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Items: 1 to 50 of 63

1.

Should we consider subcellular compartmentalization of metabolites, and if so, how do we measure them?

Wellen KE, Snyder NW.

Curr Opin Clin Nutr Metab Care. 2019 Sep;22(5):347-354. doi: 10.1097/MCO.0000000000000580.

PMID:
31365463
2.

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy.

Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16028-16035. doi: 10.1073/pnas.1906896116. Epub 2019 Jun 28.

3.

Association of serum androgens and coronary artery calcium scores in women.

Penn CA, Chan J, Mesaros C, Snyder NW, Rader DJ, Sammel MD, Dokras A.

Fertil Steril. 2019 Jun 11. pii: S0015-0282(19)30402-9. doi: 10.1016/j.fertnstert.2019.04.024. [Epub ahead of print]

PMID:
31200968
4.

A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate.

Wang W, Ishibashi J, Trefely S, Shao M, Cowan AJ, Sakers A, Lim HW, O'Connor S, Doan MT, Cohen P, Baur JA, King MT, Veech RL, Won KJ, Rabinowitz JD, Snyder NW, Gupta RK, Seale P.

Cell Metab. 2019 Jul 2;30(1):174-189.e5. doi: 10.1016/j.cmet.2019.05.005. Epub 2019 May 30.

PMID:
31155495
5.

Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females.

Fernandez S, Viola JM, Torres A, Wallace M, Trefely S, Zhao S, Affronti HC, Gengatharan JM, Guertin DA, Snyder NW, Metallo CM, Wellen KE.

Cell Rep. 2019 May 28;27(9):2772-2784.e6. doi: 10.1016/j.celrep.2019.04.112.

6.

Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer.

Dahl ES, Buj R, Leon KE, Newell JM, Imamura Y, Bitler BG, Snyder NW, Aird KM.

Mol Cancer Res. 2019 Aug;17(8):1710-1720. doi: 10.1158/1541-7786.MCR-18-1233. Epub 2019 May 20.

PMID:
31110157
7.

Preliminary results of identification and quantification of paclitaxel and its metabolites in human meconium from newborns with gestational chemotherapeutic exposure.

Cardonick E, Broadrup R, Xu P, Doan MT, Jiang H, Snyder NW.

PLoS One. 2019 Feb 20;14(2):e0211821. doi: 10.1371/journal.pone.0211821. eCollection 2019.

8.

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal.

Liu M, O'Connor RS, Trefely S, Graham K, Snyder NW, Beatty GL.

Nat Immunol. 2019 Jan 21;20(3):265-275. doi: 10.1038/s41590-018-0292-y.

9.

Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis.

Carrer A, Trefely S, Zhao S, Campbell SL, Norgard RJ, Schultz KC, Sidoli S, Parris JLD, Affronti HC, Sivanand S, Egolf S, Sela Y, Trizzino M, Gardini A, Garcia BA, Snyder NW, Stanger BZ, Wellen KE.

Cancer Discov. 2019 Mar;9(3):416-435. doi: 10.1158/2159-8290.CD-18-0567. Epub 2019 Jan 9.

PMID:
30626590
10.

Simultaneous isotope dilution quantification and metabolic tracing of deoxyribonucleotides by liquid chromatography high resolution mass spectrometry.

Kuskovsky R, Buj R, Xu P, Hofbauer S, Doan MT, Jiang H, Bostwick A, Mesaros C, Aird KM, Snyder NW.

Anal Biochem. 2019 Mar 1;568:65-72. doi: 10.1016/j.ab.2018.12.023. Epub 2018 Dec 31.

PMID:
30605633
11.

N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.

Huber K, Hofer DC, Trefely S, Pelzmann HJ, Madreiter-Sokolowski C, Duta-Mare M, Schlager S, Trausinger G, Stryeck S, Graier WF, Kolb D, Magnes C, Snyder NW, Prokesch A, Kratky D, Madl T, Wellen KE, Bogner-Strauss JG.

Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):337-348. doi: 10.1016/j.bbamcr.2018.08.017. Epub 2018 Aug 31.

12.

Gestational Diabetes Alters the Metabolomic Profile in 2nd Trimester Amniotic Fluid in a Sex-Specific Manner.

O'Neill K, Alexander J, Azuma R, Xiao R, Snyder NW, Mesaros CA, Blair IA, Pinney SE.

Int J Mol Sci. 2018 Sep 10;19(9). pii: E2696. doi: 10.3390/ijms19092696.

13.

Oral nitrite restores age-dependent phenotypes in eNOS-null mice.

Tenopoulou M, Doulias PT, Nakamoto K, Berrios K, Zura G, Li C, Faust M, Yakovishina V, Evans P, Tan L, Bennett MJ, Snyder NW, Quinn WJ 3rd, Baur JA, Atochin DN, Huang PL, Ischiropoulos H.

JCI Insight. 2018 Aug 23;3(16). pii: 122156. doi: 10.1172/jci.insight.122156. eCollection 2018 Aug 23.

14.

Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction.

Xin F, Fischer E, Krapp C, Krizman EN, Lan Y, Mesaros C, Snyder NW, Bansal A, Robinson MB, Simmons RA, Bartolomei MS.

Horm Behav. 2018 Jun;102:93-104. doi: 10.1016/j.yhbeh.2018.05.010. Epub 2018 May 18.

15.

Artefactual formation of pyruvate from in-source conversion of lactate.

Trefely S, Mesaros C, Xu P, Doan MT, Jiang H, Altinok O, Orynbayeva Z, Snyder NW.

Rapid Commun Mass Spectrom. 2018 May 8. doi: 10.1002/rcm.8159. [Epub ahead of print]

PMID:
29740888
16.

Bioorthogonal pro-metabolites for profiling short chain fatty acylation.

Sinclair WR, Shrimp JH, Zengeya TT, Kulkarni RA, Garlick JM, Luecke H, Worth AJ, Blair IA, Snyder NW, Meier JL.

Chem Sci. 2017 Dec 8;9(5):1236-1241. doi: 10.1039/c7sc00247e. eCollection 2018 Feb 7.

17.

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.

O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC.

Sci Rep. 2018 Apr 19;8(1):6289. doi: 10.1038/s41598-018-24676-6.

18.

Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca2+-NFAT signaling.

Lee JV, Berry CT, Kim K, Sen P, Kim T, Carrer A, Trefely S, Zhao S, Fernandez S, Barney LE, Schwartz AD, Peyton SR, Snyder NW, Berger SL, Freedman BD, Wellen KE.

Genes Dev. 2018 Apr 1;32(7-8):497-511. doi: 10.1101/gad.311027.117. Epub 2018 Apr 19.

19.

Lipid Synthesis Is Required to Resolve Endoplasmic Reticulum Stress and Limit Fibrotic Responses in the Lung.

Romero F, Hong X, Shah D, Kallen CB, Rosas I, Guo Z, Schriner D, Barta J, Shaghaghi H, Hoek JB, Mesaros C, Choi AM, Snyder NW, Summer R.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):225-236. doi: 10.1165/rcmb.2017-0340OC.

20.

Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.

Wang Q, Guo L, Strawser CJ, Hauser LA, Hwang WT, Snyder NW, Lynch DR, Mesaros C, Blair IA.

PLoS One. 2018 Feb 15;13(2):e0192779. doi: 10.1371/journal.pone.0192779. eCollection 2018.

21.

Defining Metabolic and Nonmetabolic Regulation of Histone Acetylation by NSAID Chemotypes.

Shrimp JH, Garlick JM, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL.

Mol Pharm. 2018 Mar 5;15(3):729-736. doi: 10.1021/acs.molpharmaceut.7b00943. Epub 2017 Dec 29.

22.

Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism.

Frederick DW, Trefely S, Buas A, Goodspeed J, Singh J, Mesaros C, Baur JA, Snyder NW.

Analyst. 2017 Nov 20;142(23):4431-4437. doi: 10.1039/c7an01378g.

