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Items: 1 to 50 of 381

1.

CRISPR/Cas9 Editing of the Polyomavirus Tumor Antigens Inhibits Merkel Cell Carcinoma Growth In Vitro.

Temblador A, Topalis D, Andrei G, Snoeck R.

Cancers (Basel). 2019 Aug 28;11(9). pii: E1260. doi: 10.3390/cancers11091260.

2.

Persistent primary cytomegalovirus infection in a kidney transplant recipient: Multi-drug resistant and compartmentalized infection leading to graft loss.

Andrei G, Van Loon E, Lerut E, Victoor J, Meijers B, Bammens B, Sprangers B, Gillemot S, Fiten P, Opdenakker G, Lagrou K, Kuypers D, Snoeck R, Naesens M.

Antiviral Res. 2019 Aug;168:203-209. doi: 10.1016/j.antiviral.2019.06.004. Epub 2019 Jun 15.

PMID:
31212020
3.

Novel Therapeutics for Epstein⁻Barr Virus.

Andrei G, Trompet E, Snoeck R.

Molecules. 2019 Mar 12;24(5). pii: E997. doi: 10.3390/molecules24050997. Review.

4.

Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.

Mohammed AF, Andrei G, Hayallah AM, Abdel-Moty SG, Snoeck R, Simons C.

Bioorg Med Chem. 2019 Mar 15;27(6):1023-1033. doi: 10.1016/j.bmc.2019.02.005. Epub 2019 Feb 2.

PMID:
30738653
5.

Antiviral activity spectrum of phenoxazine nucleoside derivatives.

Kozlovskaya LI, Andrei G, Orlov AA, Khvatov EV, Koruchekov AA, Belyaev ES, Nikolaev EN, Korshun VA, Snoeck R, Osolodkin DI, Matyugina ES, Aralov AV.

Antiviral Res. 2019 Mar;163:117-124. doi: 10.1016/j.antiviral.2019.01.010. Epub 2019 Jan 23.

PMID:
30684562
6.

Utilization of 1,3-Dioxolanes in the Synthesis of α-branched Alkyl and Aryl 9-[2-(Phosphonomethoxy)Ethyl]Purines and Study of the Influence of α-branched Substitution for Potential Biological Activity.

Pomeisl K, Pohl R, Snoeck R, Andrei G, Krečmerová M.

Nucleosides Nucleotides Nucleic Acids. 2019;38(2):119-156. doi: 10.1080/15257770.2018.1506884. Epub 2018 Dec 7.

PMID:
30526265
7.

Xanthine-based acyclic nucleoside phosphonates with potent antiviral activity against varicella-zoster virus and human cytomegalovirus.

Baszczyňski O, Kaiser MM, Česnek M, Břehová P, Jansa P, Procházková E, Dračínský M, Snoeck R, Andrei G, Janeba Z.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618813050. doi: 10.1177/2040206618813050.

8.

Synthesis, Anti-varicella-zoster virus and Anti-cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles.

Yuan WY, Chen X, Liu NN, Wen YN, Yang B, Andrei G, Snoeck R, Xiang YH, Wu YW, Jiang Z, Schols D, Zhang ZY, Wu QP.

Med Chem. 2018 Nov 8. doi: 10.2174/1573406414666181109095239. [Epub ahead of print]

PMID:
30411688
9.

Treatment of intraurethral condylomata acuminata with surgery and cidofovir instillations in two immunocompromised patients and review of the literature.

Florin HJ, Snoeck R, Van Cleynenbreugel B, Albersen M.

Antiviral Res. 2018 Oct;158:238-243. doi: 10.1016/j.antiviral.2018.08.016. Epub 2018 Aug 25.

PMID:
30153444
10.

Synthesis of a 3'-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.

Hulpia F, Noppen S, Schols D, Andrei G, Snoeck R, Liekens S, Vervaeke P, Van Calenbergh S.

Eur J Med Chem. 2018 Sep 5;157:248-267. doi: 10.1016/j.ejmech.2018.07.062. Epub 2018 Jul 29.

PMID:
30098481
11.

Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones-Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity.

Grabkowska-Drużyc M, Andrei G, Schols D, Snoeck R, Piotrowska DG.

Molecules. 2018 Jul 28;23(8). pii: E1889. doi: 10.3390/molecules23081889.

12.

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation.

Kaoukabi H, Kabri Y, Curti C, Taourirte M, Rodriguez-Ubis JC, Snoeck R, Andrei G, Vanelle P, Lazrek HB.

Eur J Med Chem. 2018 Jul 15;155:772-781. doi: 10.1016/j.ejmech.2018.06.028. Epub 2018 Jun 13.

