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Items: 1 to 50 of 905

1.

The effects of aging and cardiovascular risk factors on microvascular function assessed by near-infrared spectroscopy.

de Oliveira GV, Soares RN, Volino-Souza M, Leitão R, Murias JM, Alvares TS.

Microvasc Res. 2019 Aug 16:103911. doi: 10.1016/j.mvr.2019.103911. [Epub ahead of print]

PMID:
31425692
2.

Trends in urinary calculi composition from 2005 to 2015: a single tertiary center study.

Talati VM, Soares RMO, Khambati A, Nadler RB, Perry KT Jr.

Urolithiasis. 2019 Aug 1. doi: 10.1007/s00240-019-01151-z. [Epub ahead of print]

PMID:
31372690
3.

Intraspecies Polymorphisms in the Lipophosphoglycan of L. braziliensis Differentially Modulate Macrophage Activation via TLR4.

Vieira TDS, Rugani JN, Nogueira PM, Torrecilhas AC, Gontijo CMF, Descoteaux A, Soares RP.

Front Cell Infect Microbiol. 2019 Jul 10;9:240. doi: 10.3389/fcimb.2019.00240. eCollection 2019.

4.

Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial.

Weber B, Bersch-Ferreira ÂC, Torreglosa CR, Marcadenti A, Lara ES, da Silva JT, Costa RP, Santos RHN, Berwanger O, Bosquetti R, Pagano R, Mota LGS, de Oliveira JD, Soares RM, Galante AP, da Silva SA, Zampieri FG, Kovacs C, Amparo FC, Moreira P, da Silva RA, Dos Santos KG, Monteiro AS, Paiva CCJ, Magnoni CD, Moreira ASB, Peçanha DO, Missias KCS, de Paula LS, Marotto D, Souza P, Martins PRT, Dos Santos EM, Santos MR, Silva LP, Torres RS, Barbosa SNAA, de Pinho PM, de Araujo SHA, Veríssimo AOL, Guterres AS, Cardoso AFR, Palmeira MM, de Ataíde BRB, Costa LPS, Marinho HA, de Araújo CBP, Carvalho HMS, Maquiné RO, Caiado AC, de Matos CH, Barretta C, Specht CM, Onofrei M, Bertacco RTA, Borges LR, Bertoldi EG, Longo A, Ribas BLP, Dobke F, Pretto ADB, Bachettini NP, Gastaud A, Necchi R, Souza GC, Zuchinali P, Fracasso BM, Bobadra S, Sangali TD, Salamoni J, Garlini LM, Shirmann GS, de Los Santos MLP, Bortonili VMS, Dos Santos CP, Bragança GCM, Ambrózio CL, E Lima SB, Schiavini J, Napparo AS, Boemo JL, Nagano FEZ, Modanese PVG, Cunha NM, Frehner C, da Silva LF, Formentini FS, Ramos MEM, Ramos SS, Lucas MCS, Machado BG, Ruschel KB, Beiersdorf JR, Nunes CE, Rech RL, Damiani M, Berbigier M, Poloni S, Vian I, Russo DS, Rodrigues JA, de Moraes MAP, da Costa LM, Boklis M, El Kik RM, Adorne EF, Teixeira JM, Trescastro EP, Chiesa FL, Telles CT, Pellegrini LA, Reis LF, Cardoso RGM, Closs VE, Feres NH, da Silva NF, Silva NE, Dutra ES, Ito MK, Lima MEP, Carvalho APPF, Taboada MIS, Machado MMA, David MM, Júnior DGS, Dourado C, Fagundes VCFO, Uehara RM, Sasso S, Vieira JSO, de Oliveira BAS, Pereira JL, Rodrigues IG, Pinho CPS, Sousa ACS, Almeida AS, de Jesus MT, da Silva GB, Alves LVS, Nascimento VOG, Vieira SA, Coura AGL, Dantas CF, Leda NMFS, Medeiros AL, Andrade ACL, Pinheiro JMF, de Lima LRM, Sabino LS, de Souza CVS, Vasconcelos SML, Costa FA, Ferreira RC, Cardoso IB, Navarro LNP, Ferreira RB, Júnior AES, Silva MBG, Almeida KMM, Penafort AM, de Queirós APO, Farias GMN, Carlos DMO, Cordeiro CGNC, Vasconcelos VB, de Araújo EMVMC, Sahade V, Ribeiro CSA, Araujo GA, Gonçalves LB, Teixeira CS, Silva LMAJ, da Costa LB, Souza TS, de Jesus SO, Luna AB, da Rocha BRS, Santos MA, Neto JAF, Dias LPP, Cantanhede RCA, Morais JM, Duarte RCL, Barbosa ECB, Barbosa JMA, de Sousa RML, Dos Santos AF, Teixeira AF, Moriguchi EH, Bruscato NM, Kesties J, Vivian L, de Carli W, Shumacher M, Izar MCO, Asoo MT, Kato JT, Martins CM, Machado VA, Bittencourt CRO, de Freitas TT, Sant'Anna VAR, Lopes JD, Fischer SCPM, Pinto SL, Silva KC, Gratão LHA, Holzbach LC, Backes LM, Rodrigues MP, Deucher KLAL, Cantarelli M, Bertoni VM, Rampazzo D, Bressan J, Hermsdorff HHM, Caldas APS, Felício MB, Honório CR, da Silva A, Souza SR, Rodrigues PA, de Meneses TMX, Kumbier MCC, Barreto AL, Cavalcanti AB.

