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Wnt/β-Catenin Signaling in Liver Cancers.

Wang W, Smits R, Hao H, He C.

Cancers (Basel). 2019 Jul 2;11(7). pii: E926. doi: 10.3390/cancers11070926. Review.


Bacterial biofilms as a potential contributor to mucinous colorectal cancer formation.

Li S, Peppelenbosch MP, Smits R.

Biochim Biophys Acta Rev Cancer. 2019 Jun 12;1872(1):74-79. doi: 10.1016/j.bbcan.2019.05.009. [Epub ahead of print] Review.


Activated Signaling Pathways and Targeted Therapies in Desmoid-Type Fibromatosis: A Literature Review.

Timbergen MJM, Smits R, Grünhagen DJ, Verhoef C, Sleijfer S, Wiemer EAC.

Front Oncol. 2019 May 17;9:397. doi: 10.3389/fonc.2019.00397. eCollection 2019. Review.


HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.

Janmaat VT, Liu H, da Silva RA, Wisse PHA, Spaander MCW, Ten Hagen TLM, Smits R, Bruno MJ, Fuhler GM, Peppelenbosch MP.

Carcinogenesis. 2019 Feb 20. pii: bgz038. doi: 10.1093/carcin/bgz038. [Epub ahead of print]


Antioxidants for male subfertility.

Smits RM, Mackenzie-Proctor R, Yazdani A, Stankiewicz MT, Jordan V, Showell MG.

Cochrane Database Syst Rev. 2019 Mar 14;3:CD007411. doi: 10.1002/14651858.CD007411.pub4.


A systematic review and standardized clinical validity assessment of male infertility genes.

Oud MS, Volozonoka L, Smits RM, Vissers LELM, Ramos L, Veltman JA.

Hum Reprod. 2019 May 1;34(5):932-941. doi: 10.1093/humrep/dez022.


cOAlition S: Response to PNAS.

Kiley R, Smits RJ.

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):5859-5860. doi: 10.1073/pnas.1902136116. Epub 2019 Mar 4. No abstract available.


Relocation of inadequate resection margins in the wound bed during oral cavity oncological surgery: A feasibility study.

van Lanschot CGF, Mast H, Hardillo JA, Monserez D, Ten Hove I, Barroso EM, Cals FLJ, Smits RWH, van der Kamp MF, Meeuwis CA, Sewnaik A, Verdijk R, van Leenders GJLH, Noordhoek Hegt V, Bakker Schut TC, Baatenburg de Jong RJ, Puppels GJ, Koljenović S.

Head Neck. 2019 Jul;41(7):2159-2166. doi: 10.1002/hed.25690. Epub 2019 Feb 1.


Response to: An immunohistochemical approach to detect oncogenic CTNNB1 mutations in primary neoplastic tissues.

Dubbink HJ, Lavrijsen M, van den Bosch TPP, Smits R.

Lab Invest. 2019 Mar;99(3):445-446. doi: 10.1038/s41374-018-0183-8. Epub 2019 Jan 30. No abstract available.


Effects of L-citrulline supplementation on heat stress physiology, lactation performance and subsequent reproductive performance of sows in summer.

Liu F, de Ruyter EM, Athorn RZ, Brewster CJ, Henman DJ, Morrison RS, Smits RJ, Cottrell JJ, Dunshea FR.

J Anim Physiol Anim Nutr (Berl). 2019 Jan;103(1):251-257. doi: 10.1111/jpn.13028. Epub 2018 Nov 28.


Relevance of healthcare-associated pneumonia for empirical antibiotic therapy in the Netherlands.

Schweitzer VA, van Werkhoven CH, van Heijl I, Smits RF, Boel CHE, Bonten MJM, Postma DF, Oosterheert JJ.

Neth J Med. 2018 Nov;76(9):389-396.


Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors.

Cao W, Liu J, Wang L, Li M, Verstegen MMA, Yin Y, Ma B, Chen K, Bolkestein M, Sprengers D, van der Laan LJW, Doukas M, Kwekkeboom J, Smits R, Peppelenbosch MP, Pan Q.

Carcinogenesis. 2019 Mar 12;40(1):145-154. doi: 10.1093/carcin/bgy129.


Oncogenic STRAP Supports Hepatocellular Carcinoma Growth by Enhancing Wnt/β-Catenin Signaling.

Wang W, Li S, Liu P, Sideras K, van de Werken HJG, van der Heide M, Cao W, Lavrijsen M, Peppelenbosch MP, Bruno M, Pan Q, Smits R.

Mol Cancer Res. 2019 Feb;17(2):521-531. doi: 10.1158/1541-7786.MCR-18-0054. Epub 2018 Sep 26.


Antioxidants in fertility: impact on male and female reproductive outcomes.

