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The 'connectaholic' behind the curtain: medical student use of computer devices in the clinical setting and the influence of patients.

Clarke E, Burns J, Bruen C, Crehan M, Smyth E, Pawlikowska T.

BMC Med Educ. 2019 Oct 17;19(1):376. doi: 10.1186/s12909-019-1811-8.


ctDNA in gastric and gastroesophageal cancer: prognostic, predictive or preliminary?

Frankell AM, Smyth EC.

Clin Cancer Res. 2019 Oct 3. pii: clincanres.2774.2019. doi: 10.1158/1078-0432.CCR-19-2774. [Epub ahead of print]


Nivolumab for previously treated squamous oesophageal carcinoma.

Smyth EC, Lordick F.

Lancet Oncol. 2019 Sep 27. pii: S1470-2045(19)30621-7. doi: 10.1016/S1470-2045(19)30621-7. [Epub ahead of print] No abstract available.


Individual Patient Data Meta-Analysis of the Value of Microsatellite Instability As a Biomarker in Gastric Cancer.

Pietrantonio F, Miceli R, Raimondi A, Kim YW, Kang WK, Langley RE, Choi YY, Kim KM, Nankivell MG, Morano F, Wotherspoon A, Valeri N, Kook MC, An JY, Grabsch HI, Fucà G, Noh SH, Sohn TS, Kim S, Di Bartolomeo M, Cunningham D, Lee J, Cheong JH, Smyth EC.

J Clin Oncol. 2019 Sep 12:JCO1901124. doi: 10.1200/JCO.19.01124. [Epub ahead of print]


Late-line treatment in metastatic gastric cancer: today and tomorrow.

Smyth EC, Moehler M.

Ther Adv Med Oncol. 2019 Aug 28;11:1758835919867522. doi: 10.1177/1758835919867522. eCollection 2019. Review.


Gastric cancer: Translating novels concepts into clinical practice.

Salati M, Orsi G, Smyth E, Beretta G, De Vita F, Di Bartolomeo M, Fanotto V, Lonardi S, Morano F, Pietrantonio F, Pinto C, Rimassa L, Vasile E, Vivaldi C, Zaniboni A, Ziranu P, Cascinu S.

Cancer Treat Rev. 2019 Sep;79:101889. doi: 10.1016/j.ctrv.2019.101889. Epub 2019 Aug 14. Review.


Pathological Tumor Regression Grade Classifications in Gastrointestinal Cancers: Role on Patients' Prognosis.

Fanelli GN, Loupakis F, Smyth E, Scarpa M, Lonardi S, Pucciarelli S, Munari G, Rugge M, Valeri N, Fassan M.

Int J Surg Pathol. 2019 Aug 16:1066896919869477. doi: 10.1177/1066896919869477. [Epub ahead of print]


The A.L.A.N. score identifies prognostic classes in advanced biliary cancer patients receiving first-line chemotherapy.

Salati M, Caputo F, Cunningham D, Marcheselli L, Spallanzani A, Rimini M, Gelsomino F, Reggiani-Bonetti L, Andrikou K, Rovinelli F, Smyth E, Baratelli C, Kouvelakis K, Kalaitzaki R, Gillbanks A, Michalarea V, Cascinu S, Braconi C.

Eur J Cancer. 2019 Aug;117:84-90. doi: 10.1016/j.ejca.2019.05.030. Epub 2019 Jul 2.


Quality assurance of surgery in the randomized ST03 trial of perioperative chemotherapy in carcinoma of the stomach and gastro-oesophageal junction.

Allum WH, Smyth EC, Blazeby JM, Grabsch HI, Griffin SM, Rowley S, Cafferty FH, Langley RE, Cunningham D.

Br J Surg. 2019 Aug;106(9):1204-1215. doi: 10.1002/bjs.11184. Epub 2019 Jul 3.


Safety and Efficacy of the Addition of Lapatinib to Perioperative Chemotherapy for Resectable HER2-Positive Gastroesophageal Adenocarcinoma: A Randomized Phase 2 Clinical Trial.