Am Heart J. 2019 Sep;215:187-197. doi: 10.1016/j.ahj.2019.06.010. Epub 2019 Jun 21.

5.

Fraud and misrepresentation in retail forest products exceeds U.S. forensic wood science capacity.

Wiedenhoeft AC, Simeone J, Smith A, Parker-Forney M, Soares R, Fishman A.

PLoS One. 2019 Jul 25;14(7):e0219917. doi: 10.1371/journal.pone.0219917. eCollection 2019.

6.

Prospective cohort of AIDS patients screened for cryptococcal antigenaemia, pre-emptively treated and followed in Brazil.

Borges MASB, de Araújo Filho JA, Oliveira BJS, Moreira IS, de Paula VV, de Bastos AL, Soares RBA, Turchi MD.

PLoS One. 2019 Jul 25;14(7):e0219928. doi: 10.1371/journal.pone.0219928. eCollection 2019.

7.

LOXL3 Function Beyond Amino Oxidase and Role in Pathologies, Including Cancer.

Laurentino TS, Soares RDS, Marie SKN, Oba-Shinjo SM.

Int J Mol Sci. 2019 Jul 23;20(14). pii: E3587. doi: 10.3390/ijms20143587. Review.

8.

Superficial acral fibromyxoma in unusual location: a case report.

Crepaldi BE, Soares RD, Silveira FD, Taira RI, Matsumoto MH.

ANZ J Surg. 2019 Jul 23. doi: 10.1111/ans.15342. [Epub ahead of print] No abstract available.

PMID:
31334594
9.

Molecular characterization of Canis familiaris oral papillomavirus 1 identified in naturally infected dogs from Northeast Brazil.

Reis JDR, Oliveira LB, Santos LABO, Soares RC, Batista MVA.

Vet Dermatol. 2019 Jul 21. doi: 10.1111/vde.12776. [Epub ahead of print]

PMID:
31328325
10.

Proteomic Analysis Reveals a Predominant NFE2L2 (NRF2) Signature in Canonical Pathway and Upstream Regulator Analysis of Leishmania-Infected Macrophages.

de Menezes JPB, Khouri R, Oliveira CVS, Petersen ALOA, de Almeida TF, Mendes FRL, Rebouças ADAD, Lorentz AL, Luz NF, Lima JB, Ramos PIP, Soares RP, Rugani JN, Buck GA, Krieger MA, Marchini FK, Vivarini ÁC, Lopes UG, Borges VM, Veras PST.

Front Immunol. 2019 Jun 28;10:1362. doi: 10.3389/fimmu.2019.01362. eCollection 2019.

11.

Apical membrane protein 1-specific antibody profile and temporal changes in peripheral blood B-cell populations in Plasmodium vivax malaria.

Soares RR, Cunha CF, Ferraz-Nogueira R, Marins-Dos-Santos A, Rodrigues-da-Silva RN, da Silva Soares I, da Costa Lima-Junior J, Bertho AL, Ferreira MU, Scopel KKG.

