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Items: 1 to 50 of 163

1.

Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice.

Loonen ICM, Jansen NA, Cain SM, Schenke M, Voskuyl RA, Yung AC, Bohnet B, Kozlowski P, Thijs RD, Ferrari MD, Snutch TP, van den Maagdenberg AMJM, Tolner EA.

Brain. 2019 Feb 1;142(2):412-425. doi: 10.1093/brain/awy325.

PMID:
30649209
2.

Fast oxygen dynamics as a potential biomarker for epilepsy.

Farrell JS, Greba Q, Snutch TP, Howland JG, Teskey GC.

Sci Rep. 2018 Dec 18;8(1):17935. doi: 10.1038/s41598-018-36287-2.

3.

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg.

Marks WN, Zabder NK, Cain SM, Snutch TP, Howland JG.

Behav Brain Res. 2019 Apr 1;361:54-64. doi: 10.1016/j.bbr.2018.12.021. Epub 2018 Dec 11.

PMID:
30550952
4.

Genome Sequencing of Sub-Arctic Mesomycetozoean Sphaeroforma sirkka Strain B5, Performed with the Oxford Nanopore minION and Illumina HiSeq Systems.

Ducluzeau AL, Tyson JR, Collins RE, Snutch TP, Hassett BT.

Microbiol Resour Announc. 2018 Oct 18;7(15). pii: e00848-18. doi: 10.1128/MRA.00848-18. eCollection 2018 Oct.

5.

Effects of the T-type calcium channel antagonist Z944 on paired associates learning and locomotor activity in rats treated with the NMDA receptor antagonist MK-801.

Roebuck AJ, Marks WN, Liu MC, Tahir NB, Zabder NK, Snutch TP, Howland JG.

Psychopharmacology (Berl). 2018 Nov;235(11):3339-3350. doi: 10.1007/s00213-018-5040-3. Epub 2018 Sep 24.

PMID:
30251162
6.

T-type calcium channels in the orbitofrontal cortex mediate sensory integration as measured using a spontaneous oddity task in rats.

Marks WN, Parker ME, Zabder NK, Greba Q, Snutch TP, Howland JG.

Learn Mem. 2018 Jun 15;25(7):317-324. doi: 10.1101/lm.047332.118. Print 2018 Jul.

PMID:
29907639
7.

T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.

Garcia-Caballero A, Zhang FX, Hodgkinson V, Huang J, Chen L, Souza IA, Cain S, Kass J, Alles S, Snutch TP, Zamponi GW.

Mol Brain. 2018 May 2;11(1):24. doi: 10.1186/s13041-018-0368-5.

8.

Peripheral nerve injury increases contribution of L-type calcium channels to synaptic transmission in spinal lamina II: Role of α2δ-1 subunits.

Alles SR, Garcia E, Balasubramanyan S, Jones K, Tyson JR, Joy T, Snutch TP, Smith PA.

Mol Pain. 2018 Jan-Dec;14:1744806918765806. doi: 10.1177/1744806918765806.

9.

Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons.

Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM, Decher N.

Mol Cell Neurosci. 2018 Apr;88:330-341. doi: 10.1016/j.mcn.2018.03.002. Epub 2018 Mar 8.

PMID:
29524627
10.

CaV 3.2 drives sustained burst-firing, which is critical for absence seizure propagation in reticular thalamic neurons.

Cain SM, Tyson JR, Choi HB, Ko R, Lin PJC, LeDue JM, Powell KL, Bernier LP, Rungta RL, Yang Y, Cullis PR, O'Brien TJ, MacVicar BA, Snutch TP.

Epilepsia. 2018 Apr;59(4):778-791. doi: 10.1111/epi.14018. Epub 2018 Feb 21.

11.

Melatonin-mediated inhibition of Cav3.2 T-type Ca2+ channels induces sensory neuronal hypoexcitability through the novel protein kinase C-eta isoform.

Zhang Y, Ji H, Wang J, Sun Y, Qian Z, Jiang X, Snutch TP, Sun Y, Tao J.

J Pineal Res. 2018 May;64(4):e12476. doi: 10.1111/jpi.12476. Epub 2018 Mar 8.

PMID:
29437250
12.

Nanopore sequencing and assembly of a human genome with ultra-long reads.

