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Genetic Susceptibility to Chronic Kidney Disease - Some More Pieces for the Heritability Puzzle.

Cañadas-Garre M, Anderson K, Cappa R, Skelly R, Smyth LJ, McKnight AJ, Maxwell AP.

Front Genet. 2019 May 31;10:453. doi: 10.3389/fgene.2019.00453. eCollection 2019. Review.


Fractionated stereotactic body radiotherapy for up to five prostate cancer oligometastases: interim outcomes of a prospective clinical trial.

Bowden P, See AW, Frydenberg M, Haxhimolla H, Costello AJ, Moon D, Ruljancich P, Grummet J, Crosthwaite A, Pranavan G, Peters J, So K, Gwini SM, McKenzie DP, Nolan S, Smyth LML, Everitt C.

Int J Cancer. 2019 Jun 14. doi: 10.1002/ijc.32509. [Epub ahead of print]


High frequency of infection of lung cancer patients with the parasite Toxoplasma gondii.

Bajnok J, Tarabulsi M, Carlin H, Bown K, Southworth T, Dungwa J, Singh D, Lun ZR, Smyth L, Hide G.

ERJ Open Res. 2019 May 28;5(2). pii: 00143-2018. doi: 10.1183/23120541.00143-2018. eCollection 2019 Apr.


How Can We Show You, If You Can't See It? Trialing the Use of an Interactive Three-Dimensional Micro-CT Model in Medical Education.

O'Rourke JC, Smyth L, Webb AL, Valter K.

Anat Sci Educ. 2019 May 7. doi: 10.1002/ase.1890. [Epub ahead of print]


Genetic associations between genes in the renin-angiotensin-aldosterone system and renal disease: a systematic review and meta-analysis.

Smyth LJ, Cañadas-Garre M, Cappa RC, Maxwell AP, McKnight AJ.

BMJ Open. 2019 May 1;9(4):e026777. doi: 10.1136/bmjopen-2018-026777.


Engaging hard-to-reach populations in research on health in pregnancy: the value of Boal's simultaneous dramaturgy.

Smyth L, McClements L, Murphy P.

Arts Health. 2018 Dec 26:1-9. doi: 10.1080/17533015.2018.1555176. [Epub ahead of print]


Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach.

Faruqu FN, Wang JT, Xu L, McNickle L, Chong EM, Walters A, Gurney M, Clayton A, Smyth LA, Hider R, Sosabowski J, Al-Jamal KT.

Theranostics. 2019 Feb 28;9(6):1666-1682. doi: 10.7150/thno.27891. eCollection 2019.


Identifying optimal clinical scenarios for synchrotron microbeam radiation therapy: A treatment planning study.

Smyth LML, Day LR, Woodford K, Rogers PAW, Crosbie JC, Senthi S.

Phys Med. 2019 Apr;60:111-119. doi: 10.1016/j.ejmp.2019.03.019. Epub 2019 Mar 30.


The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population.

Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in Transplantation Network.

Am J Transplant. 2019 Feb 27. doi: 10.1111/ajt.15326. [Epub ahead of print]


Patient-Driven Discovery, Therapeutic Targeting, and Post-Clinical Validation of a Novel AKT1 Fusion-Driven Cancer.

Slotkin EK, Diolaiti D, Shukla NN, Dela Cruz FS, Clark JJ, Gundem G, Yellapantula VD, Levine MF, You D, Ma P, Pachhal S, Ibanez Sanchez G, Benayed R, Jungbluth AA, Smyth LM, Mauguen A, Gushterova I, Ding H, Spraggon L, Darnell R, Califano A, Ladanyi M, Papaemmanuil E, Kung AL, Hyman DM, Roberts SS.

Cancer Discov. 2019 May;9(5):605-616. doi: 10.1158/2159-8290.CD-18-0953. Epub 2019 Mar 15.


