Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 342


Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production.

Kakoki M, Bahnson EM, Hagaman JR, Siletzky RM, Grant R, Kayashima Y, Li F, Lee EY, Sun MT, Taylor JM, Rice JC, Almeida MF, Bahr BA, Jennette JC, Smithies O, Maeda-Smithies N.

JCI Insight. 2019 Jun 20;4(12). pii: 127660. doi: 10.1172/jci.insight.127660. eCollection 2019 Jun 20.


How It All Began: A Personal History of Gel Electrophoresis.

Smithies O.

Methods Mol Biol. 2019;1855:1-21. doi: 10.1007/978-1-4939-8793-1_1.


Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system.

Govindapillai A, Hotchkiss A, Baguma-Nibasheka M, Rose RA, Miquerol L, Smithies O, Maeda N, Pasumarthi KBS.

Sci Rep. 2018 May 2;8(1):6939. doi: 10.1038/s41598-018-25292-0.


Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice.

Li F, Kakoki M, Smid M, Boggess K, Wilder J, Hiller S, Bounajim C, Parnell SE, Sulik KK, Smithies O, Maeda-Smithies N.

Hypertension. 2018 May;71(5):894-903. doi: 10.1161/HYPERTENSIONAHA.117.10849. Epub 2018 Apr 2.


GRAF3 serves as a blood volume-sensitive rheostat to control smooth muscle contractility and blood pressure.

Bai X, Mangum K, Kakoki M, Smithies O, Mack CP, Taylor JM.

Small GTPases. 2017 Nov 3:1-10. doi: 10.1080/21541248.2017.1375602. [Epub ahead of print]


A tetraethylene glycol coat gives gold nanoparticles long in vivo half-lives with minimal increase in size.

Willett JD, Lawrence MG, Wilder JC, Smithies O.

Int J Nanomedicine. 2017 Mar 31;12:2581-2592. doi: 10.2147/IJN.S121486. eCollection 2017.


Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules.

Lawrence MG, Altenburg MK, Sanford R, Willett JD, Bleasdale B, Ballou B, Wilder J, Li F, Miner JH, Berg UB, Smithies O.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2958-2963. doi: 10.1073/pnas.1616457114. Epub 2017 Feb 28.


Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice.

Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V, Smithies O, John SW.

Science. 2017 Feb 17;355(6326):756-760. doi: 10.1126/science.aal0092.


Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia.

Li F, Fushima T, Oyanagi G, Townley-Tilson HW, Sato E, Nakada H, Oe Y, Hagaman JR, Wilder J, Li M, Sekimoto A, Saigusa D, Sato H, Ito S, Jennette JC, Maeda N, Karumanchi SA, Smithies O, Takahashi N.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13450-13455. Epub 2016 Nov 7.


Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase.

Chang AS, Grant R, Tomita H, Kim HS, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12538-12543. Epub 2016 Oct 17.


A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions.

Lawrence M, Testen A, Koklic T, Smithies O.

J Vis Exp. 2016 Feb 5;(108):e53388. doi: 10.3791/53388.


High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy.

Hathaway CK, Chang AS, Grant R, Kim HS, Madden VJ, Bagnell CR Jr, Jennette JC, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2218-22. doi: 10.1073/pnas.1600511113. Epub 2016 Feb 8.


Transforming growth factor-β1 and diabetic nephropathy.

Chang AS, Hathaway CK, Smithies O, Kakoki M.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F689-F696. doi: 10.1152/ajprenal.00502.2015. Epub 2015 Dec 30. Review.


A conversation with Oliver Smithies.

Smithies O, Neill US.

J Clin Invest. 2015 Nov 2;125(11):3997-8. doi: 10.1172/JCI84087. Epub 2015 Nov 2. No abstract available.


The whole of a scientific career: an interview with Oliver Smithies.

Smithies O, Gitschier J.

PLoS Genet. 2015 May 28;11(5):e1005224. doi: 10.1371/journal.pgen.1005224. eCollection 2015 May. No abstract available.


Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice.

Hathaway CK, Gasim AM, Grant R, Chang AS, Kim HS, Madden VJ, Bagnell CR Jr, Jennette JC, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5815-20. doi: 10.1073/pnas.1504777112. Epub 2015 Apr 20.


Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade.

Hathaway CK, Grant R, Hagaman JR, Hiller S, Li F, Xu L, Chang AS, Madden VJ, Bagnell CR, Rojas M, Kim HS, Wu B, Zhou B, Smithies O, Kakoki M.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5141-6. doi: 10.1073/pnas.1504557112. Epub 2015 Apr 6.


A conversation with Oliver Smithies.

Smithies O, Coffman T.

Annu Rev Physiol. 2015;77:1-11. doi: 10.1146/annurev-physiol-021014-071806.


Transforming growth factor beta1 and aldosterone.

Matsuki K, Hathaway CK, Chang AS, Smithies O, Kakoki M.

Curr Opin Nephrol Hypertens. 2015 Mar;24(2):139-44. doi: 10.1097/MNH.0000000000000100. Review.


Stable oligomeric clusters of gold nanoparticles: preparation, size distribution, derivatization, and physical and biological properties.

Smithies O, Lawrence M, Testen A, Horne LP, Wilder J, Altenburg M, Bleasdale B, Maeda N, Koklic T.

Langmuir. 2014 Nov 11;30(44):13394-404. doi: 10.1021/la5032637. Epub 2014 Oct 29.


Colour blindness: still too many red-green figures.

Allred SC, Schreiner WJ, Smithies O.

Nature. 2014 Jun 19;510(7505):340. doi: 10.1038/510340e. No abstract available.


The role of transforming growth factor β1 in the regulation of blood pressure.

Matsuki K, Hathaway CK, Lawrence MG, Smithies O, Kakoki M.

Curr Hypertens Rev. 2014;10(4):223-38. Review.


The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.

Bai X, Lenhart KC, Bird KE, Suen AA, Rojas M, Kakoki M, Li F, Smithies O, Mack CP, Taylor JM.

Nat Commun. 2013;4:2910. doi: 10.1038/ncomms3910.


Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1.

Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, Zaika OL, Mamenko M, Kayashima Y, Matsuki K, Hiller S, Li F, Xu L, Grant R, Bertorello AM, Smithies O.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5600-5. doi: 10.1073/pnas.1302641110. Epub 2013 Mar 15.


Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney.

Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG.

Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1629-40. doi: 10.1152/ajprenal.00246.2012. Epub 2012 Sep 26.


Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression.

Pandya K, Kohro T, Mimura I, Kobayashi M, Wada Y, Kodama T, Smithies O.

Gene Expr. 2012;15(4):183-98.


How it all began: a personal history of gel electrophoresis.

Smithies O.

Methods Mol Biol. 2012;869:1-21. doi: 10.1007/978-1-61779-821-4_1.


The kallikrein-kinin system in diabetic nephropathy.

Tomita H, Sanford RB, Smithies O, Kakoki M.

Kidney Int. 2012 Apr;81(8):733-44. doi: 10.1038/ki.2011.499. Epub 2012 Feb 8. Review.


eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype.

Li F, Hagaman JR, Kim HS, Maeda N, Jennette JC, Faber JE, Karumanchi SA, Smithies O, Takahashi N.

J Am Soc Nephrol. 2012 Apr;23(4):652-60. doi: 10.1681/ASN.2011040369. Epub 2012 Jan 26.


Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility.

Zajac B, Hakim ZS, Cameron MV, Smithies O, Taylor JM.

Methods Mol Biol. 2012;843:111-23. doi: 10.1007/978-1-61779-523-7_11.


The kallikrein-kinin system and oxidative stress.

Kayashima Y, Smithies O, Kakoki M.

Curr Opin Nephrol Hypertens. 2012 Jan;21(1):92-6. doi: 10.1097/MNH.0b013e32834d54b1. Review.


β-MyHC and cardiac hypertrophy: size does matter.