23.

Characterization of histone acylations links chromatin modifications with metabolism.

Simithy J, Sidoli S, Yuan ZF, Coradin M, Bhanu NV, Marchione DM, Klein BJ, Bazilevsky GA, McCullough CE, Magin RS, Kutateladze TG, Snyder NW, Marmorstein R, Garcia BA.

Nat Commun. 2017 Oct 26;8(1):1141. doi: 10.1038/s41467-017-01384-9.

24.

Relationship of SULT1A1 copy number variation with estrogen metabolism and human health.

Liu J, Zhao R, Ye Z, Frey AJ, Schriver ER, Snyder NW, Hebbring SJ.

J Steroid Biochem Mol Biol. 2017 Nov;174:169-175. doi: 10.1016/j.jsbmb.2017.08.017. Epub 2017 Sep 1.

25.

Metabolic tracing analysis reveals substrate-specific metabolic deficits in platelet storage lesion.

Sims C, Salliant N, Worth AJ, Parry R, Mesaros C, Blair IA, Snyder NW.

Transfusion. 2017 Nov;57(11):2683-2689. doi: 10.1111/trf.14292. Epub 2017 Aug 23.

26.

Adrenocortical carcinoma and succinate dehydrogenase gene mutations: an observational case series.

Else T, Lerario AM, Everett J, Haymon L, Wham D, Mullane M, Wilson TL, Rainville I, Rana H, Worth AJ, Snyder NW, Blair IA, McKay R, Kilbridge K, Hammer G, Barletta J, Vaidya A.

Eur J Endocrinol. 2017 Nov;177(5):439-444. doi: 10.1530/EJE-17-0358. Epub 2017 Aug 17.

PMID:
28819017
27.

Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine.

Brodnik ZD, Black EM, Clark MJ, Kornsey KN, Snyder NW, España RA.

Neuropharmacology. 2017 Oct;125:295-307. doi: 10.1016/j.neuropharm.2017.07.032. Epub 2017 Aug 1.

28.

Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure.

Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT.

Biomark Med. 2017 Jul;11(7):547-556. doi: 10.2217/bmm-2017-0087. Epub 2017 May 23.

29.

Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid.

Mesaros C, Arroyo AD, Blair IA, Snyder NW.

Prostaglandins Other Lipid Mediat. 2017 May;130:1-7. doi: 10.1016/j.prostaglandins.2017.02.004. Epub 2017 Feb 24.

30.

Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling.

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL.

Cell Chem Biol. 2017 Feb 16;24(2):231-242. doi: 10.1016/j.chembiol.2017.01.002. Epub 2017 Feb 2.

31.

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels.

Carrer A, Parris JL, Trefely S, Henry RA, Montgomery DC, Torres A, Viola JM, Kuo YM, Blair IA, Meier JL, Andrews AJ, Snyder NW, Wellen KE.

J Biol Chem. 2017 Feb 24;292(8):3312-3322. doi: 10.1074/jbc.M116.750620. Epub 2017 Jan 11.

32.

The Changing Epidemiology of Autism Spectrum Disorders.

Lyall K, Croen L, Daniels J, Fallin MD, Ladd-Acosta C, Lee BK, Park BY, Snyder NW, Schendel D, Volk H, Windham GC, Newschaffer C.

Annu Rev Public Health. 2017 Mar 20;38:81-102. doi: 10.1146/annurev-publhealth-031816-044318. Epub 2016 Dec 21. Review.

33.

FluxFix: automatic isotopologue normalization for metabolic tracer analysis.

Trefely S, Ashwell P, Snyder NW.

BMC Bioinformatics. 2016 Nov 25;17(1):485.

34.

Differences in testosterone and its precursors by sex of the offspring in meconium.

Frey AJ, Park BY, Schriver ER, Feldman DR, Parry S, Croen LA, Fallin DM, Hertz-Picciotto I, Newschaffer CJ, Snyder NW.

