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Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection.

Shim R, Wen SW, Wanrooy BJ, Rank M, Thirugnanachandran T, Ho L, Sepehrizadeh T, de Veer M, Srikanth VK, Ma H, Phan TG, Sobey CG, Wong CHY.

Transl Stroke Res. 2019 Nov 10. doi: 10.1007/s12975-019-00738-3. [Epub ahead of print]


Genome-Wide Transcriptome Analysis Reveals Intermittent Fasting-Induced Metabolic Rewiring in the Liver.

Ng GY, Kang SW, Kim J, Alli-Shaik A, Baik SH, Jo DG, Hande MP, Sobey CG, Gunaratne J, Fann DY, Arumugam TV.

Dose Response. 2019 Sep 25;17(3):1559325819876780. doi: 10.1177/1559325819876780. eCollection 2019 Jul-Sep.


Sex: A change in our guidelines to authors to ensure that this is no longer an ignored experimental variable.

Docherty JR, Stanford SC, Panattieri RA, Alexander SPH, Cirino G, George CH, Hoyer D, Izzo AA, Ji Y, Lilley E, Sobey CG, Stanley P, Stefanska B, Stephens G, Teixeira M, Ahluwalia A.

Br J Pharmacol. 2019 Aug 23. doi: 10.1111/bph.14761. [Epub ahead of print] No abstract available.


Bacteriophages in Natural and Artificial Environments.

Batinovic S, Wassef F, Knowler SA, Rice DTF, Stanton CR, Rose J, Tucci J, Nittami T, Vinh A, Drummond GR, Sobey CG, Chan HT, Seviour RJ, Petrovski S, Franks AE.

Pathogens. 2019 Jul 12;8(3). pii: E100. doi: 10.3390/pathogens8030100. Review.


microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke.

Tabet F, Lee S, Zhu W, Levin MG, Toth CL, Cuesta Torres LF, Vinh A, Kim HA, Chu HX, Evans MA, Kuzmich ME, Drummond GR, Remaley AT, Rye KA, Sobey CG, Vickers KC.

J Cereb Blood Flow Metab. 2019 Jul 11:271678X19858637. doi: 10.1177/0271678X19858637. [Epub ahead of print]


Cell-Based Therapies for Stroke: Are We There Yet?

Krause M, Phan TG, Ma H, Sobey CG, Lim R.

Front Neurol. 2019 Jun 25;10:656. doi: 10.3389/fneur.2019.00656. eCollection 2019. Review.


Immunity and hypertension: New targets to lighten the pressure.

Vinh A, Drummond GR, Sobey CG.

Br J Pharmacol. 2019 Jun;176(12):1813-1817. doi: 10.1111/bph.14659.


IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice.

Zhang SR, Nold MF, Tang SC, Bui CB, Nold CA, Arumugam TV, Drummond GR, Sobey CG, Kim HA.

Sci Rep. 2019 May 6;9(1):6922. doi: 10.1038/s41598-019-43364-7.


Aged rats have an altered immune response and worse outcomes after traumatic brain injury.

Sun M, Brady RD, Casillas-Espinosa PM, Wright DK, Semple BD, Kim HA, Mychasiuk R, Sobey CG, O'Brien TJ, Vinh A, McDonald SJ, Shultz SR.

Brain Behav Immun. 2019 Aug;80:536-550. doi: 10.1016/j.bbi.2019.04.038. Epub 2019 Apr 27.


Immune mechanisms of hypertension.

Drummond GR, Vinh A, Guzik TJ, Sobey CG.

Nat Rev Immunol. 2019 Aug;19(8):517-532. doi: 10.1038/s41577-019-0160-5. Review.


Mild Closed-Head Injury in Conscious Rats Causes Transient Neurobehavioral and Glial Disturbances: A Novel Experimental Model of Concussion.

Pham L, Shultz SR, Kim HA, Brady RD, Wortman RC, Genders SG, Hale MW, O'Shea RD, Djouma E, van den Buuse M, Church JE, Christie BR, Drummond GR, Sobey CG, McDonald SJ.

J Neurotrauma. 2019 Jul 15;36(14):2260-2271. doi: 10.1089/neu.2018.6169. Epub 2019 Apr 10.


NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development.

