Herlenius M, Chahine M, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M.

Circulation. 2015 Jul 28;132(4):230-40. doi: 10.1161/CIRCULATIONAHA.115.009800. Epub 2015 May 20.

PMID:
25995318
24.

Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes.

Poláková E, Illaste A, Niggli E, Sobie EA.

J Physiol. 2015 Mar 15;593(6):1495-507. doi: 10.1113/jphysiol.2014.278051. Epub 2014 Oct 7.

25.

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.

26.

The ryanodine receptor patchwork: knitting calcium spark dynamics.

Núñez-Acosta E, Sobie EA.

Biophys J. 2014 Dec 16;107(12):2749-2750. doi: 10.1016/j.bpj.2014.10.068. No abstract available.

27.

Calcium homeostasis in a local/global whole cell model of permeabilized ventricular myocytes with a Langevin description of stochastic calcium release.

Wang X, Weinberg SH, Hao Y, Sobie EA, Smith GD.

Am J Physiol Heart Circ Physiol. 2015 Mar 1;308(5):H510-23. doi: 10.1152/ajpheart.00296.2014. Epub 2014 Dec 5.

28.

Identification and purification of human induced pluripotent stem cell-derived atrial-like cardiomyocytes based on sarcolipin expression.

Josowitz R, Lu J, Falce C, D'Souza SL, Wu M, Cohen N, Dubois NC, Zhao Y, Sobie EA, Fishman GI, Gelb BD.

PLoS One. 2014 Jul 10;9(7):e101316. doi: 10.1371/journal.pone.0101316. eCollection 2014.

29.

Comprehensive analyses of ventricular myocyte models identify targets exhibiting favorable rate dependence.

Cummins MA, Dalal PJ, Bugana M, Severi S, Sobie EA.

PLoS Comput Biol. 2014 Mar 27;10(3):e1003543. doi: 10.1371/journal.pcbi.1003543. eCollection 2014 Mar.

30.

Multifaceted roles of miR-1s in repressing the fetal gene program in the heart.

Wei Y, Peng S, Wu M, Sachidanandam R, Tu Z, Zhang S, Falce C, Sobie EA, Lebeche D, Zhao Y.

Cell Res. 2014 Mar;24(3):278-92. doi: 10.1038/cr.2014.12. Epub 2014 Jan 31.

31.

Computer simulation of voltage sensitive calcium ion channels in a dendritic spine.

Lee P, Sobie EA, Peskin CS.

J Theor Biol. 2013 Dec 7;338:87-93. doi: 10.1016/j.jtbi.2013.08.019. Epub 2013 Aug 30.

32.

Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility.

Cummins MA, Devenyi RA, Sobie EA.

J Mol Cell Cardiol. 2013 Jul;60:161-3. doi: 10.1016/j.yjmcc.2013.04.020. Epub 2013 Apr 28. No abstract available.

PMID:
23632045
33.

Parameter sensitivity analysis of stochastic models provides insights into cardiac calcium sparks.

Lee YS, Liu OZ, Hwang HS, Knollmann BC, Sobie EA.

Biophys J. 2013 Mar 5;104(5):1142-50. doi: 10.1016/j.bpj.2012.12.055.

34.

Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses.

Poláková E, Sobie EA.

Cardiovasc Res. 2013 May 1;98(2):233-9. doi: 10.1093/cvr/cvt026. Epub 2013 Feb 7. Review.

35.

Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.

Lee YS, Liu OZ, Sobie EA.

J Mol Cell Cardiol. 2013 May;58:92-9. doi: 10.1016/j.yjmcc.2012.09.009. Epub 2012 Sep 28. Review.

36.

Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway.

LaRocca TJ, Fabris F, Chen J, Benhayon D, Zhang S, McCollum L, Schecter AD, Cheung JY, Sobie EA, Hajjar RJ, Lebeche D.

Am J Physiol Heart Circ Physiol. 2012 Aug 1;303(3):H353-67. doi: 10.1152/ajpheart.01198.2011. Epub 2012 May 18.

37.

Exploiting mathematical models to illuminate electrophysiological variability between individuals.

Sarkar AX, Christini DJ, Sobie EA.

J Physiol. 2012 Jun 1;590(11):2555-67. doi: 10.1113/jphysiol.2011.223313. Epub 2012 Apr 10. Review.

38.

Stochastic simulation of cardiac ventricular myocyte calcium dynamics and waves.

Tuan HT, Williams GS, Chikando AC, Sobie EA, Lederer WJ, Jafri MS.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4677-80. doi: 10.1109/IEMBS.2011.6091158.

39.

Regression methods for parameter sensitivity analysis: applications to cardiac arrhythmia mechanisms.

Sobie EA, Sarkar AX.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4657-60. doi: 10.1109/IEMBS.2011.6091153.

PMID:
22255376
40.

Does the Goldilocks Principle apply to calcium release restitution in heart cells?

Liu OZ, Lederer WJ, Sobie EA.

J Mol Cell Cardiol. 2012 Jan;52(1):3-6. doi: 10.1016/j.yjmcc.2011.10.014. Epub 2011 Oct 28. No abstract available.

41.

Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system.

Bao L, Kefaloyianni E, Lader J, Hong M, Morley G, Fishman GI, Sobie EA, Coetzee WA.

Circ Arrhythm Electrophysiol. 2011 Dec;4(6):926-35. doi: 10.1161/CIRCEP.111.964643. Epub 2011 Oct 9.

42.

Computational modeling of the cell cycle.

Sobie EA.

Sci Signal. 2011 Sep 20;4(192):tr11. doi: 10.1126/scisignal.2001985.

43.

Bistability in biochemical signaling models.

Sobie EA.

Sci Signal. 2011 Sep 20;4(192):tr10. doi: 10.1126/scisignal.2001964.

44.

Dynamics of calcium sparks and calcium leak in the heart.

Williams GS, Chikando AC, Tuan HT, Sobie EA, Lederer WJ, Jafri MS.

Biophys J. 2011 Sep 21;101(6):1287-96. doi: 10.1016/j.bpj.2011.07.021. Epub 2011 Sep 20.

45.

An introduction to MATLAB.

Sobie EA.

Sci Signal. 2011 Sep 13;4(191):tr7. doi: 10.1126/scisignal.2001984.

46.

An introduction to dynamical systems.

Sobie EA.

Sci Signal. 2011 Sep 13;4(191):tr6. doi: 10.1126/scisignal.2001982.

47.

Systems biology--biomedical modeling.

Sobie EA, Lee YS, Jenkins SL, Iyengar R.

Sci Signal. 2011 Sep 6;4(190):tr2. doi: 10.1126/scisignal.2001989. Review.

48.

Dynamic local changes in sarcoplasmic reticulum calcium: physiological and pathophysiological roles.

Sobie EA, Lederer WJ.

J Mol Cell Cardiol. 2012 Feb;52(2):304-11. doi: 10.1016/j.yjmcc.2011.06.024. Epub 2011 Jul 13. Review.

49.

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis.

Sarkar AX, Sobie EA.

Heart Rhythm. 2011 Nov;8(11):1749-55. doi: 10.1016/j.hrthm.2011.05.023. Epub 2011 Jun 7.

50.

Recovery of cardiac calcium release is controlled by sarcoplasmic reticulum refilling and ryanodine receptor sensitivity.

Ramay HR, Liu OZ, Sobie EA.

Cardiovasc Res. 2011 Sep 1;91(4):598-605. doi: 10.1093/cvr/cvr143. Epub 2011 May 24.

Supplemental Content

Loading ...
Support Center