Parasite Immunol. 2019 Sep;41(9):e12662. doi: 10.1111/pim.12662. Epub 2019 Jul 24.

PMID:
31271660
12.

Trends in retina specialist imaging utilization from 2012 to 2016 in the United States Medicare fee-for-service population.

Wibbelsman TD, Pandit RR, Xu D, Jenkins TL, Mellen PL, Soares RR, Obeid A, Levin H, Hsu J, Ho AC.

Am J Ophthalmol. 2019 Jun 29. pii: S0002-9394(19)30303-4. doi: 10.1016/j.ajo.2019.06.026. [Epub ahead of print]

PMID:
31265802
13.

Interaction of fibroblasts and induced pluripotent stem cells with poly(vinyl alcohol)-based hydrogel substrates.

Sanguinet EO, Siqueira NM, Menezes FC, Rasia GM, Lothhammer N, Soares RMD, Meirelles FV, Bressan FF, Bos-Mikich A.

J Biomed Mater Res B Appl Biomater. 2019 Jun 28. doi: 10.1002/jbm.b.34439. [Epub ahead of print]

PMID:
31251451
14.

Optimizing the Performance of Chromatographic Separations Using Microfluidics: Multiplexed and Quantitative Screening of Ligands and Target Molecules.

Pinto IF, Soares RRG, Aires-Barros MR, Chu V, Conde JP, Azevedo AM.

Biotechnol J. 2019 Jun 24:e1800593. doi: 10.1002/biot.201800593. [Epub ahead of print]

PMID:
31231924
15.

The influence of fatigue in evertor muscles during lateral ankle sprain.

Rodrigues KA, Soares RJ, Tomazini JE.

Foot (Edinb). 2019 May 25;40:98-104. doi: 10.1016/j.foot.2019.05.008. [Epub ahead of print]

PMID:
31229793
16.

Antiarrhythmic Effect of Sacubitril-Valsartan: Cause or Consequence of Clinical Improvement?

Valentim Gonçalves A, Pereira-da-Silva T, Galrinho A, Rio P, Moura Branco L, Soares R, Feliciano J, Ilhão Moreira R, Cruz Ferreira R.

J Clin Med. 2019 Jun 18;8(6). pii: E869. doi: 10.3390/jcm8060869.

17.

Molecular detection of Leishmania spp. in cattle from Brazil by means of PCR using internal transcribed spacer 1.

Vioti G, Leonel JAF, Lemes KM, Pereira VF, Ferreira HL, Keid LB, Madureira EH, Soares RM, Benassi JC, Oliveira TMFS.

Rev Bras Parasitol Vet. 2019 Jun 13;28(2):303-305. doi: 10.1590/S1984-29612019003.

18.

Corneal Opacification.

Soares RR, Patel R, Milman T.

JAMA Ophthalmol. 2019 Jun 13. doi: 10.1001/jamaophthalmol.2019.1646. [Epub ahead of print] No abstract available.

PMID:
31194226
19.

Effects of a rehabilitation program on microvascular function of CHD patients assessed by near-infrared spectroscopy.

Soares RN, Murias JM, Saccone F, Puga L, Moreno G, Resnik M, De Roia GF.

Physiol Rep. 2019 Jun;7(11):e14145. doi: 10.14814/phy2.14145.

20.

Clinical and therapeutic aspects of an outbreak of canine trypanosomiasis.

Echeverria JT, Soares RL, Crepaldi BA, Oliveira GG, Silva PMPD, Pupin RC, Martins TB, Cleveland HPK, Ramos CADN, Borges FA.

Rev Bras Parasitol Vet. 2019 Jun 6;28(2):320-324. doi: 10.1590/S1984-29612019018.

21.

Molecular detection of Leishmania infantum DNA according to clinical stages of leishmaniasis in dog.

Fernandes MA, Leonel JAF, Isaac JA, Benassi JC, Silva DT, Spada JCP, Pereira NWB, Ferreira HL, Keid LB, Soares RM, Oliveira TMFS.

Rev Bras Parasitol Vet. 2019 Jun 6;28(2):194-202. doi: 10.1590/S1984-29612019015.

