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Items: 1 to 50 of 1121

1.

MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.

Meixiong J, Vasavda C, Snyder SH, Dong X.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10525-10530. doi: 10.1073/pnas.1903316116. Epub 2019 May 8.

PMID:
31068464
2.

Noncatalytic functions of IPMK are essential for activation of autophagy and liver regeneration.

Guha P, Snyder SH.

Autophagy. 2019 May 8:1-2. doi: 10.1080/15548627.2019.1615305. [Epub ahead of print]

PMID:
31066329
3.

Before Hospice: Symptom Burden, Dementia, and Social Participation in the Last Year of Life.

Amjad H, Snyder SH, Wolff JL, Oh E, Samus QM.

J Palliat Med. 2019 May 6. doi: 10.1089/jpm.2018.0479. [Epub ahead of print]

PMID:
31058566
4.

Impaired Redox Signaling in Huntington's Disease: Therapeutic Implications.

Paul BD, Snyder SH.

Front Mol Neurosci. 2019 Mar 19;12:68. doi: 10.3389/fnmol.2019.00068. eCollection 2019. Review.

5.

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis.

Weyemi U, Paul BD, Bhattacharya D, Malla AP, Boufraqech M, Harraz MM, Bonner WM, Snyder SH.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7471-7476. doi: 10.1073/pnas.1820245116. Epub 2019 Mar 25.

PMID:
30910969
6.

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.

Guha P, Tyagi R, Chowdhury S, Reilly L, Fu C, Xu R, Resnick AC, Snyder SH.

Cell Rep. 2019 Mar 5;26(10):2692-2703.e7. doi: 10.1016/j.celrep.2019.02.013.

7.

Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.

Rojas T, Cheng W, Gao Z, Liu X, Wang Y, Malla AP, Chin AC, Romer LH, Snyder SH, Fu C.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3278-3287. doi: 10.1073/pnas.1817001116. Epub 2019 Feb 4.

PMID:
30718399
8.

The glutathione cycle shapes synaptic glutamate activity.

Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2701-2706. doi: 10.1073/pnas.1817885116. Epub 2019 Jan 28.

PMID:
30692251
9.

Inositol polyphosphate multikinase mediates extinction of fear memory.

Park J, Longo F, Park SJ, Lee S, Bae M, Tyagi R, Han JH, Kim S, Santini E, Klann E, Snyder SH.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2707-2712. doi: 10.1073/pnas.1812771116. Epub 2019 Jan 28.

PMID:
30692248
10.

Identification of a bilirubin receptor that may mediate a component of cholestatic itch.

Meixiong J, Vasavda C, Green D, Zheng Q, Qi L, Kwatra SG, Hamilton JP, Snyder SH, Dong X.

Elife. 2019 Jan 21;8. pii: e44116. doi: 10.7554/eLife.44116.

11.

Regulators of the transsulfuration pathway.

Sbodio JI, Snyder SH, Paul BD.

Br J Pharmacol. 2019 Feb;176(4):583-593. doi: 10.1111/bph.14446. Epub 2018 Aug 23. Review.

PMID:
30007014
12.

Inositol Hexakisphosphate Kinase-2 in Cerebellar Granule Cells Regulates Purkinje Cells and Motor Coordination via Protein 4.1N.

Nagpal L, Fu C, Snyder SH.

J Neurosci. 2018 Aug 22;38(34):7409-7419. doi: 10.1523/JNEUROSCI.1165-18.2018. Epub 2018 Jul 13.

13.

Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.

Fu C, Rojas T, Chin AC, Cheng W, Bernstein IA, Albacarys LK, Wright WW, Snyder SH.

Sci Rep. 2018 May 4;8(1):7039. doi: 10.1038/s41598-018-25468-8.

14.

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.

Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH.

Nat Commun. 2018 Apr 18;9(1):1526. doi: 10.1038/s41467-018-03948-9.

15.

Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities.

Sbodio JI, Snyder SH, Paul BD.

Antioxid Redox Signal. 2019 Apr 10;30(11):1450-1499. doi: 10.1089/ars.2017.7321. Epub 2018 May 4.

PMID:
29634350
16.

Inhibition of IP6K1 suppresses neutrophil-mediated pulmonary damage in bacterial pneumonia.

