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Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.

Merlino DJ, Barton JR, Charsar BA, Byrne MD, Rappaport JA, Smeyne RJ, Lepore AC, Snook AE, Waldman SA.

Brain Struct Funct. 2019 Nov;224(8):2983-2999. doi: 10.1007/s00429-019-01949-y. Epub 2019 Sep 4.


Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review.

Khalili M, Daniels L, Lin A, Krebs FC, Snook AE, Bekeschus S, Bowne WB, Miller V.

J Phys D Appl Phys. 2019 Oct 22;52(42). pii: 423001. doi: 10.1088/1361-6463/ab31c1. Epub 2019 Aug 6.


Biomarker targeting of colorectal cancer stem cells.

Caparosa EM, Stem J, Snook AE, Waldman SA.

Biomark Med. 2019 Aug;13(11):891-894. doi: 10.2217/bmm-2019-0227. Epub 2019 Aug 6. No abstract available.


Therapeutic targeting of gastrointestinal cancer stem cells.

Stem J, Flickinger JC Jr, Merlino D, Caparosa EM, Snook AE, Waldman SA.

Regen Med. 2019 May;14(4):331-343. doi: 10.2217/rme-2018-0146. Epub 2019 Apr 26.


Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients.

Snook AE, Baybutt TR, Xiang B, Abraham TS, Flickinger JC Jr, Hyslop T, Zhan T, Kraft WK, Sato T, Waldman SA.

J Immunother Cancer. 2019 Apr 23;7(1):104. doi: 10.1186/s40425-019-0576-2.


Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia.

Bashir B, Merlino DJ, Rappaport JA, Gnass E, Palazzo JP, Feng Y, Fearon ER, Snook AE, Waldman SA.

Hum Pathol. 2019 May;87:103-114. doi: 10.1016/j.humpath.2018.11.032. Epub 2019 Feb 2.


TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.

Abraham TS, Flickinger JC Jr, Waldman SA, Snook AE.

J Immunol. 2019 Feb 15;202(4):1301-1310. doi: 10.4049/jimmunol.1801206. Epub 2019 Jan 14.


Adenovirus-Mediated ABCC6 Gene Therapy for Heritable Ectopic Mineralization Disorders.

Huang J, Snook AE, Uitto J, Li Q.

J Invest Dermatol. 2019 Jun;139(6):1254-1263. doi: 10.1016/j.jid.2018.12.017. Epub 2019 Jan 11.


Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors.

Baybutt TR, Flickinger JC Jr, Caparosa EM, Snook AE.

Clin Pharmacol Ther. 2019 Jan;105(1):71-78. doi: 10.1002/cpt.1280. Review.


Non-thermal plasma induces immunogenic cell death in vivo in murine CT26 colorectal tumors.

Lin AG, Xiang B, Merlino DJ, Baybutt TR, Sahu J, Fridman A, Snook AE, Miller V.

Oncoimmunology. 2018 Jul 26;7(9):e1484978. doi: 10.1080/2162402X.2018.1484978. eCollection 2018.


Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress.

Flickinger JC Jr, Rodeck U, Snook AE.

Vaccines (Basel). 2018 Jul 25;6(3). pii: E48. doi: 10.3390/vaccines6030048. Review.


The swinging pendulum of cancer immunotherapy personalization.

Abraham TS, Snook AE.

Per Med. 2017 May;14(3):259-270. doi: 10.2217/pme-2016-0108. Epub 2017 May 5. Review.


Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases.

Magee MS, Abraham TS, Baybutt TR, Flickinger JC Jr, Ridge NA, Marszalowicz GP, Prajapati P, Hersperger AR, Waldman SA, Snook AE.

Cancer Immunol Res. 2018 May;6(5):509-516. doi: 10.1158/2326-6066.CIR-16-0362. Epub 2018 Apr 3.


GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress.

Kraft CL, Rappaport JA, Snook AE, Pattison AM, Lynch JP, Waldman SA.

Oncotarget. 2017 Oct 26;8(61):102923-102933. doi: 10.18632/oncotarget.22084. eCollection 2017 Nov 28.


Immunotherapy regimens for metastatic colorectal carcinomas.

Bashir B, Snook AE.

Hum Vaccin Immunother. 2018 Feb 1;14(2):250-254. doi: 10.1080/21645515.2017.1397244. Epub 2017 Dec 6. Review.


GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.

Li P, Wuthrick E, Rappaport JA, Kraft C, Lin JE, Marszalowicz G, Snook AE, Zhan T, Hyslop TM, Waldman SA.

Cancer Res. 2017 Sep 15;77(18):5095-5106. doi: 10.1158/0008-5472.CAN-17-0859.


ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice.

Li P, Lin JE, Snook AE, Waldman SA.

Toxins (Basel). 2017 Sep 12;9(9). pii: E279. doi: 10.3390/toxins9090279.


Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells.

Xiang B, Baybutt TR, Berman-Booty L, Magee MS, Waldman SA, Alexeev VY, Snook AE.

J Immunol. 2017 May 1;198(9):3507-3514. doi: 10.4049/jimmunol.1502672. Epub 2017 Mar 24.


siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer.

Perepelyuk M, Shoyele O, Birbe R, Thangavel C, Liu Y, Den RB, Snook AE, Lu B, Shoyele SA.

Mol Ther Nucleic Acids. 2017 Mar 17;6:259-268. doi: 10.1016/j.omtn.2016.12.009. Epub 2016 Dec 31.


Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.

Aka AA, Rappaport JA, Pattison AM, Sato T, Snook AE, Waldman SA.

Expert Rev Clin Pharmacol. 2017 May;10(5):549-557. doi: 10.1080/17512433.2017.1292124. Epub 2017 Apr 10. Review.


GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity.

Magee MS, Kraft CL, Abraham TS, Baybutt TR, Marszalowicz GP, Li P, Waldman SA, Snook AE.

Oncoimmunology. 2016 Sep 2;5(10):e1227897. eCollection 2016.


Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.

Pattison AM, Blomain ES, Merlino DJ, Wang F, Crissey MA, Kraft CL, Rappaport JA, Snook AE, Lynch JP, Waldman SA.

Infect Immun. 2016 Sep 19;84(10):3083-91. doi: 10.1128/IAI.00639-16. Print 2016 Oct.


Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.

Blomain ES, Merlino DJ, Pattison AM, Snook AE, Waldman SA.

Mol Pharmacol. 2016 Sep;90(3):199-204. doi: 10.1124/mol.115.103192. Epub 2016 Jun 1. Review.


Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity.

Kim GW, Lin JE, Snook AE, Aing AS, Merlino DJ, Li P, Waldman SA.

Nutr Diabetes. 2016 May 23;6:e211. doi: 10.1038/nutd.2016.18.


Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model.

Perepelyuk M, Thangavel C, Liu Y, Den RB, Lu B, Snook AE, Shoyele SA.

Mol Ther Nucleic Acids. 2016 Jan 26;5:e282. doi: 10.1038/mtna.2015.56.


Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.

Lin JE, Colon-Gonzalez F, Blomain E, Kim GW, Aing A, Stoecker B, Rock J, Snook AE, Zhan T, Hyslop TM, Tomczak M, Blumberg RS, Waldman SA.

Cancer Res. 2016 Jan 15;76(2):339-46. doi: 10.1158/0008-5472.CAN-15-1467-T.


Comparative Evaluation of Veriflow® Listeria monocytogenes to USDA and AOAC Culture Based Methods for the Detection of Listeria monocytogenes in Food.

Joelsson AC, Brown AS, Puri A, Keough MP, Gaudioso ZE, Siciliano NA, Snook AE.

J AOAC Int. 2015 Sep-Oct;98(5):1325-34. doi: 10.5740/jaoacint.15-122.


DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.

Goodwin JF, Kothari V, Drake JM, Zhao S, Dylgjeri E, Dean JL, Schiewer MJ, McNair C, Jones JK, Aytes A, Magee MS, Snook AE, Zhu Z, Den RB, Birbe RC, Gomella LG, Graham NA, Vashisht AA, Wohlschlegel JA, Graeber TG, Karnes RJ, Takhar M, Davicioni E, Tomlins SA, Abate-Shen C, Sharifi N, Witte ON, Feng FY, Knudsen KE.

Cancer Cell. 2015 Jul 13;28(1):97-113. doi: 10.1016/j.ccell.2015.06.004.


Challenges to chimeric antigen receptor (CAR)-T cell therapy for cancer.

Magee MS, Snook AE.

Discov Med. 2014 Nov;18(100):265-71. Review.


Could targeting T-helper cells aid the development of effective cancer vaccines?

Snook AE.

Immunotherapy. 2014;6(9):959-61. doi: 10.2217/imt.14.79. No abstract available.


The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer.

Wilson C, Lin JE, Li P, Snook AE, Gong J, Sato T, Liu C, Girondo MA, Rui H, Hyslop T, Waldman SA.

Cancer Epidemiol Biomarkers Prev. 2014 Nov;23(11):2328-37. doi: 10.1158/1055-9965.EPI-14-0440. Epub 2014 Oct 10.


GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer.

