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Items: 37


Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.

Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K.

Genes Dev. 2019 Jul 1;33(13-14):763-781. doi: 10.1101/gad.321901.118. Epub 2019 May 23.


High-resolution 3D imaging of fixed and cleared organoids.

Dekkers JF, Alieva M, Wellens LM, Ariese HCR, Jamieson PR, Vonk AM, Amatngalim GD, Hu H, Oost KC, Snippert HJG, Beekman JM, Wehrens EJ, Visvader JE, Clevers H, Rios AC.

Nat Protoc. 2019 Jun;14(6):1756-1771. doi: 10.1038/s41596-019-0160-8. Epub 2019 May 3.


Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids.

Bolhaqueiro ACF, Ponsioen B, Bakker B, Klaasen SJ, Kucukkose E, van Jaarsveld RH, Vivié J, Verlaan-Klink I, Hami N, Spierings DCJ, Sasaki N, Dutta D, Boj SF, Vries RGJ, Lansdorp PM, van de Wetering M, van Oudenaarden A, Clevers H, Kranenburg O, Foijer F, Snippert HJG, Kops GJPL.

Nat Genet. 2019 May;51(5):824-834. doi: 10.1038/s41588-019-0399-6. Epub 2019 Apr 29.


An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H.

Nat Med. 2019 May;25(5):838-849. doi: 10.1038/s41591-019-0422-6. Epub 2019 Apr 22.


CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition.

Post JB, Hami N, Mertens AEE, Elfrink S, Bos JL, Snippert HJG.

Oncotarget. 2019 Feb 15;10(14):1440-1457. doi: 10.18632/oncotarget.26677. eCollection 2019 Feb 15.


Long noncoding RNAs in gut stem cells.

Hatzis P, Snippert HJG.

Nat Cell Biol. 2018 Oct;20(10):1106-1107. doi: 10.1038/s41556-018-0208-y. No abstract available.


Live imaging of cell division in 3D stem-cell organoid cultures.

Bolhaqueiro ACF, van Jaarsveld RH, Ponsioen B, Overmeer RM, Snippert HJ, Kops GJPL.

Methods Cell Biol. 2018;145:91-106. doi: 10.1016/bs.mcb.2018.03.016. Epub 2018 Apr 22.


How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing.

Bollen Y, Post J, Koo BK, Snippert HJG.

Nucleic Acids Res. 2018 Jul 27;46(13):6435-6454. doi: 10.1093/nar/gky571. Review.


Integrative multi-omics analysis of intestinal organoid differentiation.

Lindeboom RG, van Voorthuijsen L, Oost KC, Rodríguez-Colman MJ, Luna-Velez MV, Furlan C, Baraille F, Jansen PW, Ribeiro A, Burgering BM, Snippert HJ, Vermeulen M.

Mol Syst Biol. 2018 Jun 26;14(6):e8227. doi: 10.15252/msb.20188227.


Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.

Huels DJ, Bruens L, Hodder MC, Cammareri P, Campbell AD, Ridgway RA, Gay DM, Solar-Abboud M, Faller WJ, Nixon C, Zeiger LB, McLaughlin ME, Morrissey E, Winton DJ, Snippert HJ, van Rheenen J, Sansom OJ.

Nat Commun. 2018 Mar 19;9(1):1132. doi: 10.1038/s41467-018-03426-2.


Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.

Oost KC, van Voorthuijsen L, Fumagalli A, Lindeboom RGH, Sprangers J, Omerzu M, Rodriguez-Colman MJ, Heinz MC, Verlaan-Klink I, Maurice MM, Burgering BMT, van Rheenen J, Vermeulen M, Snippert HJG.

Cell Rep. 2018 Feb 6;22(6):1600-1614. doi: 10.1016/j.celrep.2018.01.033.


A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression.

Fumagalli A, Suijkerbuijk SJE, Begthel H, Beerling E, Oost KC, Snippert HJ, van Rheenen J, Drost J.

Nat Protoc. 2018 Feb;13(2):235-247. doi: 10.1038/nprot.2017.137. Epub 2018 Jan 4.


Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells.

Bruens L, Snippert HJG.

Cell Stem Cell. 2017 Jul 6;21(1):3-5. doi: 10.1016/j.stem.2017.06.001. Review.


Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells.

Hindriksen S, Bramer AJ, Truong MA, Vromans MJM, Post JB, Verlaan-Klink I, Snippert HJ, Lens SMA, Hadders MA.

PLoS One. 2017 Jun 22;12(6):e0179514. doi: 10.1371/journal.pone.0179514. eCollection 2017.


In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine.

Bruens L, Ellenbroek SIJ, van Rheenen J, Snippert HJ.

Gastroenterology. 2017 Sep;153(3):674-677.e3. doi: 10.1053/j.gastro.2017.05.019. Epub 2017 May 26.


