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Items: 1 to 50 of 93

1.

Purification and kinetic characterization of the essential condensation enzymes involved in prodiginine and tambjamine biosynthesis.

Picott KJ, Deichert JA, deKemp EM, Snieckus V, Ross AC.

Chembiochem. 2019 Oct 15. doi: 10.1002/cbic.201900503. [Epub ahead of print]

PMID:
31614061
2.

Sodium Methyl Carbonate as an Effective C1 Synthon. Synthesis of Carboxylic Acids, Benzophenones, and Unsymmetrical Ketones.

Hurst TE, Deichert JA, Kapeniak L, Lee R, Harris J, Jessop PG, Snieckus V.

Org Lett. 2019 Jun 7;21(11):3882-3885. doi: 10.1021/acs.orglett.9b00773. Epub 2019 May 24.

PMID:
31125244
3.

Regioselective Functionalization of 7-Azaindole by Controlled Annular Isomerism: The Directed Metalation-Group Dance.

Dalziel ME, Patel JJ, Kaye MK, Cosman JL, Kitching MO, Snieckus V.

Angew Chem Int Ed Engl. 2019 May 27;58(22):7313-7317. doi: 10.1002/anie.201901724. Epub 2019 Apr 30.

PMID:
30875442
4.

Site-Selective and Stereoselective C-H Functionalization of N-Cyclopropylamides via a Directed Remote Metalation Strategy.

Ermolovich Y, Barysevich MV, Adamson J, Rogova O, Kaabel S, Järving I, Gathergood N, Snieckus V, Kananovich DG.

Org Lett. 2019 Feb 15;21(4):969-973. doi: 10.1021/acs.orglett.8b03955. Epub 2019 Feb 4.

PMID:
30715898
5.

Biphenyl sulfonic acid ligands for catalytic C-N cross coupling of aryl halides with anilines and secondary amines.

Wittel B, Vogel T, Scharl H, Nerdinger S, Lehnemann B, Meudt A, Snieckus V.

Bioorg Med Chem. 2018 Aug 15;26(15):4583-4593. doi: 10.1016/j.bmc.2018.07.028. Epub 2018 Jul 20.

PMID:
30061017
6.

Bacterial Catabolism of Biphenyls: Synthesis and Evaluation of Analogues.

Nerdinger S, Kuatsjah E, Hurst TE, Schlapp-Hackl I, Kahlenberg V, Wurst K, Eltis LD, Snieckus V.

Chembiochem. 2018 Jun 15. doi: 10.1002/cbic.201800231. [Epub ahead of print]

PMID:
29905982
7.

Pyrimidine as an Aryl C-H Activating Group.

Gupta S, Melanson JA, Vaillancourt L, Nugent WA, Tanoury GJ, Schatte G, Snieckus V.

Org Lett. 2018 Jul 6;20(13):3745-3748. doi: 10.1021/acs.orglett.8b01300. Epub 2018 Jun 13.

PMID:
29897779
8.

Directed Remote Lateral Metalation: Highly Substituted 2-Naphthols and BINOLs by In Situ Generation of a Directing Group.

Patel JJ, Laars M, Gan W, Board J, Kitching MO, Snieckus V.

Angew Chem Int Ed Engl. 2018 Jul 20;57(30):9425-9429. doi: 10.1002/anie.201805203. Epub 2018 Jun 21.

PMID:
29847003
9.

Amide-Directed Ru-Catalyzed Hydrodemethoxylation of ortho-Methoxy-Benzamides and -Naphthamides: A D oM Reaction Counterpart.

Zhao Y, Snieckus V.

Org Lett. 2018 May 18;20(10):2826-2830. doi: 10.1021/acs.orglett.8b00755. Epub 2018 Apr 30.

PMID:
29708758
10.

Directed ortho-Metalation and Anionic ortho-Fries Rearrangement of Polycyclic Aromatic O-Carbamates: Regioselective Synthesis of Substituted Chrysenes.

Kancherla S, Lorentzen M, Snieckus V, Jørgensen KB.

J Org Chem. 2018 Apr 6;83(7):3590-3598. doi: 10.1021/acs.joc.7b03210. Epub 2018 Mar 20.

PMID:
29542919
11.

Atropisomerism in Tertiary Biaryl 2-Amides: A Study of Ar-CO and Ar-Ar' Rotational Barriers.

Lorentzen M, Kalvet I, Sauriol F, Rantanen T, Jørgensen KB, Snieckus V.

J Org Chem. 2017 Jul 21;82(14):7300-7308. doi: 10.1021/acs.joc.7b00890. Epub 2017 Jul 7.

PMID:
28641001
12.

