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Items: 43


CD200R1 regulates eosinophilia during pulmonary fungal infection in mice.

Salek-Ardakani S, Bell T, Jagger CP, Snelgrove RJ, Hussell T.

Eur J Immunol. 2019 Jul 31. doi: 10.1002/eji.201847861. [Epub ahead of print]


Response to Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness".

Patel DF, Gaggar A, Blalock JE, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaaw0462. doi: 10.1126/scitranslmed.aaw0462.


Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.

Turnbull AR, Pyle CJ, Patel DF, Jackson PL, Hilliard TN, Regamey N, Tan HL, Brown S, Thursfield R, Short C, Mc Fie M, Alton EWFW, Gaggar A, Blalock JE, Lloyd CM, Bush A, Davies JC, Snelgrove RJ.

J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30769-6. doi: 10.1016/j.jcf.2019.05.017. [Epub ahead of print]


Zooming into the Matrix: Using Nonlinear Optical Microscopy to Visualize Collagen Remodeling in Asthmatic Airways.

Snelgrove RJ, Patel DF.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):403-405. doi: 10.1164/rccm.201904-0722ED. No abstract available.


An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.


Type 2 immunity: Expanding our view.

Lloyd CM, Snelgrove RJ.

Sci Immunol. 2018 Jul 6;3(25). pii: eaat1604. doi: 10.1126/sciimmunol.aat1604. Review.


The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease.

Patel DF, Snelgrove RJ.

Eur Respir Rev. 2018 Jun 27;27(148). pii: 180017. doi: 10.1183/16000617.0017-2018. Print 2018 Jun 30. Review.


Defective lung function following influenza virus is due to prolonged, reversible hyaluronan synthesis.

Bell TJ, Brand OJ, Morgan DJ, Salek-Ardakani S, Jagger C, Fujimori T, Cholewa L, Tilakaratna V, Östling J, Thomas M, Day AJ, Snelgrove RJ, Hussell T.

Matrix Biol. 2019 Jul;80:14-28. doi: 10.1016/j.matbio.2018.06.006. Epub 2018 Jun 20.


Tasting type 2 inflammation in the airways.

Snelgrove RJ, Lloyd CM.

J Allergy Clin Immunol. 2018 Aug;142(2):403-404. doi: 10.1016/j.jaci.2018.06.009. Epub 2018 Jun 19. No abstract available.


The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent?

Snelgrove RJ, Patel DF, Patel T, Lloyd CM.

Clin Exp Allergy. 2018 Oct;48(10):1275-1285. doi: 10.1111/cea.13191. Epub 2018 Jul 11. Review.


New Rules for Club Development: New Insights into Human Small Airway Epithelial Club Cell Ontogeny and Function.

Dean CH, Snelgrove RJ.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1355-1356. doi: 10.1164/rccm.201805-0925ED. No abstract available.


Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. eCollection 2017 Nov 16.


Neutrophils drive alveolar macrophage IL-1β release during respiratory viral infection.

Peiró T, Patel DF, Akthar S, Gregory LG, Pyle CJ, Harker JA, Birrell MA, Lloyd CM, Snelgrove RJ.

Thorax. 2018 Jun;73(6):546-556. doi: 10.1136/thoraxjnl-2017-210010. Epub 2017 Oct 27.


An NLRP3, IL-1β, Neutrophil Axis in the Respiratory Tract Leaves You Breathless.

Snelgrove RJ, Lloyd CM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):253-254. doi: 10.1164/rccm.201703-0483ED. No abstract available.


Characterisation of a murine model of the late asthmatic response.

Baker K, Raemdonck K, Snelgrove RJ, Belvisi MG, Birrell MA.

Respir Res. 2017 Apr 11;18(1):55. doi: 10.1186/s12931-017-0541-x.


The development of novel LTA4H modulators to selectively target LTB4 generation.

Low CM, Akthar S, Patel DF, Löser S, Wong CT, Jackson PL, Blalock JE, Hare SA, Lloyd CM, Snelgrove RJ.

