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Items: 1 to 50 of 184

1.

Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarction.

Laeremans H, Hackeng TM, van Zandvoort MA, Thijssen VL, Janssen BJ, Ottenheijm HC, Smits JF, Blankesteijn WM.

Circulation. 2011 Oct 11;124(15):1626-35. doi: 10.1161/CIRCULATIONAHA.110.976969. Epub 2011 Sep 19.

PMID:
21931076
2.

The Wnt/Frizzled pathway as a therapeutic target for cardiac hypertrophy: where do we stand?

ter Horst P, Smits JF, Blankesteijn WM.

Acta Physiol (Oxf). 2012 Jan;204(1):110-7. doi: 10.1111/j.1748-1716.2011.02309.x. Epub 2011 May 27. Review.

PMID:
21624093
3.

Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation.

Roumen L, Van Hoof B, Pieterse K, Hilbers PA, Custers EM, Plate R, De Gooyer M, Beugels IP, Emmen JM, Leysen D, Smits JF, Ottenheijm HC, Hermans JJ.

J Comput Chem. 2011 Aug;32(11):2441-8. doi: 10.1002/jcc.21827. Epub 2011 May 19.

PMID:
21598279
4.

Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ.

Verkaar F, van der Doelen AA, Smits JF, Blankesteijn WM, Zaman GJ.

Chem Biol. 2011 Apr 22;18(4):485-94. doi: 10.1016/j.chembiol.2011.01.015.

5.

Urinary nitric oxide metabolites and individual blood pressure progression to overt hypertension.

Baumann M, Schmaderer C, Kuznetsova T, Bartholome R, Smits JF, Richart T, Struijker-Boudier H, Staessen JA.

Eur J Cardiovasc Prev Rehabil. 2011 Aug;18(4):656-63. doi: 10.1177/1741826710389419. Epub 2011 Feb 28.

PMID:
21450631
6.

Wnt/frizzled signalling modulates the migration and differentiation of immortalized cardiac fibroblasts.

Laeremans H, Rensen SS, Ottenheijm HC, Smits JF, Blankesteijn WM.

Cardiovasc Res. 2010 Aug 1;87(3):514-23. doi: 10.1093/cvr/cvq067. Epub 2010 Feb 26.

PMID:
20189955
7.

Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ.

J Med Chem. 2010 Feb 25;53(4):1712-25. doi: 10.1021/jm901356d.

PMID:
20121113
8.

beta-Galactosidase enzyme fragment complementation for the measurement of Wnt/beta-catenin signaling.

Verkaar F, Blankesteijn WM, Smits JF, Zaman GJ.

FASEB J. 2010 Apr;24(4):1205-17. doi: 10.1096/fj.09-141671. Epub 2009 Nov 25.

PMID:
19940259
9.

Mouse strain determines the outcome of wound healing after myocardial infarction.

van den Borne SW, van de Schans VA, Strzelecka AE, Vervoort-Peters HT, Lijnen PM, Cleutjens JP, Smits JF, Daemen MJ, Janssen BJ, Blankesteijn WM.

Cardiovasc Res. 2009 Nov 1;84(2):273-82. doi: 10.1093/cvr/cvp207. Epub 2009 Jun 19.

PMID:
19542177
10.

Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling.

van den Borne SW, Isobe S, Zandbergen HR, Li P, Petrov A, Wong ND, Fujimoto S, Fujimoto A, Lovhaug D, Smits JF, Daemen MJ, Blankesteijn WM, Reutelingsperger C, Zannad F, Narula N, Vannan MA, Pitt B, Hofstra L, Narula J.

JACC Cardiovasc Imaging. 2009 Feb;2(2):187-98. doi: 10.1016/j.jcmg.2008.11.011.

11.

Effects of intrapericardial sotalol and flecainide on transmural atrial electrophysiology and atrial fibrillation.

van Brakel TJ, Hermans JJ, Accord RE, Schotten U, Smits JF, Allessie MA, Maessen JG.

J Cardiovasc Electrophysiol. 2009 Feb;20(2):207-15. doi: 10.1111/j.1540-8167.2008.01318.x. Epub 2008 Oct 30.

PMID:
19175851
12.