Catabolism of the Last Two Steroid Rings in Mycobacterium tuberculosis and Other Bacteria.

Crowe AM, Casabon I, Brown KL, Liu J, Lian J, Rogalski JC, Hurst TE, Snieckus V, Foster LJ, Eltis LD.

MBio. 2017 Apr 4;8(2). pii: e00321-17. doi: 10.1128/mBio.00321-17.

13.

Ester-directed Ru-catalyzed C-O activation/C-C coupling reaction of ortho-methoxy naphthoates with organoboroneopentylates.

Zhao Y, Snieckus V.

Chem Commun (Camb). 2016 Jan 28;52(8):1681-4. doi: 10.1039/c5cc09121g. Epub 2015 Dec 14.

PMID:
26661919
14.

A Protocol for the exo-Mono and exo,exo-Bis Functionalization of the Diazocine Ring of Tröger's Base.

Dawaigher S, Månsson K, Ascic E, Artacho J, Mårtensson R, Loganathan N, Wendt OF, Harmata M, Snieckus V, Wärnmark K.

J Org Chem. 2015 Dec 18;80(24):12006-14. doi: 10.1021/acs.joc.5b01921. Epub 2015 Nov 24.

PMID:
26597045
15.

Richard Heck (1931-2015).

Snieckus V.

Nature. 2015 Nov 19;527(7578):306. doi: 10.1038/527306a. No abstract available.

PMID:
26581284
16.

Adding a Structural Context to the Deprotometalation and Trans-Metal Trapping Chemistry of Phenyl-Substituted Benzotriazole.

Fuentes MÁ, Kennedy AR, Mulvey RE, Parkinson JA, Rantanen T, Robertson SD, Snieckus V.

Chemistry. 2015 Oct 12;21(42):14812-22. doi: 10.1002/chem.201502534. Epub 2015 Sep 21.

17.
18.

Directed Metalation-Suzuki-Miyaura Cross-Coupling Strategies: Regioselective Synthesis of Hydroxylated 1-Methyl-phenanthrenes.

Jørgensen KB, Rantanen T, Dörfler T, Snieckus V.

J Org Chem. 2015 Oct 2;80(19):9410-24. doi: 10.1021/acs.joc.5b01300. Epub 2015 Sep 30.

PMID:
26301487
19.

Resolution and Determination of the Absolute Configuration of a Twisted Bis-Lactam Analogue of Tröger's Base: A Comparative Spectroscopic and Computational Study.

Rúnarsson ÖV, Benkhäuser C, Christensen NJ, Ruiz JA, Ascic E, Harmata M, Snieckus V, Rissanen K, Fristrup P, Lützen A, Wärnmark K.

J Org Chem. 2015 Aug 21;80(16):8142-9. doi: 10.1021/acs.joc.5b01236. Epub 2015 Aug 5.

PMID:
26244379
20.

Quantitative structure-activity relationships for chronic toxicity of alkyl-chrysenes and alkyl-benz[a]anthracenes to Japanese medaka embryos (Oryzias latipes).

Lin H, Morandi GD, Brown RS, Snieckus V, Rantanen T, Jørgensen KB, Hodson PV.

Aquat Toxicol. 2015 Feb;159:109-18. doi: 10.1016/j.aquatox.2014.11.027. Epub 2014 Dec 5.

PMID:
25528422
21.

Highly enantioselective (-)-sparteine-mediated lateral metalation-functionalization of remote silyl protected ortho-ethyl N,N-dialkyl aryl O-carbamates.

Fässler J, McCubbin JA, Roglans A, Kimachi T, Hollett JW, Kunz RW, Tinkl M, Zhang Y, Wang R, Campbell M, Snieckus V.

J Org Chem. 2015 Apr 3;80(7):3368-86. doi: 10.1021/jo502561m. Epub 2015 Mar 20.

PMID:
25521308
22.

Beyond directed ortho metalation: Ru-catalyzed CAr-O activation/cross-coupling reaction by amide chelation.

Zhao Y, Snieckus V.

J Am Chem Soc. 2014 Aug 13;136(32):11224-7. doi: 10.1021/ja503819x. Epub 2014 Aug 1.

PMID:
25041584
23.

Beyond directed ortho metalation: ruthenium-catalyzed amide-directed C(Ar)-N activation/C-C coupling reaction of anthranilamides with organoboronates.

Zhao Y, Snieckus V.

Org Lett. 2014 Jun 20;16(12):3200-3. doi: 10.1021/ol501180q. Epub 2014 May 30.

PMID:
24877755
24.

Directed ortho metalation strategies. Effective regioselective routes to 1,2-, 2,3-, and 1,2,3-substituted naphthalenes.