22.

Studying effects of different protonation states of His11 and His102 in ribose-5-phosphate isomerase of Trypanosoma cruzi: an example of cooperative behavior.

Soares RF, Antunes D, Santos LHS, Rocha GV, Bastos LS, Guimarães ACR, Caffarena ER.

J Biomol Struct Dyn. 2019 Jun 11:1-10. doi: 10.1080/07391102.2019.1626769. [Epub ahead of print]

PMID:
31184542
23.

Anti-inflammatory activity of Protium spruceanum (Benth.) Engler is associated to immunomodulation and enzymes inhibition.

Amparo TR, Seibert JB, Mathias FAS, Vieira JFP, Soares RDOA, Freitas KM, Cabral VAR, Brandão GC, Santos ODHD, de Souza GHB, Vieira PMA.

J Ethnopharmacol. 2019 Sep 15;241:112024. doi: 10.1016/j.jep.2019.112024. Epub 2019 Jun 7.

PMID:
31181316
24.

Avoiding the Interference of Doxorubicin with MTT Measurements on the MCF-7 Breast Cancer Cell Line.

Luis C, Castaño-Guerrero Y, Soares R, Sales G, Fernandes R.

Methods Protoc. 2019 Apr 12;2(2). pii: E29. doi: 10.3390/mps2020029.

25.

Development and evaluation of a loop-mediated isothermal amplification assay for rapid detection of Leishmania amazonensis in skin samples.

Celeste JLL, Caldeira RL, Pires SDF, Silveira KD, Soares RP, de Andrade HM.

Exp Parasitol. 2019 Aug;203:23-29. doi: 10.1016/j.exppara.2019.05.006. Epub 2019 May 28.

PMID:
31150654
26.

Molecular effects of Microcystin-LA in tilapia (Oreochromis niloticus).

Moreira DA, Soares RM, Valente RH, Bebianno MJ, Rebelo MF.

Toxicon. 2019 Aug;166:76-82. doi: 10.1016/j.toxicon.2019.05.002. Epub 2019 May 21.

PMID:
31121173
27.

The association between near-infrared spectroscopy assessment of microvascular reactivity and flow-mediated dilation is disrupted in individuals at high risk for cardiovascular disease.

Vieira de Oliveira G, Soares RN, Volino-Souza M, Murias JM, Alvares TS.

Microcirculation. 2019 May 11:e12556. doi: 10.1111/micc.12556. [Epub ahead of print]

PMID:
31077636
28.

Experiences and Perceptions of Police Officers Concerning Their Interactions With People With Serious Mental Disorders for Compulsory Treatment.

Soares R, Pinto da Costa M.

Front Psychiatry. 2019 Apr 18;10:187. doi: 10.3389/fpsyt.2019.00187. eCollection 2019.

29.

Near-infrared spectroscopy detects transient decrements and recovery of microvascular responsiveness following prolonged forearm ischemia.

Soares RN, Somani YB, Al-Qahtani AM, Proctor DN, Murias JM.

Microvasc Res. 2019 Sep;125:103879. doi: 10.1016/j.mvr.2019.04.009. Epub 2019 Apr 30.

PMID:
31047890
30.

Neurohormonal modulation: The new paradigm of pharmacological treatment of heart failure.

Silva-Cardoso J, Brás D, Canário-Almeida F, Andrade A, Oliveira L, Pádua F, Fonseca C, Bragança N, Carvalho S, Soares R, Santos JF.

Rev Port Cardiol. 2019 Mar;38(3):175-185. doi: 10.1016/j.repc.2018.10.011. Epub 2019 Apr 24. English, Portuguese.

31.

Bartholin's gland abscess caused by Streptococcus pneumoniae in a sexually active young woman.

Soares R, Reis T, Valido F, Chaves C.

BMJ Case Rep. 2019 Apr 24;12(4). pii: e228492. doi: 10.1136/bcr-2018-228492.

PMID:
31023734
32.

High-fat diet promotes adrenaline production by visceral adipocytes.

Gomes A, Soares R, Costa R, Marino F, Cosentino M, Malagon MM, Ribeiro L.