PMID:
29945100
13.

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.

Pileggi E, Serpi M, Andrei G, Schols D, Snoeck R, Pertusati F.

Bioorg Med Chem. 2018 Jul 23;26(12):3596-3609. doi: 10.1016/j.bmc.2018.05.034. Epub 2018 May 23.

PMID:
29880251
14.

Varicella-Zoster Virus ORF9p Binding to Cellular Adaptor Protein Complex 1 Is Important for Viral Infectivity.

Lebrun M, Lambert J, Riva L, Thelen N, Rambout X, Blondeau C, Thiry M, Snoeck R, Twizere JC, Dequiedt F, Andrei G, Sadzot-Delvaux C.

J Virol. 2018 Jul 17;92(15). pii: e00295-18. doi: 10.1128/JVI.00295-18. Print 2018 Aug 1.

15.

Antiviral effect of the nucleoside analogue cidofovir in the context of sexual transmission of a gammaherpesvirus in mice.

Zeippen C, Javaux J, Snoeck R, Neyts J, Gillet L.

J Antimicrob Chemother. 2018 Aug 1;73(8):2095-2103. doi: 10.1093/jac/dky161.

PMID:
29788354
16.

Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.

Mertens B, Cristina de Araujo Nogueira T, Topalis D, Stranska R, Snoeck R, Andrei G.

Oncotarget. 2018 Apr 24;9(31):21978-22000. doi: 10.18632/oncotarget.25140. eCollection 2018 Apr 24.

17.

Amidate Prodrugs of Cyclic 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity.

Luo M, Groaz E, De Jonghe S, Snoeck R, Andrei G, Herdewijn P.

ACS Med Chem Lett. 2018 Mar 16;9(4):381-385. doi: 10.1021/acsmedchemlett.8b00079. eCollection 2018 Apr 12.

18.

Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.

Wang M, Srivastava P, Liu C, Snoeck R, Andrei G, De Jonghe S, Herdewijn P.

Eur J Med Chem. 2018 Apr 25;150:616-625. doi: 10.1016/j.ejmech.2018.03.008. Epub 2018 Mar 10.

PMID:
29550734
19.

Thymidine kinase and protein kinase in drug-resistant herpesviruses: Heads of a Lernaean Hydra.

Topalis D, Gillemot S, Snoeck R, Andrei G.

Drug Resist Updat. 2018 Mar;37:1-16. doi: 10.1016/j.drup.2018.01.003. Epub 2018 Jan 31. Review.

PMID:
29548479
20.

Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.

Bessières M, Hervin V, Roy V, Chartier A, Snoeck R, Andrei G, Lohier JF, Agrofoglio LA.

Eur J Med Chem. 2018 Feb 25;146:678-686. doi: 10.1016/j.ejmech.2018.01.086. Epub 2018 Jan 31.

PMID:
29407990
21.

Safety and tolerance of cidofovir as a 2% gel for local application in high-grade cervical intraepithelial neoplasia: A phase 1 investigation.

Bossens M, Jost M, Van Pachterbeke C, De Maertelaer V, Simon P, Frankenne F, Hubert P, Evrard B, Snoeck R.

Int J Clin Pharmacol Ther. 2018 Mar;56(3):134-141. doi: 10.5414/CP203126.

PMID:
29319498
22.

Comparison of membrane affinity-based method with size-exclusion chromatography for isolation of exosome-like vesicles from human plasma.

Stranska R, Gysbrechts L, Wouters J, Vermeersch P, Bloch K, Dierickx D, Andrei G, Snoeck R.

J Transl Med. 2018 Jan 9;16(1):1. doi: 10.1186/s12967-017-1374-6.

23.

Emimycin and its nucleoside derivatives: Synthesis and antiviral activity.

Plebanek E, Lescrinier E, Andrei G, Snoeck R, Herdewijn P, De Jonghe S.

Eur J Med Chem. 2018 Jan 20;144:93-103. doi: 10.1016/j.ejmech.2017.12.018. Epub 2017 Dec 7.

PMID:
29268134
24.

Lytic viral replication and immunopathology in a cytomegalovirus-induced mouse model of secondary hemophagocytic lymphohistiocytosis.

Brisse E, Imbrechts M, Mitera T, Vandenhaute J, Wouters CH, Snoeck R, Andrei G, Matthys P.

Virol J. 2017 Dec 19;14(1):240. doi: 10.1186/s12985-017-0908-0.

25.

