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Items: 1 to 50 of 80


Massively parallel RNA device engineering in mammalian cells with RNA-Seq.

Xiang JS, Kaplan M, Dykstra P, Hinks M, McKeague M, Smolke CD.

Nat Commun. 2019 Sep 23;10(1):4327. doi: 10.1038/s41467-019-12334-y.


Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids.

Srinivasan P, Smolke CD.

Nat Commun. 2019 Aug 12;10(1):3634. doi: 10.1038/s41467-019-11588-w.


Programmable mutually exclusive alternative splicing for generating RNA and protein diversity.

Mathur M, Kim CM, Munro SA, Rudina SS, Sawyer EM, Smolke CD.

Nat Commun. 2019 Jun 17;10(1):2673. doi: 10.1038/s41467-019-10403-w.


Production of the cyanogenic glycoside dhurrin in yeast.

Kotopka BJ, Smolke CD.

Metab Eng Commun. 2019 May 1;9:e00092. doi: 10.1016/j.mec.2019.e00092. eCollection 2019 Dec.


Synthetic biology strategies for microbial biosynthesis of plant natural products.

Cravens A, Payne J, Smolke CD.

Nat Commun. 2019 May 13;10(1):2142. doi: 10.1038/s41467-019-09848-w. Review.


Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells.

Nakamura M, Srinivasan P, Chavez M, Carter MA, Dominguez AA, La Russa M, Lau MB, Abbott TR, Xu X, Zhao D, Gao Y, Kipniss NH, Smolke CD, Bondy-Denomy J, Qi LS.

Nat Commun. 2019 Jan 14;10(1):194. doi: 10.1038/s41467-018-08158-x.


RNA Switches for Synthetic Biology.

Schmidt CM, Smolke CD.

Cold Spring Harb Perspect Biol. 2019 Jan 2;11(1). pii: a032532. doi: 10.1101/cshperspect.a032532. Review.


Synthetic biology strategies toward heterologous phytochemical production.

Kotopka BJ, Li Y, Smolke CD.

Nat Prod Rep. 2018 Sep 19;35(9):902-920. doi: 10.1039/c8np00028j. Review.


Complete biosynthesis of noscapine and halogenated alkaloids in yeast.

Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3922-E3931. doi: 10.1073/pnas.1721469115. Epub 2018 Apr 2.


Strategies for microbial synthesis of high-value phytochemicals.

Li S, Li Y, Smolke CD.

Nat Chem. 2018 Apr;10(4):395-404. doi: 10.1038/s41557-018-0013-z. Epub 2018 Mar 22. Review.


Regulation of T cell proliferation with drug-responsive microRNA switches.

Wong RS, Chen YY, Smolke CD.

Nucleic Acids Res. 2018 Feb 16;46(3):1541-1552. doi: 10.1093/nar/gkx1228.


Mammalian synthetic biology for studying the cell.

Mathur M, Xiang JS, Smolke CD.

J Cell Biol. 2017 Jan 2;216(1):73-82. doi: 10.1083/jcb.201611002. Epub 2016 Dec 8. Review.


Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification.

Wang YH, McKeague M, Hsu TM, Smolke CD.

Cell Syst. 2016 Dec 21;3(6):549-562.e7. doi: 10.1016/j.cels.2016.10.008. Epub 2016 Nov 10.


Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines.

McKeague M, Wang YH, Cravens A, Win MN, Smolke CD.

Metab Eng. 2016 Nov;38:191-203. doi: 10.1016/j.ymben.2016.08.003. Epub 2016 Aug 9.


Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.

Li Y, Smolke CD.

Nat Commun. 2016 Jul 5;7:12137. doi: 10.1038/ncomms12137.


Opportunities in the design and application of RNA for gene expression control.

McKeague M, Wong RS, Smolke CD.

Nucleic Acids Res. 2016 Apr 20;44(7):2987-99. doi: 10.1093/nar/gkw151. Epub 2016 Mar 11. Review.


Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices.

Wei KY, Smolke CD.

J Biol Eng. 2015 Nov 20;9:21. doi: 10.1186/s13036-015-0019-7. eCollection 2015.