Pandya K, Smithies O.

Circ Res. 2011 Sep 2;109(6):609-10. doi: 10.1161/CIRCRESAHA.111.252619. No abstract available.


Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.

Fox R, Kim HS, Reddick RL, Kujoth GC, Prolla TA, Tsutsumi S, Wada Y, Smithies O, Maeda N.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8779-84. doi: 10.1073/pnas.1106344108. Epub 2011 May 9.


A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy.

Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2070-5. doi: 10.1073/pnas.1018766108. Epub 2011 Jan 18. Erratum in: Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3453.


Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells.

Hatada S, Walton W, Hatada T, Wofford A, Fox R, Liu N, Lill MC, Fair JH, Kirby SL, Smithies O.

Exp Hematol. 2011 Mar;39(3):375-83, 383.e1-4. doi: 10.1016/j.exphem.2010.12.007. Epub 2010 Dec 22.


Science brick by brick.

Smithies O.

Nature. 2010 Oct 14;467(7317):S6. doi: 10.1038/467S6a. No abstract available.


Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy.

Konno T, Chen D, Wang L, Wakimoto H, Teekakirikul P, Nayor M, Kawana M, Eminaga S, Gorham JM, Pandya K, Smithies O, Naya FJ, Olson EN, Seidman JG, Seidman CE.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18097-102. doi: 10.1073/pnas.1012826107. Epub 2010 Oct 5.


Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia.

Messadi E, Vincent MP, Griol-Charhbili V, Mandet C, Colucci J, Krege JH, Bruneval P, Bouby N, Smithies O, Alhenc-Gelas F, Richer C.

FASEB J. 2010 Dec;24(12):4691-700. doi: 10.1096/fj.10-165902. Epub 2010 Jul 28.


Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.

Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED.

Endocrinology. 2010 Aug;151(8):3536-42. doi: 10.1210/en.2010-0256. Epub 2010 May 25.


Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.

Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. doi: 10.1073/pnas.1005144107. Epub 2010 May 17.


Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990.

Koller BH, Marrack P, Kappler JW, Smithies O.

J Immunol. 2010 May 1;184(9):4592-5. No abstract available.


Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure.

Tsai YS, Xu L, Smithies O, Maeda N.

Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19084-9. doi: 10.1073/pnas.0909657106. Epub 2009 Nov 2.


Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.

Scott NJ, Ellmers LJ, Lainchbury JG, Maeda N, Smithies O, Richards AM, Cameron VA.

Biochim Biophys Acta. 2009 Dec;1792(12):1175-84. doi: 10.1016/j.bbadis.2009.09.009. Epub 2009 Sep 24.


Mouse models of diabetic nephropathy.

Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; Animal Models of Diabetic Complications Consortium.

J Am Soc Nephrol. 2009 Dec;20(12):2503-12. doi: 10.1681/ASN.2009070721. Epub 2009 Sep 3. Review.


Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin.

Huby AC, Rastaldi MP, Caron K, Smithies O, Dussaule JC, Chatziantoniou C.

PLoS One. 2009 Aug 21;4(8):e6721. doi: 10.1371/journal.pone.0006721.


Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain.

Pandya K, Porter K, Rockman HA, Smithies O.

Eur J Heart Fail. 2009 Jul;11(7):648-52. doi: 10.1093/eurjhf/hfp073.


Gender-dependent survival of allogeneic trophoblast stem cells in liver.

Epple-Farmer J, Debeb BG, Smithies O, Binas B.

Cell Transplant. 2009;18(7):769-76. doi: 10.3727/096368909X470856. Epub 2009 Apr 29.


The kallikrein-kinin system in health and in diseases of the kidney.

Kakoki M, Smithies O.

Kidney Int. 2009 May;75(10):1019-30. doi: 10.1038/ki.2008.647. Epub 2009 Feb 4. Review.


RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice.

Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R.

Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1205-10. doi: 10.1073/pnas.0812436106. Epub 2009 Jan 21.

Supplemental Content

Loading ...
Support Center