The Anti-Human Immunodeficiency Virus Drug Tenofovir, a Reverse Transcriptase Inhibitor, Also Targets the Herpes Simplex Virus DNA Polymerase.

Andrei G, Gillemot S, Topalis D, Snoeck R.

J Infect Dis. 2018 Feb 14;217(5):790-801. doi: 10.1093/infdis/jix605.

PMID:
29186456
26.

Lymphocyte-independent pathways underlie the pathogenesis of murine cytomegalovirus-associated secondary haemophagocytic lymphohistiocytosis.

Brisse E, Imbrechts M, Mitera T, Vandenhaute J, Berghmans N, Boon L, Wouters C, Snoeck R, Andrei G, Matthys P.

Clin Exp Immunol. 2018 Apr;192(1):104-119. doi: 10.1111/cei.13084. Epub 2018 Jan 18.

27.

A European multi-centre External Quality Assessment (EQA) study on phenotypic and genotypic methods used for Herpes Simplex Virus (HSV) drug resistance testing.

Afshar B, Bibby DF, Piorkowska R, Ohemeng-Kumi N, Snoeck R, Andrei G, Gillemot S, Morfin F, Frobert E, Burrel S, Boutolleau D, Crowley B, Mbisa JL.

J Clin Virol. 2017 Nov;96:89-93. doi: 10.1016/j.jcv.2017.10.002. Epub 2017 Oct 6.

PMID:
29031157
28.

Virtual Screening of Acyclovir Derivatives as Potential Antiviral Agents: Design, Synthesis, and Biological Evaluation of New Acyclic Nucleoside ProTides.

Derudas M, Vanpouille C, Carta D, Zicari S, Andrei G, Snoeck R, Brancale A, Margolis L, Balzarini J, McGuigan C.

J Med Chem. 2017 Sep 28;60(18):7876-7896. doi: 10.1021/acs.jmedchem.7b01009. Epub 2017 Sep 19.

29.

Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides.

Głowacka IE, Andrei G, Schols D, Snoeck R, Gawron K.

Arch Pharm (Weinheim). 2017 Sep;350(9). doi: 10.1002/ardp.201700166. Epub 2017 Aug 1.

PMID:
28763115
30.

New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.

Krečmerová M, Dračínský M, Snoeck R, Balzarini J, Pomeisl K, Andrei G.

Bioorg Med Chem. 2017 Sep 1;25(17):4637-4648. doi: 10.1016/j.bmc.2017.06.046. Epub 2017 Jul 6.

PMID:
28757102
31.

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.

Luo M, Groaz E, Andrei G, Snoeck R, Kalkeri R, Ptak RG, Hartman T, Buckheit RW Jr, Schols D, De Jonghe S, Herdewijn P.

J Med Chem. 2017 Jul 27;60(14):6220-6238. doi: 10.1021/acs.jmedchem.7b00416. Epub 2017 Jul 6.

PMID:
28682067
32.

Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.

Pertusati F, Serafini S, Albadry N, Snoeck R, Andrei G.

Antiviral Res. 2017 Jul;143:262-268. doi: 10.1016/j.antiviral.2017.04.013. Epub 2017 Apr 25.

PMID:
28454912
33.

Antiviral and Cytostatic Evaluation of 5-(1-Halo-2-sulfonylvinyl)- and 5-(2-Furyl)uracil Nucleosides.

Wen Z, Suzol SH, Peng J, Liang Y, Snoeck R, Andrei G, Liekens S, Wnuk SF.

Arch Pharm (Weinheim). 2017 Apr;350(3-4). doi: 10.1002/ardp.201700023. Epub 2017 Mar 17.

PMID:
28304114
34.

Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).

Wen YN, Zhang ZF, Liu NN, Andrei G, Snoeck R, Xiang YH, Schols D, Chen X, Zhang ZY, Zhang QS, Wu QP.

Med Chem. 2017;13(5):453-464. doi: 10.2174/1573406413666170307165236.

PMID:
28290250
35.
36.
37.

Acyclic nucleoside phosphonates containing the amide bond.

Głowacka IE, Piotrowska DG, Andrei G, Schols D, Snoeck R, Wróblewski AE.

Monatsh Chem. 2016;147(12):2163-2177. Epub 2016 Oct 26.

38.

Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates.

Głowacka IE, Gulej R, Grzonkowski P, Andrei G, Schols D, Snoeck R, Piotrowska DG.

Molecules. 2016 Oct 26;21(11). pii: E1420.

39.

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures.

Piotrowska DG, Andrei G, Schols D, Snoeck R, Łysakowska M.