Harrison IP, Vinh A, Johnson IRD, Luong R, Drummond GR, Sobey CG, Tiganis T, Williams ED, O' Leary JJ, Brooks DA, Selemidis S.

Oncotarget. 2018 Oct 23;9(83):35378-35393. doi: 10.18632/oncotarget.26237. eCollection 2018 Oct 23.


Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.

Krishnan SM, Ling YH, Huuskes BM, Ferens DM, Saini N, Chan CT, Diep H, Kett MM, Samuel CS, Kemp-Harper BK, Robertson AAB, Cooper MA, Peter K, Latz E, Mansell AS, Sobey CG, Drummond GR, Vinh A.

Cardiovasc Res. 2019 Mar 15;115(4):776-787. doi: 10.1093/cvr/cvy252.


Local Injection of Endothelin-1 in the Early Neonatal Rat Brain Models Ischemic Damage Associated with Motor Impairment and Diffuse Loss in Brain Volume.

Wright JL, Chu HX, Kagan BJ, Ermine CM, Kauhausen JA, Parish CL, Sobey CG, Thompson LH.

Neuroscience. 2018 Nov 21;393:110-122. doi: 10.1016/j.neuroscience.2018.09.043. Epub 2018 Oct 6.


IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke.

Zhang SR, Piepke M, Chu HX, Broughton BR, Shim R, Wong CH, Lee S, Evans MA, Vinh A, Sakkal S, Arumugam TV, Magnus T, Huber S, Gelderblom M, Drummond GR, Sobey CG, Kim HA.

JCI Insight. 2018 Sep 20;3(18). pii: 121560. doi: 10.1172/jci.insight.121560. eCollection 2018 Sep 20.


Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke.

Poh L, Kang SW, Baik SH, Ng GYQ, She DT, Balaganapathy P, Dheen ST, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV.

Brain Behav Immun. 2019 Jan;75:34-47. doi: 10.1016/j.bbi.2018.09.001. Epub 2018 Sep 5.


Amnion epithelial cells - a novel therapy for ischemic stroke?

Evans MA, Broughton BRS, Drummond GR, Ma H, Phan TG, Wallace EM, Lim R, Sobey CG.

Neural Regen Res. 2018 Aug;13(8):1346-1349. doi: 10.4103/1673-5374.235223.


Phase 1 Trial of Amnion Cell Therapy for Ischemic Stroke.

Phan TG, Ma H, Lim R, Sobey CG, Wallace EM.

Front Neurol. 2018 Jun 7;9:198. doi: 10.3389/fneur.2018.00198. eCollection 2018.


Epigenetic regulation of inflammation in stroke.

Ng GY, Lim YA, Sobey CG, Dheen T, Fann DY, Arumugam TV.

Ther Adv Neurol Disord. 2018 Apr 26;11:1756286418771815. doi: 10.1177/1756286418771815. eCollection 2018. Review.


Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, Karamyan VT, Vemuganti R, Sobey CG, Mattson MP, Jo DG, Arumugam TV.

Hum Mol Genet. 2018 Jul 1;27(13):2405. doi: 10.1093/hmg/ddy138. No abstract available.


Notch signaling and neuronal death in stroke.

Arumugam TV, Baik SH, Balaganapathy P, Sobey CG, Mattson MP, Jo DG.

Prog Neurobiol. 2018 Jun - Aug;165-167:103-116. doi: 10.1016/j.pneurobio.2018.03.002. Epub 2018 Mar 21. Review.


Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2018 Apr;175(7):987-993. doi: 10.1111/bph.14153.


Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke.

Evans MA, Kim HA, Ling YH, Uong S, Vinh A, De Silva TM, Arumugam TV, Clarkson AN, Zosky GR, Drummond GR, Broughton BRS, Sobey CG.

Neuromolecular Med. 2018 Mar;20(1):147-159. doi: 10.1007/s12017-018-8484-z. Epub 2018 Feb 23.


Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, Karamyan VT, Vemuganti R, Sobey CG, Mattson MP, Jo DG, Arumugam TV.

Hum Mol Genet. 2018 May 1;27(9):1497-1513. doi: 10.1093/hmg/ddy057. Erratum in: Hum Mol Genet. 2018 Jul 1;27(13):2405.


Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke.