Hou Q, Liu F, Chakraborty A, Jia Y, Prasad A, Yu H, Zhao L, Ye K, Snyder SH, Xu Y, Luo HR.

Sci Transl Med. 2018 Apr 4;10(435). pii: eaal4045. doi: 10.1126/scitranslmed.aal4045.

17.

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.

Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH.

Science. 2018 Apr 27;360(6387):449-453. doi: 10.1126/science.aan4665. Epub 2018 Mar 29.

18.

Cysteine Metabolism in Neuronal Redox Homeostasis.

Paul BD, Sbodio JI, Snyder SH.

Trends Pharmacol Sci. 2018 May;39(5):513-524. doi: 10.1016/j.tips.2018.02.007. Epub 2018 Mar 9. Review.

19.

Bryostatin-1 alleviates experimental multiple sclerosis.

Kornberg MD, Smith MD, Shirazi HA, Calabresi PA, Snyder SH, Kim PM.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2186-2191. doi: 10.1073/pnas.1719902115. Epub 2018 Feb 12.

20.

Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington's disease.

Sbodio JI, Snyder SH, Paul BD.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):780-785. doi: 10.1073/pnas.1717877115. Epub 2018 Jan 9.

21.

Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH.

Circ Res. 2018 Feb 2;122(3):457-472. doi: 10.1161/CIRCRESAHA.117.311983. Epub 2017 Dec 26.

22.

TRPV1 is a physiological regulator of μ-opioid receptors.

Scherer PC, Zaccor NW, Neumann NM, Vasavda C, Barrow R, Ewald AJ, Rao F, Sumner CJ, Snyder SH.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13561-13566. doi: 10.1073/pnas.1717005114. Epub 2017 Dec 4.

23.

Gasotransmitter hydrogen sulfide signaling in neuronal health and disease.

Paul BD, Snyder SH.

Biochem Pharmacol. 2018 Mar;149:101-109. doi: 10.1016/j.bcp.2017.11.019. Epub 2017 Dec 1. Review.

24.

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding.

Vasavda C, Zaccor NW, Scherer PC, Sumner CJ, Snyder SH.

J Vis Exp. 2017 Jun 9;(124). doi: 10.3791/55561.

25.

DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice.

Terrillion CE, Abazyan B, Yang Z, Crawford J, Shevelkin AV, Jouroukhin Y, Yoo KH, Cho CH, Roychaudhuri R, Snyder SH, Jang MH, Pletnikov MV.

Neuropsychopharmacology. 2017 Oct;42(11):2242-2251. doi: 10.1038/npp.2017.129. Epub 2017 Jun 20.

26.

Antidepressant Actions of Ketamine Mediated by the Mechanistic Target of Rapamycin, Nitric Oxide, and Rheb.

Harraz MM, Snyder SH.

Neurotherapeutics. 2017 Jul;14(3):728-733. doi: 10.1007/s13311-017-0540-0. Review.

27.

Palliative Care, Spiritual Care, and Clinical Ethics: Widely Available, but Underused.

Snyder SH, Sederstrom N, Mansel JK, Groninger H.

Chest. 2017 Jun;151(6):1404-1406. doi: 10.1016/j.chest.2017.03.034. No abstract available.

PMID:
28599939
28.

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, Troncoso JC, Duan W, Snyder SH, Ranum LPW, Thompson LM, Lloyd TE, Ross CA, Rothstein JD.

Neuron. 2017 Apr 5;94(1):93-107.e6. doi: 10.1016/j.neuron.2017.03.023.

29.

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.

Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C.

Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Review.

30.

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Harraz MM, Snyder SH.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2036-2041. doi: 10.1073/pnas.1700165114. Epub 2017 Feb 2.

31.

Complementary roles of gasotransmitters CO and H2S in sleep apnea.

Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR.

Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1413-1418. doi: 10.1073/pnas.1620717114. Epub 2017 Jan 23.

32.

H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea.

Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR.

Sci Signal. 2016 Aug 16;9(441):ra80. doi: 10.1126/scisignal.aaf3204.

33.

A Life of Neurotransmitters.

Snyder SH.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:1-11. doi: 10.1146/annurev-pharmtox-010716-104511. Epub 2016 Jul 22.

PMID:
27483340
34.

Transcriptional control of amino acid homeostasis is disrupted in Huntington's disease.