Eur J Nutr. 2019 Apr 22. doi: 10.1007/s00394-019-01971-0. [Epub ahead of print]

PMID:
31011795
33.

Congenital Transmission of Toxoplasma gondii After Experimental Reinfection With Brazilian Typical Strains in Chronically Infected Sheep.

Chiebao DP, Pena HF, Passarelli D, Santín T, Pulz LH, Strefezzi RF, Sevá AP, Martins CM, Lopes EG, Grisi Filho JHH, Gennari SM, Soares RM.

Front Vet Sci. 2019 Apr 2;6:93. doi: 10.3389/fvets.2019.00093. eCollection 2019.

34.

Histoplasmosis, An Underdiagnosed Disease Affecting People Living With HIV/AIDS in Brazil: Results of a Multicenter Prospective Cohort Study Using Both Classical Mycology Tests and Histoplasma Urine Antigen Detection.

Falci DR, Monteiro AA, Braz Caurio CF, Magalhães TCO, Xavier MO, Basso RP, Melo M, Schwarzbold AV, Ferreira PRA, Vidal JE, Marochi JP, Godoy CSM, Soares RBA, Paste A, Bay MB, Pereira-Chiccola VL, Damasceno LS, Leitão TDMJS, Pasqualotto AC.

Open Forum Infect Dis. 2019 Apr 13;6(4):ofz073. doi: 10.1093/ofid/ofz073. eCollection 2019 Apr.

35.

Histatin 5 and human lactoferrin inhibit biofilm formation of a fluconazole resistant Candida albicans clinical isolate.

Curvelo JAR, Moraes DC, Anjos CAD, Portela MB, Soares RMA.

An Acad Bras Cienc. 2019;91(1):e20180045. doi: 10.1590/0001-3765201920180045. Epub 2019 Apr 8.

36.

Paracentric Inversions Differentiate the Conservative Karyotypes in Two Centropomus Species (Teleostei: Centropomidae).

Borges AT, Cioffi MB, Bertollo LAC, Soares RX, Costa GWWF, Molina WF.

Cytogenet Genome Res. 2019;157(4):239-248. doi: 10.1159/000499748. Epub 2019 Apr 17.

PMID:
30991393
37.

Molecular, serological, pathological, immunohistochemical and microbiological investigation of Brucella spp. in marine mammals of Brazil reveals new cetacean hosts.

Sánchez-Sarmiento AM, Carvalho VL, Díaz-Delgado J, Ressio RA, Fernandes NCCA, Guerra JM, Sacristán C, Groch KR, Silvestre-Perez N, Ferreira-Machado E, Costa-Silva S, Navas-Suárez P, Meirelles ACO, Favero C, Marigo J, Bertozzi CP, Colosio AC, Marcondes MCC, Cremer MJ, Dos Santos Silva N, Ferreira Neto JS, Keid LB, Soares R, Sierra E, Fernández A, Catão-Dias JL.

Transbound Emerg Dis. 2019 Jul;66(4):1674-1692. doi: 10.1111/tbed.13203. Epub 2019 May 20.

PMID:
30980699
38.

Quinoxaline-1,4-dioxide derivatives inhibitory action in melanoma and brain tumor cells.

Silva L, Coelho P, Soares R, Prudêncio C, Vieira M.

Future Med Chem. 2019 Apr;11(7):645-657. doi: 10.4155/fmc-2018-0251. Epub 2019 Apr 9.

PMID:
30964331
39.

Minimizing the Influence of Fluorescent Tags on IgG Partition in PEG-Salt Aqueous Two-Phase Systems for Rapid Screening Applications.

São Pedro MN, Azevedo AM, Aires-Barros MR, Soares RRG.

Biotechnol J. 2019 Aug;14(8):e1800640. doi: 10.1002/biot.201800640. Epub 2019 May 17.

PMID:
30957974
40.

Effect of a Multifaceted Quality Improvement Intervention on the Prescription of Evidence-Based Treatment in Patients at High Cardiovascular Risk in Brazil: The BRIDGE Cardiovascular Prevention Cluster Randomized Clinical Trial.

