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Items: 1 to 50 of 73

1.

Synthetic biology strategies toward heterologous phytochemical production.

Kotopka BJ, Li Y, Smolke CD.

Nat Prod Rep. 2018 Jun 13. doi: 10.1039/c8np00028j. [Epub ahead of print] Review.

PMID:
29897091
2.

Complete biosynthesis of noscapine and halogenated alkaloids in yeast.

Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E3922-E3931. doi: 10.1073/pnas.1721469115. Epub 2018 Apr 2.

PMID:
29610307
3.

Strategies for microbial synthesis of high-value phytochemicals.

Li S, Li Y, Smolke CD.

Nat Chem. 2018 Apr;10(4):395-404. doi: 10.1038/s41557-018-0013-z. Epub 2018 Mar 22. Review.

PMID:
29568052
4.

Regulation of T cell proliferation with drug-responsive microRNA switches.

Wong RS, Chen YY, Smolke CD.

Nucleic Acids Res. 2018 Feb 16;46(3):1541-1552. doi: 10.1093/nar/gkx1228.

5.

Mammalian synthetic biology for studying the cell.

Mathur M, Xiang JS, Smolke CD.

J Cell Biol. 2017 Jan 2;216(1):73-82. doi: 10.1083/jcb.201611002. Epub 2016 Dec 8. Review.

6.

Design and Construction of Generalizable RNA-Protein Hybrid Controllers by Level-Matched Genetic Signal Amplification.

Wang YH, McKeague M, Hsu TM, Smolke CD.

Cell Syst. 2016 Dec 21;3(6):549-562.e7. doi: 10.1016/j.cels.2016.10.008. Epub 2016 Nov 10.

7.

Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines.

McKeague M, Wang YH, Cravens A, Win MN, Smolke CD.

Metab Eng. 2016 Nov;38:191-203. doi: 10.1016/j.ymben.2016.08.003. Epub 2016 Aug 9.

8.

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast.

Li Y, Smolke CD.

Nat Commun. 2016 Jul 5;7:12137. doi: 10.1038/ncomms12137.

9.

Opportunities in the design and application of RNA for gene expression control.

McKeague M, Wong RS, Smolke CD.

Nucleic Acids Res. 2016 Apr 20;44(7):2987-99. doi: 10.1093/nar/gkw151. Epub 2016 Mar 11. Review.

10.

Engineering dynamic cell cycle control with synthetic small molecule-responsive RNA devices.

Wei KY, Smolke CD.

J Biol Eng. 2015 Nov 20;9:21. doi: 10.1186/s13036-015-0019-7. eCollection 2015.

11.

Optimization of yeast-based production of medicinal protoberberine alkaloids.

Galanie S, Smolke CD.

Microb Cell Fact. 2015 Sep 16;14:144. doi: 10.1186/s12934-015-0332-3.

12.

In Vitro Screening and in Silico Modeling of RNA-Based Gene Expression Control.

McKeague M, Wang YH, Smolke CD.

ACS Chem Biol. 2015 Nov 20;10(11):2463-2467. doi: 10.1021/acschembio.5b00518. Epub 2015 Sep 22.

13.

Complete biosynthesis of opioids in yeast.

Galanie S, Thodey K, Trenchard IJ, Filsinger Interrante M, Smolke CD.

Science. 2015 Sep 4;349(6252):1095-100. doi: 10.1126/science.aac9373. Epub 2015 Aug 13.

14.

High-throughput cellular RNA device engineering.

Townshend B, Kennedy AB, Xiang JS, Smolke CD.

Nat Methods. 2015 Oct;12(10):989-94. doi: 10.1038/nmeth.3486. Epub 2015 Aug 10.

15.

De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast.

Trenchard IJ, Siddiqui MS, Thodey K, Smolke CD.

Metab Eng. 2015 Sep;31:74-83. doi: 10.1016/j.ymben.2015.06.010. Epub 2015 Jul 10.

16.

Control of alphavirus-based gene expression using engineered riboswitches.

Bell CL, Yu D, Smolke CD, Geall AJ, Beard CW, Mason PW.

Virology. 2015 Sep;483:302-11. doi: 10.1016/j.virol.2015.04.023. Epub 2015 May 23.

17.

Engineering strategies for the fermentative production of plant alkaloids in yeast.

Trenchard IJ, Smolke CD.

