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Items: 49


The Bacterial Chromatin Protein HupA Can Remodel DNA and Associates with the Nucleoid in Clostridium difficile.

Oliveira Paiva AM, Friggen AH, Qin L, Douwes R, Dame RT, Smits WK.

J Mol Biol. 2019 Feb 15;431(4):653-672. doi: 10.1016/j.jmb.2019.01.001. Epub 2019 Jan 8.


Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea.

Li C, Harmanus C, Zhu D, Meng X, Wang S, Duan J, Liu S, Fu C, Zhou P, Liu R, Wu A, Kuijper EJ, Smits WK, Fu L, Sun X.

Emerg Microbes Infect. 2018 Dec 12;7(1):211. doi: 10.1038/s41426-018-0211-1.


Genome Location Dictates the Transcriptional Response to PolC Inhibition in Clostridium difficile.

van Eijk E, Boekhoud IM, Kuijper EJ, Bos-Sanders IMJG, Wright G, Smits WK.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01363-18. doi: 10.1128/AAC.01363-18. Print 2019 Feb.


Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation.

Gachet S, El-Chaar T, Avran D, Genesca E, Catez F, Quentin S, Delord M, Thérizols G, Briot D, Meunier G, Hernandez L, Pla M, Smits WK, Buijs-Gladdines JG, Van Loocke W, Menschaert G, André-Schmutz I, Taghon T, Van Vlierberghe P, Meijerink JP, Baruchel A, Dombret H, Clappier E, Diaz JJ, Gazin C, de Thé H, Sigaux F, Soulier J.

Cancer Discov. 2018 Dec;8(12):1614-1631. doi: 10.1158/2159-8290.CD-17-0831. Epub 2018 Sep 28.


Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections.

Baktash A, Terveer EM, Zwittink RD, Hornung BVH, Corver J, Kuijper EJ, Smits WK.

Front Microbiol. 2018 Jun 12;9:1242. doi: 10.3389/fmicb.2018.01242. eCollection 2018. Review.


Proteomic identification of Axc, a novel beta-lactamase with carbapenemase activity in a meropenem-resistant clinical isolate of Achromobacter xylosoxidans.

Fleurbaaij F, Henneman AA, Corver J, Knetsch CW, Smits WK, Nauta ST, Giera M, Dragan I, Kumar N, Lawley TD, Verhoeven A, van Leeuwen HC, Kuijper EJ, Hensbergen PJ.

Sci Rep. 2018 May 25;8(1):8181. doi: 10.1038/s41598-018-26079-z.


The evolving epidemic of Clostridium difficile 630.

Roberts AP, Smits WK.

Anaerobe. 2018 Oct;53:2-4. doi: 10.1016/j.anaerobe.2018.04.015. Epub 2018 Apr 27.


A helicase-containing module defines a family of pCD630-like plasmids in Clostridium difficile.

Smits WK, Weese JS, Roberts AP, Harmanus C, Hornung B.

Anaerobe. 2018 Feb;49:78-84. doi: 10.1016/j.anaerobe.2017.12.005. Epub 2017 Dec 12.


DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens.

van Eijk E, Wittekoek B, Kuijper EJ, Smits WK.

J Antimicrob Chemother. 2017 May 1;72(5):1275-1284. doi: 10.1093/jac/dkw548. Review.


Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile.

van Eijk E, Paschalis V, Green M, Friggen AH, Larson MA, Spriggs K, Briggs GS, Soultanas P, Smits WK.

Open Biol. 2016 Dec;6(12). pii: 160272. doi: 10.1098/rsob.160272.


IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study.

Li Y, Buijs-Gladdines JG, Canté-Barrett K, Stubbs AP, Vroegindeweij EM, Smits WK, van Marion R, Dinjens WN, Horstmann M, Kuiper RP, Buijsman RC, Zaman GJ, van der Spek PJ, Pieters R, Meijerink JP.

PLoS Med. 2016 Dec 20;13(12):e1002200. doi: 10.1371/journal.pmed.1002200. eCollection 2016 Dec.


Interspecies Interactions between Clostridium difficile and Candida albicans.

van Leeuwen PT, van der Peet JM, Bikker FJ, Hoogenkamp MA, Oliveira Paiva AM, Kostidis S, Mayboroda OA, Smits WK, Krom BP.

mSphere. 2016 Nov 9;1(6). pii: e00187-16. eCollection 2016 Nov-Dec.


SNP-ing out the differences: Investigating differences between Clostridium difficile lab strains.

Smits WK.

Virulence. 2017 Aug 18;8(6):613-617. doi: 10.1080/21505594.2016.1250998. Epub 2016 Oct 28. No abstract available.


The Signal Sequence of the Abundant Extracellular Metalloprotease PPEP-1 Can Be Used to Secrete Synthetic Reporter Proteins in Clostridium difficile.