Smyth EC, Rowley S, Cafferty FH, Allum W, Grabsch HI, Stenning S, Wotherspoon A, Alderson D, Crosby T, Mansoor W, Waters JS, Neville-Webbe H, Darby S, Dent J, Seymour M, Thompson J, Sothi S, Blazeby J, Langley RE, Cunningham D.

JAMA Oncol. 2019 Jun 20. doi: 10.1001/jamaoncol.2019.1179. [Epub ahead of print]


Social networks for young patients with cancer: the time for system agility.

Ben-Aharon I, Goshen-Lago T, Fontana E, Smyth E, Guren M, Caballero C, Lordick F.

Lancet Oncol. 2019 Jun;20(6):765. doi: 10.1016/S1470-2045(19)30346-8. No abstract available. Erratum in: Lancet Oncol. 2019 Jul;20(7):e346.


More is not always better: triplet chemotherapy and advanced gastric cancer.

Fokter-Dovnik N, Smyth EC.

Lancet Gastroenterol Hepatol. 2019 Jul;4(7):490-491. doi: 10.1016/S2468-1253(19)30145-1. Epub 2019 May 14. No abstract available.


Treatment patterns, survival and economic outcomes in Medicare-enrolled, older patients with HR+/HER2- metastatic breast cancer.

Goyal RK, Carter GC, Nagar SP, Smyth EN, Price GL, Huang YJ, Li L, Davis KL, Kaye JA.

Curr Med Res Opin. 2019 Oct;35(10):1699-1710. doi: 10.1080/03007995.2019.1615422. Epub 2019 Jun 12.


Injury prevention strategies specific to pre-elite athletes competing in Olympic and professional sports - A systematic review.

Smyth EA, Newman P, Waddington G, Weissensteiner JR, Drew MK.

J Sci Med Sport. 2019 Aug;22(8):887-901. doi: 10.1016/j.jsams.2019.03.002. Epub 2019 Mar 12. Review.


The 4th St. Gallen EORTC Gastrointestinal Cancer Conference: Controversial issues in the multimodal primary treatment of gastric, junctional and oesophageal adenocarcinoma.

Lutz MP, Zalcberg JR, Ducreux M, Adenis A, Allum W, Aust D, Carneiro F, Grabsch HI, Laurent-Puig P, Lordick F, Möhler M, Mönig S, Obermannova R, Piessen G, Riddell A, Röcken C, Roviello F, Schneider PM, Seewald S, Smyth E, van Cutsem E, Verheij M, Wagner AD, Otto F.

Eur J Cancer. 2019 May;112:1-8. doi: 10.1016/j.ejca.2019.01.106. Epub 2019 Mar 15. Review.


Pseudoprogression on treatment with immune-checkpoint inhibitors in patients with gastrointestinal malignancies: Case series and short literature review.

Michalarea V, Fontana E, Garces AI, Williams A, Smyth EC, Picchia S, Rao S, Chau I, Cunningham D, Bali MA.

Curr Probl Cancer. 2019 Feb 21. pii: S0147-0272(18)30318-0. doi: 10.1016/j.currproblcancer.2019.01.008. [Epub ahead of print]


Quenching by sodium thiosulfate does not influence 16S rRNA gene sequencing profiles of reclaimed water from three sites in the Mid-Atlantic, United States.

Allard SM, Solaiman S, Callahan MT, Bui A, Craddock H, Haymaker J, Foust D, Duncan R, Smyth E, Mongodin EF, Hashem F, May E, Micallef SA, Sapkota AR.

Environ Res. 2019 May;172:296-300. doi: 10.1016/j.envres.2019.02.022. Epub 2019 Feb 15.


Little cigars and cigarillos harbor diverse bacterial communities that differ between the tobacco and the wrapper.

Chattopadhyay S, Smyth EM, Kulkarni P, Babik KR, Reid M, Hittle LE, Clark PI, Mongodin EF, Sapkota AR.

PLoS One. 2019 Feb 22;14(2):e0211705. doi: 10.1371/journal.pone.0211705. eCollection 2019.


Pharmacological impact of antiretroviral therapy on platelet function to investigate human immunodeficiency virus-associated cardiovascular risk.

Taylor KA, Smyth E, Rauzi F, Cerrone M, Khawaja AA, Gazzard B, Nelson M, Boffito M, Emerson M.