Sbodio JI, Snyder SH, Paul BD.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8843-8. doi: 10.1073/pnas.1608264113. Epub 2016 Jul 19.

35.

Developmental Alcohol Exposure Impairs Activity-Dependent S-Nitrosylation of NDEL1 for Neuronal Maturation.

Saito A, Taniguchi Y, Kim SH, Selvakumar B, Perez G, Ballinger MD, Zhu X, Sabra J, Jallow M, Yan P, Ito K, Rajendran S, Hirotsune S, Wynshaw-Boris A, Snyder SH, Sawa A, Kamiya A.

Cereb Cortex. 2017 Aug 1;27(8):3918-3929. doi: 10.1093/cercor/bhw201.

36.

Foreword.

Snyder SH.

Adv Pharmacol. 2016;76:xiii-xv. doi: 10.1016/S1054-3589(16)30043-6. No abstract available.

PMID:
27288083
37.

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

Scherer PC, Ding Y, Liu Z, Xu J, Mao H, Barrow JC, Wei N, Zheng N, Snyder SH, Rao F.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3503-8. doi: 10.1073/pnas.1525580113. Epub 2016 Mar 14.

38.

Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade.

Guha P, Harraz MM, Snyder SH.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1417-22. doi: 10.1073/pnas.1524860113. Epub 2016 Jan 19. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 7;114(10 ):E2066-E2067.

39.

Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.

Harraz MM, Tyagi R, Cortés P, Snyder SH.

Mol Psychiatry. 2016 Mar;21(3):313-9. doi: 10.1038/mp.2015.211. Epub 2016 Jan 19.

40.

Human GAPDH Is a Target of Aspirin's Primary Metabolite Salicylic Acid and Its Derivatives.

Choi HW, Tian M, Manohar M, Harraz MM, Park SW, Schroeder FC, Snyder SH, Klessig DF.

PLoS One. 2015 Nov 25;10(11):e0143447. doi: 10.1371/journal.pone.0143447. eCollection 2015.

41.

H2S: A Novel Gasotransmitter that Signals by Sulfhydration.

Paul BD, Snyder SH.

Trends Biochem Sci. 2015 Nov;40(11):687-700. doi: 10.1016/j.tibs.2015.08.007. Epub 2015 Oct 1. Review.

42.

Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.

Fu C, Xu J, Li RJ, Crawford JA, Khan AB, Ma TM, Cha JY, Snowman AM, Pletnikov MV, Snyder SH.

J Neurosci. 2015 Aug 5;35(31):11056-67. doi: 10.1523/JNEUROSCI.1069-15.2015.

43.

Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.

Ahmed I, Sbodio JI, Harraz MM, Tyagi R, Grima JC, Albacarys LK, Hubbi ME, Xu R, Kim S, Paul BD, Snyder SH.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9751-6. doi: 10.1073/pnas.1511810112. Epub 2015 Jul 20.

44.

Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine.

Harraz MM, Snyder SH.

CNS Neurol Disord Drug Targets. 2015;14(6):757-63. Review.

45.

Protein kinase G-regulated production of H2S governs oxygen sensing.

Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR.

Sci Signal. 2015 Apr 21;8(373):ra37. doi: 10.1126/scisignal.2005846.

46.

Protein sulfhydration.

Paul BD, Snyder SH.

Methods Enzymol. 2015;555:79-90. doi: 10.1016/bs.mie.2014.11.021. Epub 2015 Jan 14.

PMID:
25747476
47.

Vernon B. Mountcastle 1918-2015.

Snyder SH.

Nat Neurosci. 2015 Mar;18(3):318. doi: 10.1038/nn.3958. Epub 2015 Feb 16. No abstract available.

PMID:
25686477
48.

Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.

Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S.

Cell Rep. 2015 Feb 10;10(5):684-693. doi: 10.1016/j.celrep.2015.01.014. Epub 2015 Feb 7.

49.

Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1.

Rao F, Xu J, Fu C, Cha JY, Gadalla MM, Xu R, Barrow JC, Snyder SH.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1773-8. doi: 10.1073/pnas.1424642112. Epub 2015 Jan 23.

50.

Neurodegeneration in Huntington's disease involves loss of cystathionine γ-lyase.

Paul BD, Snyder SH.

Cell Cycle. 2014;13(16):2491-3. doi: 10.4161/15384101.2014.950538. No abstract available.

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