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Performance of human papillomavirus testing on self-collected versus clinician-collected samples for the detection of cervical intraepithelial neoplasia of grade 2 or worse: a randomised, paired screen-positive, non-inferiority trial.

Polman NJ, Ebisch RMF, Heideman DAM, Melchers WJG, Bekkers RLM, Molijn AC, Meijer CJLM, Quint WGV, Snijders PJF, Massuger LFAG, van Kemenade FJ, Berkhof J.

Lancet Oncol. 2019 Feb;20(2):229-238. doi: 10.1016/S1470-2045(18)30763-0. Epub 2019 Jan 15.


HPV-based cervical screening: Rationale, expectations and future perspectives of the new Dutch screening programme.

Polman NJ, Snijders PJF, Kenter GG, Berkhof J, Meijer CJLM.

Prev Med. 2019 Feb;119:108-117. doi: 10.1016/j.ypmed.2018.12.021. Epub 2018 Dec 27. Review.


Management of HPV-positive women in cervical screening using results from two consecutive screening rounds.

Polman NJ, Veldhuijzen NJ, Heideman DAM, Snijders PJF, Meijer CJLM, Berkhof J.

Int J Cancer. 2019 May 1;144(9):2339-2346. doi: 10.1002/ijc.32004. Epub 2019 Jan 10.


HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV.

Kremer WW, van Zummeren M, Heideman DAM, Lissenberg-Witte BI, Snijders PJF, Steenbergen RDM, Dreyer G, Meijer CJLM.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3297. doi: 10.3390/ijms19113297.


Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation.

Leeman A, Ebisch RMF, Kasius A, Bosgraaf RP, Jenkins D, van de Sandt MM, de Strooper LMA, Heideman DAM, Snijders PJF, Massuger LFAG, Bekkers RLM, Meijer CJLM, van Kemenade FJ, Quint WGV, Melchers WJG.

Gynecol Oncol. 2018 Nov;151(2):311-318. doi: 10.1016/j.ygyno.2018.09.006. Epub 2018 Sep 13.


Publisher Correction: The molecular landscape of head and neck cancer.

Leemans CR, Snijders PJF, Brakenhoff RH.

Nat Rev Cancer. 2018 Oct;18(10):662. doi: 10.1038/s41568-018-0057-9.


Genome-wide microRNA analysis of HPV-positive self-samples yields novel triage markers for early detection of cervical cancer.

Snoek BC, Verlaat W, Babion I, Novianti PW, van de Wiel MA, Wilting SM, van Trommel NE, Bleeker MCG, Massuger LFAG, Melchers WJG, Sie D, Heideman DAM, Snijders PJF, Meijer CJLM, Steenbergen RDM.

Int J Cancer. 2019 Jan 15;144(2):372-379. doi: 10.1002/ijc.31855. Epub 2018 Nov 4.


Virological and Serological Predictors of Anal High-grade Squamous Intraepithelial Lesions Among Human Immunodeficiency Virus-positive Men Who Have Sex With Men.

Marra E, Siegenbeek van Heukelom ML, Leeman A, Waterboer T, Meijer CJLM, Snijders PJF, King AJ, Cairo I, van Eeden A, Brokking W, van der Weele P, Quint W, Prins JM, de Vries HJC, Schim van der Loeff MF.

Clin Infect Dis. 2019 Apr 8;68(8):1377-1387. doi: 10.1093/cid/ciy719.


HPV E4 expression and DNA hypermethylation of CADM1, MAL, and miR124-2 genes in cervical cancer and precursor lesions.

Zummeren MV, Kremer WW, Leeman A, Bleeker MCG, Jenkins D, Sandt MV, Doorbar J, Heideman DAM, Steenbergen RDM, Snijders PJF, Kenter GG, Quint WGV, Berkhof J, Meijer CJLM.

Mod Pathol. 2018 Dec;31(12):1842-1850. doi: 10.1038/s41379-018-0101-z. Epub 2018 Aug 22.


Detection of hypermethylated genes as markers for cervical screening in women living with HIV.

Kremer WW, Van Zummeren M, Novianti PW, Richter KL, Verlaat W, Snijders PJ, Heideman DA, Steenbergen RD, Dreyer G, Meijer CJ.

J Int AIDS Soc. 2018 Aug;21(8):e25165. doi: 10.1002/jia2.25165.


Host-cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical pre-cancer.

Verlaat W, Van Leeuwen RW, Novianti PW, Schuuring E, Meijer CJLM, Van Der Zee AGJ, Snijders PJF, Heideman DAM, Steenbergen RDM, Wisman GBA.