Br J Pharmacol. 2019 Apr;176(7):879-889. doi: 10.1111/bph.14589. Epub 2019 Mar 14.


Genomic loss of heterozygosity and survival in the REAL3 trial.

Smyth EC, Cafferkey C, Loehr A, Waddell T, Begum R, Peckitt C, Harding TC, Nguyen M, Okines AF, Raponi M, Rao S, Watkins D, Starling N, Middleton GW, Wadsley J, Mansoor W, Crosby T, Wotherspoon A, Chau I, Cunningham D.

Oncotarget. 2018 Nov 30;9(94):36654-36665. doi: 10.18632/oncotarget.26336. eCollection 2018 Nov 30.


Immune Checkpoint Inhibitors in the Treatment of Gastroesophageal Cancer.

Chénard-Poirier M, Smyth EC.

Drugs. 2019 Jan;79(1):1-10. doi: 10.1007/s40265-018-1032-1. Review.


Food for thought. Malnutrition risk associated with increased risk of healthcare-associated infection.

Fitzpatrick F, Skally M, O'Hanlon C, Foley M, Houlihan J, Gaughan L, Smith O, Moore B, Cunneen S, Sweeney E, Dinesh B, O'Connell K, Smyth E, Humphreys H, Burns K.

J Hosp Infect. 2019 Mar;101(3):300-304. doi: 10.1016/j.jhin.2018.12.012. Epub 2018 Dec 25.


Two steps forward and one step back.

Lordick F, Smyth EC.

Nat Rev Clin Oncol. 2019 Feb;16(2):69-70. doi: 10.1038/s41571-018-0154-4. No abstract available.


Dialysis independence following single-agent daratumumab in refractory myeloma with renal failure.

Smyth E, Glavey S, Melotti D, Thornton P, Sargent J, Conlon P, Murphy P, Quinn J.

Ir J Med Sci. 2019 Aug;188(3):1079-1080. doi: 10.1007/s11845-018-1951-6. Epub 2018 Dec 19. No abstract available.


Chemotherapy and novel targeted therapies for operable esophageal and gastroesophageal junctional cancer.

van den Ende T, Smyth E, Hulshof MCCM, van Laarhoven HWM.

Best Pract Res Clin Gastroenterol. 2018 Oct - Dec;36-37:45-52. doi: 10.1016/j.bpg.2018.11.005. Epub 2018 Nov 22. Review.


A seven-Gene Signature assay improves prognostic risk stratification of perioperative chemotherapy treated gastroesophageal cancer patients from the MAGIC trial.

Smyth EC, Nyamundanda G, Cunningham D, Fontana E, Ragulan C, Tan IB, Lin SJ, Wotherspoon A, Nankivell M, Fassan M, Lampis A, Hahne JC, Davies AR, Lagergren J, Gossage JA, Maisey N, Green M, Zylstra JL, Allum WH, Langley RE, Tan P, Valeri N, Sadanandam A.

Ann Oncol. 2018 Dec 1;29(12):2356-2362. doi: 10.1093/annonc/mdy407.


Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic gastric cancer: a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS.

Muro K, Van Cutsem E, Narita Y, Pentheroudakis G, Baba E, Li J, Ryu MH, Zamaniah WIW, Yong WP, Yeh KH, Kato K, Lu Z, Cho BC, Nor IM, Ng M, Chen LT, Nakajima TE, Shitara K, Kawakami H, Tsushima T, Yoshino T, Lordick F, Martinelli E, Smyth EC, Arnold D, Minami H, Tabernero J, Douillard JY.

Ann Oncol. 2019 Jan 1;30(1):19-33. doi: 10.1093/annonc/mdy502.


Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with metastatic oesophageal cancer: a JSMO-ESMO initiative endorsed by CSCO, KSMO, MOS, SSO and TOS.

Muro K, Lordick F, Tsushima T, Pentheroudakis G, Baba E, Lu Z, Cho BC, Nor IM, Ng M, Chen LT, Kato K, Li J, Ryu MH, Zamaniah WIW, Yong WP, Yeh KH, Nakajima TE, Shitara K, Kawakami H, Narita Y, Yoshino T, Van Cutsem E, Martinelli E, Smyth EC, Arnold D, Minami H, Tabernero J, Douillard JY.