Machline-Carrion MJ, Soares RM, Damiani LP, Campos VB, Sampaio B, Fonseca FH, Izar MC, Amodeo C, Pontes-Neto OM, Santos JY, Gomes SPDC, Saraiva JFK, Ramacciotti E, Barros E Silva PGM, Lopes RD, Brandão da Silva N, Guimarães HP, Piegas L, Stein AT, Berwanger O; BRIDGE Cardiovascular Prevention Investigators.

JAMA Cardiol. 2019 May 1;4(5):408-417. doi: 10.1001/jamacardio.2019.0649.

PMID:
30942842
41.

In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes.

Pereira I, Fraga S, Maltez L, Requicha J, Guardão L, Oliveira J, Prada J, Alves H, Santos JD, Teixeira JP, Pereira JE, Soares R, Gama FM.

J Biomed Mater Res A. 2019 Aug;107(8):1678-1689. doi: 10.1002/jbm.a.36683. Epub 2019 Apr 12.

PMID:
30920095
42.

Factors associated with the development of Congenital Zika Syndrome: a case-control study.

Lima GP, Rozenbaum D, Pimentel C, Frota ACC, Vivacqua D, Machado ES, Sztajnbok F, Abreu T, Soares RA, Hofer CB.

BMC Infect Dis. 2019 Mar 22;19(1):277. doi: 10.1186/s12879-019-3908-4.

43.

Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model.

Silva C, Sampaio-Pinto V, Andrade S, Rodrigues I, Costa R, Guerreiro S, Carvalho E, Pinto-do-Ó P, Nascimento DS, Soares R.

Cell Physiol Biochem. 2019;52(3):503-516. doi: 10.33594/000000036.

44.

Corrigendum: Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease.

Passos LSA, Magalhães LMD, Soares RP, Marques AF, Alves MLR, Giunchetti RC, Nunes MDCP, Gollob KJ, Dutra WO.

Front Immunol. 2019 Mar 5;10:367. doi: 10.3389/fimmu.2019.00367. eCollection 2019.

45.

Soybean-modified polyamide-6 mats as a long-term cutaneous wound covering.

Dias FTG, Ingracio AR, Nicoletti NF, Menezes FC, Dall Agnol L, Marinowic DR, Soares RMD, da Costa JC, Falavigna A, Bianchi O.

Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:957-968. doi: 10.1016/j.msec.2019.02.019. Epub 2019 Feb 8.

PMID:
30889770
46.

Warburg Effect Inversion: Adiposity shifts central primary metabolism in MCF-7 breast cancer cells.

Luis C, Duarte F, Faria I, Jarak I, Oliveira PF, Alves MG, Soares R, Fernandes R.

Life Sci. 2019 Apr 15;223:38-46. doi: 10.1016/j.lfs.2019.03.016. Epub 2019 Mar 9.

PMID:
30862570
47.

CD99 Expression in Glioblastoma Molecular Subtypes and Role in Migration and Invasion.

Cardoso LC, Soares RDS, Laurentino TS, Lerario AM, Marie SKN, Oba-Shinjo SM.

Int J Mol Sci. 2019 Mar 6;20(5). pii: E1137. doi: 10.3390/ijms20051137.

48.

Invasive fungal infection by Cryptococcus neoformans var. grubii with bone marrow and meningeal involvement in a HIV-infected patient: a case report.

Vechi HT, Theodoro RC, de Oliveira AL, Gomes RMODS, Soares RDA, Freire MG, Bay MB.

BMC Infect Dis. 2019 Mar 4;19(1):220. doi: 10.1186/s12879-019-3831-8.

49.

Non-invasive and in vivo assessment of upper and lower limb skeletal muscle oxidative metabolism activity and microvascular responses to glucose ingestion in humans.

Soares R, Colosio A, Murias JM, Pogliaghi S.

Appl Physiol Nutr Metab. 2019 Feb 25. doi: 10.1139/apnm-2018-0866. [Epub ahead of print]

PMID:
30802136
50.

IRRITABLE BOWEL SYNDROME, FOOD INTOLERANCE AND NON- CELIAC GLUTEN SENSITIVITY. A NEW CLINICAL CHALLENGE.

Soares RLS.

Arq Gastroenterol. 2018 Oct-Dec;55(4):417-422. doi: 10.1590/S0004-2803.201800000-88. Review.

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