Sci Rep. 2017 Mar 17;7:44449. doi: 10.1038/srep44449.


Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors.

Weiss G, Lai C, Fife ME, Grabiec AM, Tildy B, Snelgrove RJ, Xin G, Lloyd CM, Hussell T.

Mucosal Immunol. 2017 Jul;10(4):1021-1030. doi: 10.1038/mi.2016.104. Epub 2016 Dec 14.


Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.

Baker K, Raemdonck K, Dekkak B, Snelgrove RJ, Ford J, Shala F, Belvisi MG, Birrell MA.

Respir Res. 2016 Jun 2;17(1):67. doi: 10.1186/s12931-016-0384-x.


Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.

Akthar S, Patel DF, Beale RC, Peiró T, Xu X, Gaggar A, Jackson PL, Blalock JE, Lloyd CM, Snelgrove RJ.

Nat Commun. 2015 Sep 24;6:8423. doi: 10.1038/ncomms9423.


Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33.

Castanhinha S, Sherburn R, Walker S, Gupta A, Bossley CJ, Buckley J, Ullmann N, Grychtol R, Campbell G, Maglione M, Koo S, Fleming L, Gregory L, Snelgrove RJ, Bush A, Lloyd CM, Saglani S.

J Allergy Clin Immunol. 2015 Aug;136(2):312-22.e7. doi: 10.1016/j.jaci.2015.01.016. Epub 2015 Mar 5.


CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue.

Stack G, Jones E, Marsden M, Stacey MA, Snelgrove RJ, Lacaze P, Jacques LC, Cuff SM, Stanton RJ, Gallimore AM, Hussell T, Wilkinson GW, Ghazal P, Taylor PR, Humphreys IR.

PLoS Pathog. 2015 Feb 5;11(2):e1004641. doi: 10.1371/journal.ppat.1004641. eCollection 2015 Feb.


Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD.

Eltom S, Dale N, Raemdonck KR, Stevenson CS, Snelgrove RJ, Sacitharan PK, Recchi C, Wavre-Shapton S, McAuley DF, O'Kane C, Belvisi MG, Birrell MA.

PLoS One. 2014 Jun 27;9(6):e101087. doi: 10.1371/journal.pone.0101087. eCollection 2014.


Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.

Stacey MA, Marsden M, Pham N TA, Clare S, Dolton G, Stack G, Jones E, Klenerman P, Gallimore AM, Taylor PR, Snelgrove RJ, Lawley TD, Dougan G, Benedict CA, Jones SA, Wilkinson GW, Humphreys IR.

Cell Host Microbe. 2014 Apr 9;15(4):471-83. doi: 10.1016/j.chom.2014.03.003.


Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations.

Snelgrove RJ, Gregory LG, Peiró T, Akthar S, Campbell GA, Walker SA, Lloyd CM.

J Allergy Clin Immunol. 2014 Sep;134(3):583-592.e6. doi: 10.1016/j.jaci.2014.02.002. Epub 2014 Mar 15.


OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC, Horwood NJ, Hussell T.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2289-94. doi: 10.1073/pnas.1321071111. Epub 2014 Jan 27.


Benzodiazepine augmented γ-amino-butyric acid signaling increases mortality from pneumonia in mice.

Sanders RD, Godlee A, Fujimori T, Goulding J, Xin G, Salek-Ardakani S, Snelgrove RJ, Ma D, Maze M, Hussell T.

Crit Care Med. 2013 Jul;41(7):1627-36. doi: 10.1097/CCM.0b013e31827c0c8d.


MMP-9 cleaves SP-D and abrogates its innate immune functions in vitro.

Bratcher PE, Weathington NM, Nick HJ, Jackson PL, Snelgrove RJ, Gaggar A.

PLoS One. 2012;7(7):e41881. doi: 10.1371/journal.pone.0041881. Epub 2012 Jul 30.