Ann Oncol. 2019 Jan 1;30(1):34-43. doi: 10.1093/annonc/mdy498.


Gut microbiota-dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes.

Bromberg JS, Hittle L, Xiong Y, Saxena V, Smyth EM, Li L, Zhang T, Wagner C, Fricke WF, Simon T, Brinkman CC, Mongodin EF.

JCI Insight. 2018 Oct 4;3(19). pii: 121045. doi: 10.1172/jci.insight.121045.


Value of a hospital-wide point prevalence survey of carbapenemase-producing Enterobacterales - low-level prevalence confirmed.

Cafferkey J, Skally M, Finn C, Donlon S, Fitzpatrick M, Burns K, O'Connell K, Fitzpatrick F, Smyth E, Humphreys H.

J Hosp Infect. 2019 Feb;101(2):191-194. doi: 10.1016/j.jhin.2018.09.004. Epub 2018 Sep 17. No abstract available.


Immunotherapy is not for all comers in chemotherapy-refractory advanced gastric cancer. Better predictive biomarkers are needed.

Smyth EC, Cervantes A.

Ann Oncol. 2018 Oct 1;29(10):2027-2028. doi: 10.1093/annonc/mdy331. No abstract available.


MUC16 Mutations and Prognosis in Gastric Cancer: A Little Goes a Long Way.

Smyth EC, Fitzgerald RC.

JAMA Oncol. 2018 Dec 1;4(12):1698-1699. doi: 10.1001/jamaoncol.2018.2803. No abstract available.


Job satisfaction and career intentions of registered nurses in primary health care: an integrative review.

Halcomb E, Smyth E, McInnes S.

BMC Fam Pract. 2018 Aug 7;19(1):136. doi: 10.1186/s12875-018-0819-1. Review.


Lymph node regression and survival following neoadjuvant chemotherapy in oesophageal adenocarcinoma.

Davies AR, Myoteri D, Zylstra J, Baker CR, Wulaningsih W, Van Hemelrijck M, Maisey N, Allum WH, Smyth E, Gossage JA, Lagergren J, Cunningham D, Green M; Guy's and St Thomas' Oesophago-Gastric Research Group and PROGRESS Study Group.

Br J Surg. 2018 Nov;105(12):1639-1649. doi: 10.1002/bjs.10900. Epub 2018 Jul 26.


Paradoxical Bactericidal Effects of Hydrophobic Lung Surfactant Proteins and Their Peptide Mimics Using Liposome Molecular Trojan.

Dutta K, Nag K, Booth V, Smyth E, Dueck H, Fritzen-Garcia M, Ghosh C, Panda AK.

J Oleo Sci. 2018 Aug 1;67(8):1043-1057. doi: 10.5650/jos.ess18026. Epub 2018 Jul 17.


Treatment patterns and health care resource use in patients receiving multiple lines of therapy for metastatic squamous cell carcinoma of the head and neck in the United Kingdom.

La EM, Smyth EN, Talbird SE, Li L, Kaye JA, Lin AB, Bowman L.

Eur J Cancer Care (Engl). 2018 Sep;27(5):e12862. doi: 10.1111/ecc.12862. Epub 2018 Jun 21.


Translational research and application of basic biology to clinical trial development in GI cancers.

Smyth E, Khan K, Valeri N.

Ann Transl Med. 2018 May;6(9):164. doi: 10.21037/atm.2018.05.05. Review.


Sensory dominance and multisensory integration as screening tools in aging.

Murray MM, Eardley AF, Edginton T, Oyekan R, Smyth E, Matusz PJ.

Sci Rep. 2018 Jun 11;8(1):8901. doi: 10.1038/s41598-018-27288-2.


Pembrolizumab versus paclitaxel in gastro-oesophageal adenocarcinoma.

Smyth EC, Petty RD.

Lancet. 2018 Jul 14;392(10142):97-98. doi: 10.1016/S0140-6736(18)31277-7. Epub 2018 Jun 4. No abstract available.


Peri-operative therapy for operable gastroesophageal adenocarcinoma: past, present and future.