Epigenetics. 2018;13(7):769-778. doi: 10.1080/15592294.2018.1507197. Epub 2018 Aug 24.


Molecular heterogeneity in human papillomavirus-dependent and -independent vulvar carcinogenesis.

Swarts DRA, Voorham QJM, van Splunter AP, Wilting SM, Sie D, Pronk D, van Beurden M, Heideman DAM, Snijders PJF, Meijer CJLM, Steenbergen RDM, Bleeker MCG.

Cancer Med. 2018 Sep;7(9):4542-4553. doi: 10.1002/cam4.1633. Epub 2018 Jul 20.


Three-tiered score for Ki-67 and p16ink4a improves accuracy and reproducibility of grading CIN lesions.

van Zummeren M, Leeman A, Kremer WW, Bleeker MCG, Jenkins D, van de Sandt M, Heideman DAM, Steenbergen R, Snijders PJF, Quint WGV, Berkhof J, Meijer CJLM.

J Clin Pathol. 2018 Nov;71(11):981-988. doi: 10.1136/jclinpath-2018-205271. Epub 2018 Jul 16.


Triage of high-risk HPV-positive women in population-based screening by miRNA expression analysis in cervical scrapes; a feasibility study.

Babion I, Snoek BC, Novianti PW, Jaspers A, van Trommel N, Heideman DAM, Meijer CJLM, Snijders PJF, Steenbergen RDM, Wilting SM.

Clin Epigenetics. 2018 Jun 7;10:76. doi: 10.1186/s13148-018-0509-9. eCollection 2018.


Evaluation of human-papillomavirus testing and visual inspection for cervical cancer screening in Rwanda.

Umulisa MC, Franceschi S, Baussano I, Tenet V, Uwimbabazi M, Rugwizangoga B, Heideman DAM, Uyterlinde AM, Darragh TM, Snijders PJF, Sayinzoga F, Clifford GM.

BMC Womens Health. 2018 Apr 24;18(1):59. doi: 10.1186/s12905-018-0549-5.


Cervical cancer risk in HPV-positive women after a negative FAM19A4/mir124-2 methylation test: A post hoc analysis in the POBASCAM trial with 14 year follow-up.

De Strooper LMA, Berkhof J, Steenbergen RDM, Lissenberg-Witte BI, Snijders PJF, Meijer CJLM, Heideman DAM.

Int J Cancer. 2018 Sep 15;143(6):1541-1548. doi: 10.1002/ijc.31539. Epub 2018 Apr 27.


Identification and Validation of a 3-Gene Methylation Classifier for HPV-Based Cervical Screening on Self-Samples.

Verlaat W, Snoek BC, Heideman DAM, Wilting SM, Snijders PJF, Novianti PW, van Splunter AP, Peeters CFW, van Trommel NE, Massuger LFAG, Bekkers RLM, Melchers WJG, van Kemenade FJ, Berkhof J, van de Wiel MA, Meijer CJLM, Steenbergen RDM.

Clin Cancer Res. 2018 Jul 15;24(14):3456-3464. doi: 10.1158/1078-0432.CCR-17-3615. Epub 2018 Apr 9.


The molecular landscape of head and neck cancer.

Leemans CR, Snijders PJF, Brakenhoff RH.

Nat Rev Cancer. 2018 May;18(5):269-282. doi: 10.1038/nrc.2018.11. Epub 2018 Mar 2. Review. Erratum in: Nat Rev Cancer. 2018 Oct;18(10):662.


Evaluation of cytology versus human papillomavirus-based cervical cancer screening algorithms in Bhutan.

Tshomo U, Franceschi S, Tshokey T, Tobgay T, Baussano I, Tenet V, Heideman DAM, Snijders PJF, Clifford GM.

Oncotarget. 2017 Aug 2;8(42):72438-72446. doi: 10.18632/oncotarget.19783. eCollection 2017 Sep 22.


Evaluation of the Clinical Performance of the HPV-Risk Assay Using the VALGENT-3 Panel.

Polman NJ, Oštrbenk A, Xu L, Snijders PJF, Meijer CJLM, Poljak M, Heideman DAM, Arbyn M.

J Clin Microbiol. 2017 Dec;55(12):3544-3551. doi: 10.1128/JCM.01282-17. Epub 2017 Oct 11.


HPV-positive women with normal cytology remain at increased risk of CIN3 after a negative repeat HPV test.

Polman NJ, Veldhuijzen NJ, Heideman DAM, Snijders PJF, Meijer CJLM, Berkhof J.

Br J Cancer. 2017 Nov 7;117(10):1557-1561. doi: 10.1038/bjc.2017.309. Epub 2017 Sep 7.


