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Items: 38


Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy.

Bertero A, Fields PA, Smith AST, Leonard A, Beussman K, Sniadecki NJ, Kim DH, Tse HF, Pabon L, Shendure J, Noble WS, Murry CE.

J Cell Biol. 2019 Aug 8. pii: jcb.201902117. doi: 10.1083/jcb.201902117. [Epub ahead of print]


The consequence of substrates of large-scale rigidity on actin network tension in adherent cells.

Manifacier I, Beussman KM, Han SJ, Sniadecki NJ, About I, Milan JL.

Comput Methods Biomech Biomed Engin. 2019 Jun 17:1-10. doi: 10.1080/10255842.2019.1629428. [Epub ahead of print]


Contractile forces in platelet aggregates under microfluidic shear gradients reflect platelet inhibition and bleeding risk.

Ting LH, Feghhi S, Taparia N, Smith AO, Karchin A, Lim E, John AS, Wang X, Rue T, White NJ, Sniadecki NJ.

Nat Commun. 2019 Mar 13;10(1):1204. doi: 10.1038/s41467-019-09150-9.


Hyaluronan-CD44 interactions mediate contractility and migration in periodontal ligament cells.

Al-Rekabi Z, Fura AM, Juhlin I, Yassin A, Popowics TE, Sniadecki NJ.

Cell Adh Migr. 2019 Dec;13(1):138-150. doi: 10.1080/19336918.2019.1568140. Epub 2019 Feb 8.


LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion.

Chi C, Leonard A, Knight WE, Beussman KM, Zhao Y, Cao Y, Londono P, Aune E, Trembley MA, Small EM, Jeong MY, Walker LA, Xu H, Sniadecki NJ, Taylor MR, Buttrick PM, Song K.

Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):556-565. doi: 10.1073/pnas.1808618116. Epub 2018 Dec 24.


Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues.

Leonard A, Bertero A, Powers JD, Beussman KM, Bhandari S, Regnier M, Murry CE, Sniadecki NJ.

J Mol Cell Cardiol. 2018 May;118:147-158. doi: 10.1016/j.yjmcc.2018.03.016. Epub 2018 Mar 28.


Cell Mechanics of Craniosynostosis.

Al-Rekabi Z, Cunningham ML, Sniadecki NJ.

ACS Biomater Sci Eng. 2017 Nov 13;3(11):2733-2743. doi: 10.1021/acsbiomaterials.6b00557. Epub 2016 Dec 14.


The desmoplakin-intermediate filament linkage regulates cell mechanics.

Broussard JA, Yang R, Huang C, Nathamgari SSP, Beese AM, Godsel LM, Hegazy MH, Lee S, Zhou F, Sniadecki NJ, Green KJ, Espinosa HD.

Mol Biol Cell. 2017 Nov 7;28(23):3156-3164. doi: 10.1091/mbc.E16-07-0520. Epub 2017 May 11.


Real-Time Force and Frequency Analysis of Engineered Human Heart Tissue Derived from Induced Pluripotent Stem Cells Using Magnetic Sensing.

Bielawski KS, Leonard A, Bhandari S, Murry CE, Sniadecki NJ.

Tissue Eng Part C Methods. 2016 Oct;22(10):932-940. doi: 10.1089/ten.TEC.2016.0257. Epub 2016 Sep 28.


Spatial and temporal coordination of traction forces in one-dimensional cell migration.

Han SJ, Rodriguez ML, Al-Rekabi Z, Sniadecki NJ.

Cell Adh Migr. 2016 Sep 2;10(5):529-539. Epub 2016 Aug 11.


Nonmuscle Myosin IIA Regulates Platelet Contractile Forces Through Rho Kinase and Myosin Light-Chain Kinase.

Feghhi S, Tooley WW, Sniadecki NJ.

J Biomech Eng. 2016 Oct 1;138(10). doi: 10.1115/1.4034489.


Glycoprotein Ib-IX-V Complex Transmits Cytoskeletal Forces That Enhance Platelet Adhesion.

Feghhi S, Munday AD, Tooley WW, Rajsekar S, Fura AM, Kulman JD, López JA, Sniadecki NJ.

Biophys J. 2016 Aug 9;111(3):601-608. doi: 10.1016/j.bpj.2016.06.023.


In silico CDM model sheds light on force transmission in cell from focal adhesions to nucleus.

Milan JL, Manifacier I, Beussman KM, Han SJ, Sniadecki NJ, About I, Chabrand P.

J Biomech. 2016 Sep 6;49(13):2625-2634. doi: 10.1016/j.jbiomech.2016.05.031. Epub 2016 Jun 4.


Activation of the IGF1 pathway mediates changes in cellular contractility and motility in single-suture craniosynostosis.

Al-Rekabi Z, Wheeler MM, Leonard A, Fura AM, Juhlin I, Frazar C, Smith JD, Park SS, Gustafson JA, Clarke CM, Cunningham ML, Sniadecki NJ.

J Cell Sci. 2016 Feb 1;129(3):483-91. doi: 10.1242/jcs.175976. Epub 2015 Dec 11.


Micropost arrays for measuring stem cell-derived cardiomyocyte contractility.

Beussman KM, Rodriguez ML, Leonard A, Taparia N, Thompson CR, Sniadecki NJ.

Methods. 2016 Feb 1;94:43-50. doi: 10.1016/j.ymeth.2015.09.005. Epub 2015 Sep 3.


Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes.

Kuppusamy KT, Jones DC, Sperber H, Madan A, Fischer KA, Rodriguez ML, Pabon L, Zhu WZ, Tulloch NL, Yang X, Sniadecki NJ, Laflamme MA, Ruzzo WL, Murry CE, Ruohola-Baker H.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2785-94. doi: 10.1073/pnas.1424042112. Epub 2015 May 11.


Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells.

Yang X, Rodriguez M, Pabon L, Fischer KA, Reinecke H, Regnier M, Sniadecki NJ, Ruohola-Baker H, Murry CE.

J Mol Cell Cardiol. 2014 Jul;72:296-304. doi: 10.1016/j.yjmcc.2014.04.005. Epub 2014 Apr 13.


Measuring the contractile forces of human induced pluripotent stem cell-derived cardiomyocytes with arrays of microposts.

Rodriguez ML, Graham BT, Pabon LM, Han SJ, Murry CE, Sniadecki NJ.

J Biomech Eng. 2014 May;136(5):051005. doi: 10.1115/1.4027145.


Micropatterning on micropost arrays.

Sniadecki NJ, Han SJ, Ting LH, Feghhi S.

Methods Cell Biol. 2014;121:61-73. doi: 10.1016/B978-0-12-800281-0.00005-1.


Enhanced contractility with 2-deoxy-ATP and EMD 57033 is correlated with reduced myofibril structure and twitch power in neonatal cardiomyocytes.

Rodriguez AG, Rodriguez ML, Han SJ, Sniadecki NJ, Regnier M.

Integr Biol (Camb). 2013 Nov;5(11):1366-73. doi: 10.1039/c3ib40135a. Epub 2013 Sep 10.


Simple replica micromolding of biocompatible styrenic elastomers.

Borysiak MD, Bielawski KS, Sniadecki NJ, Jenkel CF, Vogt BD, Posner JD.

Lab Chip. 2013 Jul 21;13(14):2773-84. doi: 10.1039/c3lc50426c.


Decoupling substrate stiffness, spread area, and micropost density: a close spatial relationship between traction forces and focal adhesions.

Han SJ, Bielawski KS, Ting LH, Rodriguez ML, Sniadecki NJ.

Biophys J. 2012 Aug 22;103(4):640-8. doi: 10.1016/j.bpj.2012.07.023.


Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions.

Ting LH, Jahn JR, Jung JI, Shuman BR, Feghhi S, Han SJ, Rodriguez ML, Sniadecki NJ.

Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2220-9. doi: 10.1152/ajpheart.00975.2011. Epub 2012 Mar 23.


Mechanobiology of platelets: techniques to study the role of fluid flow and platelet retraction forces at the micro- and nano-scale.

Feghhi S, Sniadecki NJ.

Int J Mol Sci. 2011;12(12):9009-30. doi: 10.3390/ijms12129009. Epub 2011 Dec 7. Review.


Substrate stiffness increases twitch power of neonatal cardiomyocytes in correlation with changes in myofibril structure and intracellular calcium.

Rodriguez AG, Han SJ, Regnier M, Sniadecki NJ.

Biophys J. 2011 Nov 16;101(10):2455-64. doi: 10.1016/j.bpj.2011.09.057. Epub 2011 Nov 15.


Simulations of the contractile cycle in cell migration using a bio-chemical-mechanical model.

Han SJ, Sniadecki NJ.

Comput Methods Biomech Biomed Engin. 2011 May;14(5):459-68. doi: 10.1080/10255842.2011.554412.


Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis.

Raghavan S, Shen CJ, Desai RA, Sniadecki NJ, Nelson CM, Chen CS.

J Cell Sci. 2010 Sep 1;123(Pt 17):2877-83. doi: 10.1242/jcs.055079. Epub 2010 Aug 3.


Mechanical tugging force regulates the size of cell-cell junctions.

Liu Z, Tan JL, Cohen DM, Yang MT, Sniadecki NJ, Ruiz SA, Nelson CM, Chen CS.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):9944-9. doi: 10.1073/pnas.0914547107. Epub 2010 May 12.


Platelet retraction force measurements using flexible post force sensors.

Liang XM, Han SJ, Reems JA, Gao D, Sniadecki NJ.

Lab Chip. 2010 Apr 21;10(8):991-8. doi: 10.1039/b918719g. Epub 2010 Jan 20.


A tiny touch: activation of cell signaling pathways with magnetic nanoparticles.

Sniadecki NJ.

Endocrinology. 2010 Feb;151(2):451-7. doi: 10.1210/en.2009-0932. Epub 2009 Dec 16. Review.


Magnetic microposts for mechanical stimulation of biological cells: fabrication, characterization, and analysis.

Sniadecki NJ, Lamb CM, Liu Y, Chen CS, Reich DH.

Rev Sci Instrum. 2008 Apr;79(4):044302. doi: 10.1063/1.2906228.


Magnetic microposts as an approach to apply forces to living cells.

Sniadecki NJ, Anguelouch A, Yang MT, Lamb CM, Liu Z, Kirschner SB, Liu Y, Reich DH, Chen CS.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14553-8. Epub 2007 Sep 5.


Shear force at the cell-matrix interface: enhanced analysis for microfabricated post array detectors.

Lemmon CA, Sniadecki NJ, Ruiz SA, Tan JL, Romer LH, Chen CS.

Mech Chem Biosyst. 2005;2(1):1-16.


Nanotechnology for cell-substrate interactions.

Sniadecki NJ, Desai RA, Ruiz SA, Chen CS.

Ann Biomed Eng. 2006 Jan;34(1):59-74. Epub 2006 Mar 9. Review.


Emergent patterns of growth controlled by multicellular form and mechanics.

Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11594-9. Epub 2005 Jul 27.


Induced pressure pumping in polymer microchannels via field-effect flow control.

Sniadecki NJ, Lee CS, Sivanesan P, DeVoe DL.

Anal Chem. 2004 Apr 1;76(7):1942-7.


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