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Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers.

Bocksteins E, Snyders DJ, Holmgren M.

Sci Rep. 2017 Jan 31;7:41646. doi: 10.1038/srep41646.


Dromedary immune response and specific Kv2.1 antibody generation using a specific immunization approach.

Hassiki R, Labro AJ, Benlasfar Z, Vincke C, Somia M, El Ayeb M, Muyldermans S, Snyders DJ, Bouhaouala-Zahar B.

Int J Biol Macromol. 2016 Dec;93(Pt A):167-171. doi: 10.1016/j.ijbiomac.2016.06.031. Epub 2016 Jun 16.


The anticonvulsant retigabine suppresses neuronal KV2-mediated currents.

Stas JI, Bocksteins E, Jensen CS, Schmitt N, Snyders DJ.

Sci Rep. 2016 Oct 13;6:35080. doi: 10.1038/srep35080.


Targeted deletion of the Kv6.4 subunit causes male sterility due to disturbed spermiogenesis.

Regnier G, Bocksteins E, Marei WF, Pintelon I, Timmermans JP, Leroy JLMR, Snyders DJ.

Reprod Fertil Dev. 2017 Aug;29(8):1567-1575. doi: 10.1071/RD16075.


Gambierol and n-alkanols inhibit Shaker Kv channel via distinct binding sites outside the K(+) pore.

Martínez-Morales E, Kopljar I, Rainier JD, Tytgat J, Snyders DJ, Labro AJ.

Toxicon. 2016 Sep 15;120:57-60. doi: 10.1016/j.toxicon.2016.07.017. Epub 2016 Jul 28.


The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons.

Regnier G, Bocksteins E, Van de Vijver G, Snyders DJ, van Bogaert PP.

Physiol Rep. 2016 Mar;4(6). pii: e12731. doi: 10.14814/phy2.12731. Epub 2016 Mar 31.


Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.

Kopljar I, Grottesi A, de Block T, Rainier JD, Tytgat J, Labro AJ, Snyders DJ.

Neuropharmacology. 2016 Aug;107:160-167. doi: 10.1016/j.neuropharm.2016.03.010. Epub 2016 Mar 5.


Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.

Labro AJ, Priest MF, Lacroix JJ, Snyders DJ, Bezanilla F.

Nat Commun. 2015 Dec 17;6:10173. doi: 10.1038/ncomms10173.


Alkanols inhibit voltage-gated K(+) channels via a distinct gating modifying mechanism that prevents gate opening.

Martínez-Morales E, Kopljar I, Snyders DJ, Labro AJ.

Sci Rep. 2015 Nov 30;5:17402. doi: 10.1038/srep17402.


Modulation of Closed-State Inactivation in Kv2.1/Kv6.4 Heterotetramers as Mechanism for 4-AP Induced Potentiation.

Stas JI, Bocksteins E, Labro AJ, Snyders DJ.

PLoS One. 2015 Oct 27;10(10):e0141349. doi: 10.1371/journal.pone.0141349. eCollection 2015.


The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini.

Bocksteins E, Mayeur E, Van Tilborg A, Regnier G, Timmermans JP, Snyders DJ.

PLoS One. 2014 Jun 5;9(6):e98960. doi: 10.1371/journal.pone.0098960. eCollection 2014.


Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.

Martinez-Morales E, Snyders DJ, Labro AJ.

Biophys J. 2014 Jan 7;106(1):134-44. doi: 10.1016/j.bpj.2013.11.025.


The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state.

Kopljar I, Labro AJ, de Block T, Rainier JD, Tytgat J, Snyders DJ.

J Gen Physiol. 2013 Mar;141(3):359-69. doi: 10.1085/jgp.201210890. Epub 2013 Feb 11.


Molecular mechanism for depolarization-induced modulation of Kv channel closure.

Labro AJ, Lacroix JJ, Villalba-Galea CA, Snyders DJ, Bezanilla F.

J Gen Physiol. 2012 Nov;140(5):481-93. doi: 10.1085/jgp.201210817. Epub 2012 Oct 15.


Being flexible: the voltage-controllable activation gate of kv channels.