Selection of women at risk for cervical cancer in an HIV-infected South African population.

Van Zummeren M, Kremer WW, Van Aardt MC, Breytenbach E, Richter KL, Rozendaal L, Witte BI, De Strooper LMA, Hesselink AT, Heideman DAM, Snijders PJF, Steenbergen RDM, Dreyer G, Meijer CJLM.

AIDS. 2017 Sep 10;31(14):1945-1953. doi: 10.1097/QAD.0000000000001583.


Stratifying HPV-positive women for CIN3+ risk after one and two rounds of HPV-based screening.

Veldhuijzen NJ, Polman NJ, Snijders PJF, Meijer CJLM, Berkhof J.

Int J Cancer. 2017 Oct 15;141(8):1551-1560. doi: 10.1002/ijc.30865. Epub 2017 Jul 18.


Human Papillomavirus Triage of Women With Atypical Squamous Cells of Undetermined Significance-Reduction of Overtreatment Needed.

Meijer CJLM, Snijders PJF.

JAMA Oncol. 2017 Oct 1;3(10):1310-1311. doi: 10.1001/jamaoncol.2017.1522. No abstract available.


Evaluation of the performance of Human Papillomavirus testing in paired urine and clinician-collected cervical samples among women aged over 30 years in Bhutan.

Tshomo U, Franceschi S, Tshokey T, Tobgay T, Baussano I, Tenet V, Snijders PJ, Gheit T, Tommasino M, Vorsters A, Clifford GM.

Virol J. 2017 Apr 8;14(1):74. doi: 10.1186/s12985-017-0744-2.


Evaluation of p16/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women.

Ebisch RM, van der Horst J, Hermsen M, Rijstenberg LL, Vedder JE, Bulten J, Bosgraaf RP, Verhoef VM, Heideman DA, Snijders PJ, Meijer CJ, van Kemenade FJ, Massuger LF, Melchers WJ, Bekkers RL, Siebers AG.

Mod Pathol. 2017 Jul;30(7):1021-1031. doi: 10.1038/modpathol.2017.16. Epub 2017 Mar 17.


Genome-wide DNA Methylation Profiling Reveals Methylation Markers Associated with 3q Gain for Detection of Cervical Precancer and Cancer.

Verlaat W, Snijders PJF, Novianti PW, Wilting SM, De Strooper LMA, Trooskens G, Vandersmissen J, Van Criekinge W, Wisman GBA, Meijer CJLM, Heideman DAM, Steenbergen RDM.

Clin Cancer Res. 2017 Jul 15;23(14):3813-3822. doi: 10.1158/1078-0432.CCR-16-2641. Epub 2017 Jan 24.


Non-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment.

Kuiper JL, Hashemi SM, Thunnissen E, Snijders PJ, Grünberg K, Bloemena E, Sie D, Postmus PE, Heideman DA, Smit EF.

Br J Cancer. 2016 Dec 6;115(12):1504-1512. doi: 10.1038/bjc.2016.372. Epub 2016 Nov 22.


Immortalization capacity of HPV types is inversely related to chromosomal instability.

Schütze DM, Krijgsman O, Snijders PJ, Ylstra B, Weischenfeldt J, Mardin BR, Stütz AM, Korbel JO, de Winter JP, Meijer CJ, Quint WG, Bosch L, Wilting SM, Steenbergen RD.

Oncotarget. 2016 Jun 21;7(25):37608-37621. doi: 10.18632/oncotarget.8058.


Safety of extending screening intervals beyond five years in cervical screening programmes with testing for high risk human papillomavirus: 14 year follow-up of population based randomised cohort in the Netherlands.

Dijkstra MG, van Zummeren M, Rozendaal L, van Kemenade FJ, Helmerhorst TJ, Snijders PJ, Meijer CJ, Berkhof J.

BMJ. 2016 Oct 4;355:i4924. doi: 10.1136/bmj.i4924. Erratum in: BMJ. 2016 Oct 27;355:i5782.


Good performance of p16/ki-67 dual-stained cytology for surveillance of women treated for high-grade CIN.

Polman NJ, Uijterwaal MH, Witte BI, Berkhof J, van Kemenade FJ, Spruijt JW, van Baal WM, Graziosi PG, van Dijken DK, Verheijen RH, Helmerhorst TJ, Steenbergen RD, Heideman DA, Ridder R, Snijders PJ, Meijer CJ.

Int J Cancer. 2017 Jan 15;140(2):423-430. doi: 10.1002/ijc.30449. Epub 2016 Oct 11.


Higher HPV16 and HPV18 Penile Viral Loads Are Associated With Decreased Human Papillomavirus Clearance in Uncircumcised Kenyan Men.