Oliveira Paiva AM, Friggen AH, Hossein-Javaheri S, Smits WK.

ACS Synth Biol. 2016 Dec 16;5(12):1376-1382. Epub 2016 Jun 23.


Lentiviral gene transfer into human and murine hematopoietic stem cells: size matters.

Canté-Barrett K, Mendes RD, Smits WK, van Helsdingen-van Wijk YM, Pieters R, Meijerink JP.

BMC Res Notes. 2016 Jun 16;9:312. doi: 10.1186/s13104-016-2118-z.


MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.

Canté-Barrett K, Spijkers-Hagelstein JA, Buijs-Gladdines JG, Uitdehaag JC, Smits WK, van der Zwet J, Buijsman RC, Zaman GJ, Pieters R, Meijerink JP.

Leukemia. 2016 Sep;30(9):1832-43. doi: 10.1038/leu.2016.83. Epub 2016 Apr 22.


Clostridium difficile infection.

Smits WK, Lyras D, Lacy DB, Wilcox MH, Kuijper EJ.

Nat Rev Dis Primers. 2016 Apr 7;2:16020. doi: 10.1038/nrdp.2016.20. Review.


Complete genome sequence of BS49 and draft genome sequence of BS34A, Bacillus subtilis strains carrying Tn916.

Browne HP, Anvar SY, Frank J, Lawley TD, Roberts AP, Smits WK.

FEMS Microbiol Lett. 2015 Jan;362(3):1-4. doi: 10.1093/femsle/fnu050. Epub 2014 Dec 21.


Complete genome sequence of the Clostridium difficile laboratory strain 630Δerm reveals differences from strain 630, including translocation of the mobile element CTn5.

van Eijk E, Anvar SY, Browne HP, Leung WY, Frank J, Schmitz AM, Roberts AP, Smits WK.

BMC Genomics. 2015 Jan 31;16:31. doi: 10.1186/s12864-015-1252-7.


The HtrA-like protease CD3284 modulates virulence of Clostridium difficile.

Bakker D, Buckley AM, de Jong A, van Winden VJ, Verhoeks JP, Kuipers OP, Douce GR, Kuijper EJ, Smits WK, Corver J.

Infect Immun. 2014 Oct;82(10):4222-32. doi: 10.1128/IAI.02336-14. Epub 2014 Jul 21.


PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events.

Mendes RD, Sarmento LM, Canté-Barrett K, Zuurbier L, Buijs-Gladdines JG, Póvoa V, Smits WK, Abecasis M, Yunes JA, Sonneveld E, Horstmann MA, Pieters R, Barata JT, Meijerink JP.

Blood. 2014 Jul 24;124(4):567-78. doi: 10.1182/blood-2014-03-562751. Epub 2014 Jun 5.


Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP, Barquist L, Martin MJ, Goulding D, Duncan SH, Flint HJ, Dougan G, Choudhary JS, Lawley TD.

BMC Genomics. 2014 Feb 25;15:160. doi: 10.1186/1471-2164-15-160.


Hype or hypervirulence: a reflection on problematic C. difficile strains.

Smits WK.

Virulence. 2013 Oct 1;4(7):592-6. doi: 10.4161/viru.26297. Epub 2013 Sep 10. Review.


Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.

Zuurbier L, Gutierrez A, Mullighan CG, Canté-Barrett K, Gevaert AO, de Rooi J, Li Y, Smits WK, Buijs-Gladdines JG, Sonneveld E, Look AT, Horstmann M, Pieters R, Meijerink JP.

Haematologica. 2014 Jan;99(1):94-102. doi: 10.3324/haematol.2013.090233. Epub 2013 Aug 23.


C. difficile 630Δerm Spo0A regulates sporulation, but does not contribute to toxin production, by direct high-affinity binding to target DNA.

Rosenbusch KE, Bakker D, Kuijper EJ, Smits WK.

PLoS One. 2012;7(10):e48608. doi: 10.1371/journal.pone.0048608. Epub 2012 Oct 31.


TcdC does not significantly repress toxin expression in Clostridium difficile 630ΔErm.

Bakker D, Smits WK, Kuijper EJ, Corver J.

PLoS One. 2012;7(8):e43247. doi: 10.1371/journal.pone.0043247. Epub 2012 Aug 17.


Chromosomal replication initiation machinery of low-G+C-content Firmicutes.

Briggs GS, Smits WK, Soultanas P.

J Bacteriol. 2012 Oct;194(19):5162-70. doi: 10.1128/JB.00865-12. Epub 2012 Jul 13. Review.


The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.

Zuurbier L, Petricoin EF 3rd, Vuerhard MJ, Calvert V, Kooi C, Buijs-Gladdines JG, Smits WK, Sonneveld E, Veerman AJ, Kamps WA, Horstmann M, Pieters R, Meijerink JP.