Molecular imaging of interstitial alterations in remodeling myocardium after myocardial infarction.

van den Borne SW, Isobe S, Verjans JW, Petrov A, Lovhaug D, Li P, Zandbergen HR, Ni Y, Frederik P, Zhou J, Arbo B, Rogstad A, Cuthbertson A, Chettibi S, Reutelingsperger C, Blankesteijn WM, Smits JF, Daemen MJ, Zannad F, Vannan MA, Narula N, Pitt B, Hofstra L, Narula J.

J Am Coll Cardiol. 2008 Dec 9;52(24):2017-28. doi: 10.1016/j.jacc.2008.07.067.

13.

Comparison of the effects of intrapericardial and intravenous aldosterone infusions on left ventricular fibrosis in rats.

Minnaard-Huiban M, Hermans JJ, Essen Hv, Bitsch N, Smits JF.

Eur J Heart Fail. 2008 Dec;10(12):1166-71. doi: 10.1016/j.ejheart.2008.09.012. Epub 2008 Nov 11.

14.

Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats.

Baumann M, Janssen BJ, Rob Hermans JJ, Bartholome R, Smits JF, Struijker Boudier HA.

Acta Physiol (Oxf). 2009 Jun;196(2):231-7. doi: 10.1111/j.1748-1716.2008.01916.x. Epub 2008 Oct 23.

PMID:
18983459
15.

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.

Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ.

Cell Signal. 2009 Jan;21(1):22-33. doi: 10.1016/j.cellsig.2008.09.008. Epub 2008 Sep 25.

PMID:
18929644
16.

G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors.

Verkaar F, van Rosmalen JW, Blomenröhr M, van Koppen CJ, Blankesteijn WM, Smits JF, Zaman GJ.

Biotechnol Annu Rev. 2008;14:253-74. doi: 10.1016/S1387-2656(08)00010-0. Review.

PMID:
18606367
17.

Defective intercellular adhesion complex in myocardium predisposes to infarct rupture in humans.

van den Borne SW, Narula J, Voncken JW, Lijnen PM, Vervoort-Peters HT, Dahlmans VE, Smits JF, Daemen MJ, Blankesteijn WM.

J Am Coll Cardiol. 2008 Jun 3;51(22):2184-92. doi: 10.1016/j.jacc.2008.02.056.

18.

The Wnt/frizzled pathway in cardiovascular development and disease: friend or foe?

van de Schans VA, Smits JF, Blankesteijn WM.

Eur J Pharmacol. 2008 May 13;585(2-3):338-45. doi: 10.1016/j.ejphar.2008.02.093. Epub 2008 Mar 18. Review.

PMID:
18417121
19.

Increased matrix metalloproteinase-8 and -9 activity in patients with infarct rupture after myocardial infarction.

van den Borne SW, Cleutjens JP, Hanemaaijer R, Creemers EE, Smits JF, Daemen MJ, Blankesteijn WM.

Cardiovasc Pathol. 2009 Jan-Feb;18(1):37-43. doi: 10.1016/j.carpath.2007.12.012. Epub 2008 Mar 4.

PMID:
18402833
20.

The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy.

Blankesteijn WM, van de Schans VA, ter Horst P, Smits JF.

Trends Pharmacol Sci. 2008 Apr;29(4):175-80. doi: 10.1016/j.tips.2008.01.003. Epub 2008 Mar 14. Review.

PMID:
18342376
21.

Sustained tubulo-interstitial protection in SHRs by transient losartan treatment: an effect of decelerated aging?

Baumann M, Bartholome R, Peutz-Kootstra CJ, Smits JF, Struijker-Boudier HA.

Am J Hypertens. 2008 Feb;21(2):177-82. doi: 10.1038/ajh.2007.30. Epub 2008 Jan 10.

PMID:
18188163
22.

Prehypertensive renin-angiotensin-aldosterone system blockade in spontaneously hypertensive rats ameliorates the loss of long-term vascular function.

Baumann M, Megens R, Bartholome R, Dolff S, van Zandvoort MA, Smits JF, Struijker-Boudier HA, De Mey JG.

Hypertens Res. 2007 Sep;30(9):853-61.

PMID:
18037779
23.