Senkomago V, Backes DM, Hudgens MG, Poole C, Meshnick SR, Agot K, Moses S, Snijders PJ, Meijer CJ, Hesselink AT, Schlecht NF, Bailey RC, Smith JS.

Sex Transm Dis. 2016 Sep;43(9):572-8. doi: 10.1097/OLQ.0000000000000500.


Somatic mutation in PIK3CA is a late event in cervical carcinogenesis.

Verlaat W, Snijders PJ, van Moorsel MI, Bleeker M, Rozendaal L, Sie D, Ylstra B, Meijer CJ, Steenbergen RD, Heideman DA.

J Pathol Clin Res. 2015 Sep 21;1(4):207-11. doi: 10.1002/cjp2.27. eCollection 2015 Oct.


DNA hypermethylation analysis in sputum of asymptomatic subjects at risk for lung cancer participating in the NELSON trial: argument for maximum screening interval of 2 years.

Hubers AJ, Heideman DA, Duin S, Witte BI, de Koning HJ, Groen HJ, Prinsen CF, Bolijn AS, Wouters M, van der Meer SE, Steenbergen RD, Snijders PJ, Uyterlinde A, Berkhof H, Smit EF, Thunnissen E.

J Clin Pathol. 2017 Mar;70(3):250-254. doi: 10.1136/jclinpath-2016-203734. Epub 2016 Aug 5.


Management of high-risk HPV-positive women for detection of cervical (pre)cancer.

Luttmer R, De Strooper LM, Steenbergen RD, Berkhof J, Snijders PJ, Heideman DA, Meijer CJ.

Expert Rev Mol Diagn. 2016 Sep;16(9):961-74. doi: 10.1080/14737159.2016.1217157. Epub 2016 Aug 5. Review.


Performance of CADM1/MAL-methylation analysis for monitoring of women treated for high-grade CIN.

Uijterwaal MH, van Zummeren M, Kocken M, Luttmer R, Berkhof J, Witte BI, van Baal WM, Graziosi GCM, Verheijen RHM, Helmerhorst TJM, van Dijken DKE, Spruijt JWM, van Kemenade FJ, Fransen-Daalmeijer N, Bekker-Lettink M, Heideman DAM, Snijders PJF, Steenbergen RDM, Meijer CJLM.

Gynecol Oncol. 2016 Oct;143(1):135-142. doi: 10.1016/j.ygyno.2016.07.089. Epub 2016 Jul 16.


Cutaneous human papillomavirus genotypes in different kinds of skin lesions in Argentina.

Correa RM, Vladimirsky S, Heideman DA, Coringrato M, Abeldaño A, Olivares L, Del Aguila R, Alonio LV, Snijders PJ, Picconi MA.

J Med Virol. 2017 Feb;89(2):352-357. doi: 10.1002/jmv.24631. Epub 2016 Jul 27.


FAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women.

Luttmer R, De Strooper LM, Dijkstra MG, Berkhof J, Snijders PJ, Steenbergen RD, van Kemenade FJ, Rozendaal L, Helmerhorst TJ, Verheijen RH, Ter Harmsel WA, van Baal WM, Graziosi PG, Quint WG, Spruijt JW, van Dijken DK, Heideman DA, Meijer CJ.

Br J Cancer. 2016 Aug 23;115(5):579-87. doi: 10.1038/bjc.2016.200. Epub 2016 Jul 14.


Correction for Geraets et al., Clinical Evaluation of a GP5+/6+-Based Luminex Assay Having Full High-Risk Human Papillomavirus Genotyping Capability and an Internal Control.

Geraets DT, Cuschieri K, de Koning MNC, van Doorn LJ, Snijders PJF, Meijer CJLM, Quint WGV, Arbyn M.

J Clin Microbiol. 2016 Jul;54(7):1927. doi: 10.1128/JCM.00753-16. No abstract available.


Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence.

Wilting SM, Miok V, Jaspers A, Boon D, Sørgård H, Lando M, Snoek BC, van Wieringen WN, Meijer CJ, Lyng H, Snijders PJ, Steenbergen RD.

Oncotarget. 2016 Jul 12;7(28):43805-43819. doi: 10.18632/oncotarget.9698.


Comparison of Two Widely Used Human Papillomavirus Detection and Genotyping Methods, GP5+/6+-Based PCR Followed by Reverse Line Blot Hybridization and Multiplex Type-Specific E7-Based PCR.

Clifford GM, Vaccarella S, Franceschi S, Tenet V, Umulisa MC, Tshomo U, Dondog B, Vorsters A, Tommasino M, Heideman DA, Snijders PJ, Gheit T.