Author Correction: HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman DM, Piha-Paul SA, Won H, Rodon J, Saura C, Shapiro GI, Juric D, Quinn DI, Moreno V, Doger B, Mayer IA, Boni V, Calvo E, Loi S, Lockhart AC, Erinjeri JP, Scaltriti M, Ulaner GA, Patel J, Tang J, Beer H, Selcuklu SD, Hanrahan AJ, Bouvier N, Melcer M, Murali R, Schram AM, Smyth LM, Jhaveri K, Li BT, Drilon A, Harding JJ, Iyer G, Taylor BS, Berger MF, Cutler RE Jr, Xu F, Butturini A, Eli LD, Mann G, Farrell C, Lalani AS, Bryce RP, Arteaga CL, Meric-Bernstam F, Baselga J, Solit DB.

Nature. 2019 Feb;566(7745):E11-E12. doi: 10.1038/s41586-019-0974-0.


Development of an Orthotopic Intrasplenic Xenograft Mouse Model of Canine Histiocytic Sarcoma and Its Use in Evaluating the Efficacy of Treatment with Dasatinib.

Takada M, Smyth LA, Hix JM, Corner SM, Kiupel M, Yuzbasiyan-Gurkan V.

Comp Med. 2019 Feb 1;69(1):22-28. doi: 10.30802/AALAS-CM-18-000065. Epub 2019 Feb 4.


Application of carbon nanotubes in cancer vaccines: Achievements, challenges and chances.

Hassan HAFM, Diebold SS, Smyth LA, Walters AA, Lombardi G, Al-Jamal KT.

J Control Release. 2019 Mar 10;297:79-90. doi: 10.1016/j.jconrel.2019.01.017. Epub 2019 Jan 16. Review.


Operant conditioning of the motor-evoked potential and locomotion in people with and without chronic incomplete spinal cord injury.

Thompson AK, Fiorenza G, Smyth L, Favale B, Brangaccio J, Sniffen J.

J Neurophysiol. 2019 Mar 1;121(3):853-866. doi: 10.1152/jn.00557.2018. Epub 2019 Jan 9.


Phase II Study of Weekly Paclitaxel with Trastuzumab and Pertuzumab in Patients with Human Epidermal Growth Receptor 2 Overexpressing Metastatic Breast Cancer: 5-Year Follow-up.

Wang R, Smyth LM, Iyengar N, Chandarlapaty S, Modi S, Jochelson M, Patil S, Norton L, Hudis CA, Dang CT.

Oncologist. 2019 Jan 2. pii: theoncologist.2018-0512. doi: 10.1634/theoncologist.2018-0512. [Epub ahead of print]


Validation of differentially methylated microRNAs identified from an epigenome-wide association study; Sanger and next generation sequencing approaches.

Smyth LJ, Maxwell AP, Benson KA, Kilner J, McKay GJ, McKnight AJ.

BMC Res Notes. 2018 Oct 29;11(1):767. doi: 10.1186/s13104-018-3872-x.


Influence of Age on the Clinical Outcome of Breast Cancer for Men and the Development of Second Primary Cancers.

Cronin PA, Romanoff A, Zabor EC, Stempel M, Eaton A, Smyth LM, Ho AY, Morrow M, El-Tamer M, Gemignani ML.

Ann Surg Oncol. 2018 Dec;25(13):3858-3866. doi: 10.1245/s10434-018-6767-0. Epub 2018 Oct 8.


Information on Genetic Variants Does Not Increase Identification of Individuals at Risk of Esophageal Adenocarcinoma Compared to Clinical Risk Factors.

Kunzmann AT, Cañadas Garre M, Thrift AP, McMenamin ÚC, Johnston BT, Cardwell CR, Anderson LA, Spence AD, Lagergren J, Xie SH, Smyth LJ, McKnight AJ, Coleman HG.

Gastroenterology. 2019 Jan;156(1):43-45. doi: 10.1053/j.gastro.2018.09.038. Epub 2018 Sep 19.


The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.

Razavi P, Chang MT, Xu G, Bandlamudi C, Ross DS, Vasan N, Cai Y, Bielski CM, Donoghue MTA, Jonsson P, Penson A, Shen R, Pareja F, Kundra R, Middha S, Cheng ML, Zehir A, Kandoth C, Patel R, Huberman K, Smyth LM, Jhaveri K, Modi S, Traina TA, Dang C, Zhang W, Weigelt B, Li BT, Ladanyi M, Hyman DM, Schultz N, Robson ME, Hudis C, Brogi E, Viale A, Norton L, Dickler MN, Berger MF, Iacobuzio-Donahue CA, Chandarlapaty S, Scaltriti M, Reis-Filho JS, Solit DB, Taylor BS, Baselga J.