Labro AJ, Snyders DJ.

Front Pharmacol. 2012 Sep 13;3:168. eCollection 2012.


Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channels.

Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G.

J Biol Chem. 2012 Oct 19;287(43):36158-67. doi: 10.1074/jbc.M112.382085. Epub 2012 Aug 29. Erratum in: J Biol Chem. 2013 Apr 12;288(15):10951.


Quantitative single-cell ion-channel gene expression profiling through an improved qRT-PCR technique combined with whole cell patch clamp.

Veys K, Labro AJ, De Schutter E, Snyders DJ.

J Neurosci Methods. 2012 Jul 30;209(1):227-34. doi: 10.1016/j.jneumeth.2012.06.008. Epub 2012 Jun 20.


Kv3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons.

Bocksteins E, Van de Vijver G, Van Bogaert PP, Snyders DJ.

Am J Physiol Cell Physiol. 2012 Aug 15;303(4):C406-15. doi: 10.1152/ajpcell.00343.2011. Epub 2012 Jun 6.


The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.

Bocksteins E, Labro AJ, Snyders DJ, Mohapatra DP.

PLoS One. 2012;7(5):e37143. doi: 10.1371/journal.pone.0037143. Epub 2012 May 17.


Electrically silent Kv subunits: their molecular and functional characteristics.

Bocksteins E, Snyders DJ.

Physiology (Bethesda). 2012 Apr;27(2):73-84. doi: 10.1152/physiol.00023.2011. Review.


Functional interactions between residues in the S1, S4, and S5 domains of Kv2.1.

Bocksteins E, Ottschytsch N, Timmermans JP, Labro AJ, Snyders DJ.

Eur Biophys J. 2011 Jun;40(6):783-93. doi: 10.1007/s00249-011-0694-3. Epub 2011 Apr 1.


The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.

Labro AJ, Boulet IR, Choveau FS, Mayeur E, Bruyns T, Loussouarn G, Raes AL, Snyders DJ.

J Biol Chem. 2011 Jan 7;286(1):717-25. doi: 10.1074/jbc.M110.146977. Epub 2010 Nov 8.


KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

Choveau FS, Rodriguez N, Abderemane Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G.

J Biol Chem. 2011 Jan 7;286(1):707-16. doi: 10.1074/jbc.M110.146324. Epub 2010 Oct 12.


The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.

Labro AJ, Boulet IR, Timmermans JP, Ottschytsch N, Snyders DJ.

J Mol Cell Cardiol. 2010 Jun;48(6):1096-104. doi: 10.1016/j.yjmcc.2009.10.027. Epub 2009 Nov 11. Review.


Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.

Bocksteins E, Labro AJ, Mayeur E, Bruyns T, Timmermans JP, Adriaensen D, Snyders DJ.

J Biol Chem. 2009 Nov 13;284(46):31625-34. doi: 10.1074/jbc.M109.039479. Epub 2009 Aug 28.


A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol.

Kopljar I, Labro AJ, Cuypers E, Johnson HW, Rainier JD, Tytgat J, Snyders DJ.

Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9896-901. doi: 10.1073/pnas.0812471106. Epub 2009 May 29.


Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neurons.

Bocksteins E, Raes AL, Van de Vijver G, Bruyns T, Van Bogaert PP, Snyders DJ.

Am J Physiol Cell Physiol. 2009 Jun;296(6):C1271-8. doi: 10.1152/ajpcell.00088.2009. Epub 2009 Apr 8.


Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.

Labro AJ, Raes AL, Grottesi A, Van Hoorick D, Sansom MS, Snyders DJ.

J Gen Physiol. 2008 Dec;132(6):667-80. doi: 10.1085/jgp.200810048.


A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.

Labro AJ, Grottesi A, Sansom MS, Raes AL, Snyders DJ.

Am J Physiol Cell Physiol. 2008 Jun;294(6):C1476-84. doi: 10.1152/ajpcell.00479.2007. Epub 2008 Apr 2.


Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.

Cuypers E, Abdel-Mottaleb Y, Kopljar I, Rainier JD, Raes AL, Snyders DJ, Tytgat J.