J Clin Microbiol. 2016 Aug;54(8):2031-8. doi: 10.1128/JCM.00618-16. Epub 2016 May 25.


Human papillomavirus infection in Rwanda at the moment of implementation of a national HPV vaccination programme.

Ngabo F, Franceschi S, Baussano I, Umulisa MC, Snijders PJ, Uyterlinde AM, Lazzarato F, Tenet V, Gatera M, Binagwaho A, Clifford GM.

BMC Infect Dis. 2016 May 24;16:225. doi: 10.1186/s12879-016-1539-6.


p16/Ki-67 dual-stained cytology for detecting cervical (pre)cancer in a HPV-positive gynecologic outpatient population.

Luttmer R, Dijkstra MG, Snijders PJ, Berkhof J, van Kemenade FJ, Rozendaal L, Helmerhorst TJ, Verheijen RH, Ter Harmsel WA, van Baal WM, Graziosi PG, Quint WG, Spruijt JW, van Dijken DK, Heideman DA, Meijer CJ.

Mod Pathol. 2016 Aug;29(8):870-8. doi: 10.1038/modpathol.2016.80. Epub 2016 May 6.


Urine testing to monitor the impact of HPV vaccination in Bhutan and Rwanda.

Franceschi S, Chantal Umulisa M, Tshomo U, Gheit T, Baussano I, Tenet V, Tshokey T, Gatera M, Ngabo F, Van Damme P, Snijders PJ, Tommasino M, Vorsters A, Clifford GM.

Int J Cancer. 2016 Aug 1;139(3):518-26. doi: 10.1002/ijc.30092. Epub 2016 Apr 15.


The clinical value of HPV genotyping in triage of women with high-risk-HPV-positive self-samples.

Ebisch RM, de Kuyper-de Ridder GM, Bosgraaf RP, Massuger LF, IntHout J, Verhoef VM, Heideman DA, Snijders PJ, Meijer CJ, van Kemenade FJ, Bulten J, Siebers AG, Bekkers RL, Melchers WJ.

Int J Cancer. 2016 Aug 1;139(3):691-9. doi: 10.1002/ijc.30090. Epub 2016 Apr 7.


Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women.

De Strooper LMA, Verhoef VMJ, Berkhof J, Hesselink AT, de Bruin HME, van Kemenade FJ, Bosgraaf RP, Bekkers RLM, Massuger LFAG, Melchers WJG, Steenbergen RDM, Snijders PJF, Meijer CJLM, Heideman DAM.

Gynecol Oncol. 2016 May;141(2):341-347. doi: 10.1016/j.ygyno.2016.02.012. Epub 2016 Mar 3.


A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17(+) cell frequency.

Punt S, Dronkers EA, Welters MJ, Goedemans R, Koljenović S, Bloemena E, Snijders PJ, Gorter A, van der Burg SH, Baatenburg de Jong RJ, Jordanova ES.

Cancer Immunol Immunother. 2016 Apr;65(4):393-403. doi: 10.1007/s00262-016-1805-x. Epub 2016 Feb 22.


Clinical validation of Anyplex™ II HPV HR Detection according to the guidelines for HPV test requirements for cervical cancer screening.

Hesselink AT, Sahli R, Berkhof J, Snijders PJ, van der Salm ML, Agard D, Bleeker MC, Heideman DA.

J Clin Virol. 2016 Mar;76:36-9. doi: 10.1016/j.jcv.2016.01.009. Epub 2016 Jan 15.


Presence of human papillomavirus in semen in relation to semen quality.

Luttmer R, Dijkstra MG, Snijders PJ, Hompes PG, Pronk DT, Hubeek I, Berkhof J, Heideman DA, Meijer CJ.

Hum Reprod. 2016 Feb;31(2):280-6. doi: 10.1093/humrep/dev317. Epub 2016 Jan 2.


Congenital sideroblastic anemia due to mutations in the mitochondrial HSP70 homologue HSPA9.

Schmitz-Abe K, Ciesielski SJ, Schmidt PJ, Campagna DR, Rahimov F, Schilke BA, Cuijpers M, Rieneck K, Lausen B, Linenberger ML, Sendamarai AK, Guo C, Hofmann I, Newburger PE, Matthews D, Shimamura A, Snijders PJ, Towne MC, Niemeyer CM, Watson HG, Dziegiel MH, Heeney MM, May A, Bottomley SS, Swinkels DW, Markianos K, Craig EA, Fleming MD.

Blood. 2015 Dec 17;126(25):2734-8. doi: 10.1182/blood-2015-09-659854. Epub 2015 Oct 21.

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