Cancer Cell. 2018 Sep 10;34(3):427-438.e6. doi: 10.1016/j.ccell.2018.08.008.


PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.

Rustenhoven J, Smith AM, Smyth LC, Jansson D, Scotter EL, Swanson MEV, Aalderink M, Coppieters N, Narayan P, Handley R, Overall C, Park TIH, Schweder P, Heppner P, Curtis MA, Faull RLM, Dragunow M.

Mol Neurodegener. 2018 Aug 20;13(1):44. doi: 10.1186/s13024-018-0277-1.


Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model.

Smyth LML, Donoghue JF, Ventura JA, Livingstone J, Bailey T, Day LRJ, Crosbie JC, Rogers PAW.

Sci Rep. 2018 Aug 13;8(1):12044. doi: 10.1038/s41598-018-30543-1.


Markers for human brain pericytes and smooth muscle cells.

Smyth LCD, Rustenhoven J, Scotter EL, Schweder P, Faull RLM, Park TIH, Dragunow M.

J Chem Neuroanat. 2018 Oct;92:48-60. doi: 10.1016/j.jchemneu.2018.06.001. Epub 2018 Jun 7.


Unique and shared inflammatory profiles of human brain endothelia and pericytes.

Smyth LCD, Rustenhoven J, Park TI, Schweder P, Jansson D, Heppner PA, O'Carroll SJ, Mee EW, Faull RLM, Curtis M, Dragunow M.

J Neuroinflammation. 2018 May 11;15(1):138. doi: 10.1186/s12974-018-1167-8.


Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

Emmerson A, Trevelin SC, Mongue-Din H, Becker PD, Ortiz C, Smyth LA, Peng Q, Elgueta R, Sawyer G, Ivetic A, Lechler RI, Lombardi G, Shah AM.

J Clin Invest. 2018 Jul 2;128(7):3088-3101. doi: 10.1172/JCI97490. Epub 2018 Jun 11.


The transobturator suburethral sling: a safe and effective option for all degrees of post prostatectomy urinary incontinence.

Sullivan JF, Stassen PN, Moran D, Bolton EM, Smyth LG, Browne CM, Forde JC, Tal R, Lynch TH.

Can J Urol. 2018 Apr;25(2):9268-9272.


Regulatory T cell-derived extracellular vesicles modify dendritic cell function.

Tung SL, Boardman DA, Sen M, Letizia M, Peng Q, Cianci N, Dioni L, Carlin LM, Lechler R, Bollati V, Lombardi G, Smyth LA.

Sci Rep. 2018 Apr 17;8(1):6065. doi: 10.1038/s41598-018-24531-8.


Computational prediction of chemical reactions: current status and outlook.

Engkvist O, Norrby PO, Selmi N, Lam YH, Peng Z, Sherer EC, Amberg W, Erhard T, Smyth LA.

Drug Discov Today. 2018 Jun;23(6):1203-1218. doi: 10.1016/j.drudis.2018.02.014. Epub 2018 Mar 3. Review.


Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction.

Rustenhoven J, Smyth LC, Jansson D, Schweder P, Aalderink M, Scotter EL, Mee EW, Faull RLM, Park TI, Dragunow M.

BMC Neurosci. 2018 Feb 22;19(1):6. doi: 10.1186/s12868-018-0405-4.


Galectin-1 is required for the regulatory function of B cells.

Alhabbab R, Blair P, Smyth LA, Ratnasothy K, Peng Q, Moreau A, Lechler R, Elgueta R, Lombardi G.

Sci Rep. 2018 Feb 9;8(1):2725. doi: 10.1038/s41598-018-19965-z.


HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

Hyman DM, Piha-Paul SA, Won H, Rodon J, Saura C, Shapiro GI, Juric D, Quinn DI, Moreno V, Doger B, Mayer IA, Boni V, Calvo E, Loi S, Lockhart AC, Erinjeri JP, Scaltriti M, Ulaner GA, Patel J, Tang J, Beer H, Selcuklu SD, Hanrahan AJ, Bouvier N, Melcer M, Murali R, Schram AM, Smyth LM, Jhaveri K, Li BT, Drilon A, Harding JJ, Iyer G, Taylor BS, Berger MF, Cutler RE Jr, Xu F, Butturini A, Eli LD, Mann G, Farrell C, Lalani AS, Bryce RP, Arteaga CL, Meric-Bernstam F, Baselga J, Solit DB.

Nature. 2018 Feb 8;554(7691):189-194. doi: 10.1038/nature25475. Epub 2018 Jan 31. Erratum in: Nature. 2019 Feb;566(7745):E11-E12.


Autologous stem cell transplant and combination immunotherapy of rituximab and interferon-α induces prolonged clinical and molecular remissions in patients with follicular lymphoma.

Smyth L, Buckstein R, Pennell N, Weerasinghe R, Cheung MC, Imrie K, Spaner D, Piliotis E, Chodirker L, Reis M, Ghorab Z, Zhang L, Boudreau V, Miliken A, Berinstein N.

Br J Haematol. 2019 Feb;184(3):469-472. doi: 10.1111/bjh.15118. Epub 2018 Jan 30. No abstract available.


Characterization of Diffuse Intrinsic Pontine Glioma Radiosensitivity using Synchrotron Microbeam Radiotherapy and Conventional Radiation Therapy In Vitro.

Smyth LM, Rogers PAW, Crosbie JC, Donoghue JF.

Radiat Res. 2018 Feb;189(2):146-155. doi: 10.1667/RR4633.1.


Hand hygiene "hall monitors": Leveraging the Hawthorne effect.

McDonald EG, Smyth E, Smyth L, Lee TC.

Am J Infect Control. 2018 Jun;46(6):706-707. doi: 10.1016/j.ajic.2017.11.030. Epub 2018 Feb 1.


Characterization of Diffuse Intrinsic Pontine Glioma Radiosensitivity using Synchrotron Microbeam Radiotherapy and Conventional Radiation Therapy In Vitro.

Smyth LM, Rogers PAW, Crosbie JC, Donoghue JF.

Radiat Res. 2017 Nov 30. doi: 10.1667/RR14633.1. [Epub ahead of print]


Corticosteroid treatment is associated with increased filamentous fungal burden in allergic fungal disease.

Fraczek MG, Chishimba L, Niven RM, Bromley M, Simpson A, Smyth L, Denning DW, Bowyer P.

J Allergy Clin Immunol. 2018 Aug;142(2):407-414. doi: 10.1016/j.jaci.2017.09.039. Epub 2017 Nov 6.


Risk adjusted therapy in chronic lymphocytic leukemia: a phase II cancer trials Ireland (CTRIAL-IE [ICORG 07-01]) study of fludarabine, cyclophosphamide, and rituximab therapy evaluating response adapted, abbreviated frontline therapy with FCR in non-del(17p) CLL.

Appleby N, O'Brien D, Quinn FM, Smyth L, Kelly J, Parker I, Scott K, Cahill MR, Crotty G, Enright H, Hennessy B, Hodgson A, Leahy M, O'Leary H, O'Dwyer M, Hayat A, Vandenberghe EA.

Leuk Lymphoma. 2018 Jun;59(6):1338-1347. doi: 10.1080/10428194.2017.1376746. Epub 2017 Sep 19.


Design and implementation of a custom next generation sequencing panel for selected vitamin D associated genes.

Benson KA, Chand S, Maxwell AP, Smyth LJ, Kilner J, Borrows R, McKnight AJ.

BMC Res Notes. 2017 Jul 28;10(1):348. doi: 10.1186/s13104-017-2664-z.


AKT Inhibition in Solid Tumors With AKT1 Mutations.

Hyman DM, Smyth LM, Donoghue MTA, Westin SN, Bedard PL, Dean EJ, Bando H, El-Khoueiry AB, Pérez-Fidalgo JA, Mita A, Schellens JHM, Chang MT, Reichel JB, Bouvier N, Selcuklu SD, Soumerai TE, Torrisi J, Erinjeri JP, Ambrose H, Barrett JC, Dougherty B, Foxley A, Lindemann JPO, McEwen R, Pass M, Schiavon G, Berger MF, Chandarlapaty S, Solit DB, Banerji U, Baselga J, Taylor BS.

