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The glutathione cycle shapes synaptic glutamate activity.

Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2701-2706. doi: 10.1073/pnas.1817885116. Epub 2019 Jan 28.


Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.

Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH.

Nat Commun. 2018 Apr 18;9(1):1526. doi: 10.1038/s41467-018-03948-9.


Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity.

Kornberg MD, Bhargava P, Kim PM, Putluri V, Snowman AM, Putluri N, Calabresi PA, Snyder SH.

Science. 2018 Apr 27;360(6387):449-453. doi: 10.1126/science.aan4665. Epub 2018 Mar 29.


Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Fu C, Tyagi R, Chin AC, Rojas T, Li RJ, Guha P, Bernstein IA, Rao F, Xu R, Cha JY, Xu J, Snowman AM, Semenza GL, Snyder SH.

Circ Res. 2018 Feb 2;122(3):457-472. doi: 10.1161/CIRCRESAHA.117.311983. Epub 2017 Dec 26.


Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Fu C, Xu J, Cheng W, Rojas T, Chin AC, Snowman AM, Harraz MM, Snyder SH.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2036-2041. doi: 10.1073/pnas.1700165114. Epub 2017 Feb 2.


Inositol Hexakisphosphate Kinase-3 Regulates the Morphology and Synapse Formation of Cerebellar Purkinje Cells via Spectrin/Adducin.

Fu C, Xu J, Li RJ, Crawford JA, Khan AB, Ma TM, Cha JY, Snowman AM, Pletnikov MV, Snyder SH.

J Neurosci. 2015 Aug 5;35(31):11056-67. doi: 10.1523/JNEUROSCI.1069-15.2015.


Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease.

Paul BD, Sbodio JI, Xu R, Vandiver MS, Cha JY, Snowman AM, Snyder SH.

Nature. 2014 May 1;509(7498):96-100. doi: 10.1038/nature13136. Epub 2014 Mar 26.


Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death.

Xu R, Sen N, Paul BD, Snowman AM, Rao F, Vandiver MS, Xu J, Snyder SH.

Sci Signal. 2013 Apr 2;6(269):ra22. doi: 10.1126/scisignal.2003405. Erratum in: Sci Signal. 2013 Apr 30;6(273):er1.


Sulfhydration mediates neuroprotective actions of parkin.

Vandiver MS, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko HS, Lee YI, Dawson VL, Dawson TM, Sen N, Snyder SH.

Nat Commun. 2013;4:1626. doi: 10.1038/ncomms2623.


Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase.

Kim S, Kim SF, Maag D, Maxwell MJ, Resnick AC, Juluri KR, Chakraborty A, Koldobskiy MA, Cha SH, Barrow R, Snowman AM, Snyder SH.

Cell Metab. 2011 Feb 2;13(2):215-21. doi: 10.1016/j.cmet.2011.01.007.


Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2.

Chakraborty A, Werner JK Jr, Koldobskiy MA, Mustafa AK, Juluri KR, Pietropaoli J, Snowman AM, Snyder SH.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2205-9. doi: 10.1073/pnas.1019381108. Epub 2011 Jan 24.


Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.

Chakraborty A, Koldobskiy MA, Bello NT, Maxwell M, Potter JJ, Juluri KR, Maag D, Kim S, Huang AS, Dailey MJ, Saleh M, Snowman AM, Moran TH, Mezey E, Snyder SH.

Cell. 2010 Dec 10;143(6):897-910. doi: 10.1016/j.cell.2010.11.032.


p53-mediated apoptosis requires inositol hexakisphosphate kinase-2.

Koldobskiy MA, Chakraborty A, Werner JK Jr, Snowman AM, Juluri KR, Vandiver MS, Kim S, Heletz S, Snyder SH.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20947-51. doi: 10.1073/pnas.1015671107. Epub 2010 Nov 15.


GAPDH mediates nitrosylation of nuclear proteins.

Kornberg MD, Sen N, Hara MR, Juluri KR, Nguyen JV, Snowman AM, Law L, Hester LD, Snyder SH.

Nat Cell Biol. 2010 Nov;12(11):1094-100. doi: 10.1038/ncb2114. Epub 2010 Oct 24.


HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

Chakraborty A, Koldobskiy MA, Sixt KM, Juluri KR, Mustafa AK, Snowman AM, van Rossum DB, Patterson RL, Snyder SH.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1134-9. doi: 10.1073/pnas.0711168105. Epub 2008 Jan 14.


Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event.

Bhandari R, Saiardi A, Ahmadibeni Y, Snowman AM, Resnick AC, Kristiansen TZ, Molina H, Pandey A, Werner JK Jr, Juluri KR, Xu Y, Prestwich GD, Parang K, Snyder SH.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15305-10. Epub 2007 Sep 14. Erratum in: Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21171-3.


From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.

Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3456-9. Epub 2007 Feb 20.


Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.

Resnick AC, Snowman AM, Kang BN, Hurt KJ, Snyder SH, Saiardi A.

Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12783-8. Epub 2005 Aug 25.


Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases.

Saiardi A, Resnick AC, Snowman AM, Wendland B, Snyder SH.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1911-4. Epub 2005 Jan 21.


Phosphorylation of proteins by inositol pyrophosphates.

Saiardi A, Bhandari R, Resnick AC, Snowman AM, Snyder SH.

Science. 2004 Dec 17;306(5704):2101-5.


Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON.

Jaffrey SR, Benfenati F, Snowman AM, Czernik AJ, Snyder SH.

Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3199-204. Epub 2002 Feb 26.


