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Items: 1 to 50 of 186


Mind the gap: Micro-expansion joints drastically decrease the bending of FIB-milled cryo-lamellae.

Wolff G, Limpens RWAL, Zheng S, Snijder EJ, Agard DA, Koster AJ, Bárcena M.

J Struct Biol. 2019 Dec 1;208(3). pii: S1047-8477(19)30200-X. doi: 10.1016/j.jsb.2019.09.006. Epub 2019 Sep 16.


The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.

Ogando NS, Ferron F, Decroly E, Canard B, Posthuma CC, Snijder EJ.

Front Microbiol. 2019 Aug 7;10:1813. doi: 10.3389/fmicb.2019.01813. eCollection 2019. Review.


Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.

Yoon JS, Kim G, Jarhad DB, Kim HR, Shin YS, Qu S, Sahu PK, Kim HO, Lee HW, Wang SB, Kong YJ, Chang TS, Ogando NS, Kovacikova K, Snijder EJ, Posthuma CC, van Hemert MJ, Jeong LS.

J Med Chem. 2019 Jul 11;62(13):6346-6362. doi: 10.1021/acs.jmedchem.9b00781. Epub 2019 Jun 20.


Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

de Wilde AH, Boomaars-van der Zanden AL, de Jong AWM, Bárcena M, Snijder EJ, Posthuma CC.

J Virol. 2019 Aug 28;93(18). pii: e00490-19. doi: 10.1128/JVI.00490-19. Print 2019 Sep 15.


Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy.

Melia CE, Peddie CJ, de Jong AWM, Snijder EJ, Collinson LM, Koster AJ, van der Schaar HM, van Kuppeveld FJM, Bárcena M.

MBio. 2019 Jun 11;10(3). pii: e00951-19. doi: 10.1128/mBio.00951-19.


Cyclophilins and cyclophilin inhibitors in nidovirus replication.

de Wilde AH, Pham U, Posthuma CC, Snijder EJ.

Virology. 2018 Sep;522:46-55. doi: 10.1016/j.virol.2018.06.011. Epub 2018 Jul 12. Review.


Transcriptional and Translational Landscape of Equine Torovirus.

Stewart H, Brown K, Dinan AM, Irigoyen N, Snijder EJ, Firth AE.

J Virol. 2018 Aug 16;92(17). pii: e00589-18. doi: 10.1128/JVI.00589-18. Print 2018 Sep 1.


The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles.

Melia CE, van der Schaar HM, de Jong AWM, Lyoo HR, Snijder EJ, Koster AJ, van Kuppeveld FJM, Bárcena M.

MBio. 2018 Apr 17;9(2). pii: e00420-18. doi: 10.1128/mBio.00420-18.


Nonstructural proteins nsp2TF and nsp2N of porcine reproductive and respiratory syndrome virus (PRRSV) play important roles in suppressing host innate immune responses.

Li Y, Shang P, Shyu D, Carrillo C, Naraghi-Arani P, Jaing CJ, Renukaradhya GJ, Firth AE, Snijder EJ, Fang Y.

Virology. 2018 Apr;517:164-176. doi: 10.1016/j.virol.2017.12.017. Epub 2018 Jan 8.


Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

de Wilde AH, Zevenhoven-Dobbe JC, Beugeling C, Chatterji U, de Jong D, Gallay P, Szuhai K, Posthuma CC, Snijder EJ.

Virology. 2018 Apr;517:148-156. doi: 10.1016/j.virol.2017.11.022. Epub 2017 Dec 15.


Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication.

Oudshoorn D, Rijs K, Limpens RWAL, Groen K, Koster AJ, Snijder EJ, Kikkert M, Bárcena M.

MBio. 2017 Nov 21;8(6). pii: e01658-17. doi: 10.1128/mBio.01658-17.


Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles.

Melia CE, van der Schaar HM, Lyoo H, Limpens RWAL, Feng Q, Wahedi M, Overheul GJ, van Rij RP, Snijder EJ, Koster AJ, Bárcena M, van Kuppeveld FJM.