Respiratory viral infections: knowledge based therapeutics.

Hussell T, Godlee A, Salek-Ardakani S, Snelgrove RJ.

Curr Opin Immunol. 2012 Aug;24(4):438-43. doi: 10.1016/j.coi.2012.06.001. Epub 2012 Jul 5. Review.


Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

Hardison MT, Brown MD, Snelgrove RJ, Blalock JE, Jackson P.

Front Biosci (Elite Ed). 2012 Jun 1;4:2402-9.


Pulmonary innate lymphoid cells regulate repair and remodeling after acute lung injury.

Snelgrove RJ.

Expert Rev Anti Infect Ther. 2012 Mar;10(3):281-4. doi: 10.1586/eri.12.15.


OX40 ligand fusion protein delivered simultaneously with the BCG vaccine provides superior protection against murine Mycobacterium tuberculosis infection.

Snelgrove RJ, Cornere MM, Edwards L, Dagg B, Keeble J, Rodgers A, Lyonga DE, Stewart GR, Young DB, Walker B, Hussell T.

J Infect Dis. 2012 Mar 15;205(6):975-83. doi: 10.1093/infdis/jir868. Epub 2012 Feb 7.


Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema.

De Oliveira EO, Wang K, Kong HS, Kim S, Miessau M, Snelgrove RJ, Shim YM, Paige M.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6746-50. doi: 10.1016/j.bmcl.2011.09.048. Epub 2011 Sep 20.


Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases.

Snelgrove RJ.

Eur J Pharmacol. 2011 Sep 30;667(1-3):1-5. doi: 10.1016/j.ejphar.2011.05.073. Epub 2011 Jun 7. Review.


Airway immune homeostasis and implications for influenza-induced inflammation.

Snelgrove RJ, Godlee A, Hussell T.

Trends Immunol. 2011 Jul;32(7):328-34. doi: 10.1016/ Epub 2011 May 24. Review.


Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme.

Snelgrove RJ.

Thorax. 2011 Jun;66(6):550-1. doi: 10.1136/thoraxjnl-2011-200234. Epub 2011 Apr 17.


A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A, Gaggar A, Shastry S, Rowe SM, Shim YM, Hussell T, Blalock JE.

Science. 2010 Oct 1;330(6000):90-4. doi: 10.1126/science.1190594. Epub 2010 Sep 2.


Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.

O'Reilly PJ, Hardison MT, Jackson PL, Xu X, Snelgrove RJ, Gaggar A, Galin FS, Blalock JE.

J Neuroimmunol. 2009 Dec 10;217(1-2):51-4. doi: 10.1016/j.jneuroim.2009.09.020. Epub 2009 Oct 28.


A critical function for CD200 in lung immune homeostasis and the severity of influenza infection.

Snelgrove RJ, Goulding J, Didierlaurent AM, Lyonga D, Vekaria S, Edwards L, Gwyer E, Sedgwick JD, Barclay AN, Hussell T.

Nat Immunol. 2008 Sep;9(9):1074-83. doi: 10.1038/ni.1637. Epub 2008 Jul 27.


A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection.

Humphreys IR, Edwards L, Snelgrove RJ, Rae AJ, Coyle AJ, Hussell T.

Eur J Immunol. 2006 Nov;36(11):2928-38.


An absence of reactive oxygen species improves the resolution of lung influenza infection.

Snelgrove RJ, Edwards L, Rae AJ, Hussell T.

Eur J Immunol. 2006 Jun;36(6):1364-73.


A role for dendritic cells in the dissemination of mycobacterial infection.

Humphreys IR, Stewart GR, Turner DJ, Patel J, Karamanou D, Snelgrove RJ, Young DB.

Microbes Infect. 2006 Apr;8(5):1339-46. Epub 2006 Mar 24.


Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent manner.

Edwards L, Williams AE, Krieg AM, Rae AJ, Snelgrove RJ, Hussell T.

Eur J Immunol. 2005 Jan;35(1):273-81.

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