Evans MA, Lim R, Kim HA, Chu HX, Gardiner-Mann CV, Taylor KWE, Chan CT, Brait VH, Lee S, Dinh QN, Vinh A, Phan TG, Srikanth VK, Ma H, Arumugam TV, Fann DY, Poh L, Hunt CPJ, Pouton CW, Haynes JM, Selemidis S, Kwan W, Teo L, Bourne JA, Neumann S, Young S, Gowing EK, Drummond GR, Clarkson AN, Wallace EM, Sobey CG, Broughton BRS.

Stroke. 2018 Mar;49(3):700-709. doi: 10.1161/STROKEAHA.117.019136. Epub 2018 Jan 30.


Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology.

Alexander SPH, Roberts RE, Broughton BRS, Sobey CG, George CH, Stanford SC, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Mangum J, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2018 Feb;175(3):407-411. doi: 10.1111/bph.14112. No abstract available.


Diagnosing and Treating Hypertensive Disorders of Pregnancy? The Answer May Now Be Less BAFF-ling.

Chan CT, Lieu M, Sobey CG, Drummond GR, Vinh A.

Hypertension. 2017 Nov;70(5):884-886. doi: 10.1161/HYPERTENSIONAHA.117.09849. Epub 2017 Sep 18. No abstract available.


Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice.

Evans MA, Kim HA, De Silva TM, Arumugam TV, Clarkson AN, Drummond GR, Zosky GR, Broughton BR, Sobey CG.

J Cereb Blood Flow Metab. 2018 Nov;38(11):1968-1978. doi: 10.1177/0271678X17719208. Epub 2017 Aug 23.


Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts.

George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S, Ahluwalia A.

Br J Pharmacol. 2017 Sep;174(17):2801-2804. doi: 10.1111/bph.13925. No abstract available.


Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma.

Sun M, Brady RD, Wright DK, Kim HA, Zhang SR, Sobey CG, Johnstone MR, O'Brien TJ, Semple BD, McDonald SJ, Shultz SR.

Brain Behav Immun. 2017 Nov;66:359-371. doi: 10.1016/j.bbi.2017.08.005. Epub 2017 Aug 3.


Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy.

To EE, Vlahos R, Luong R, Halls ML, Reading PC, King PT, Chan C, Drummond GR, Sobey CG, Broughton BRS, Starkey MR, van der Sluis R, Lewin SR, Bozinovski S, O'Neill LAJ, Quach T, Porter CJH, Brooks DA, O'Leary JJ, Selemidis S.

Nat Commun. 2017 Jul 12;8(1):69. doi: 10.1038/s41467-017-00057-x.


Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress.

Dinh QN, Drummond GR, Kemp-Harper BK, Diep H, De Silva TM, Kim HA, Vinh A, Robertson AAB, Cooper MA, Mansell A, Chrissobolis S, Sobey CG.

Aging (Albany NY). 2017 Jun 28;9(6):1595-1606. doi: 10.18632/aging.101255.


Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke.

Balaganapathy P, Baik SH, Mallilankaraman K, Sobey CG, Jo DG, Arumugam TV.

J Cereb Blood Flow Metab. 2018 Oct;38(10):1781-1795. doi: 10.1177/0271678X17715956. Epub 2017 Jun 15.


Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.

Fann DY, Lim YA, Cheng YL, Lok KZ, Chunduri P, Baik SH, Drummond GR, Dheen ST, Sobey CG, Jo DG, Chen CL, Arumugam TV.

Mol Neurobiol. 2018 Feb;55(2):1082-1096. doi: 10.1007/s12035-017-0394-9. Epub 2017 Jan 14.


Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes.

Tare M, Kalidindi RS, Bubb KJ, Parkington HC, Boon WM, Li X, Sobey CG, Drummond GR, Ritchie RH, Kemp-Harper BK.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Apr;390(4):397-408. doi: 10.1007/s00210-016-1336-1. Epub 2017 Jan 10.


Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension.

Dinh QN, Chrissobolis S, Diep H, Chan CT, Ferens D, Drummond GR, Sobey CG.

Pharmacol Res. 2017 Feb;116:70-76. doi: 10.1016/j.phrs.2016.12.032. Epub 2016 Dec 23.


The opposing roles of NO and oxidative stress in cardiovascular disease.

