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Items: 1 to 50 of 101

1.

Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.

de Rubio RG, Ransom RF, Malik S, Yule DI, Anantharam A, Smrcka AV.

Sci Signal. 2018 Sep 11;11(547). pii: eaan1210. doi: 10.1126/scisignal.aan1210.

PMID:
30206135
2.

Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes.

Nash CA, Brown LM, Malik S, Cheng X, Smrcka AV.

J Mol Cell Cardiol. 2018 Aug;121:51-59. doi: 10.1016/j.yjmcc.2018.06.002. Epub 2018 Jun 7.

PMID:
29885334
3.

G protein βγ subunits directly interact with and activate phospholipase Cϵ.

Madukwe JC, Garland-Kuntz EE, Lyon AM, Smrcka AV.

J Biol Chem. 2018 Apr 27;293(17):6387-6397. doi: 10.1074/jbc.RA118.002354. Epub 2018 Mar 13.

PMID:
29535186
4.

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5.

Stoveken HM, Larsen SD, Smrcka AV, Tall GG.

Mol Pharmacol. 2018 May;93(5):477-488. doi: 10.1124/mol.117.111476. Epub 2018 Feb 23.

PMID:
29476042
5.

Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration.

To JY, Smrcka AV.

J Biol Chem. 2018 Feb 2;293(5):1570-1578. doi: 10.1074/jbc.RA117.000964. Epub 2017 Dec 19.

PMID:
29259127
6.

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.

Kim KD, Bae S, Capece T, Nedelkovska H, de Rubio RG, Smrcka AV, Jun CD, Jung W, Park B, Kim TI, Kim M.

Nat Commun. 2017 May 15;8:15365. doi: 10.1038/ncomms15365.

7.

PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation.

Strazza M, Azoulay-Alfaguter I, Peled M, Smrcka AV, Skolnik EY, Srivastava S, Mor A.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2693-2698. doi: 10.1073/pnas.1612900114. Epub 2017 Feb 17.

8.

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.

Tong J, Liu X, Vickstrom C, Li Y, Yu L, Lu Y, Smrcka AV, Liu QS.

J Neurosci. 2017 Mar 15;37(11):3030-3044. doi: 10.1523/JNEUROSCI.2810-16.2017. Epub 2017 Feb 16.

9.

Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.

DiStefano PV, Smrcka AV, Glading AJ.

PLoS One. 2016 Sep 9;11(9):e0162338. doi: 10.1371/journal.pone.0162338. eCollection 2016.

10.

Phospholipase C-ε signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury.

Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A.

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L517-24. doi: 10.1152/ajplung.00069.2016. Epub 2016 Jul 1.

11.

Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist.

Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG.

Mol Pharmacol. 2016 Sep;90(3):214-24. doi: 10.1124/mol.116.104828. Epub 2016 Jun 23.

12.

Inhibition of G Protein βγ Subunit Signaling Abrogates Nephritis in Lupus-Prone Mice.

Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH.

Arthritis Rheumatol. 2016 Sep;68(9):2244-56. doi: 10.1002/art.39673.

13.

Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ.

Surve CR, To JY, Malik S, Kim M, Smrcka AV.

Sci Signal. 2016 Feb 23;9(416):ra22. doi: 10.1126/scisignal.aad8163.

PMID:
26905427
14.

Fingerprinting G protein-coupled receptor signaling.

Smrcka AV.

Sci Signal. 2015 Dec 1;8(405):fs20. doi: 10.1126/scisignal.aad8140.

PMID:
26628679
15.

Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 and Ras-associating domains of phospholipase Cϵ.

Dusaban SS, Kunkel MT, Smrcka AV, Brown JH.

J Biol Chem. 2015 Oct 30;290(44):26776-83. doi: 10.1074/jbc.M115.676098. Epub 2015 Sep 8.

16.

Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites.

Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW.

Mol Pharmacol. 2015 Oct;88(4):758-67. doi: 10.1124/mol.115.099556. Epub 2015 Jul 23.

17.

Regulation of phosphatidylinositol-specific phospholipase C at the nuclear envelope in cardiac myocytes.

Smrcka AV.

J Cardiovasc Pharmacol. 2015 Mar;65(3):203-10. doi: 10.1097/FJC.0000000000000195. Review.

18.

G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway.

Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV.

Mol Biol Cell. 2015 Mar 15;26(6):1188-98. doi: 10.1091/mbc.E14-10-1476. Epub 2015 Jan 21.

19.

Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents.

Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J.

J Immunol. 2014 Oct 1;193(7):3803-15. doi: 10.4049/jimmunol.1400571. Epub 2014 Sep 3.

20.

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.

Oldenburger A, Timens W, Bos S, Smit M, Smrcka AV, Laurent AC, Cao J, Hylkema M, Meurs H, Maarsingh H, Lezoualc'h F, Schmidt M.

FASEB J. 2014 Nov;28(11):4617-28. doi: 10.1096/fj.13-248930. Epub 2014 Aug 7.

21.

A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.

Surve CR, Lehmann D, Smrcka AV.

J Biol Chem. 2014 Jun 20;289(25):17791-801. doi: 10.1074/jbc.M114.576827. Epub 2014 May 7.

22.

Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression.

Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC.

J Am Coll Cardiol. 2014 Jun 17;63(23):2549-2557. doi: 10.1016/j.jacc.2014.02.587. Epub 2014 Apr 2.

23.

M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency.

Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV.

J Biol Chem. 2014 Apr 18;289(16):11206-18. doi: 10.1074/jbc.M113.538546. Epub 2014 Mar 4.