Interplay between metabolic identities in the intestinal crypt supports stem cell function.

Rodríguez-Colman MJ, Schewe M, Meerlo M, Stigter E, Gerrits J, Pras-Raves M, Sacchetti A, Hornsveld M, Oost KC, Snippert HJ, Verhoeven-Duif N, Fodde R, Burgering BM.

Nature. 2017 Mar 16;543(7645):424-427. doi: 10.1038/nature21673. Epub 2017 Mar 8.


Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

Verissimo CS, Overmeer RM, Ponsioen B, Drost J, Mertens S, Verlaan-Klink I, Gerwen BV, van der Ven M, Wetering MV, Egan DA, Bernards R, Clevers H, Bos JL, Snippert HJ.

Elife. 2016 Nov 15;5. pii: e18489. doi: 10.7554/eLife.18489.


Colonic Crypts: Safe Haven from Microbial Products.

Snippert HJ.

Cell. 2016 Jun 16;165(7):1564-1566. doi: 10.1016/j.cell.2016.06.003.


The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system.

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V.

Gut Microbes. 2015;6(6):398-403. doi: 10.1080/19490976.2015.1109767.


Sequential cancer mutations in cultured human intestinal stem cells.

Drost J, van Jaarsveld RH, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, Sachs N, Overmeer RM, Offerhaus GJ, Begthel H, Korving J, van de Wetering M, Schwank G, Logtenberg M, Cuppen E, Snippert HJ, Medema JP, Kops GJ, Clevers H.

Nature. 2015 May 7;521(7550):43-7. doi: 10.1038/nature14415. Epub 2015 Apr 29.


Microbiota controls the homeostasis of glial cells in the gut lamina propria.

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V.

Neuron. 2015 Jan 21;85(2):289-95. doi: 10.1016/j.neuron.2014.12.037. Epub 2015 Jan 8.


Stem cell dynamics in homeostasis and cancer of the intestine.

Vermeulen L, Snippert HJ.

Nat Rev Cancer. 2014 Jul;14(7):468-80. doi: 10.1038/nrc3744. Epub 2014 Jun 12. Review.


Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

Ritsma L, Ellenbroek SIJ, Zomer A, Snippert HJ, de Sauvage FJ, Simons BD, Clevers H, van Rheenen J.

Nature. 2014 Mar 20;507(7492):362-365. doi: 10.1038/nature12972. Epub 2014 Feb 16.


Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.

Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H.

EMBO Rep. 2014 Jan;15(1):62-9. doi: 10.1002/embr.201337799. Epub 2013 Dec 15.


Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.

Pilz GA, Shitamukai A, Reillo I, Pacary E, Schwausch J, Stahl R, Ninkovic J, Snippert HJ, Clevers H, Godinho L, Guillemot F, Borrell V, Matsuzaki F, Götz M.

Nat Commun. 2013;4:2125. doi: 10.1038/ncomms3125.


Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation.

Bardehle S, Krüger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I, Dimou L, Götz M.

Nat Neurosci. 2013 May;16(5):580-6. doi: 10.1038/nn.3371. Epub 2013 Mar 31.


Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H.

Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. Epub 2012 Aug 1.


Slide preparation for single-cell-resolution imaging of fluorescent proteins in their three-dimensional near-native environment.

Snippert HJ, Schepers AG, Delconte G, Siersema PD, Clevers H.

Nat Protoc. 2011 Jul 28;6(8):1221-8. doi: 10.1038/nprot.2011.365.


Tracking adult stem cells.

Snippert HJ, Clevers H.

EMBO Rep. 2011 Feb;12(2):113-22. doi: 10.1038/embor.2010.216. Epub 2011 Jan 21. Review.


Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H.

Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28.


Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H.

Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016/j.cell.2010.09.016.


Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.

Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.


Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Barker N, Huch M, Kujala P, van de Wetering M, Snippert HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M, Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ, Wright N, Poulsom R, Clevers H.

Cell Stem Cell. 2010 Jan 8;6(1):25-36. doi: 10.1016/j.stem.2009.11.013.


Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.

Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H.

Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29.


Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine.

Snippert HJ, van Es JH, van den Born M, Begthel H, Stange DE, Barker N, Clevers H.

Gastroenterology. 2009 Jun;136(7):2187-2194.e1. doi: 10.1053/j.gastro.2009.03.002. Epub 2009 Mar 24.


Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgård R.

Nat Genet. 2008 Nov;40(11):1291-9. doi: 10.1038/ng.239. Epub 2008 Oct 12.


The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation.

Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, Heller EJ, Qi X, Lawton LN, Williams CJ, Georgopoulos K.

Genes Dev. 2008 May 1;22(9):1174-89. doi: 10.1101/gad.1642808.

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