Groom K, Hussain SM, Morin J, Nilewski C, Rantanen T, Snieckus V.

Org Lett. 2014 May 2;16(9):2378-81. doi: 10.1021/ol500707w. Epub 2014 Apr 24.

PMID:
24762122
25.

A practical in situ generation of the Schwartz reagent. Reduction of tertiary amides to aldehydes and hydrozirconation.

Zhao Y, Snieckus V.

Org Lett. 2014 Jan 17;16(2):390-3. doi: 10.1021/ol403183a. Epub 2013 Dec 20.

PMID:
24359276
26.

Reductive cleavage of aryl O-carbamates to phenols by the Schwartz reagent. Expedient link to the directed ortho metalation strategy.

Morin J, Zhao Y, Snieckus V.

Org Lett. 2013 Aug 16;15(16):4102-5. doi: 10.1021/ol401547d. Epub 2013 Aug 6.

PMID:
23919281
27.

Tröger's base twisted amides: endo functionalization and synthesis of an inverted crown ether.

Artacho J, Ascic E, Rantanen T, Wallentin CJ, Dawaigher S, Bergquist KE, Harmata M, Snieckus V, Wärnmark K.

Org Lett. 2012 Sep 21;14(18):4706-9. Epub 2012 Sep 7.

PMID:
22958089
28.

Organic chemistry: Directors extend their reach.

Kitching MO, Snieckus V.

Nature. 2012 Jun 27;486(7404):478-9. doi: 10.1038/486478a. No abstract available.

PMID:
22739310
29.

Dizincation of a 2-substituted thiophene: constructing a cage with a [16]crown-4 zincocyclic core.

Balloch L, Garden JA, Kennedy AR, Mulvey RE, Rantanen T, Robertson SD, Snieckus V.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6934-7. doi: 10.1002/anie.201203344. Epub 2012 Jun 8.

PMID:
22685018
30.

Palladium-catalyzed cross-coupling: a historical contextual perspective to the 2010 Nobel Prize.

Johansson Seechurn CC, Kitching MO, Colacot TJ, Snieckus V.

Angew Chem Int Ed Engl. 2012 May 21;51(21):5062-85. doi: 10.1002/anie.201107017. Epub 2012 May 9.

PMID:
22573393
31.

Copper-catalyzed cross-coupling interrupted by an opportunistic Smiles rearrangement: an efficient domino approach to dibenzoxazepinones.

Kitching MO, Hurst TE, Snieckus V.

Angew Chem Int Ed Engl. 2012 Mar 19;51(12):2925-9. doi: 10.1002/anie.201106786. Epub 2012 Feb 6. No abstract available.

PMID:
22311826
32.

In situ anionic shielding for regioselective metalation: directed peri and iterative metalation routes to polyfunctionalized 7-azaindoles.

Schneider C, David E, Toutov AA, Snieckus V.

Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2722-6. doi: 10.1002/anie.201108016. Epub 2012 Feb 1.

PMID:
22298342
33.

Twisted amide analogues of Tröger's base.

Artacho J, Ascic E, Rantanen T, Karlsson J, Wallentin CJ, Wang R, Wendt OF, Harmata M, Snieckus V, Wärnmark K.

Chemistry. 2012 Jan 23;18(4):1038-42. doi: 10.1002/chem.201103228. Epub 2012 Jan 10. No abstract available.

PMID:
22234879
34.

Toxicity of hydroxylated alkyl-phenanthrenes to the early life stages of Japanese medaka (Oryzias latipes).

Fallahtafti S, Rantanen T, Brown RS, Snieckus V, Hodson PV.

Aquat Toxicol. 2012 Jan 15;106-107:56-64. doi: 10.1016/j.aquatox.2011.10.007. Epub 2011 Oct 18.

PMID:
22071127
35.

Directed aromatic functionalization.

Snieckus V.

Beilstein J Org Chem. 2011;7:1215-8. doi: 10.3762/bjoc.7.141. Epub 2011 Sep 6. No abstract available.

36.

Directed ortho-metalation-cross-coupling strategies. One-pot Suzuki reaction to biaryl and heterobiaryl sulfonamides.

Schneider C, Broda E, Snieckus V.

Org Lett. 2011 Jul 15;13(14):3588-91. doi: 10.1021/ol201175g. Epub 2011 Jun 15.

PMID:
21675709
37.

Suzuki-Miyaura cross-coupling of aryl carbamates and sulfamates: experimental and computational studies.

Quasdorf KW, Antoft-Finch A, Liu P, Silberstein AL, Komaromi A, Blackburn T, Ramgren SD, Houk KN, Snieckus V, Garg NK.