Optimization of yeast-based production of medicinal protoberberine alkaloids.

Galanie S, Smolke CD.

Microb Cell Fact. 2015 Sep 16;14:144. doi: 10.1186/s12934-015-0332-3.


In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control.

McKeague M, Wang YH, Smolke CD.

ACS Chem Biol. 2015 Nov 20;10(11):2463-2467. doi: 10.1021/acschembio.5b00518. Epub 2015 Sep 22.


Complete biosynthesis of opioids in yeast.

Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante M, Smolke CD.

Science. 2015 Sep 4;349(6252):1095-100. doi: 10.1126/science.aac9373. Epub 2015 Aug 13.


High-throughput cellular RNA device engineering.

Townshend B, Kennedy AB, Xiang JS, Smolke CD.

Nat Methods. 2015 Oct;12(10):989-94. doi: 10.1038/nmeth.3486. Epub 2015 Aug 10.


De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast.

Trenchard IJ, Siddiqui MS, Thodey K, Smolke CD.

Metab Eng. 2015 Sep;31:74-83. doi: 10.1016/j.ymben.2015.06.010. Epub 2015 Jul 10.


Control of alphavirus-based gene expression using engineered riboswitches.

Bell CL, Yu D, Smolke CD, Geall AJ, Beard CW, Mason PW.

Virology. 2015 Sep;483:302-11. doi: 10.1016/j.virol.2015.04.023. Epub 2015 May 23.


Engineering strategies for the fermentative production of plant alkaloids in yeast.

Trenchard IJ, Smolke CD.

Metab Eng. 2015 Jul;30:96-104. doi: 10.1016/j.ymben.2015.05.001. Epub 2015 May 14.


Synthetic feedback control using an RNAi-based gene-regulatory device.

Bloom RJ, Winkler SM, Smolke CD.

J Biol Eng. 2015 Apr 14;9:5. doi: 10.1186/s13036-015-0002-3. eCollection 2015.


Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance.

Chang AL, McKeague M, Smolke CD.

Methods Enzymol. 2014;549:451-66. doi: 10.1016/B978-0-12-801122-5.00019-2.


Protein-responsive ribozyme switches in eukaryotic cells.

Kennedy AB, Vowles JV, d'Espaux L, Smolke CD.

Nucleic Acids Res. 2014 Oct 29;42(19):12306-21. doi: 10.1093/nar/gku875. Epub 2014 Oct 1.


A system for multilocus chromosomal integration and transformation-free selection marker rescue.

Siddiqui MS, Choksi A, Smolke CD.

FEMS Yeast Res. 2014 Dec;14(8):1171-85. doi: 10.1111/1567-1364.12210. Epub 2014 Oct 10.


A quantitative framework for the forward design of synthetic miRNA circuits.

Bloom RJ, Winkler SM, Smolke CD.

Nat Methods. 2014 Nov;11(11):1147-53. doi: 10.1038/nmeth.3100. Epub 2014 Sep 14.


A microbial biomanufacturing platform for natural and semisynthetic opioids.

Thodey K, Galanie S, Smolke CD.

Nat Chem Biol. 2014 Oct;10(10):837-44. doi: 10.1038/nchembio.1613. Epub 2014 Aug 24.


Synthetic RNA switches for yeast metabolic engineering: screening recombinant enzyme libraries.

Michener JK, Smolke CD.

Methods Mol Biol. 2014;1152:125-36. doi: 10.1007/978-1-4939-0563-8_7.


Realizing the potential of synthetic biology.

Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R.

Nat Rev Mol Cell Biol. 2014 Apr;15(4):289-94. doi: 10.1038/nrm3767. Epub 2014 Mar 12. Review.


Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing.

Beisel CL, Bloom RJ, Smolke CD.

Methods Mol Biol. 2014;1111:259-67. doi: 10.1007/978-1-62703-755-6_19.


Kinetic and equilibrium binding characterization of aptamers to small molecules using a label-free, sensitive, and scalable platform.

Chang AL, McKeague M, Liang JC, Smolke CD.