Metab Eng. 2015 Jul;30:96-104. doi: 10.1016/j.ymben.2015.05.001. Epub 2015 May 14.

18.

Synthetic feedback control using an RNAi-based gene-regulatory device.

Bloom RJ, Winkler SM, Smolke CD.

J Biol Eng. 2015 Apr 14;9:5. doi: 10.1186/s13036-015-0002-3. eCollection 2015.

19.

Facile characterization of aptamer kinetic and equilibrium binding properties using surface plasmon resonance.

Chang AL, McKeague M, Smolke CD.

Methods Enzymol. 2014;549:451-66. doi: 10.1016/B978-0-12-801122-5.00019-2.

20.

Protein-responsive ribozyme switches in eukaryotic cells.

Kennedy AB, Vowles JV, d'Espaux L, Smolke CD.

Nucleic Acids Res. 2014 Oct 29;42(19):12306-21. doi: 10.1093/nar/gku875. Epub 2014 Oct 1.

21.

A system for multilocus chromosomal integration and transformation-free selection marker rescue.

Siddiqui MS, Choksi A, Smolke CD.

FEMS Yeast Res. 2014 Dec;14(8):1171-85. doi: 10.1111/1567-1364.12210. Epub 2014 Oct 10.

22.

A quantitative framework for the forward design of synthetic miRNA circuits.

Bloom RJ, Winkler SM, Smolke CD.

Nat Methods. 2014 Nov;11(11):1147-53. doi: 10.1038/nmeth.3100. Epub 2014 Sep 14.

PMID:
25218181
23.

A microbial biomanufacturing platform for natural and semisynthetic opioids.

Thodey K, Galanie S, Smolke CD.

Nat Chem Biol. 2014 Oct;10(10):837-44. doi: 10.1038/nchembio.1613. Epub 2014 Aug 24.

24.

Synthetic RNA switches for yeast metabolic engineering: screening recombinant enzyme libraries.

Michener JK, Smolke CD.

Methods Mol Biol. 2014;1152:125-36. doi: 10.1007/978-1-4939-0563-8_7.

25.

Realizing the potential of synthetic biology.

Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R.

Nat Rev Mol Cell Biol. 2014 Apr;15(4):289-94. doi: 10.1038/nrm3767. Epub 2014 Mar 12. Review.

PMID:
24622617
26.

Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing.

Beisel CL, Bloom RJ, Smolke CD.

Methods Mol Biol. 2014;1111:259-67. doi: 10.1007/978-1-62703-755-6_19.

PMID:
24549626
27.

Kinetic and equilibrium binding characterization of aptamers to small molecules using a label-free, sensitive, and scalable platform.

Chang AL, McKeague M, Liang JC, Smolke CD.

Anal Chem. 2014 Apr 1;86(7):3273-8. doi: 10.1021/ac5001527. Epub 2014 Mar 14.

28.

Dynamically reshaping signaling networks to program cell fate via genetic controllers.

Galloway KE, Franco E, Smolke CD.

Science. 2013 Sep 20;341(6152):1235005. doi: 10.1126/science.1235005. Epub 2013 Aug 15.

29.

Molecular tools for chemical biotechnology.

Galanie S, Siddiqui MS, Smolke CD.

Curr Opin Biotechnol. 2013 Dec;24(6):1000-9. doi: 10.1016/j.copbio.2013.03.001. Epub 2013 Mar 23. Review.

30.

Synthetic biology: advancing the design of diverse genetic systems.

Wang YH, Wei KY, Smolke CD.

Annu Rev Chem Biomol Eng. 2013;4:69-102. doi: 10.1146/annurev-chembioeng-061312-103351. Epub 2013 Feb 13. Review.

31.

A yeast-based rapid prototype platform for gene control elements in mammalian cells.

Wei KY, Chen YY, Smolke CD.

Biotechnol Bioeng. 2013 Apr;110(4):1201-10. doi: 10.1002/bit.24792. Epub 2013 Jan 17.

PMID:
23184812
32.

A versatile cis-blocking and trans-activation strategy for ribozyme characterization.

Kennedy AB, Liang JC, Smolke CD.

Nucleic Acids Res. 2013 Jan;41(2):e41. doi: 10.1093/nar/gks1036. Epub 2012 Nov 15.

33.

Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases.