Cell Rep. 2017 Oct 17;21(3):587-599. doi: 10.1016/j.celrep.2017.09.068.


Host Factors in Coronavirus Replication.

de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ.

Curr Top Microbiol Immunol. 2018;419:1-42. doi: 10.1007/82_2017_25. Review.


Suramin inhibits Zika virus replication by interfering with virus attachment and release of infectious particles.

Albulescu IC, Kovacikova K, Tas A, Snijder EJ, van Hemert MJ.

Antiviral Res. 2017 Jul;143:230-236. doi: 10.1016/j.antiviral.2017.04.016. Epub 2017 Apr 28.


Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.

Posthuma CC, Te Velthuis AJW, Snijder EJ.

Virus Res. 2017 Apr 15;234:58-73. doi: 10.1016/j.virusres.2017.01.023. Epub 2017 Feb 6. Review.


Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus.

Oudshoorn D, van der Hoeven B, Limpens RW, Beugeling C, Snijder EJ, Bárcena M, Kikkert M.

MBio. 2016 Dec 6;7(6). pii: e01991-16. doi: 10.1128/mBio.01991-16.


Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

de Wilde AH, Falzarano D, Zevenhoven-Dobbe JC, Beugeling C, Fett C, Martellaro C, Posthuma CC, Feldmann H, Perlman S, Snijder EJ.

Virus Res. 2017 Jan 15;228:7-13. doi: 10.1016/j.virusres.2016.11.011. Epub 2016 Nov 10.


The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing.

Snijder EJ, Decroly E, Ziebuhr J.

Adv Virus Res. 2016;96:59-126. doi: 10.1016/bs.aivir.2016.08.008. Epub 2016 Sep 14. Review.


The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection.

Delang L, Li C, Tas A, Quérat G, Albulescu IC, De Burghgraeve T, Guerrero NA, Gigante A, Piorkowski G, Decroly E, Jochmans D, Canard B, Snijder EJ, Pérez-Pérez MJ, van Hemert MJ, Coutard B, Leyssen P, Neyts J.

Sci Rep. 2016 Aug 22;6:31819. doi: 10.1038/srep31819.


A novel role for poly(C) binding proteins in programmed ribosomal frameshifting.

Napthine S, Treffers EE, Bell S, Goodfellow I, Fang Y, Firth AE, Snijder EJ, Brierley I.

Nucleic Acids Res. 2016 Jul 8;44(12):5491-503. doi: 10.1093/nar/gkw480. Epub 2016 Jun 2.


Identification and Characterization of a Ribose 2'-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales.

Zeng C, Wu A, Wang Y, Xu S, Tang Y, Jin X, Wang S, Qin L, Sun Y, Fan C, Snijder EJ, Neuman BW, Chen Y, Ahola T, Guo D.

J Virol. 2016 Jul 11;90(15):6675-6685. doi: 10.1128/JVI.00658-16. Print 2016 Aug 1.


Biogenesis and architecture of arterivirus replication organelles.

van der Hoeven B, Oudshoorn D, Koster AJ, Snijder EJ, Kikkert M, Bárcena M.

Virus Res. 2016 Jul 15;220:70-90. doi: 10.1016/j.virusres.2016.04.001. Epub 2016 Apr 9. Review.


Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive.

Lehmann KC, Gorbalenya AE, Snijder EJ, Posthuma CC.

Virology. 2016 Jan;487:68-74. doi: 10.1016/j.virol.2015.10.002. Epub 2015 Oct 23.


Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses.

Lehmann KC, Gulyaeva A, Zevenhoven-Dobbe JC, Janssen GM, Ruben M, Overkleeft HS, van Veelen PA, Samborskiy DV, Kravchenko AA, Leontovich AM, Sidorov IA, Snijder EJ, Posthuma CC, Gorbalenya AE.

Nucleic Acids Res. 2015 Sep 30;43(17):8416-34. doi: 10.1093/nar/gkv838. Epub 2015 Aug 24.


Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.

Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.

Nature. 2015 Sep 3;525(7567):144. doi: 10.1038/nature14555. Epub 2015 Jul 8. No abstract available.


Suramin inhibits chikungunya virus replication through multiple mechanisms.

Albulescu IC, van Hoolwerff M, Wolters LA, Bottaro E, Nastruzzi C, Yang SC, Tsay SC, Hwu JR, Snijder EJ, van Hemert MJ.

Antiviral Res. 2015 Sep;121:39-46. doi: 10.1016/j.antiviral.2015.06.013. Epub 2015 Jun 22.


Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.

Peters HL, Jochmans D, de Wilde AH, Posthuma CC, Snijder EJ, Neyts J, Seley-Radtke KL.

Bioorg Med Chem Lett. 2015 Aug 1;25(15):2923-6. doi: 10.1016/j.bmcl.2015.05.039. Epub 2015 May 23.


Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.

Lehmann KC, Hooghiemstra L, Gulyaeva A, Samborskiy DV, Zevenhoven-Dobbe JC, Snijder EJ, Gorbalenya AE, Posthuma CC.

J Gen Virol. 2015 Sep;96(9):2643-55. doi: 10.1099/vir.0.000209. Epub 2015 Jun 3.


A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.

de Wilde AH, Wannee KF, Scholte FE, Goeman JJ, Ten Dijke P, Snijder EJ, Kikkert M, van Hemert MJ.

J Virol. 2015 Aug;89(16):8318-33. doi: 10.1128/JVI.01029-15. Epub 2015 Jun 3.


In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.

van Kasteren PB, Knaap RC, van den Elzen P, Snijder EJ, Balasuriya UB, van den Born E, Kikkert M.

Vet Microbiol. 2015 Jul 9;178(1-2):132-7. doi: 10.1016/j.vetmic.2015.04.018. Epub 2015 Apr 30.


Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.

Treffers EE, Tas A, Scholte FE, Van MN, Heemskerk MT, de Ru AH, Snijder EJ, van Hemert MJ, van Veelen PA.

Proteomics. 2015 Jul;15(13):2267-80. doi: 10.1002/pmic.201400581. Epub 2015 Apr 22.


Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication.

Scholte FE, Tas A, Albulescu IC, Žusinaite E, Merits A, Snijder EJ, van Hemert MJ.

J Virol. 2015 Apr;89(8):4457-69. doi: 10.1128/JVI.03612-14. Epub 2015 Feb 4.


Proteolytic processing of the porcine reproductive and respiratory syndrome virus replicase.

Li Y, Tas A, Sun Z, Snijder EJ, Fang Y.

Virus Res. 2015 Apr 16;202:48-59. doi: 10.1016/j.virusres.2014.12.027. Epub 2014 Dec 31.


What we know but do not understand about nidovirus helicases.

Lehmann KC, Snijder EJ, Posthuma CC, Gorbalenya AE.

Virus Res. 2015 Apr 16;202:12-32. doi: 10.1016/j.virusres.2014.12.001. Epub 2014 Dec 8. Review.


Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.

Bailey-Elkin BA, Knaap RC, Johnson GG, Dalebout TJ, Ninaber DK, van Kasteren PB, Bredenbeek PJ, Snijder EJ, Kikkert M, Mark BL.

J Biol Chem. 2014 Dec 12;289(50):34667-82. doi: 10.1074/jbc.M114.609644. Epub 2014 Oct 15.


One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.

Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3900-9. doi: 10.1073/pnas.1323705111. Epub 2014 Sep 2.


An in vitro assay to study chikungunya virus RNA synthesis and the mode of action of inhibitors.

Albulescu IC, Tas A, Scholte FE, Snijder EJ, van Hemert MJ.

J Gen Virol. 2014 Dec;95(Pt 12):2683-92. doi: 10.1099/vir.0.069690-0. Epub 2014 Aug 18.


Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.

Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X.

J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29.


Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral.