Jain M, Koren S, Miga KH, Quick J, Rand AC, Sasani TA, Tyson JR, Beggs AD, Dilthey AT, Fiddes IT, Malla S, Marriott H, Nieto T, O'Grady J, Olsen HE, Pedersen BS, Rhie A, Richardson H, Quinlan AR, Snutch TP, Tee L, Paten B, Phillippy AM, Simpson JT, Loman NJ, Loose M.

Nat Biotechnol. 2018 Apr;36(4):338-345. doi: 10.1038/nbt.4060. Epub 2018 Jan 29.

13.

MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome.

Tyson JR, O'Neil NJ, Jain M, Olsen HE, Hieter P, Snutch TP.

Genome Res. 2018 Feb;28(2):266-274. doi: 10.1101/gr.221184.117. Epub 2017 Dec 22.

14.

The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels.

Proft J, Rzhepetskyy Y, Lazniewska J, Zhang FX, Cain SM, Snutch TP, Zamponi GW, Weiss N.

Sci Rep. 2017 Sep 14;7(1):11513. doi: 10.1038/s41598-017-11591-5.

15.

MinION Analysis and Reference Consortium: Phase 2 data release and analysis of R9.0 chemistry.

Jain M, Tyson JR, Loose M, Ip CLC, Eccles DA, O'Grady J, Malla S, Leggett RM, Wallerman O, Jansen HJ, Zalunin V, Birney E, Brown BL, Snutch TP, Olsen HE; MinION Analysis and Reference Consortium.

F1000Res. 2017 May 31;6:760. doi: 10.12688/f1000research.11354.1. eCollection 2017.

16.

GABAB receptors suppress burst-firing in reticular thalamic neurons.

Cain SM, Garcia E, Waheed Z, Jones KL, Bushell TJ, Snutch TP.

Channels (Austin). 2017 Nov 2;11(6):574-586. doi: 10.1080/19336950.2017.1358836. Epub 2017 Aug 22.

17.

Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg.

Sekar S, Omran E, Gopalakrishnan V, Howland JG, Snutch TP, Taghibiglou C.

Epilepsy Res. 2017 Oct;136:1-4. doi: 10.1016/j.eplepsyres.2017.07.004. Epub 2017 Jul 12.

PMID:
28719803
18.

Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: Reversal by the T-type calcium channel antagonist Z944.

Henbid MT, Marks WN, Collins MJ, Cain SM, Snutch TP, Howland JG.

Exp Neurol. 2017 Oct;296:16-22. doi: 10.1016/j.expneurol.2017.06.022. Epub 2017 Jun 26.

PMID:
28658605
19.

Recent advances in the development of T-type calcium channel blockers for pain intervention.

Snutch TP, Zamponi GW.

Br J Pharmacol. 2018 Jun;175(12):2375-2383. doi: 10.1111/bph.13906. Epub 2017 Jul 12. Review.

PMID:
28608534
20.

C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins.

Hirano M, Takada Y, Wong CF, Yamaguchi K, Kotani H, Kurokawa T, Mori MX, Snutch TP, Ronjat M, De Waard M, Mori Y.

J Biol Chem. 2017 Jun 2;292(22):9365-9381. doi: 10.1074/jbc.M117.778829. Epub 2017 Apr 4.

21.

In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures.

Cain SM, Bohnet B, LeDue J, Yung AC, Garcia E, Tyson JR, Alles SR, Han H, van den Maagdenberg AM, Kozlowski P, MacVicar BA, Snutch TP.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2401-2406. doi: 10.1073/pnas.1614447114. Epub 2017 Feb 21.

22.

Heantos-4, a natural plant extract used in the treatment of drug addiction, modulates T-type calcium channels and thalamocortical burst-firing.

Cain SM, Ahn S, Garcia E, Zhang Y, Waheed Z, Tyson JR, Yang Y, Van Sung T, Phillips AG, Snutch TP.

Mol Brain. 2016 Dec 5;9(1):94.

23.

The T-type calcium channel antagonist Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.

Marks WN, Greba Q, Cain SM, Snutch TP, Howland JG.

Neuroscience. 2016 Sep 22;332:121-9. doi: 10.1016/j.neuroscience.2016.06.035. Epub 2016 Jun 27.

PMID:
27365170
24.

The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg.

Marks WN, Cain SM, Snutch TP, Howland JG.

Neurobiol Dis. 2016 Oct;94:106-15. doi: 10.1016/j.nbd.2016.06.001. Epub 2016 Jun 6.

PMID:
27282256
25.