Ritchie RH, Drummond GR, Sobey CG, De Silva TM, Kemp-Harper BK.

Pharmacol Res. 2017 Feb;116:57-69. doi: 10.1016/j.phrs.2016.12.017. Epub 2016 Dec 15. Review.


Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.

Ling YH, Krishnan SM, Chan CT, Diep H, Ferens D, Chin-Dusting J, Kemp-Harper BK, Samuel CS, Hewitson TD, Latz E, Mansell A, Sobey CG, Drummond GR.

Pharmacol Res. 2017 Feb;116:77-86. doi: 10.1016/j.phrs.2016.12.015. Epub 2016 Dec 13.


Cell-specific mineralocorticoid receptors: future therapeutic targets for stroke?

Dinh QN, Drummond GR, Sobey CG, Chrissobolis S.

Neural Regen Res. 2016 Aug;11(8):1230-1. doi: 10.4103/1673-5374.189173. No abstract available.


Corrigendum: Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus.

Devi S, Li A, Westhorpe CL, Lo CY, Abeynaike LD, Snelgrove SL, Hall P, Ooi JD, Sobey CG, Kitching AR, Hickey MJ.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446a. No abstract available.


Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor.

Dinh QN, Young MJ, Evans MA, Drummond GR, Sobey CG, Chrissobolis S.

Brain Res. 2016 Apr 15;1637:146-153. doi: 10.1016/j.brainres.2016.02.034. Epub 2016 Feb 26.


Evidence of CCR2-independent transmigration of Ly6C(hi) monocytes into the brain after permanent cerebral ischemia in mice.

Chu HX, Kim HA, Lee S, Broughton BRS, Drummond GR, Sobey CG.

Brain Res. 2016 Apr 15;1637:118-127. doi: 10.1016/j.brainres.2016.02.030. Epub 2016 Feb 24.


Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries.

Ku JM, Sleeman MW, Sobey CG, Andrews ZB, Miller AA.

Clin Exp Pharmacol Physiol. 2016 Apr;43(4):468-75. doi: 10.1111/1440-1681.12548.


Effect of a Selective Mas Receptor Agonist in Cerebral Ischemia In Vitro and In Vivo.

Lee S, Evans MA, Chu HX, Kim HA, Widdop RE, Drummond GR, Sobey CG.

PLoS One. 2015 Nov 5;10(11):e0142087. doi: 10.1371/journal.pone.0142087. eCollection 2015.


MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents.

Samson AL, Ju L, Ah Kim H, Zhang SR, Lee JA, Sturgeon SA, Sobey CG, Jackson SP, Schoenwaelder SM.

Sci Rep. 2015 Nov 4;5:16171. doi: 10.1038/srep16171.


Risk of Major Cardiovascular Events in People with Down Syndrome.

Sobey CG, Judkins CP, Sundararajan V, Phan TG, Drummond GR, Srikanth VK.

PLoS One. 2015 Sep 30;10(9):e0137093. doi: 10.1371/journal.pone.0137093. eCollection 2015.


Obligatory Role for B Cells in the Development of Angiotensin II-Dependent Hypertension.

Chan CT, Sobey CG, Lieu M, Ferens D, Kett MM, Diep H, Kim HA, Krishnan SM, Lewis CV, Salimova E, Tipping P, Vinh A, Samuel CS, Peter K, Guzik TJ, Kyaw TS, Toh BH, Bobik A, Drummond GR.

Hypertension. 2015 Nov;66(5):1023-33. doi: 10.1161/HYPERTENSIONAHA.115.05779. Epub 2015 Sep 8.


Danger signals in stroke.

Gelderblom M, Sobey CG, Kleinschnitz C, Magnus T.

Ageing Res Rev. 2015 Nov;24(Pt A):77-82. doi: 10.1016/j.arr.2015.07.004. Epub 2015 Jul 22. Review.


Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.

Krishnan SM, Dowling JK, Ling YH, Diep H, Chan CT, Ferens D, Kett MM, Pinar A, Samuel CS, Vinh A, Arumugam TV, Hewitson TD, Kemp-Harper BK, Robertson AA, Cooper MA, Latz E, Mansell A, Sobey CG, Drummond GR.

Br J Pharmacol. 2016 Feb;173(4):752-65. doi: 10.1111/bph.13230. Epub 2015 Jul 31.

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