J Steroid Biochem Mol Biol. 2017 Mar;167:78-85. doi: 10.1016/j.jsbmb.2016.11.010. Epub 2016 Nov 18.

35.

Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants.

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM.

Reprod Toxicol. 2017 Jan;67:1-9. doi: 10.1016/j.reprotox.2016.11.007. Epub 2016 Nov 6.

36.

Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry.

Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW.

Steroids. 2016 Dec;116:60-66. doi: 10.1016/j.steroids.2016.10.003. Epub 2016 Oct 13.

37.

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE.

Cell Rep. 2016 Oct 18;17(4):1037-1052. doi: 10.1016/j.celrep.2016.09.069.

38.
39.

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR.

J Clin Invest. 2016 Jul 1;126(7):2642-60. doi: 10.1172/JCI85796. Epub 2016 Jun 13.

40.

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism.

Worth AJ, Marchione DM, Parry RC, Wang Q, Gillespie KP, Saillant NN, Sims C, Mesaros C, Snyder NW, Blair IA.

J Vis Exp. 2016 Apr 4;(110):e53941. doi: 10.3791/53941.

41.

AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment.

Daurio NA, Tuttle SW, Worth AJ, Song EY, Davis JM, Snyder NW, Blair IA, Koumenis C.

Cancer Res. 2016 Jun 1;76(11):3295-306. doi: 10.1158/0008-5472.CAN-15-2197. Epub 2016 Mar 28.

42.

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

Kawalekar OU, O' Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD Jr, Patel PR, Guedan S, Scholler J, Keith B, Snyder NW, Blair IA, Milone MC, June CH.

Immunity. 2016 Mar 15;44(3):712. doi: 10.1016/j.immuni.2016.02.023. Epub 2016 Mar 15. No abstract available.

43.

LC-quadrupole/Orbitrap high-resolution mass spectrometry enables stable isotope-resolved simultaneous quantification and ¹³C-isotopic labeling of acyl-coenzyme A thioesters.

Frey AJ, Feldman DR, Trefely S, Worth AJ, Basu SS, Snyder NW.

Anal Bioanal Chem. 2016 May;408(13):3651-8. doi: 10.1007/s00216-016-9448-5. Epub 2016 Mar 11.

44.

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation.

Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T.

Elife. 2016 Feb 19;5. pii: e11612. doi: 10.7554/eLife.11612.

45.

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

Kawalekar OU, O'Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD Jr, Patel PR, Guedan S, Scholler J, Keith B, Snyder NW, Blair IA, Milone MC, June CH.

Immunity. 2016 Feb 16;44(2):380-90. doi: 10.1016/j.immuni.2016.01.021. Erratum in: Immunity. 2016 Mar 15;44(3):712. Snyder, Nathaniel [corrected to Snyder, Nathaniel W]; Blair, Ian [corrected to Blair, Ian A]. Erratum in: Immunity. 2016 Mar 15;44(3):712.

46.

Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.

Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Margulies KB, Rame JE.

Circulation. 2016 Feb 23;133(8):706-16. doi: 10.1161/CIRCULATIONAHA.115.017545. Epub 2016 Jan 27.

47.

Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers.

Wang Q, Zhang S, Guo L, Busch CM, Jian W, Weng N, Snyder NW, Rangiah K, Mesaros C, Blair IA.

Bioanalysis. 2015;7(22):2895-911. doi: 10.4155/bio.15.195. Epub 2015 Sep 22.

48.

Translational metabolomics in cancer research.

Snyder NW, Mesaros C, Blair IA.

Biomark Med. 2015;9(9):821-34. doi: 10.2217/bmm.15.52. Epub 2015 Sep 1. Review.

49.

Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets.

Worth AJ, Basu SS, Deutsch EC, Hwang WT, Snyder NW, Lynch DR, Blair IA.

Bioanalysis. 2015;7(15):1843-55. doi: 10.4155/bio.15.118.

50.

Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.

Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA.

Bioanalysis. 2015;7(9):1157-73. doi: 10.4155/bio.15.53. Review.

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