Michener JK, Nielsen J, Smolke CD.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19504-9. doi: 10.1073/pnas.1212287109. Epub 2012 Nov 5.

34.

A high-throughput, quantitative cell-based screen for efficient tailoring of RNA device activity.

Liang JC, Chang AL, Kennedy AB, Smolke CD.

Nucleic Acids Res. 2012 Nov 1;40(20):e154. doi: 10.1093/nar/gks636. Epub 2012 Jul 18.

35.

High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch.

Michener JK, Smolke CD.

Metab Eng. 2012 Jul;14(4):306-16. doi: 10.1016/j.ymben.2012.04.004. Epub 2012 Apr 25.

PMID:
22554528
36.

Synthetic biology: emerging methodologies to catalyze the metabolic engineering design cycle.

Smolke CD, Tyo KE.

Metab Eng. 2012 May;14(3):187-8. doi: 10.1016/j.ymben.2012.03.009. Epub 2012 Mar 23. No abstract available.

PMID:
22465683
37.

Synthetic biology: advancing biological frontiers by building synthetic systems.

Chen YY, Galloway KE, Smolke CD.

Genome Biol. 2012 Feb 20;13(2):240. doi: 10.1186/gb-2012-13-2-240. Review.

38.

Rational design and tuning of ribozyme-based devices.

Liang JC, Smolke CD.

Methods Mol Biol. 2012;848:439-54. doi: 10.1007/978-1-61779-545-9_27.

PMID:
22315085
39.

Synthetic RNA switches as a tool for temporal and spatial control over gene expression.

Chang AL, Wolf JJ, Smolke CD.

Curr Opin Biotechnol. 2012 Oct;23(5):679-88. doi: 10.1016/j.copbio.2012.01.005. Epub 2012 Feb 3. Review.

40.

Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools.

Siddiqui MS, Thodey K, Trenchard I, Smolke CD.

FEMS Yeast Res. 2012 Mar;12(2):144-70. doi: 10.1111/j.1567-1364.2011.00774.x. Epub 2012 Jan 11. Review.

41.

From DNA to targeted therapeutics: bringing synthetic biology to the clinic.

Chen YY, Smolke CD.

Sci Transl Med. 2011 Oct 26;3(106):106ps42. doi: 10.1126/scitranslmed.3002944. Review.

42.

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways.

Michener JK, Thodey K, Liang JC, Smolke CD.

Metab Eng. 2012 May;14(3):212-22. doi: 10.1016/j.ymben.2011.09.004. Epub 2011 Sep 18. Review.

43.

Engineering biological systems with synthetic RNA molecules.

Liang JC, Bloom RJ, Smolke CD.

Mol Cell. 2011 Sep 16;43(6):915-26. doi: 10.1016/j.molcel.2011.08.023. Review.

44.

Cell biology. Bringing it together with RNA.

Thodey K, Smolke CD.

Science. 2011 Jul 22;333(6041):412-3. doi: 10.1126/science.1209685. No abstract available.

PMID:
21778388
45.

Synthetic RNA modules for fine-tuning gene expression levels in yeast by modulating RNase III activity.

Babiskin AH, Smolke CD.

Nucleic Acids Res. 2011 Oct;39(19):8651-64. doi: 10.1093/nar/gkr445. Epub 2011 Jul 6.

46.

Informing biological design by integration of systems and synthetic biology.

Smolke CD, Silver PA.

Cell. 2011 Mar 18;144(6):855-9. doi: 10.1016/j.cell.2011.02.020.

47.

A synthetic library of RNA control modules for predictable tuning of gene expression in yeast.

Babiskin AH, Smolke CD.

Mol Syst Biol. 2011 Mar 1;7:471. doi: 10.1038/msb.2011.4.

48.

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules.

Babiskin AH, Smolke CD.

Nucleic Acids Res. 2011 Jul;39(12):5299-311. doi: 10.1093/nar/gkr090. Epub 2011 Feb 25.

49.

Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing.

Beisel CL, Chen YY, Culler SJ, Hoff KG, Smolke CD.

Nucleic Acids Res. 2011 Apr;39(7):2981-94. doi: 10.1093/nar/gkq954. Epub 2010 Dec 11.

50.

Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins.

Culler SJ, Hoff KG, Smolke CD.

Science. 2010 Nov 26;330(6008):1251-5. doi: 10.1126/science.1192128.

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