24.

PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.

Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Heller Brown J.

Sci Signal. 2013 Dec 17;6(306):ra108. doi: 10.1126/scisignal.2004405.

25.

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z.

FASEB J. 2014 Feb;28(2):880-90. doi: 10.1096/fj.13-234997. Epub 2013 Nov 18.

26.

WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes.

Sun Z, Smrcka AV, Chen S.

J Biol Chem. 2013 Jun 7;288(23):16715-25. doi: 10.1074/jbc.M113.462564. Epub 2013 Apr 26.

27.

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.

Smrcka AV.

Trends Pharmacol Sci. 2013 May;34(5):290-8. doi: 10.1016/j.tips.2013.02.006. Epub 2013 Apr 1. Review.

28.

Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV.

Cell. 2013 Mar 28;153(1):216-27. doi: 10.1016/j.cell.2013.02.047.

29.

Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.

Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3609-14. doi: 10.1073/pnas.1217355110. Epub 2013 Feb 11.

30.

G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.

31.

Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.

McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR.

Cell Signal. 2012 Jun;24(6):1351-60. doi: 10.1016/j.cellsig.2012.01.011. Epub 2012 Jan 28.

32.

Role of phospholipase Cε in physiological phosphoinositide signaling networks.

Smrcka AV, Brown JH, Holz GG.

Cell Signal. 2012 Jun;24(6):1333-43. doi: 10.1016/j.cellsig.2012.01.009. Epub 2012 Jan 20. Review.

33.

Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting.

Lin Y, Smrcka AV.

Mol Pharmacol. 2011 Oct;80(4):551-7. doi: 10.1124/mol.111.073072. Epub 2011 Jul 7. Review.

34.

Direct-reversible binding of small molecules to G protein βγ subunits.

Seneviratne AM, Burroughs M, Giralt E, Smrcka AV.

Biochim Biophys Acta. 2011 Sep;1814(9):1210-8. doi: 10.1016/j.bbapap.2011.05.010. Epub 2011 May 18.

35.

Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes.

Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV.

J Biol Chem. 2011 Jul 1;286(26):23012-21. doi: 10.1074/jbc.M111.231993. Epub 2011 May 5.

36.

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans.

Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG.

Islets. 2011 May-Jun;3(3):121-8. Epub 2011 May 1.

37.

Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits.

Kamal FA, Smrcka AV, Blaxall BC.

J Mol Cell Cardiol. 2011 Oct;51(4):462-7. doi: 10.1016/j.yjmcc.2011.01.006. Epub 2011 Jan 21. Review.

38.

Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf).

Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG.

J Biol Chem. 2011 Jan 28;286(4):2625-35. doi: 10.1074/jbc.M110.178897. Epub 2010 Nov 29.

39.

Conformational flexibility and binding interactions of the G protein βγ heterodimer.

Park MS, Smrcka AV, Stern HA.

Proteins. 2011 Feb;79(2):518-27. doi: 10.1002/prot.22899.

40.

Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.

J Physiol. 2010 Dec 15;588(Pt 24):4871-89. doi: 10.1113/jphysiol.2010.198424. Epub 2010 Nov 1. Erratum in: J Physiol. 2012 Mar 15;590(Pt 6):1511.

41.

Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes.

Gaudy AM, Clementi AH, Campbell JS, Smrcka AV, Mooney RA.

J Biol Chem. 2010 Dec 31;285(53):41356-65. doi: 10.1074/jbc.M110.159111. Epub 2010 Oct 26.

42.

Rational design of a selective covalent modifier of G protein βγ subunits.

Dessal AL, Prades R, Giralt E, Smrcka AV.

Mol Pharmacol. 2011 Jan;79(1):24-33. doi: 10.1124/mol.110.068155. Epub 2010 Sep 29.

43.

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.

Casey LM, Pistner AR, Belmonte SL, Migdalovich D, Stolpnik O, Nwakanma FE, Vorobiof G, Dunaevsky O, Matavel A, Lopes CM, Smrcka AV, Blaxall BC.

Circ Res. 2010 Aug 20;107(4):532-9. doi: 10.1161/CIRCRESAHA.110.217075. Epub 2010 Jun 24.

44.

NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes.

Smrcka AV, Kichik N, Tarragó T, Burroughs M, Park MS, Itoga NK, Stern HA, Willardson BM, Giralt E.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):639-44. doi: 10.1073/pnas.0909503107. Epub 2009 Dec 16.

45.

Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1.

Serasinghe MN, Seneviratne AM, Smrcka AV, Yoon Y.

J Biol Chem. 2010 Jan 1;285(1):620-30. doi: 10.1074/jbc.M109.027508. Epub 2009 Oct 28.

46.

Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.

Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D.

J Biol Chem. 2009 Oct 16;284(42):28599-606. doi: 10.1074/jbc.M109.047282. Epub 2009 Aug 27.

47.

Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits.

Park MS, Dessal AL, Smrcka AV, Stern HA.

J Chem Inf Model. 2009 Feb;49(2):437-43. doi: 10.1021/ci800384q.

48.
49.

Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.

Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV.

J Biol Chem. 2009 Jan 16;284(3):1514-22. doi: 10.1074/jbc.M806994200. Epub 2008 Oct 27.

50.

G protein betagamma subunits as targets for small molecule therapeutic development.

Smrcka AV, Lehmann DM, Dessal AL.

Comb Chem High Throughput Screen. 2008 Jun;11(5):382-95. Review.

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