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Items: 1 to 50 of 232

1.

Anti-Myelin Proteolipid Protein Peptide Monoclonal Antibodies Recognize Cell Surface Proteins on Developing Neurons and Inhibit Their Differentiation.

Sobel RA, Eaton MJ, Jaju PD, Lowry E, Hinojoza JR.

J Neuropathol Exp Neurol. 2019 Sep 1;78(9):819-843. doi: 10.1093/jnen/nlz058.

2.

Glioneuronal Tumor With Features of Ganglioglioma and Neurocytoma Arising in the Fourth Ventricle: A Report of 2 Unusual Cases and a Review of Infratentorial Gangliogliomas.

Harrison W, Elsamadicy AA, McMahon JT, Chagoya G, Sobel RA, McLendon RE, Adamson C.

J Neuropathol Exp Neurol. 2019 Sep 1;78(9):780-787. doi: 10.1093/jnen/nlz060.

PMID:
31361005
3.

IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.

Zhang X, Kiapour N, Kapoor S, Khan T, Thamilarasan M, Tao Y, Cohen S, Miller R, Sobel RA, Markovic-Plese S.

J Immunol. 2019 Sep 1;203(5):1142-1150. doi: 10.4049/jimmunol.1900311. Epub 2019 Jul 24.

4.

Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet.

Singh AB, Kan CFK, Kraemer FB, Sobel RA, Liu J.

Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E880-E894. doi: 10.1152/ajpendo.00503.2018. Epub 2019 Feb 5.

PMID:
30721098
5.

DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis.

Graham KL, Werner BJ, Moyer KM, Patton AK, Krois CR, Yoo HS, Tverskoy M, LaJevic M, Napoli JL, Sobel RA, Zabel BA, Butcher EC.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3126-3135. doi: 10.1073/pnas.1817669116. Epub 2019 Feb 4.

6.

Correction: Peroxisome proliferator-activated receptor (PPAR)α expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.

Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L.

J Exp Med. 2018 Jun 4;215(6):1765. doi: 10.1084/jem.2006183905142018c. Epub 2018 May 17. No abstract available.

7.

Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function.

Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH.

J Immunol. 2018 Apr 15;200(8):2592-2602. doi: 10.4049/jimmunol.1701231. Epub 2018 Mar 12.

8.

Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N.

J Immunol. 2018 Apr 15;200(8):3000-3007. doi: 10.4049/jimmunol.1700407. Epub 2018 Mar 2.

9.

Microhemorrhage-associated tissue iron enhances the risk for Aspergillus fumigatus invasion in a mouse model of airway transplantation.

Hsu JL, Manouvakhova OV, Clemons KV, Inayathullah M, Tu AB, Sobel RA, Tian A, Nazik H, Pothineni VR, Pasupneti S, Jiang X, Dhillon GS, Bedi H, Rajadas J, Haas H, Aurelian L, Stevens DA, Nicolls MR.

Sci Transl Med. 2018 Feb 21;10(429). pii: eaag2616. doi: 10.1126/scitranslmed.aag2616.

10.

Epitope Mapping of SERCA2a Identifies an Antigenic Determinant That Induces Mainly Atrial Myocarditis in A/J Mice.

Krishnan B, Massilamany C, Basavalingappa RH, Gangaplara A, Rajasekaran RA, Afzal MZ, Khalilzad-Sharghi V, Zhou Y, Riethoven JJ, Nandi SS, Mishra PK, Sobel RA, Strande JL, Steffen D, Reddy J.

J Immunol. 2018 Jan 15;200(2):523-537. doi: 10.4049/jimmunol.1701090. Epub 2017 Dec 11.

11.

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.

Sagan SA, Cruz-Herranz A, Spencer CM, Ho PP, Steinman L, Green AJ, Sobel RA, Zamvil SS.

J Vis Exp. 2017 Aug 21;(126). doi: 10.3791/56185.

12.

Lack of Efficacy of Liposomal Amphotericin B Against Acute and Chronic Trypanosoma cruzi Infection in Mice.

Clemons KV, Sobel RA, Martinez M, Correa-Oliveira R, Stevens DA.

Am J Trop Med Hyg. 2017 Oct;97(4):1141-1146. doi: 10.4269/ajtmh.16-0975. Epub 2017 Aug 18.

13.

T cells targeting neuromyelitis optica autoantigen aquaporin-4 cause paralysis and visual system injury.

Cruz-Herranz A, Sagan SA, Sobel RA, Green AJ, Zamvil SS.

J Nat Sci. 2017 May;3(5). pii: e358.

14.

Editor's Note: Transitions at the JNEN.

Sobel RA.

J Neuropathol Exp Neurol. 2017 May 1;76(5):336. doi: 10.1093/jnen/nlx019. No abstract available.

PMID:
28419288
15.

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14781-14786. doi: 10.1073/pnas.1617859114. Epub 2016 Dec 8.

16.

Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice.