Aggelis V, Cunningham D, Lordick F, Smyth EC.

Ann Oncol. 2018 Jun 1;29(6):1377-1385. doi: 10.1093/annonc/mdy183.


COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer.

Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG.

Oncogene. 2018 Aug;37(34):4735-4749. doi: 10.1038/s41388-018-0318-9. Epub 2018 May 16.


Intestinal failure: the evolving demographic and patient outcomes on home parenteral nutrition.

Brown SK, Davies N, Smyth E, Heather N, Cole C, Keys SC, Beattie RM, Batra A.

Acta Paediatr. 2018 Dec;107(12):2207-2211. doi: 10.1111/apa.14401. Epub 2018 Jun 8.


Reducing challenging behaviour of adults with intellectual disabilities in supported accommodation: A cluster randomized controlled trial of setting-wide positive behaviour support.

McGill P, Vanono L, Clover W, Smyth E, Cooper V, Hopkins L, Barratt N, Joyce C, Henderson K, Sekasi S, Davis S, Deveau R.

Res Dev Disabil. 2018 Oct;81:143-154. doi: 10.1016/j.ridd.2018.04.020. Epub 2018 May 8.


Immune Checkpoint Inhibition in Gastro-Oesophageal Cancer.

Smyth E, Thuss-Patience PC.

Oncol Res Treat. 2018;41(5):272-280. doi: 10.1159/000489099. Epub 2018 Apr 27. Review.


Plant controls on Late Quaternary whole ecosystem structure and function.

Jeffers ES, Whitehouse NJ, Lister A, Plunkett G, Barratt P, Smyth E, Lamb P, Dee MW, Brooks SJ, Willis KJ, Froyd CA, Watson JE, Bonsall MB.

Ecol Lett. 2018 Jun;21(6):814-825. doi: 10.1111/ele.12944. Epub 2018 Mar 30.


Synchronous metastatic gastric cancer-molecular background and clinical implications with special attention to mismatch repair deficiency.

Polom K, Böger C, Smyth E, Marrelli D, Behrens HM, Marano L, Becker T, Lordick F, Röcken C, Roviello F.

Eur J Surg Oncol. 2018 May;44(5):626-631. doi: 10.1016/j.ejso.2018.02.208. Epub 2018 Mar 2.


An interdisciplinary approach to improve surgical antimicrobial prophylaxis.

Conaty O, Gaughan L, Downey C, Carolan N, Brophy MJ, Kavanagh R, McNamara DAA, Smyth E, Burns K, Fitzpatrick F.

Int J Health Care Qual Assur. 2018 Mar 12;31(2):162-172. doi: 10.1108/IJHCQA-05-2017-0078.


Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández-Mateos J, Khan K, Lampis A, Eason K, Huntingford I, Burke R, Rata M, Koh DM, Tunariu N, Collins D, Hulkki-Wilson S, Ragulan C, Spiteri I, Moorcraft SY, Chau I, Rao S, Watkins D, Fotiadis N, Bali M, Darvish-Damavandi M, Lote H, Eltahir Z, Smyth EC, Begum R, Clarke PA, Hahne JC, Dowsett M, de Bono J, Workman P, Sadanandam A, Fassan M, Sansom OJ, Eccles S, Starling N, Braconi C, Sottoriva A, Robinson SP, Cunningham D, Valeri N.

Science. 2018 Feb 23;359(6378):920-926. doi: 10.1126/science.aao2774.


Prognostic value of pathological lymph node status and primary tumour regression grading following neoadjuvant chemotherapy - results from the MRC OE02 oesophageal cancer trial.

Davarzani N, Hutchins GGA, West NP, Hewitt LC, Nankivell M, Cunningham D, Allum WH, Smyth E, Valeri N, Langley RE, Grabsch HI.

Histopathology. 2018 Jun;72(7):1180-1188. doi: 10.1111/his.13491. Epub 2018 Mar 25.


Hand hygiene "hall monitors": Leveraging the Hawthorne effect.

McDonald EG, Smyth E, Smyth L, Lee TC.

Am J Infect Control. 2018 Jun;46(6):706-707. doi: 10.1016/j.ajic.2017.11.030. Epub 2018 Feb 1.


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