Identification and characterization of a novel inositol hexakisphosphate kinase.

Saiardi A, Nagata E, Luo HR, Snowman AM, Snyder SH.

J Biol Chem. 2001 Oct 19;276(42):39179-85. Epub 2001 Aug 13.


Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate.

Saiardi A, Nagata E, Luo HR, Sawa A, Luo X, Snowman AM, Snyder SH.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2306-11. Epub 2001 Feb 13.


Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.

Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH.

Curr Biol. 1999 Nov 18;9(22):1323-6.


CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.

Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH.

Neuron. 1998 Jan;20(1):115-24.


Cloned and expressed rat Ca2+-sensing receptor.

Ruat M, Snowman AM, Hester LD, Snyder SH.

J Biol Chem. 1996 Mar 15;271(11):5972-5.


Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.

Ruat M, Molliver ME, Snowman AM, Snyder SH.

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3161-5.


The association of endogenous Go alpha with the purified omega-conotoxin GVIA receptor.

McEnery MW, Snowman AM, Snyder SH.

J Biol Chem. 1994 Jan 7;269(1):5-8.


Immunological characterization of proteins associated with the purified omega-conotoxin GVIA receptor.

McEnery MW, Snowman AM, Seagar MJ, Copeland TD, Takahashi M.

Ann N Y Acad Sci. 1993 Dec 20;707:386-91. No abstract available.


Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, Murphy WJ.

Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9730-4.


High brain densities of the immunophilin FKBP colocalized with calcineurin.

Steiner JP, Dawson TM, Fotuhi M, Glatt CE, Snowman AM, Cohen N, Snyder SH.

Nature. 1992 Aug 13;358(6387):584-7.


Purified omega-conotoxin GVIA receptor of rat brain resembles a dihydropyridine-sensitive L-type calcium channel.

McEnery MW, Snowman AM, Sharp AH, Adams ME, Snyder SH.

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11095-9. Erratum in: Proc Natl Acad Sci U S A 1992 Apr 1;89(7):3164.


[3H]opipramol labels a novel binding site and sigma receptors in rat brain membranes.

Ferris CD, Hirsch DJ, Brooks BP, Snowman AM, Snyder SH.

Mol Pharmacol. 1991 Feb;39(2):199-204.


Evidence for subtypes of the omega-conotoxin GVIA receptor. Identification of the properties intrinsic to the high-affinity receptor.

McEnery MW, Snowman AM, Snyder SH.

Ann N Y Acad Sci. 1991;635:435-7. No abstract available.


Cetirizine: actions on neurotransmitter receptors.

Snowman AM, Snyder SH.

J Allergy Clin Immunol. 1990 Dec;86(6 Pt 2):1025-8.


Odorant-binding protein. Characterization of ligand binding.

Pevsner J, Hou V, Snowman AM, Snyder SH.

J Biol Chem. 1990 Apr 15;265(11):6118-25.


Differential effects of amiodarone and desethylamiodarone on calcium antagonist receptors.

Wagner JA, Weisman HF, Levine JH, Snowman AM, Snyder SH.

J Cardiovasc Pharmacol. 1990 Mar;15(3):501-7.


Alterations in calcium antagonist receptors and sodium-calcium exchange in cardiomyopathic hamster tissues.

Wagner JA, Weisman HF, Snowman AM, Reynolds IJ, Weisfeldt ML, Snyder SH.

Circ Res. 1989 Jul;65(1):205-14.


High-affinity cannabinoid binding site: regulation by ions, ascorbic acid, and nucleotides.

Nye JS, Snowman AM, Voglmaier S, Snyder SH.

J Neurochem. 1989 Jun;52(6):1892-7.


Novel antipsychotic drugs share high affinity for sigma receptors.

Largent BL, Wikström H, Snowman AM, Snyder SH.

Eur J Pharmacol. 1988 Oct 18;155(3):345-7. No abstract available.


Omega-conotoxin GVIA binding to a high-affinity receptor in brain: characterization, calcium sensitivity, and solubilization.

Wagner JA, Snowman AM, Biswas A, Olivera BM, Snyder SH.

J Neurosci. 1988 Sep;8(9):3354-9.


Phenylalkylamine-sensitive calcium channels in osteoblast-like osteosarcoma cells. Characterization by ligand binding and single channel recordings.

Guggino SE, Wagner JA, Snowman AM, Hester LD, Sacktor B, Snyder SH.

J Biol Chem. 1988 Jul 25;263(21):10155-61.


Calcium antagonist receptors. Clinical and physiological relevance.

Wagner JA, Guggino SE, Reynolds IJ, Snowman AM, Biswas A, Olivera BM, Snyder SH.

Ann N Y Acad Sci. 1988;522:116-33. Review. No abstract available.


Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicity.

Wagner JA, Snowman AM, Olivera BM, Snyder SH.

N Engl J Med. 1987 Dec 24;317(26):1669. No abstract available.


Receptor effects of cetirizine.

Snyder SH, Snowman AM.

Ann Allergy. 1987 Dec;59(6 Pt 2):4-8.


Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine.

D'Amato RJ, Largent BL, Snowman AM, Snyder SH.

J Pharmacol Exp Ther. 1987 Jul;242(1):364-71.


Huntington's disease: increased number and altered regulation of benzodiazepine receptor complexes in frontal cerebral cortex.

Trifiletti RR, Snowman AM, Whitehouse PJ, Marcus KA, Snyder SH.

Neurology. 1987 Jun;37(6):916-22.


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