Eur J Med Chem. 2017 Jan 27;126:84-100. doi: 10.1016/j.ejmech.2016.10.002. Epub 2016 Oct 4.

PMID:
27750154
40.

Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase.

Topalis D, Gillemot S, Snoeck R, Andrei G.

Nucleic Acids Res. 2016 Nov 16;44(20):9530-9554. Epub 2016 Sep 29. Review.

41.

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor.

Musella S, di Sarno V, Ciaglia T, Sala M, Spensiero A, Scala MC, Ostacolo C, Andrei G, Balzarini J, Snoeck R, Novellino E, Campiglia P, Bertamino A, Gomez-Monterrey IM.

Eur J Med Chem. 2016 Nov 29;124:773-781. doi: 10.1016/j.ejmech.2016.09.014. Epub 2016 Sep 7.

PMID:
27639368
42.

New Isoxazolidine-Conjugates of Quinazolinones-Synthesis, Antiviral and Cytostatic Activity.

Piotrowska DG, Andrei G, Schols D, Snoeck R, Grabkowska-Drużyc M.

Molecules. 2016 Jul 22;21(7). pii: E959. doi: 10.3390/molecules21070959.

43.

Cidofovir is active against human papillomavirus positive and negative head and neck and cervical tumor cells by causing DNA damage as one of its working mechanisms.

Mertens B, Nogueira T, Stranska R, Naesens L, Andrei G, Snoeck R.

Oncotarget. 2016 Jul 26;7(30):47302-47318. doi: 10.18632/oncotarget.10100.

44.

Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient.

Bauters T, Bordon V, Florin L, Padalko E, Andrei G, Gillemot S, Fiten P, Opdenakker G, Snoeck R, Laureys G.

Antiviral Res. 2016 Aug;132:149-53. doi: 10.1016/j.antiviral.2016.05.020. Epub 2016 Jun 11. No abstract available.

PMID:
27296901
45.

Design, Synthesis, and Molecular Docking Studies of a Conjugated Thiadiazole-Thiourea Scaffold as Antituberculosis Agents.

Tatar E, Karakuş S, Küçükgüzel ŞG, Öktem Okullu S, Ünübol N, Kocagöz T, De Clercq E, Andrei G, Snoeck R, Pannecouque C, Kalaycı S, Şahin F, Sriram D, Yogeeswari P, Küçükgüzel İ.

Biol Pharm Bull. 2016;39(4):502-15. doi: 10.1248/bpb.b15-00698.

46.

Exploring the purine core of 3'-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics.

Hulpia F, Balzarini J, Schols D, Andrei G, Snoeck R, Van Calenbergh S.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1970-2. doi: 10.1016/j.bmcl.2016.03.005. Epub 2016 Mar 3.

PMID:
26965865
47.

Mouse Cytomegalovirus Infection in BALB/c Mice Resembles Virus-Associated Secondary Hemophagocytic Lymphohistiocytosis and Shows a Pathogenesis Distinct from Primary Hemophagocytic Lymphohistiocytosis.

Brisse E, Imbrechts M, Put K, Avau A, Mitera T, Berghmans N, Rutgeerts O, Waer M, Ninivaggi M, Kelchtermans H, Boon L, Snoeck R, Wouters CH, Andrei G, Matthys P.

J Immunol. 2016 Apr 1;196(7):3124-34. doi: 10.4049/jimmunol.1501035. Epub 2016 Feb 22.

48.

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides.

Wen YN, Zhang ZF, Liu NN, Xiang YH, Zhang ZY, Andrei G, Snoeck R, Schols D, Zhang QS, Wu QP.

Nucleosides Nucleotides Nucleic Acids. 2016;35(3):147-60. doi: 10.1080/15257770.2015.1115523. Epub 2016 Feb 8.

PMID:
26854981
49.

Resistance to the nucleotide analogue cidofovir in HPV(+) cells: a multifactorial process involving UMP/CMP kinase 1.

Topalis D, Nogueira TC, De Schutter T, El Amri C, Krečmerová M, Naesens L, Balzarini J, Andrei G, Snoeck R.

Oncotarget. 2016 Mar 1;7(9):10386-401. doi: 10.18632/oncotarget.7006.

50.

2-(2,4-Dioxy-1,2,3,4-Tetrahydropyrimidin-1-yl)-N-(4-Phenoxyphenyl)-Acetamides as a Novel Class of Cytomegalovirus Replication Inhibitors.

Babkov DA, Paramonova MP, Ozerov AA, Khandazhinskaya AL, Snoeck R, Andrei G, Novikov MS.

Acta Naturae. 2015 Oct-Dec;7(4):142-5.

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