J Am Chem Soc. 2011 Apr 27;133(16):6352-63. doi: 10.1021/ja200398c. Epub 2011 Apr 1.

38.

Iridium-catalyzed C-H activation versus directed ortho metalation: complementary borylation of aromatics and heteroaromatics.

Hurst TE, Macklin TK, Becker M, Hartmann E, Kügel W, Parisienne-La Salle JC, Batsanov AS, Marder TB, Snieckus V.

Chemistry. 2010 Jul 19;16(27):8155-61. doi: 10.1002/chem.201000401.

PMID:
20533457
39.

Combined directed ortho metalation-halogen dance (HD) synthetic strategies. HD-anionic ortho fries rearrangement and double HD sequences.

Miller RE, Rantanen T, Ogilvie KA, Groth U, Snieckus V.

Org Lett. 2010 May 21;12(10):2198-201. doi: 10.1021/ol100493v.

PMID:
20397661
40.

On the mechanism of the directed ortho and remote metalation reactions of N,N-dialkylbiphenyl 2-carboxamides.

Tilly D, Fu JM, Zhao BP, Alessi M, Castanet AS, Snieckus V, Mortier J.

Org Lett. 2010 Jan 1;12(1):68-71. doi: 10.1021/ol902268h.

PMID:
19994874
41.

N,N-diethyl O-carbamate: directed metalation group and orthogonal Suzuki-Miyaura cross-coupling partner.

Antoft-Finch A, Blackburn T, Snieckus V.

J Am Chem Soc. 2009 Dec 16;131(49):17750-2. doi: 10.1021/ja907700e.

PMID:
19928763
42.

Synthesis of substituted imidazo[1,5-a]pyrazines via mono-, di-, and directed remote metalation strategies.

Board J, Wang JX, Crew AP, Jin M, Foreman K, Mulvihill MJ, Snieckus V.

Org Lett. 2009 Nov 19;11(22):5118-21. doi: 10.1021/ol901889e.

PMID:
19842687
43.

Combined directed ortho and remote metalation-Suzuki cross-coupling strategies. Efficient synthesis of heteroaryl-fused benzopyranones from biaryl O-carbamates.

James CA, Coelho AL, Gevaert M, Forgione P, Snieckus V.

J Org Chem. 2009 Jun 5;74(11):4094-103. doi: 10.1021/jo900146d.

PMID:
19441801
45.

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD.

PLoS Pathog. 2009 Mar;5(3):e1000344. doi: 10.1371/journal.ppat.1000344. Epub 2009 Mar 20.

46.

Carbanionic Friedel-Crafts equivalents. regioselective directed ortho and remote metalation-C-N cross coupling routes to acridones and dibenzo[b,f]azepinones.

MacNeil SL, Gray M, Gusev DG, Briggs LE, Snieckus V.

J Org Chem. 2008 Dec 19;73(24):9710-9. doi: 10.1021/jo801856n.

PMID:
19053602
47.

Palladium-catalyzed direct heck arylation of dual pi-deficient/pi-excessive heteroaromatics. Synthesis of C-5 arylated imidazo[1,5-a]pyrazines.

Wang JX, McCubbin JA, Jin M, Laufer RS, Mao Y, Crew AP, Mulvihill MJ, Snieckus V.

Org Lett. 2008 Jul 17;10(14):2923-6. doi: 10.1021/ol800761r. Epub 2008 Jun 25.

PMID:
18576663
48.

Anionic Indole N-carbamoyl N --> C translocation. A directed remote metalation route to 2-Aryl- and 2-heteroarylindoles. synthesis of benz[a]carbazoles and Indeno[1,2-b]indoles.

Zhao Z, Jaworski A, Piel I, Snieckus V.

Org Lett. 2008 Jul 3;10(13):2617-20. doi: 10.1021/ol800307g. Epub 2008 Jun 11.

PMID:
18543941
49.

Carbamoyl translocations by an anionic ortho-fries and cumulenolate alpha-acylation pathway: regioselective synthesis of polysubstituted chromone 3- and 8-carboxamides.

Macklin TK, Panteleev J, Snieckus V.

Angew Chem Int Ed Engl. 2008;47(11):2097-101. doi: 10.1002/anie.200704360. No abstract available.

PMID:
18266267
50.

3,3'-dipyridyl BINOL ligands. Synthesis and application in enantioselective addition of Et2Zn to aldehydes.

Milburn RR, Hussain SM, Prien O, Ahmed Z, Snieckus V.

Org Lett. 2007 Oct 25;9(22):4403-6. Epub 2007 Sep 28.

PMID:
17900193

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