Smits RM, Mackenzie-Proctor R, Fleischer K, Showell MG.

Fertil Steril. 2018 Sep;110(4):578-580. doi: 10.1016/j.fertnstert.2018.05.028. Review.


The role of placebo effects in immune-related conditions: mechanisms and clinical considerations.

Smits RM, Veldhuijzen DS, Wulffraat NM, Evers AWM.

Expert Rev Clin Immunol. 2018 Sep;14(9):761-770. doi: 10.1080/1744666X.2018.1516144. Epub 2018 Sep 10. Review.


Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands.

Rafique W, Kramer V, Pardo T, Smits R, Spilhaug MM, Hoepping A, Savio E, Engler H, Kuljs R, Amaral H, Riss PJ.

ACS Omega. 2018 Jul 31;3(7):7567-7579. doi: 10.1021/acsomega.8b00975. Epub 2018 Jul 9.


Post-weaning and whole-of-life performance of pigs is determined by live weight at weaning and the complexity of the diet fed after weaning.

Collins CL, Pluske JR, Morrison RS, McDonald TN, Smits RJ, Henman DJ, Stensland I, Dunshea FR.

Anim Nutr. 2017 Dec;3(4):372-379. doi: 10.1016/j.aninu.2017.01.001. Epub 2017 Jan 6.


Cognitive correlates of α4β2 nicotinic acetylcholine receptors in mild Alzheimer's dementia.

Sabri O, Meyer PM, Gräf S, Hesse S, Wilke S, Becker GA, Rullmann M, Patt M, Luthardt J, Wagenknecht G, Hoepping A, Smits R, Franke A, Sattler B, Tiepolt S, Fischer S, Deuther-Conrad W, Hegerl U, Barthel H, Schönknecht P, Brust P.

Brain. 2018 Jun 1;141(6):1840-1854. doi: 10.1093/brain/awy099.


Evaluation of bone resection margins of segmental mandibulectomy for oral squamous cell carcinoma.

Smits RWH, Ten Hove I, Dronkers EAC, Bakker Schut TC, Mast H, Baatenburg de Jong RJ, Wolvius EB, Puppels GJ, Koljenović S.

Int J Oral Maxillofac Surg. 2018 Aug;47(8):959-964. doi: 10.1016/j.ijom.2018.03.006. Epub 2018 Mar 28.


Optimal cancer care: what essential elements of care would help haematological cancer patients obtain and understand information about their disease and its treatment and impact?

Bryant J, Smits R, Turon H, Sanson-Fisher R, Engel J.

Support Care Cancer. 2018 Aug;26(8):2843-2849. doi: 10.1007/s00520-018-4140-2. Epub 2018 Mar 9.


Exploring the Metabolism of (+)-[18F]Flubatine in Vitro and in Vivo: LC-MS/MS Aided Identification of Radiometabolites in a Clinical PET Study.

Ludwig FA, Fischer S, Smits R, Deuther-Conrad W, Hoepping A, Tiepolt S, Patt M, Sabri O, Brust P.

Molecules. 2018 Feb 20;23(2). pii: E464. doi: 10.3390/molecules23020464.


A novel tissue-based ß-catenin gene and immunohistochemical analysis to exclude familial adenomatous polyposis among children with hepatoblastoma tumors.

Dubbink HJ, Hollink IHIM, Avenca Valente C, Wang W, Liu P, Doukas M, van Noesel MM, Dinjens WNM, Wagner A, Smits R.

Pediatr Blood Cancer. 2018 Jun;65(6):e26991. doi: 10.1002/pbc.26991. Epub 2018 Feb 15.


Raman spectroscopy for assessment of bone resection margins in mandibulectomy for oral cavity squamous cell carcinoma.

Barroso EM, Ten Hove I, Bakker Schut TC, Mast H, van Lanschot CGF, Smits RWH, Caspers PJ, Verdijk R, Noordhoek Hegt V, Baatenburg de Jong RJ, Wolvius EB, Puppels GJ, Koljenović S.

Eur J Cancer. 2018 Mar;92:77-87. doi: 10.1016/j.ejca.2018.01.068. Epub 2018 Feb 8.


A simple filter model to guide the allocation of healthcare resources for improving the treatment of depression among cancer patients.

Sanson-Fisher RW, Noble NE, Searles AM, Deeming S, Smits RE, Oldmeadow CJ, Bryant J.

BMC Cancer. 2018 Feb 6;18(1):125. doi: 10.1186/s12885-018-4009-2.


Distorted Beliefs about Luck and Skill and Their Relation to Gambling Problems and Gambling Behavior in Dutch Gamblers.

Cowie ME, Stewart SH, Salmon J, Collins P, Al-Hamdani M, Boffo M, Salemink E, de Jong D, Smits R, Wiers RW.