MinION Analysis and Reference Consortium: Phase 1 data release and analysis.

Ip CLC, Loose M, Tyson JR, de Cesare M, Brown BL, Jain M, Leggett RM, Eccles DA, Zalunin V, Urban JM, Piazza P, Bowden RJ, Paten B, Mwaigwisya S, Batty EM, Simpson JT, Snutch TP, Birney E, Buck D, Goodwin S, Jansen HJ, O'Grady J, Olsen HE; MinION Analysis and Reference Consortium.

F1000Res. 2015 Oct 15;4:1075. doi: 10.12688/f1000research.7201.1. eCollection 2015.

26.

The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans.

Marks WN, Cavanagh ME, Greba Q, Cain SM, Snutch TP, Howland JG.

Eur J Neurosci. 2016 Jan;43(1):25-40. doi: 10.1111/ejn.13110. Epub 2015 Nov 25.

PMID:
26490879
27.

Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice.

Poetschke C, Dragicevic E, Duda J, Benkert J, Dougalis A, DeZio R, Snutch TP, Striessnig J, Liss B.

Sci Rep. 2015 Sep 18;5:13688. doi: 10.1038/srep13688.

28.

A concerted action of L- and T-type Ca(2+) channels regulates locus coeruleus pacemaking.

Matschke LA, Bertoune M, Roeper J, Snutch TP, Oertel WH, Rinné S, Decher N.

Mol Cell Neurosci. 2015 Sep;68:293-302. doi: 10.1016/j.mcn.2015.08.012. Epub 2015 Aug 25.

PMID:
26319746
29.

Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model.

Casillas-Espinosa PM, Hicks A, Jeffreys A, Snutch TP, O'Brien TJ, Powell KL.

PLoS One. 2015 Aug 14;10(8):e0130012. doi: 10.1371/journal.pone.0130012. eCollection 2015.

30.

CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy.

Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ.

Genes Dev. 2015 Jul 15;29(14):1535-51. doi: 10.1101/gad.260869.115.

31.

Differential cerebellar GABAA receptor expression in mice with mutations in CaV2.1 (P/Q-type) calcium channels.

Kaja S, Payne AJ, Nielsen EØ, Thompson CL, van den Maagdenberg AM, Koulen P, Snutch TP.

Neuroscience. 2015 Sep 24;304:198-208. doi: 10.1016/j.neuroscience.2015.07.044. Epub 2015 Jul 21.

32.

The Triggle effect.

Snutch TP, Zamponi GW.

Biochem Pharmacol. 2015 Nov 15;98(2):322-6. doi: 10.1016/j.bcp.2015.07.003. Epub 2015 Jul 20. Review.

PMID:
26206192
33.

The cellular mechanisms of neuronal swelling underlying cytotoxic edema.

Rungta RL, Choi HB, Tyson JR, Malik A, Dissing-Olesen L, Lin PJC, Cain SM, Cullis PR, Snutch TP, MacVicar BA.

Cell. 2015 Apr 23;161(3):610-621. doi: 10.1016/j.cell.2015.03.029.

34.

The unusual suspects: Regulation of retinal calcium channels by somatostatin.

Hildebrand ME, Snutch TP.

Channels (Austin). 2015;9(2):61-2. doi: 10.1080/19336950.2015.1018000. No abstract available.

35.

Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels.

Zhang Y, Qin W, Qian Z, Liu X, Wang H, Gong S, Sun YG, Snutch TP, Jiang X, Tao J.

Sci Signal. 2014 Oct 7;7(346):ra94. doi: 10.1126/scisignal.2005283.

PMID:
25292213
36.

Epigallocatechin-3-gallate elicits Ca2+ spike in MCF-7 breast cancer cells: essential role of Cav3.2 channels.

Ranzato E, Magnelli V, Martinotti S, Waheed Z, Cain SM, Snutch TP, Marchetti C, Burlando B.

Cell Calcium. 2014 Oct;56(4):285-95. doi: 10.1016/j.ceca.2014.09.002. Epub 2014 Sep 15.

PMID:
25260713
37.

Thalamocortical neurons display suppressed burst-firing due to an enhanced Ih current in a genetic model of absence epilepsy.

Cain SM, Tyson JR, Jones KL, Snutch TP.

Pflugers Arch. 2015 Jun;467(6):1367-82. doi: 10.1007/s00424-014-1549-4. Epub 2014 Jun 24.

38.

Low threshold T-type calcium channels as targets for novel epilepsy treatments.