Delang L, Segura Guerrero N, Tas A, Quérat G, Pastorino B, Froeyen M, Dallmeier K, Jochmans D, Herdewijn P, Bello F, Snijder EJ, de Lamballerie X, Martina B, Neyts J, van Hemert MJ, Leyssen P.

J Antimicrob Chemother. 2014 Oct;69(10):2770-84. doi: 10.1093/jac/dku209. Epub 2014 Jun 20.


Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ.

Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19.


Transactivation of programmed ribosomal frameshifting by a viral protein.

Li Y, Treffers EE, Napthine S, Tas A, Zhu L, Sun Z, Bell S, Mark BL, van Veelen PA, van Hemert MJ, Firth AE, Brierley I, Snijder EJ, Fang Y.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2172-81. doi: 10.1073/pnas.1321930111. Epub 2014 May 13.


Viral OTU deubiquitinases: a structural and functional comparison.

Bailey-Elkin BA, van Kasteren PB, Snijder EJ, Kikkert M, Mark BL.

PLoS Pathog. 2014 Mar 27;10(3):e1003894. doi: 10.1371/journal.ppat.1003894. eCollection 2014 Mar. Review.


Inhibition of dengue and chikungunya virus infections by RIG-I-mediated type I interferon-independent stimulation of the innate antiviral response.

Olagnier D, Scholte FE, Chiang C, Albulescu IC, Nichols C, He Z, Lin R, Snijder EJ, van Hemert MJ, Hiscott J.

J Virol. 2014 Apr;88(8):4180-94. doi: 10.1128/JVI.03114-13. Epub 2014 Jan 29.


The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.

Matthews KL, Coleman CM, van der Meer Y, Snijder EJ, Frieman MB.

J Gen Virol. 2014 Apr;95(Pt 4):874-82. doi: 10.1099/vir.0.062059-0. Epub 2014 Jan 17.


Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.

Deng Z, Lehmann KC, Li X, Feng C, Wang G, Zhang Q, Qi X, Yu L, Zhang X, Feng W, Wu W, Gong P, Tao Y, Posthuma CC, Snijder EJ, Gorbalenya AE, Chen Z.

Nucleic Acids Res. 2014 Mar;42(5):3464-77. doi: 10.1093/nar/gkt1310. Epub 2013 Dec 24.


Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.

Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM.

Nature. 2014 Jan 30;505(7485):691-5. doi: 10.1038/nature12862. Epub 2013 Nov 27. Erratum in: Nature. 2015 Sep 3;525(7567):144.


Arterivirus molecular biology and pathogenesis.

Snijder EJ, Kikkert M, Fang Y.

J Gen Virol. 2013 Oct;94(Pt 10):2141-63. doi: 10.1099/vir.0.056341-0. Epub 2013 Aug 12. Review.


Characterization of synthetic Chikungunya viruses based on the consensus sequence of recent E1-226V isolates.

Scholte FE, Tas A, Martina BE, Cordioli P, Narayanan K, Makino S, Snijder EJ, van Hemert MJ.

PLoS One. 2013 Aug 1;8(8):e71047. doi: 10.1371/journal.pone.0071047. Print 2013.


The footprint of genome architecture in the largest genome expansion in RNA viruses.

Lauber C, Goeman JJ, Parquet Mdel C, Nga PT, Snijder EJ, Morita K, Gorbalenya AE.

PLoS Pathog. 2013;9(7):e1003500. doi: 10.1371/journal.ppat.1003500. Epub 2013 Jul 18.


Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group.

de Groot RJ, Baker SC, Baric RS, Brown CS, Drosten C, Enjuanes L, Fouchier RA, Galiano M, Gorbalenya AE, Memish ZA, Perlman S, Poon LL, Snijder EJ, Stephens GM, Woo PC, Zaki AM, Zambon M, Ziebuhr J.

J Virol. 2013 Jul;87(14):7790-2. doi: 10.1128/JVI.01244-13. Epub 2013 May 15. No abstract available.

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