Front Psychol. 2017 Dec 22;8:2245. doi: 10.3389/fpsyg.2017.02245. eCollection 2017.


Luck, come here! Automatic approach tendencies toward gambling cues in moderate- to high-risk gamblers.

Boffo M, Smits R, Salmon JP, Cowie ME, de Jong DTHA, Salemink E, Collins P, Stewart SH, Wiers RW.

Addiction. 2018 Feb;113(2):289-298. doi: 10.1111/add.14071. Epub 2017 Nov 27.


Erratum to: Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.

Wang W, Pan Q, Fuhler GM, Smits R, Peppelenbosch MP.

J Gastroenterol. 2018 Apr;53(4):576-577. doi: 10.1007/s00535-017-1392-4.


Procedures for the GMP-Compliant Production and Quality Control of [18F]PSMA-1007: A Next Generation Radiofluorinated Tracer for the Detection of Prostate Cancer.

Cardinale J, Martin R, Remde Y, Schäfer M, Hienzsch A, Hübner S, Zerges AM, Marx H, Hesse R, Weber K, Smits R, Hoepping A, Müller M, Neels OC, Kopka K.

Pharmaceuticals (Basel). 2017 Sep 27;10(4). pii: E77. doi: 10.3390/ph10040077.


Access to clinical trials among oncology patients: results of a cross sectional survey.

Carey M, Boyes AW, Smits R, Bryant J, Waller A, Olver I.

BMC Cancer. 2017 Sep 18;17(1):653. doi: 10.1186/s12885-017-3644-3.


Raman spectroscopy for cancer detection and cancer surgery guidance: translation to the clinics.

Santos IP, Barroso EM, Bakker Schut TC, Caspers PJ, van Lanschot CGF, Choi DH, van der Kamp MF, Smits RWH, van Doorn R, Verdijk RM, Noordhoek Hegt V, von der Thüsen JH, van Deurzen CHM, Koppert LB, van Leenders GJLH, Ewing-Graham PC, van Doorn HC, Dirven CMF, Busstra MB, Hardillo J, Sewnaik A, Ten Hove I, Mast H, Monserez DA, Meeuwis C, Nijsten T, Wolvius EB, Baatenburg de Jong RJ, Puppels GJ, Koljenović S.

Analyst. 2017 Aug 21;142(17):3025-3047. doi: 10.1039/c7an00957g. Review.


Dynamics of Proliferative and Quiescent Stem Cells in Liver Homeostasis and Injury.

Cao W, Chen K, Bolkestein M, Yin Y, Verstegen MMA, Bijvelds MJC, Wang W, Tuysuz N, Ten Berge D, Sprengers D, Metselaar HJ, van der Laan LJW, Kwekkeboom J, Smits R, Peppelenbosch MP, Pan Q.

Gastroenterology. 2017 Oct;153(4):1133-1147. doi: 10.1053/j.gastro.2017.07.006. Epub 2017 Jul 14.


Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization.

Formentini L, Santacatterina F, Núñez de Arenas C, Stamatakis K, López-Martínez D, Logan A, Fresno M, Smits R, Murphy MP, Cuezva JM.

Cell Rep. 2017 May 9;19(6):1202-1213. doi: 10.1016/j.celrep.2017.04.036.


A discrete in continuous mathematical model of cardiac progenitor cells formation and growth as spheroid clusters (Cardiospheres).

Di Costanzo E, Giacomello A, Messina E, Natalini R, Pontrelli G, Rossi F, Smits R, Twarogowska M.

Math Med Biol. 2018 Mar 14;35(1):121-144. doi: 10.1093/imammb/dqw022.


Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Feb;214(2):565. doi: 10.1084/jem.2016067501052017c. Epub 2017 Jan 9. No abstract available.


Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.

Wang W, Pan Q, Fuhler GM, Smits R, Peppelenbosch MP.

J Gastroenterol. 2017 Apr;52(4):419-431. doi: 10.1007/s00535-016-1299-5. Epub 2016 Dec 29. Review. Erratum in: J Gastroenterol. 2017 Oct 11;:.


Bacterial Biofilms in Colorectal Cancer Initiation and Progression.

Li S, Konstantinov SR, Smits R, Peppelenbosch MP.

Trends Mol Med. 2017 Jan;23(1):18-30. doi: 10.1016/j.molmed.2016.11.004. Epub 2016 Dec 13.


Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Jan;214(1):143-163. doi: 10.1084/jem.20160675. Epub 2016 Dec 15. Erratum in: J Exp Med. 2017 Feb;214(2):565.


Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling.

Wang W, Xu L, Liu P, Jairam K, Yin Y, Chen K, Sprengers D, Peppelenbosch MP, Pan Q, Smits R.