Toxicon. 2008 May;51(6):974-83. doi: 10.1016/j.toxicon.2008.01.004. Epub 2008 Jan 12.


Role of the S6 C-terminus in KCNQ1 channel gating.

Boulet IR, Labro AJ, Raes AL, Snyders DJ.

J Physiol. 2007 Dec 1;585(Pt 2):325-37. Epub 2007 Oct 11.


The aromatic cluster in KCHIP1b affects Kv4 inactivation gating.

Van Hoorick D, Raes A, Snyders DJ.

J Physiol. 2007 Sep 15;583(Pt 3):959-69. Epub 2007 Jul 19.


A single hERG mutation underlying a spectrum of acquired and congenital long QT syndrome phenotypes.

Saenen JB, Paulussen AD, Jongbloed RJ, Marcelis CL, Gilissen RA, Aerssens J, Snyders DJ, Raes AL.

J Mol Cell Cardiol. 2007 Jul;43(1):63-72. Epub 2007 May 4.


Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.

Saenen JB, Labro AJ, Raes A, Snyders DJ.

Biophys J. 2006 Dec 15;91(12):4381-91. Epub 2006 Sep 22.


Functional effects of a KCNQ1 mutation associated with the long QT syndrome.

Boulet IR, Raes AL, Ottschytsch N, Snyders DJ.

Cardiovasc Res. 2006 Jun 1;70(3):466-74. Epub 2006 Feb 28.


Domain analysis of Kv6.3, an electrically silent channel.

Ottschytsch N, Raes AL, Timmermans JP, Snyders DJ.

J Physiol. 2005 Nov 1;568(Pt 3):737-47. Epub 2005 Aug 11.


HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency.

Paulussen AD, Raes A, Jongbloed RJ, Gilissen RA, Wilde AA, Snyders DJ, Smeets HJ, Aerssens J.

Cardiovasc Res. 2005 Aug 15;67(3):467-75.


Differential modulation of Kv4 kinetics by KCHIP1 splice variants.

Van Hoorick D, Raes A, Keysers W, Mayeur E, Snyders DJ.

Mol Cell Neurosci. 2003 Oct;24(2):357-66.


Gating of shaker-type channels requires the flexibility of S6 caused by prolines.

Labro AJ, Raes AL, Bellens I, Ottschytsch N, Snyders DJ.

J Biol Chem. 2003 Dec 12;278(50):50724-31. Epub 2003 Sep 17.


A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency.

Paulussen A, Raes A, Matthijs G, Snyders DJ, Cohen N, Aerssens J.

J Biol Chem. 2002 Dec 13;277(50):48610-6. Epub 2002 Sep 26.


Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.

Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7986-91.


Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.

Rich TC, Yeola SW, Tamkun MM, Snyders DJ.

Am J Physiol Cell Physiol. 2002 Jan;282(1):C161-71.


Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes.

Rolf S, Haverkamp W, Borggrefe M, Musshoff U, Eckardt L, Mergenthaler J, Snyders DJ, Pongs O, Speckmann EJ, Breithardt G, Madeja M.

Naunyn Schmiedebergs Arch Pharmacol. 2000 Jul;362(1):22-31.


Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currents.

Longobardo M, González T, Navarro-Polanco R, Caballero R, Delpón E, Tamargo J, Snyders DJ, Tamkun MM, Valenzuela C.

Br J Pharmacol. 2000 May;130(2):391-401.


Structure and function of cardiac potassium channels.

Snyders DJ.

Cardiovasc Res. 1999 May;42(2):377-90. Review.


Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line.

Franqueza L, Valenzuela C, Eck J, Tamkun MM, Tamargo J, Snyders DJ.

Cardiovasc Res. 1999 Jan;41(1):212-9.


Distinct domains of the voltage-gated K+ channel Kv beta 1.3 beta-subunit affect voltage-dependent gating.

Uebele VN, England SK, Gallagher DJ, Snyders DJ, Bennett PB, Tamkun MM.

Am J Physiol. 1998 Jun;274(6):C1485-95. doi: 10.1152/ajpcell.1998.274.6.C1485.


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