Basavalingappa RH, Massilamany C, Krishnan B, Gangaplara A, Kang G, Khalilzad-Sharghi V, Han Z, Othman S, Li Q, Riethoven JJ, Sobel RA, Steffen D, Reddy J.

Am J Pathol. 2016 Dec;186(12):3160-3175. doi: 10.1016/j.ajpath.2016.08.005.

17.

The central vein sign and its clinical evaluation for the diagnosis of multiple sclerosis: a consensus statement from the North American Imaging in Multiple Sclerosis Cooperative.

Sati P, Oh J, Constable RT, Evangelou N, Guttmann CR, Henry RG, Klawiter EC, Mainero C, Massacesi L, McFarland H, Nelson F, Ontaneda D, Rauscher A, Rooney WD, Samaraweera AP, Shinohara RT, Sobel RA, Solomon AJ, Treaba CA, Wuerfel J, Zivadinov R, Sicotte NL, Pelletier D, Reich DS; NAIMS Cooperative.

Nat Rev Neurol. 2016 Dec;12(12):714-722. doi: 10.1038/nrneurol.2016.166. Epub 2016 Nov 11. Review.

PMID:
27834394
18.

Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression.

Varrin-Doyer M, Pekarek KL, Spencer CM, Bernard CC, Sobel RA, Cree BA, Schulze-Topphoff U, Zamvil SS.

Neurol Neuroimmunol Neuroinflamm. 2016 Sep 21;3(5):e272. eCollection 2016 Oct.

19.

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.

McArdel SL, Brown DR, Sobel RA, Sharpe AH.

J Immunol. 2016 Oct 15;197(8):3038-3048. Epub 2016 Aug 31.

20.

IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation.

Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL.

Brain. 2016 Jul;139(Pt 7):1939-57. doi: 10.1093/brain/aww113. Epub 2016 May 31.

21.

Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.

Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4777-82. doi: 10.1073/pnas.1603907113. Epub 2016 Apr 13.

22.

CNS accumulation of regulatory B cells is VLA-4-dependent.

Lehmann-Horn K, Sagan SA, Winger RC, Spencer CM, Bernard CC, Sobel RA, Zamvil SS.

Neurol Neuroimmunol Neuroinflamm. 2016 Mar 9;3(2):e212. doi: 10.1212/NXI.0000000000000212. eCollection 2016 Apr.

23.

Lysia K.S. Forno, MD February 14, 1918-May 8, 2015.

Herrick MK, Sobel RA.

J Neuropathol Exp Neurol. 2015 Dec;74(12):1180-2. No abstract available.

PMID:
26904767
24.

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.

Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Meyer Zu Horste G, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK.

Cell. 2015 Dec 3;163(6):1413-27. doi: 10.1016/j.cell.2015.10.068. Epub 2015 Nov 19.

25.

IL-21R signaling is critical for induction of spontaneous experimental autoimmune encephalomyelitis.

Lee Y, Mitsdoerffer M, Xiao S, Gu G, Sobel RA, Kuchroo VK.

J Clin Invest. 2015 Nov 2;125(11):4011-20. doi: 10.1172/JCI75933. Epub 2015 Sep 28.

26.

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH.

J Exp Med. 2015 Sep 21;212(10):1603-21. doi: 10.1084/jem.20141030. Epub 2015 Sep 14.

27.

B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.

Lehmann-Horn K, Sagan SA, Bernard CC, Sobel RA, Zamvil SS.

Ann Neurol. 2015 May;77(5):902-8. doi: 10.1002/ana.24387. Epub 2015 Mar 28.

28.

Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation.

Xiao S, Brooks CR, Sobel RA, Kuchroo VK.

J Immunol. 2015 Feb 15;194(4):1602-8. doi: 10.4049/jimmunol.1402632. Epub 2015 Jan 12.

29.

A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease.

Graham KL, Zhang JV, Lewén S, Burke TM, Dang T, Zoudilova M, Sobel RA, Butcher EC, Zabel BA.

PLoS One. 2014 Dec 1;9(12):e112925. doi: 10.1371/journal.pone.0112925. eCollection 2014.

30.

Podoplanin negatively regulates CD4+ effector T cell responses.

Peters A, Burkett PR, Sobel RA, Buckley CD, Watson SP, Bettelli E, Kuchroo VK.

J Clin Invest. 2015 Jan;125(1):129-40. doi: 10.1172/JCI74685. Epub 2014 Nov 21.

31.

Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.

Shetty A, Gupta SG, Varrin-Doyer M, Weber MS, Prod'homme T, Molnarfi N, Ji N, Nelson PA, Patarroyo JC, Schulze-Topphoff U, Fogal SE, Forsthuber T, Sobel RA, Bernard CC, Slavin AJ, Zamvil SS.

Neurol Neuroimmunol Neuroinflamm. 2014 Aug 14;1(2):e22. doi: 10.1212/NXI.0000000000000022. eCollection 2014 Aug.

32.

SJL mice infected with Acanthamoeba castellanii develop central nervous system autoimmunity through the generation of cross-reactive T cells for myelin antigens.