Marszalowicz GP, Snook AE, Magee MS, Merlino D, Berman-Booty LD, Waldman SA.

Oncotarget. 2014 Oct 15;5(19):9460-71.


A novel CDX2 isoform regulates alternative splicing.

Witek ME, Snook AE, Lin JE, Blomain ES, Xiang B, Magee MS, Waldman SA.

PLoS One. 2014 Aug 7;9(8):e104293. doi: 10.1371/journal.pone.0104293. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e112164. Magee, Michael [corrected to Magee, Michael S].


Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection.

Hersperger AR, Siciliano NA, DeHaven BC, Snook AE, Eisenlohr LC.

J Virol. 2014 Aug;88(16):9472-5. doi: 10.1128/JVI.01464-14. Epub 2014 Jun 4.


Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment.

Hayes CS, Shicora AC, Keough MP, Snook AE, Burns MR, Gilmour SK.

Cancer Immunol Res. 2014 Mar;2(3):274-85. doi: 10.1158/2326-6066.CIR-13-0120-T. Epub 2013 Oct 7.


Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy.

Snook AE, Magee MS, Schulz S, Waldman SA.

Eur J Immunol. 2014 Jul;44(7):1956-66. doi: 10.1002/eji.201444539. Epub 2014 May 21.


Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C.

Witek M, Blomain ES, Magee MS, Xiang B, Waldman SA, Snook AE.

Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1188-95. doi: 10.1016/j.ijrobp.2013.12.043.


Intestinal GUCY2C prevents TGF-╬▓ secretion coordinating desmoplasia and hyperproliferation in colorectal cancer.

Gibbons AV, Lin JE, Kim GW, Marszalowicz GP, Li P, Stoecker BA, Blomain ES, Rattan S, Snook AE, Schulz S, Waldman SA.

Cancer Res. 2013 Nov 15;73(22):6654-66. doi: 10.1158/0008-5472.CAN-13-0887. Epub 2013 Oct 1.


Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis.

Blomain ES, Lin JE, Kraft CL, Trela UT, Rock JM, Aing AS, Snook AE, Waldman SA.

Expert Rev Clin Pharmacol. 2013 Sep;6(5):557-64. doi: 10.1586/17512433.2013.827406. Epub 2013 Aug 24. Review.


Colorectal cancer immunotherapy.

Xiang B, Snook AE, Magee MS, Waldman SA.

Discov Med. 2013 May;15(84):301-8. Review.


Advances in cancer immunotherapy.

Snook AE, Waldman SA.

Discov Med. 2013 Feb;15(81):120-5. Review.


Immunotherapeutic strategies to target prognostic and predictive markers of cancer.

Magee MS, Snook AE, Marszalowicz GP, Waldman SA.

Biomark Med. 2013 Feb;7(1):23-35. doi: 10.2217/bmm.12.110. Review.


GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.

Lin JE, Snook AE, Li P, Stoecker BA, Kim GW, Magee MS, Garcia AV, Valentino MA, Hyslop T, Schulz S, Waldman SA.

PLoS One. 2012;7(2):e31686. doi: 10.1371/journal.pone.0031686. Epub 2012 Feb 22.


Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C.

Snook AE, Magee MS, Marszalowicz GP, Schulz S, Waldman SA.

Cancer Immunol Immunother. 2012 May;61(5):713-23. doi: 10.1007/s00262-011-1133-0. Epub 2011 Nov 6.


GUCY2C-targeted cancer immunotherapy: past, present and future.

Snook AE, Magee MS, Waldman SA.

Immunol Res. 2011 Dec;51(2-3):161-9. doi: 10.1007/s12026-011-8253-7. Review.


A uroguanylin-GUCY2C endocrine axis regulates feeding in mice.

Valentino MA, Lin JE, Snook AE, Li P, Kim GW, Marszalowicz G, Magee MS, Hyslop T, Schulz S, Waldman SA.

J Clin Invest. 2011 Sep;121(9):3578-88. doi: 10.1172/JCI57925. Epub 2011 Aug 25.


Functional macroautophagy induction by influenza A virus without a contribution to major histocompatibility complex class II-restricted presentation.

Comber JD, Robinson TM, Siciliano NA, Snook AE, Eisenlohr LC.

J Virol. 2011 Jul;85(13):6453-63. doi: 10.1128/JVI.02122-10. Epub 2011 Apr 27.


Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics.

Lin JE, Valentino M, Marszalowicz G, Magee MS, Li P, Snook AE, Stoecker BA, Chang C, Waldman SA.

Toxins (Basel). 2010 Aug;2(8):2028-54. doi: 10.3390/toxins2082028. Epub 2010 Aug 5. Review.

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