Anal Chem. 2014 Apr 1;86(7):3273-8. doi: 10.1021/ac5001527. Epub 2014 Mar 14.


Dynamically reshaping signaling networks to program cell fate via genetic controllers.

Galloway KE, Franco E, Smolke CD.

Science. 2013 Sep 20;341(6152):1235005. doi: 10.1126/science.1235005. Epub 2013 Aug 15.


Molecular tools for chemical biotechnology.

Galanie S, Siddiqui MS, Smolke CD.

Curr Opin Biotechnol. 2013 Dec;24(6):1000-9. doi: 10.1016/j.copbio.2013.03.001. Epub 2013 Mar 23. Review.


Synthetic biology: advancing the design of diverse genetic systems.

Wang YH, Wei KY, Smolke CD.

Annu Rev Chem Biomol Eng. 2013;4:69-102. doi: 10.1146/annurev-chembioeng-061312-103351. Epub 2013 Feb 13. Review.


A yeast-based rapid prototype platform for gene control elements in mammalian cells.

Wei KY, Chen YY, Smolke CD.

Biotechnol Bioeng. 2013 Apr;110(4):1201-10. doi: 10.1002/bit.24792. Epub 2013 Jan 17.


A versatile cis-blocking and trans-activation strategy for ribozyme characterization.

Kennedy AB, Liang JC, Smolke CD.

Nucleic Acids Res. 2013 Jan;41(2):e41. doi: 10.1093/nar/gks1036. Epub 2012 Nov 15.


Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases.

Michener JK, Nielsen J, Smolke CD.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19504-9. doi: 10.1073/pnas.1212287109. Epub 2012 Nov 5.


A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity.

Liang JC, Chang AL, Kennedy AB, Smolke CD.

Nucleic Acids Res. 2012 Nov 1;40(20):e154. doi: 10.1093/nar/gks636. Epub 2012 Jul 18.


High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch.

Michener JK, Smolke CD.

Metab Eng. 2012 Jul;14(4):306-16. doi: 10.1016/j.ymben.2012.04.004. Epub 2012 Apr 25.


Synthetic biology: emerging methodologies to catalyze the metabolic engineering design cycle.

Smolke CD, Tyo KE.

Metab Eng. 2012 May;14(3):187-8. doi: 10.1016/j.ymben.2012.03.009. Epub 2012 Mar 23. No abstract available.


Synthetic biology: advancing biological frontiers by building synthetic systems.

Chen YY, Galloway KE, Smolke CD.

Genome Biol. 2012 Feb 20;13(2):240. doi: 10.1186/gb-2012-13-2-240. Review.


Rational design and tuning of ribozyme-based devices.

Liang JC, Smolke CD.

Methods Mol Biol. 2012;848:439-54. doi: 10.1007/978-1-61779-545-9_27.


Synthetic RNA switches as a tool for temporal and spatial control over gene expression.

Chang AL, Wolf JJ, Smolke CD.

Curr Opin Biotechnol. 2012 Oct;23(5):679-88. doi: 10.1016/j.copbio.2012.01.005. Epub 2012 Feb 3. Review.


Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools.

Siddiqui MS, Thodey K, Trenchard I, Smolke CD.

FEMS Yeast Res. 2012 Mar;12(2):144-70. doi: 10.1111/j.1567-1364.2011.00774.x. Epub 2012 Jan 11. Review.


From DNA to targeted therapeutics: bringing synthetic biology to the clinic.

Chen YY, Smolke CD.

Sci Transl Med. 2011 Oct 26;3(106):106ps42. doi: 10.1126/scitranslmed.3002944. Review.


Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways.

Michener JK, Thodey K, Liang JC, Smolke CD.

Metab Eng. 2012 May;14(3):212-22. doi: 10.1016/j.ymben.2011.09.004. Epub 2011 Sep 18. Review.


Engineering biological systems with synthetic RNA molecules.

Liang JC, Bloom RJ, Smolke CD.

Mol Cell. 2011 Sep 16;43(6):915-26. doi: 10.1016/j.molcel.2011.08.023. Review.

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