Transient prehypertensive treatment in spontaneously hypertensive rats: a comparison of spironolactone and losartan regarding long-term blood pressure and target organ damage.

Baumann M, Hermans JJ, Janssen BJ, Peutz-Kootstra C, Witzke O, Heemann U, Smits JF, Boudier HA.

J Hypertens. 2007 Dec;25(12):2504-11.

PMID:
17984673
24.

Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.

Minnaard-Huiban M, Emmen JM, Roumen L, Beugels IP, Cohuet GM, van Essen H, Ruijters E, Pieterse K, Hilbers PA, Ottenheijm HC, Plate R, de Gooyer ME, Smits JF, Hermans JJ.

Endocrinology. 2008 Jan;149(1):28-31. Epub 2007 Sep 20.

PMID:
17884944
25.

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics.

Roumen L, Sanders MP, Pieterse K, Hilbers PA, Plate R, Custers E, de Gooyer M, Smits JF, Beugels I, Emmen J, Ottenheijm HC, Leysen D, Hermans JJ.

J Comput Aided Mol Des. 2007 Aug;21(8):455-71. Epub 2007 Jul 24.

26.

Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy.

van de Schans VA, van den Borne SW, Strzelecka AE, Janssen BJ, van der Velden JL, Langen RC, Wynshaw-Boris A, Smits JF, Blankesteijn WM.

Hypertension. 2007 Mar;49(3):473-80. Epub 2007 Jan 8.

PMID:
17210832
27.

Transient AT1 receptor-inhibition in prehypertensive spontaneously hypertensive rats results in maintained cardiac protection until advanced age.

Baumann M, Janssen BJ, Hermans JJ, Peutz-Kootstra C, Witzke O, Smits JF, Struijker Boudier HA.

J Hypertens. 2007 Jan;25(1):207-15.

PMID:
17143193
28.

Biologically relevant effects of mRNA amplification on gene expression profiles.

van Haaften RI, Schroen B, Janssen BJ, van Erk A, Debets JJ, Smeets HJ, Smits JF, van den Wijngaard A, Pinto YM, Evelo CT.

BMC Bioinformatics. 2006 Apr 11;7:200.

29.

Alterations in mouse cardiac proteome after in vivo myocardial infarction: permanent ischaemia versus ischaemia-reperfusion.

De Celle T, Vanrobaeys F, Lijnen P, Blankesteijn WM, Heeneman S, Van Beeumen J, Devreese B, Smits JF, Janssen BJ.

Exp Physiol. 2005 Jul;90(4):593-606. Epub 2005 Apr 15.

30.

Functional and structural postglomerular alterations in the kidney of prehypertensive spontaneously hypertensive rats.

Baumann M, van Essen H, Hermans JJ, Smits JF, Struijker-Boudier HA.

Clin Exp Hypertens. 2004 Oct-Nov;26(7-8):663-72.

PMID:
15702621
31.

Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy.

Schroen B, Heymans S, Sharma U, Blankesteijn WM, Pokharel S, Cleutjens JP, Porter JG, Evelo CT, Duisters R, van Leeuwen RE, Janssen BJ, Debets JJ, Smits JF, Daemen MJ, Crijns HJ, Bornstein P, Pinto YM.

Circ Res. 2004 Sep 3;95(5):515-22. Epub 2004 Jul 29.

PMID:
15284191
32.

Long-term structural and functional consequences of cardiac ischaemia-reperfusion injury in vivo in mice.

De Celle T, Cleutjens JP, Blankesteijn WM, Debets JJ, Smits JF, Janssen BJ.

Exp Physiol. 2004 Sep;89(5):605-15. Epub 2004 Jul 15.

33.

Sustained protective effects of 7-monohydroxyethylrutoside in an in vivo model of cardiac ischemia-reperfusion.

De Celle T, Heeringa P, Strzelecka AE, Bast A, Smits JF, Janssen BJ.

Eur J Pharmacol. 2004 Jun 28;494(2-3):205-12.

PMID:
15212976
34.

Intrapericardial delivery enhances cardiac effects of sotalol and atenolol.

van Brakel TJ, Hermans JJ, Janssen BJ, van Essen H, Botterhuis N, Smits JF, Maessen JG.