Massilamany C, Marciano-Cabral F, Rocha-Azevedo Bd, Jamerson M, Gangaplara A, Steffen D, Zabad R, Illes Z, Sobel RA, Reddy J.

PLoS One. 2014 May 30;9(5):e98506. doi: 10.1371/journal.pone.0098506. eCollection 2014.

33.

Uncovering cryptic glycan markers in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE).

Wang D, Bhat R, Sobel RA, Huang W, Wang LX, Olsson T, Steinman L.

Drug Dev Res. 2014 May;75(3):172-88. doi: 10.1002/ddr.21169. Epub 2014 Mar 11.

34.

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.

Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS.

J Exp Med. 2013 Dec 16;210(13):2921-37. doi: 10.1084/jem.20130699. Epub 2013 Dec 9.

35.

Aspergillus fumigatus invasion increases with progressive airway ischemia.

Hsu JL, Khan MA, Sobel RA, Jiang X, Clemons KV, Nguyen TT, Stevens DA, Martinez M, Nicolls MR.

PLoS One. 2013 Oct 14;8(10):e77136. doi: 10.1371/journal.pone.0077136. eCollection 2013.

36.

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH.

Nat Immunol. 2013 Nov;14(11):1166-72. doi: 10.1038/ni.2730. Epub 2013 Sep 29.

37.

Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.

Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE.

J Exp Med. 2013 Jul 1;210(7):1301-9.

38.

Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

Kurnellas MP, Adams CM, Sobel RA, Steinman L, Rothbard JB.

Sci Transl Med. 2013 Apr 3;5(179):179ra42. doi: 10.1126/scitranslmed.3005681.

39.

Induction and molecular signature of pathogenic TH17 cells.

Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK.

Nat Immunol. 2012 Oct;13(10):991-9. doi: 10.1038/ni.2416. Epub 2012 Sep 9.

40.

Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis.

Kurnellas MP, Brownell SE, Su L, Malkovskiy AV, Rajadas J, Dolganov G, Chopra S, Schoolnik GK, Sobel RA, Webster J, Ousman SS, Becker RA, Steinman L, Rothbard JB.

J Biol Chem. 2012 Oct 19;287(43):36423-34. doi: 10.1074/jbc.M112.371229. Epub 2012 Sep 6.

41.

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK.

Nat Med. 2012 Sep;18(9):1394-400.

42.

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice.

Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12105-10. doi: 10.1073/pnas.1120914109. Epub 2012 Jul 5.

43.

Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice.

Han MH, Lundgren DH, Jaiswal S, Chao M, Graham KL, Garris CS, Axtell RC, Ho PP, Lock CB, Woodard JI, Brownell SE, Zoudilova M, Hunt JF, Baranzini SE, Butcher EC, Raine CS, Sobel RA, Han DK, Weissman I, Steinman L.

J Exp Med. 2012 Jul 2;209(7):1325-34. doi: 10.1084/jem.20101974. Epub 2012 Jun 25.

44.

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity.

Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS.

PLoS One. 2012;7(3):e33797. doi: 10.1371/journal.pone.0033797. Epub 2012 Mar 30.

45.

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells.

Anderson AC, Chandwaskar R, Lee DH, Sullivan JM, Solomon A, Rodriguez-Manzanet R, Greve B, Sobel RA, Kuchroo VK.

J Immunol. 2012 Mar 1;188(5):2084-92. doi: 10.4049/jimmunol.1102186. Epub 2012 Jan 25.

46.

Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation.

Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK.

Immunity. 2011 Dec 23;35(6):986-96. doi: 10.1016/j.immuni.2011.10.015. Epub 2011 Dec 15.

47.

Acamprosate modulates experimental autoimmune encephalomyelitis.

Sternberg Z, Cesario A, Rittenhouse-Olson K, Sobel RA, Leung YK, Pankewycz O, Zhu B, Whitcomb T, Sternberg DS, Munschauer FE.

Inflammopharmacology. 2012 Feb;20(1):39-48. doi: 10.1007/s10787-011-0097-1. Epub 2011 Nov 17. Erratum in: Inflammopharmacology. 2012 Feb;20(1):49. Leung, Yi-Kan [added].

PMID:
22090150
48.

Apparent expression of varicella-zoster virus proteins in latency resulting from reactivity of murine and rabbit antibodies with human blood group a determinants in sensory neurons.

Zerboni L, Sobel RA, Lai M, Triglia R, Steain M, Abendroth A, Arvin A.

J Virol. 2012 Jan;86(1):578-83. doi: 10.1128/JVI.05950-11. Epub 2011 Oct 19.

49.

Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.

Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH.

J Clin Immunol. 2011 Dec;31(6):1010-20. doi: 10.1007/s10875-011-9579-6. Epub 2011 Aug 17.

50.

Aberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.

Qi X, Disatnik MH, Shen N, Sobel RA, Mochly-Rosen D.

Mol Biol Cell. 2011 Jan 15;22(2):256-65. doi: 10.1091/mbc.E10-06-0551. Epub 2010 Nov 30.

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