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Items: 30


Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity.

Arunsan P, Ittiprasert W, Smout MJ, Cochran CJ, Mann VH, Chaiyadet S, Karinshak SE, Sripa B, Young ND, Sotillo J, Loukas A, Brindley PJ, Laha T.

Elife. 2019 Jan 15;8. pii: e41463. doi: 10.7554/eLife.41463.


Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties.

Wangchuk P, Apte SH, Smout MJ, Groves PL, Loukas A, Doolan DL.

Int J Mol Sci. 2018 Nov 6;19(11). pii: E3490. doi: 10.3390/ijms19113490.


Structural Variants of a Liver Fluke Derived Granulin Peptide Potently Stimulate Wound Healing.

Dastpeyman M, Bansal PS, Wilson D, Sotillo J, Brindley PJ, Loukas A, Smout MJ, Daly NL.

J Med Chem. 2018 Oct 11;61(19):8746-8753. doi: 10.1021/acs.jmedchem.8b00898. Epub 2018 Sep 24.


Structural Characterisation of Predicted Helical Regions in the Chironex fleckeri CfTX-1 Toxin.

Andreosso A, Bansal PS, Smout MJ, Wilson D, Seymour JE, Daly NL.

Mar Drugs. 2018 Jun 7;16(6). pii: E201. doi: 10.3390/md16060201.


Developmental Sensitivity in Schistosoma mansoni to Puromycin To Establish Drug Selection of Transgenic Schistosomes.

Yan HB, Smout MJ, Ju C, Folley AE, Skinner DE, Mann VH, Loukas A, Hu W, Brindley PJ, Rinaldi G.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02568-17. doi: 10.1128/AAC.02568-17. Print 2018 Aug.


Granulin Secreted by the Food-Borne Liver Fluke Opisthorchis viverrini Promotes Angiogenesis in Human Endothelial Cells.

Haugen B, Karinshak SE, Mann VH, Popratiloff A, Loukas A, Brindley PJ, Smout MJ.

Front Med (Lausanne). 2018 Feb 16;5:30. doi: 10.3389/fmed.2018.00030. eCollection 2018.


Mission Accomplished? We Need a Guide to the 'Post Release' World of Wolbachia for Aedes-borne Disease Control.

Ritchie SA, van den Hurk AF, Smout MJ, Staunton KM, Hoffmann AA.

Trends Parasitol. 2018 Mar;34(3):217-226. doi: 10.1016/ Epub 2018 Jan 23. Review.


Spine-bellied sea snake (Hydrophis curtus) venom shows greater skeletal myotoxicity compared with cardiac myotoxicity.

Neale V, Smout MJ, Seymour JE.

Toxicon. 2018 Mar 1;143:108-117. doi: 10.1016/j.toxicon.2018.01.009. Epub 2018 Jan 31.


Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases.

Sundaraneedi MK, Tedla BA, Eichenberger RM, Becker L, Pickering D, Smout MJ, Rajan S, Wangchuk P, Keene FR, Loukas A, Collins JG, Pearson MS.

PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006134. doi: 10.1371/journal.pntd.0006134. eCollection 2017 Dec.


Conotoxin Φ-MiXXVIIA from the Superfamily G2 Employs a Novel Cysteine Framework that Mimics Granulin and Displays Anti-Apoptotic Activity.

Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14973-14976. doi: 10.1002/anie.201708927. Epub 2017 Oct 24.


Development of a Potent Wound Healing Agent Based on the Liver Fluke Granulin Structural Fold.

Bansal PS, Smout MJ, Wilson D, Cobos Caceres C, Dastpeyman M, Sotillo J, Seifert J, Brindley PJ, Loukas A, Daly NL.

J Med Chem. 2017 May 25;60(10):4258-4266. doi: 10.1021/acs.jmedchem.7b00047. Epub 2017 May 3.


Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms.

Wangchuk P, Giacomin PR, Pearson MS, Smout MJ, Loukas A.

Sci Rep. 2016 Aug 30;6:32101. doi: 10.1038/srep32101.


Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris.

Wangchuk P, Pearson MS, Giacomin PR, Becker L, Sotillo J, Pickering D, Smout MJ, Loukas A.

PLoS Negl Trop Dis. 2016 Aug 4;10(8):e0004908. doi: 10.1371/journal.pntd.0004908. eCollection 2016 Aug.


Carcinogenic Parasite Secretes Growth Factor That Accelerates Wound Healing and Potentially Promotes Neoplasia.

Smout MJ, Sotillo J, Laha T, Papatpremsiri A, Rinaldi G, Pimenta RN, Chan LY, Johnson MS, Turnbull L, Whitchurch CB, Giacomin PR, Moran CS, Golledge J, Daly N, Sripa B, Mulvenna JP, Brindley PJ, Loukas A.

PLoS Pathog. 2015 Oct 20;11(10):e1005209. doi: 10.1371/journal.ppat.1005209. eCollection 2015 Oct.


Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM).

Rinaldi G, Loukas A, Brindley PJ, Irelan JT, Smout MJ.

Int J Parasitol Drugs Drug Resist. 2015 Aug 6;5(3):141-8. doi: 10.1016/j.ijpddr.2015.07.002. eCollection 2015 Dec.


Cytometric analysis, genetic manipulation and antibiotic selection of the snail embryonic cell line Bge from Biomphalaria glabrata, the intermediate host of Schistosoma mansoni.

Rinaldi G, Yan H, Nacif-Pimenta R, Matchimakul P, Bridger J, Mann VH, Smout MJ, Brindley PJ, Knight M.

Int J Parasitol. 2015 Jul;45(8):527-35. doi: 10.1016/j.ijpara.2015.02.012. Epub 2015 Apr 20.


Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells.

Papatpremsiri A, Smout MJ, Loukas A, Brindley PJ, Sripa B, Laha T.

Exp Parasitol. 2015 Jan;148:17-23. doi: 10.1016/j.exppara.2014.11.004. Epub 2014 Nov 13.


Auto-induction for high yield expression of recombinant novel isoallergen tropomyosin from King prawn (Melicertus latisulcatus) for improved diagnostics and immunotherapeutics.

Koeberl M, Kamath SD, Saptarshi SR, Smout MJ, Rolland JM, O'Hehir RE, Lopata AL.

J Immunol Methods. 2014 Dec 15;415:6-16. doi: 10.1016/j.jim.2014.10.008. Epub 2014 Oct 27.


Dose and time dependence of box jellyfish antivenom.

Andreosso A, Smout MJ, Seymour JE.

J Venom Anim Toxins Incl Trop Dis. 2014 Aug 12;20:34. doi: 10.1186/1678-9199-20-34. eCollection 2014.


Reversible paralysis of Schistosoma mansoni by forchlorfenuron, a phenylurea cytokinin that affects septins.

Zeraik AE, Galkin VE, Rinaldi G, Garratt RC, Smout MJ, Loukas A, Mann VH, Araujo AP, DeMarco R, Brindley PJ.

Int J Parasitol. 2014 Jul;44(8):523-31. doi: 10.1016/j.ijpara.2014.03.010. Epub 2014 Apr 21.


Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII.

You H, McManus DP, Hu W, Smout MJ, Brindley PJ, Gobert GN.

PLoS Pathog. 2013 Mar;9(3):e1003254. doi: 10.1371/journal.ppat.1003254. Epub 2013 Mar 28.


The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer.

Sripa B, Brindley PJ, Mulvenna J, Laha T, Smout MJ, Mairiang E, Bethony JM, Loukas A.

Trends Parasitol. 2012 Oct;28(10):395-407. doi: 10.1016/ Epub 2012 Sep 1. Review.


Expression, refolding and purification of Ov-GRN-1, a granulin-like growth factor from the carcinogenic liver fluke, that causes proliferation of mammalian host cells.

Smout MJ, Mulvenna JP, Jones MK, Loukas A.

Protein Expr Purif. 2011 Oct;79(2):263-70. doi: 10.1016/j.pep.2011.06.018. Epub 2011 Jul 2.


Infection with the carcinogenic human liver fluke, Opisthorchis viverrini.

Smout MJ, Sripa B, Laha T, Mulvenna J, Gasser RB, Young ND, Bethony JM, Brindley PJ, Loukas A.

Mol Biosyst. 2011 May;7(5):1367-75. doi: 10.1039/c0mb00295j. Epub 2011 Feb 11. Review.


A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.

Smout MJ, Kotze AC, McCarthy JS, Loukas A.

PLoS Negl Trop Dis. 2010 Nov 16;4(11):e885. doi: 10.1371/journal.pntd.0000885.


The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini.

Mulvenna J, Sripa B, Brindley PJ, Gorman J, Jones MK, Colgrave ML, Jones A, Nawaratna S, Laha T, Suttiprapa S, Smout MJ, Loukas A.

Proteomics. 2010 Mar;10(5):1063-78. doi: 10.1002/pmic.200900393.


A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells.

Smout MJ, Laha T, Mulvenna J, Sripa B, Suttiprapa S, Jones A, Brindley PJ, Loukas A.

PLoS Pathog. 2009 Oct;5(10):e1000611. doi: 10.1371/journal.ppat.1000611. Epub 2009 Oct 9.


Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini.

Laha T, Pinlaor P, Mulvenna J, Sripa B, Sripa M, Smout MJ, Gasser RB, Brindley PJ, Loukas A.

BMC Genomics. 2007 Jun 22;8:189.


Isolation of cDNAs encoding secreted and transmembrane proteins from Schistosoma mansoni by a signal sequence trap method.

Smyth D, McManus DP, Smout MJ, Laha T, Zhang W, Loukas A.

Infect Immun. 2003 May;71(5):2548-54.


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