J Clin Oncol. 2017 Jul 10;35(20):2251-2259. doi: 10.1200/JCO.2017.73.0143. Epub 2017 May 10. Erratum in: J Clin Oncol. 2019 Feb 1;37(4):360.


Effect of day of the week on short- and long-term mortality after emergency general surgery.

Gillies MA, Lone NI, Pearse RM, Haddow C, Smyth L, Parks RW, Walsh TS, Harrison EM.

Br J Surg. 2017 Jun;104(7):936-945. doi: 10.1002/bjs.10507. Epub 2017 Mar 21.


A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel.

Smyth LM, Monson KR, Jhaveri K, Drilon A, Li BT, Abida W, Iyer G, Gerecitano JF, Gounder M, Harding JJ, Voss MH, Makker V, Ho AL, Razavi P, Iasonos A, Bialer P, Lacouture ME, Teitcher JB, Erinjeri JP, Katabi N, Fury MG, Hyman DM.

Invest New Drugs. 2017 Dec;35(6):742-750. doi: 10.1007/s10637-017-0445-0. Epub 2017 Mar 9.


Pathologic Complete Response with Neoadjuvant Doxorubicin and Cyclophosphamide Followed by Paclitaxel with Trastuzumab and Pertuzumab in Patients with HER2-Positive Early Stage Breast Cancer: A Single Center Experience.

Singh JC, Mamtani A, Barrio A, Morrow M, Sugarman S, Jones LW, Yu AF, Argolo D, Smyth LM, Modi S, Schweber S, Boafo C, Patil S, Norton L, Baselga J, Hudis CA, Dang C.

Oncologist. 2017 Feb;22(2):139-143. doi: 10.1634/theoncologist.2016-0268. Epub 2017 Feb 6.


Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance.

Smyth LA, Meader L, Xiao F, Woodward M, Brady HJ, Lechler R, Lombardi G.

Clin Exp Immunol. 2017 May;188(2):219-225. doi: 10.1111/cei.12931. Epub 2017 Mar 2.


Transient myeloproliferative disorder in an infant with PTPN11 mutation.

Malone A, Wlodarski M, Nolan B, Smyth L, Smith OP.

Br J Haematol. 2017 Apr;177(1):11. doi: 10.1111/bjh.14517. Epub 2017 Jan 20. No abstract available.


Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study.

Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, Parks R, Walsh TS, Lone NI.

Br J Anaesth. 2017 Jan;118(1):123-131. doi: 10.1093/bja/aew396.


Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

Boardman DA, Philippeos C, Fruhwirth GO, Ibrahim MA, Hannen RF, Cooper D, Marelli-Berg FM, Watt FM, Lechler RI, Maher J, Smyth LA, Lombardi G.

Am J Transplant. 2017 Apr;17(4):931-943. doi: 10.1111/ajt.14185. Epub 2017 Feb 1.


Brain Pericytes As Mediators of Neuroinflammation.

Rustenhoven J, Jansson D, Smyth LC, Dragunow M.

Trends Pharmacol Sci. 2017 Mar;38(3):291-304. doi: 10.1016/ Epub 2016 Dec 22. Review.


Treg therapy in transplantation: a general overview.

Romano M, Tung SL, Smyth LA, Lombardi G.

Transpl Int. 2017 Aug;30(8):745-753. doi: 10.1111/tri.12909. Epub 2017 Feb 6. Review.


What Is Direct Allorecognition?

Boardman DA, Jacob J, Smyth LA, Lombardi G, Lechler RI.

Curr Transplant Rep. 2016;3(4):275-283. Epub 2016 Oct 7. Review.


Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.

Jansson D, Scotter EL, Rustenhoven J, Coppieters N, Smyth LC, Oldfield RL, Bergin PS, Mee EW, Graham ES, Faull RL, Dragunow M.

J Neuroinflammation. 2016 Sep 21;13(1):249.


The disorganized family: institutions, practices and normativity.

Smyth L.

Br J Sociol. 2016 Dec;67(4):678-696. doi: 10.1111/1468-4446.12217. Epub 2016 Sep 14.


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