Haematologica. 2012 Sep;97(9):1405-13. doi: 10.3324/haematol.2011.059030. Epub 2012 Apr 4.


Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites.

Collier C, Machón C, Briggs GS, Smits WK, Soultanas P.

Nucleic Acids Res. 2012 Jan;40(2):739-50. doi: 10.1093/nar/gkr785. Epub 2011 Sep 27.


In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia.

Homminga I, Zwaan CM, Manz CY, Parker C, Bantia S, Smits WK, Higginbotham F, Pieters R, Meijerink JP.

Blood. 2011 Aug 25;118(8):2184-90. doi: 10.1182/blood-2011-02-337840. Epub 2011 Jul 5.


Primosomal proteins DnaD and DnaB are recruited to chromosomal regions bound by DnaA in Bacillus subtilis.

Smits WK, Merrikh H, Bonilla CY, Grossman AD.

J Bacteriol. 2011 Feb;193(3):640-8. doi: 10.1128/JB.01253-10. Epub 2010 Nov 19.


The transcriptional regulator Rok binds A+T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis.

Smits WK, Grossman AD.

PLoS Genet. 2010 Nov 11;6(11):e1001207. doi: 10.1371/journal.pgen.1001207.


NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols.

Zuurbier L, Homminga I, Calvert V, te Winkel ML, Buijs-Gladdines JG, Kooi C, Smits WK, Sonneveld E, Veerman AJ, Kamps WA, Horstmann M, Petricoin EF 3rd, Pieters R, Meijerink JP.

Leukemia. 2010 Dec;24(12):2014-22. doi: 10.1038/leu.2010.204. Epub 2010 Sep 23.


When simple sequence comparison fails: the cryptic case of the shared domains of the bacterial replication initiation proteins DnaB and DnaD.

Marston FY, Grainger WH, Smits WK, Hopcroft NH, Green M, Hounslow AM, Grossman AD, Craven CJ, Soultanas P.

Nucleic Acids Res. 2010 Nov;38(20):6930-42. doi: 10.1093/nar/gkq465. Epub 2010 Jun 28.


Ordered association of helicase loader proteins with the Bacillus subtilis origin of replication in vivo.

Smits WK, Goranov AI, Grossman AD.

Mol Microbiol. 2010 Jan;75(2):452-61. doi: 10.1111/j.1365-2958.2009.06999.x. Epub 2009 Dec 4.


Ubiquitous late competence genes in Bacillus species indicate the presence of functional DNA uptake machineries.

Kovács AT, Smits WK, Mirończuk AM, Kuipers OP.

Environ Microbiol. 2009 Aug;11(8):1911-22. doi: 10.1111/j.1462-2920.2009.01937.x. Epub 2009 May 14. Review.


Bistability, epigenetics, and bet-hedging in bacteria.

Veening JW, Smits WK, Kuipers OP.

Annu Rev Microbiol. 2008;62:193-210. doi: 10.1146/annurev.micro.62.081307.163002. Review.


Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis.

Lulko AT, Veening JW, Buist G, Smits WK, Blom EJ, Beekman AC, Bron S, Kuipers OP.

Appl Environ Microbiol. 2007 Aug;73(16):5354-62. Epub 2007 Jun 22.


Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis.

Smits WK, Bongiorni C, Veening JW, Hamoen LW, Kuipers OP, Perego M.

Mol Microbiol. 2007 Jul;65(1):103-20.


Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.

Smits WK, Hoa TT, Hamoen LW, Kuipers OP, Dubnau D.

Mol Microbiol. 2007 Apr;64(2):368-81.


Phenotypic variation in bacteria: the role of feedback regulation.

Smits WK, Kuipers OP, Veening JW.

Nat Rev Microbiol. 2006 Apr;4(4):259-71. Review.


Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development.

Smits WK, Eschevins CC, Susanna KA, Bron S, Kuipers OP, Hamoen LW.

Mol Microbiol. 2005 May;56(3):604-14.


The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.

Albano M, Smits WK, Ho LT, Kraigher B, Mandic-Mulec I, Kuipers OP, Dubnau D.

J Bacteriol. 2005 Mar;187(6):2010-9.


Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis.

Veening JW, Smits WK, Hamoen LW, Jongbloed JD, Kuipers OP.

Appl Environ Microbiol. 2004 Nov;70(11):6809-15.


Genome2D: a visualization tool for the rapid analysis of bacterial transcriptome data.

Baerends RJ, Smits WK, de Jong A, Hamoen LW, Kok J, Kuipers OP.

Genome Biol. 2004;5(5):R37. Epub 2004 Apr 5.


Improving the predictive value of the competence transcription factor (ComK) binding site in Bacillus subtilis using a genomic approach.

Hamoen LW, Smits WK, de Jong A, Holsappel S, Kuipers OP.

Nucleic Acids Res. 2002 Dec 15;30(24):5517-28.

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