J Cardiovasc Pharmacol. 2004 Jul;44(1):50-6.

PMID:
15175557
35.

Tissue angiotensin-converting enzyme in imposed and physiological flow-related arterial remodeling in mice.

Hilgers RH, Schiffers PM, Aartsen WM, Fazzi GE, Smits JF, De Mey JG.

Arterioscler Thromb Vasc Biol. 2004 May;24(5):892-7. Epub 2004 Mar 18.

PMID:
15031129
36.

Changes in vascular distensibility during angiotensin-converting enzyme inhibition involve bradykinin type 2 receptors.

Aartsen WM, Hilgers RH, Schiffers PM, Daemen MJ, De Mey JG, Smits JF.

J Vasc Res. 2004 Jan-Feb;41(1):18-27. Epub 2004 Jan 12.

PMID:
14726629
37.

The role of locally expressed angiotensin converting enzyme in cardiac remodeling after myocardial infarction in mice.

Aartsen WM, Schuijt MP, Danser AH, Daemen MJ, Smits JF.

Cardiovasc Res. 2002 Nov;56(2):205-13.

PMID:
12393091
38.

Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice.

Creemers EE, Davis JN, Parkhurst AM, Leenders P, Dowdy KB, Hapke E, Hauet AM, Escobar PG, Cleutjens JP, Smits JF, Daemen MJ, Zile MR, Spinale FG.

Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H364-71. Epub 2002 Sep 26.

39.

N-acetyl-Ser-Asp-Lys-Pro inhibits phosphorylation of Smad2 in cardiac fibroblasts.

Pokharel S, Rasoul S, Roks AJ, van Leeuwen RE, van Luyn MJ, Deelman LE, Smits JF, Carretero O, van Gilst WH, Pinto YM.

Hypertension. 2002 Aug;40(2):155-61.

PMID:
12154106
40.

The wnt-frizzled cascade in cardiovascular disease.

van Gijn ME, Daemen MJ, Smits JF, Blankesteijn WM.

Cardiovasc Res. 2002 Jul;55(1):16-24. Review. No abstract available.

PMID:
12062705
41.

Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification.

Janssen BJ, Smits JF.

Am J Physiol Regul Integr Comp Physiol. 2002 Jun;282(6):R1545-64. Review.

42.

Pharmacokinetic advantage of intrapericardially applied substances in the rat.

Hermans JJ, van Essen H, Struijker-Boudier HA, Johnson RM, Theeuwes F, Smits JF.

J Pharmacol Exp Ther. 2002 May;301(2):672-8.

PMID:
11961072
43.

Problem-based learning: the Maastricht experience.

Struijker Boudier HA, Smits JF.

Trends Pharmacol Sci. 2002 Apr;23(4):164. No abstract available.

PMID:
11931989
44.

Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart.

Dumont EA, Reutelingsperger CP, Smits JF, Daemen MJ, Doevendans PA, Wellens HJ, Hofstra L.

Nat Med. 2001 Dec;7(12):1352-5. Erratum in: Nat Med 2002 Jan;8(1):87.

PMID:
11726977
45.

Preferential renal and mesenteric vasodilation induced by barnidipine and amlodipine in spontaneously hypertensive rats.

Janssen BJ, Kam KL, Smits JF.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Nov;364(5):414-21.

PMID:
11692224
46.

Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice.

Blankesteijn WM, Creemers E, Lutgens E, Cleutjens JP, Daemen MJ, Smits JF.

Acta Physiol Scand. 2001 Sep;173(1):75-82. Review.

PMID:
11678729
47.

Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.

Nuyens D, Stengl M, Dugarmaa S, Rossenbacker T, Compernolle V, Rudy Y, Smits JF, Flameng W, Clancy CE, Moons L, Vos MA, Dewerchin M, Benndorf K, Collen D, Carmeliet E, Carmeliet P.

Nat Med. 2001 Sep;7(9):1021-7.

PMID:
11533705
48.

Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure?

Creemers EE, Cleutjens JP, Smits JF, Daemen MJ.

Circ Res. 2001 Aug 3;89(3):201-10. Review.

PMID:
11485970
49.

Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.

Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA.

Cardiovasc Res. 2001 Jun;50(3):516-24.

PMID:
11376627
50.

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