Neoplasia. 2016 Dec;18(12):711-723. doi: 10.1016/j.neo.2016.10.004. Epub 2016 Nov 13.


Radiation dosimetry of the α4β2 nicotinic receptor ligand (+)-[18F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results.

Kranz M, Sattler B, Tiepolt S, Wilke S, Deuther-Conrad W, Donat CK, Fischer S, Patt M, Schildan A, Patt J, Smits R, Hoepping A, Steinbach J, Sabri O, Brust P.

EJNMMI Phys. 2016 Dec;3(1):25. Epub 2016 Oct 21.


Microglia-induced activation of non-canonical Wnt signaling aggravates neurodegeneration in demyelinating disorders.

Shimizu T, Smits R, Ikenaka K.

Mol Cell Biol. 2016 Nov;36(21):2728-2741. doi: 10.1128/MCB.00139-16. Epub 2016 Aug 22.


Water Concentration Analysis by Raman Spectroscopy to Determine the Location of the Tumor Border in Oral Cancer Surgery.

Barroso EM, Smits RW, van Lanschot CG, Caspers PJ, Ten Hove I, Mast H, Sewnaik A, Hardillo JA, Meeuwis CA, Verdijk R, Noordhoek Hegt V, Baatenburg de Jong RJ, Wolvius EB, Bakker Schut TC, Koljenović S, Puppels GJ.

Cancer Res. 2016 Oct 15;76(20):5945-5953. Epub 2016 Aug 16.


Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration.

Das AM, Bolkestein M, van der Klok T, Oude Ophuis CM, Vermeulen CE, Rens JA, Dinjens WN, Atmodimedjo PN, Verhoef C, Koljenović S, Smits R, Ten Hagen TL, Eggermont AM.

Eur J Cancer. 2016 Oct;66:34-46. doi: 10.1016/j.ejca.2016.06.020. Epub 2016 Aug 11.


Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage.

Ikpa PT, Sleddens HF, Steinbrecher KA, Peppelenbosch MP, de Jonge HR, Smits R, Bijvelds MJ.

Histochem Cell Biol. 2016 Oct;146(4):445-55. doi: 10.1007/s00418-016-1453-4. Epub 2016 May 31.


Enhanced copper-mediated (18)F-fluorination of aryl boronic esters provides eight radiotracers for PET applications.

Preshlock S, Calderwood S, Verhoog S, Tredwell M, Huiban M, Hienzsch A, Gruber S, Wilson TC, Taylor NJ, Cailly T, Schedler M, Collier TL, Passchier J, Smits R, Mollitor J, Hoepping A, Mueller M, Genicot C, Mercier J, Gouverneur V.

Chem Commun (Camb). 2016 Jun 28;52(54):8361-4. doi: 10.1039/c6cc03295h.


Deregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway.

Duhamel S, Girondel C, Dorn JF, Tanguay PL, Voisin L, Smits R, Maddox PS, Meloche S.

Cell Cycle. 2016 Jun 17;15(12):1631-42. doi: 10.1080/15384101.2016.1183851. Epub 2016 May 6.


Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV.

Wang W, Xu L, Brandsma JH, Wang Y, Hakim MS, Zhou X, Yin Y, Fuhler GM, van der Laan LJ, van der Woude CJ, Sprengers D, Metselaar HJ, Smits R, Poot RA, Peppelenbosch MP, Pan Q.

Sci Rep. 2016 May 6;6:25482. doi: 10.1038/srep25482.


Complication rate of uterine morcellation in laparoscopic supracervical hysterectomy: a retrospective cohort study.

Smits RM, De Kruif JH, Van Heteren CF.

Eur J Obstet Gynecol Reprod Biol. 2016 Apr;199:179-82. doi: 10.1016/j.ejogrb.2016.02.022. Epub 2016 Feb 21.


Development of a Novel Nonpeptidic (18)F-Labeled Radiotracer for in Vivo Imaging of Oxytocin Receptors with Positron Emission Tomography.

Wenzel B, Mollitor J, Deuther-Conrad W, Dukic-Stefanovic S, Kranz M, Vraka C, Teodoro R, Günther R, Donat CK, Ludwig FA, Fischer S, Smits R, Wadsak W, Mitterhauser M, Steinbach J, Hoepping A, Brust P.

J Med Chem. 2016 Mar 10;59(5):1800-17. doi: 10.1021/acs.jmedchem.5b01080. Epub 2016 Feb 3.


Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates.

Vigante B, Rucins M, Plotniece A, Pajuste K, Luntena I, Cekavicus B, Bisenieks E, Smits R, Duburs G, Sobolev A.

Molecules. 2015 Nov 12;20(11):20341-54. doi: 10.3390/molecules201119697.

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