Powell KL, Cain SM, Snutch TP, O'Brien TJ.

Br J Clin Pharmacol. 2014 May;77(5):729-39. doi: 10.1111/bcp.12205. Review.

39.

Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers.

Borzenko A, Pajouhesh H, Morrison JL, Tringham E, Snutch TP, Schafer LL.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3257-61. doi: 10.1016/j.bmcl.2013.03.114. Epub 2013 Apr 4.

PMID:
23639535
40.

Advances in voltage-gated calcium channel structure, function and physiology.

Zamponi GW, Snutch TP.

Biochim Biophys Acta. 2013 Jul;1828(7):1521. doi: 10.1016/j.bbamem.2013.03.014. Epub 2013 Mar 18. No abstract available.

41.

Modulation of low-voltage-activated T-type Ca²⁺ channels.

Zhang Y, Jiang X, Snutch TP, Tao J.

Biochim Biophys Acta. 2013 Jul;1828(7):1550-9. doi: 10.1016/j.bbamem.2012.08.032. Epub 2012 Sep 10. Review.

42.

T-type calcium channels in burst-firing, network synchrony, and epilepsy.

Cain SM, Snutch TP.

Biochim Biophys Acta. 2013 Jul;1828(7):1572-8. doi: 10.1016/j.bbamem.2012.07.028. Epub 2012 Aug 2. Review.

43.

Voltage-Gated Calcium Channels in Epilepsy.

Cain SM, Snutch TP.

In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

44.

Structure-activity relationships of trimethoxybenzyl piperazine N-type calcium channel inhibitors.

Pajouhesh H, Feng ZP, Zhang L, Pajouhesh H, Jiang X, Hendricson A, Dong H, Tringham E, Ding Y, Vanderah TW, Porreca F, Belardetti F, Zamponi GW, Mitscher LA, Snutch TP.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4153-8. doi: 10.1016/j.bmcl.2012.04.054. Epub 2012 Apr 19.

45.

Repression of a potassium channel by nuclear hormone receptor and TGF-β signaling modulates insulin signaling in Caenorhabditis elegans.

Park D, Jones KL, Lee H, Snutch TP, Taubert S, Riddle DL.

PLoS Genet. 2012;8(2):e1002519. doi: 10.1371/journal.pgen.1002519. Epub 2012 Feb 16.

46.

T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures.

Tringham E, Powell KL, Cain SM, Kuplast K, Mezeyova J, Weerapura M, Eduljee C, Jiang X, Smith P, Morrison JL, Jones NC, Braine E, Rind G, Fee-Maki M, Parker D, Pajouhesh H, Parmar M, O'Brien TJ, Snutch TP.

Sci Transl Med. 2012 Feb 15;4(121):121ra19. doi: 10.1126/scitranslmed.3003120.

47.

Characterization of the substituted N-triazole oxindole TROX-1, a small-molecule, state-dependent inhibitor of Ca(V)2 calcium channels.

Swensen AM, Herrington J, Bugianesi RM, Dai G, Haedo RJ, Ratliff KS, Smith MM, Warren VA, Arneric SP, Eduljee C, Parker D, Snutch TP, Hoyt SB, London C, Duffy JL, Kaczorowski GJ, McManus OB.

Mol Pharmacol. 2012 Mar;81(3):488-97. doi: 10.1124/mol.111.075226. Epub 2011 Dec 21.

PMID:
22188924
48.

Identification of sodium channel isoforms that mediate action potential firing in lamina I/II spinal cord neurons.

Hildebrand ME, Mezeyova J, Smith PL, Salter MW, Tringham E, Snutch TP.

Mol Pain. 2011 Sep 12;7:67. doi: 10.1186/1744-8069-7-67.

49.

Amyotrophic lateral sclerosis-immunoglobulins selectively interact with neuromuscular junctions expressing P/Q-type calcium channels.

Gonzalez LE, Kotler ML, Vattino LG, Conti E, Reisin RC, Mulatz KJ, Snutch TP, Uchitel OD.

J Neurochem. 2011 Nov;119(4):826-38. doi: 10.1111/j.1471-4159.2011.07462.x. Epub 2011 Oct 3.

50.

Voltage-gated calcium channels and disease.

Cain SM, Snutch TP.

Biofactors. 2011 May-Jun;37(3):197-205. doi: 10.1002/biof.158. Review.

PMID:
21698699

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