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Items: 43


Bromodomain inhibitor I-BET151 suppresses immune responses during fungal-immune interaction.

Domínguez-Andrés J, Ferreira AV, Jansen T, Smithers N, Prinjha RK, Furze RC, Netea MG.

Eur J Immunol. 2019 Jun 17. doi: 10.1002/eji.201848081. [Epub ahead of print]


Establishment of a pulmonary epithelial barrier on biodegradable poly-L-lactic-acid membranes.

Montesanto S, Smithers NP, Bucchieri F, Brucato V, La Carrubba V, Davies DE, Conforti F.

PLoS One. 2019 Jan 17;14(1):e0210830. doi: 10.1371/journal.pone.0210830. eCollection 2019.


Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation.

Chabert C, Khochbin S, Rousseaux S, Veyrenc S, Furze R, Smithers N, Prinjha RK, Schlattner U, Pison C, Dubouchaud H.

Int J Mol Sci. 2018 Jul 30;19(8). pii: E2224. doi: 10.3390/ijms19082224.


Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL.

Bardini M, Trentin L, Rizzo F, Vieri M, Savino AM, Garrido Castro P, Fazio G, Van Roon EHJ, Kerstjens M, Smithers N, Prinjha RK, Te Kronnie G, Basso G, Stam RW, Pieters R, Biondi A, Cazzaniga G.

Mol Cancer Ther. 2018 Aug;17(8):1705-1716. doi: 10.1158/1535-7163.MCT-17-1123. Epub 2018 May 10.


Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins.

Chabert C, Khochbin S, Rousseaux S, Furze R, Smithers N, Prinjha R, Schlattner U, Pison C, Dubouchaud H.

Sci Rep. 2017 Sep 21;7(1):12133. doi: 10.1038/s41598-017-12112-0.


Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus.

Loxham M, Smart DE, Bedke NJ, Smithers NP, Filippi I, Blume C, Swindle EJ, Tariq K, Howarth PH, Holgate ST, Davies DE.

Mucosal Immunol. 2018 Mar;11(2):404-414. doi: 10.1038/mi.2017.63. Epub 2017 Jul 5.


Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis.

Huang W, Haynes AC, Mukherjee R, Wen L, Latawiec D, Tepikin AV, Criddle DN, Prinjha RK, Smithers N, Sutton R.

Pancreatology. 2017 Sep - Oct;17(5):689-697. doi: 10.1016/j.pan.2017.06.005. Epub 2017 Jun 10.


TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz VLJ.

J Exp Med. 2017 May 1;214(5):1269-1280. doi: 10.1084/jem.20161117. Epub 2017 Mar 29.


Protocadherin-1 Localization and Cell-Adhesion Function in Airway Epithelial Cells in Asthma.

Faura Tellez G, Willemse BW, Brouwer U, Nijboer-Brinksma S, Vandepoele K, Noordhoek JA, Heijink I, de Vries M, Smithers NP, Postma DS, Timens W, Wiffen L, van Roy F, Holloway JW, Lackie PM, Nawijn MC, Koppelman GH.

PLoS One. 2016 Oct 4;11(10):e0163967. doi: 10.1371/journal.pone.0163967. eCollection 2016.


IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit.

Hill AR, Donaldson JE, Blume C, Smithers N, Tezera L, Tariq K, Dennison P, Rupani H, Edwards MJ, Howarth PH, Grainge C, Davies DE, Swindle EJ.

Tissue Barriers. 2016 Jun 28;4(3):e1206378. doi: 10.1080/21688370.2016.1206378. eCollection 2016 Jul-Sep.


Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin.

Cruickshank MN, Ford J, Cheung LC, Heng J, Singh S, Wells J, Failes TW, Arndt GM, Smithers N, Prinjha RK, Anderson D, Carter KW, Gout AM, Lassmann T, O'Reilly J, Cole CH, Kotecha RS, Kees UR.

Leukemia. 2017 Jan;31(1):40-50. doi: 10.1038/leu.2016.165. Epub 2016 Jun 13.


Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations.

Vries Md, Bedke N, Smithers NP, Loxham M, Howarth PH, Nawijn MC, Davies DE.

Eur Respir J. 2016 Mar;47(3):783-91. doi: 10.1183/13993003.00171-2015. Epub 2016 Feb 11.


Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.

Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A.

J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21.


Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling.

Heinemann A, Cullinane C, De Paoli-Iseppi R, Wilmott JS, Gunatilake D, Madore J, Strbenac D, Yang JY, Gowrishankar K, Tiffen JC, Prinjha RK, Smithers N, McArthur GA, Hersey P, Gallagher SJ.

Oncotarget. 2015 Aug 28;6(25):21507-21.


Syk tyrosine kinase is critical for B cell antibody responses and memory B cell survival.

Ackermann JA, Nys J, Schweighoffer E, McCleary S, Smithers N, Tybulewicz VL.

J Immunol. 2015 May 15;194(10):4650-6. doi: 10.4049/jimmunol.1500461. Epub 2015 Apr 10.


Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells.

de Vries M, Smithers NP, Howarth PH, Nawijn MC, Davies DE.

Eur Respir J. 2015 Jun;45(6):1745-8. doi: 10.1183/09031936.00206514. Epub 2015 Mar 5. No abstract available.


Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.

Park-Min KH, Lim E, Lee MJ, Park SH, Giannopoulou E, Yarilina A, van der Meulen M, Zhao B, Smithers N, Witherington J, Lee K, Tak PP, Prinjha RK, Ivashkiv LB.

Nat Commun. 2014 Nov 13;5:5418. doi: 10.1038/ncomms6418.


The epigenetic regulator I-BET151 induces BIM-dependent apoptosis and cell cycle arrest of human melanoma cells.

Gallagher SJ, Mijatov B, Gunatilake D, Tiffen JC, Gowrishankar K, Jin L, Pupo GM, Cullinane C, Prinjha RK, Smithers N, McArthur GA, Rizos H, Hersey P.

J Invest Dermatol. 2014 Nov;134(11):2795-2805. doi: 10.1038/jid.2014.243. Epub 2014 Jun 6.


Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762.

Chaidos A, Caputo V, Gouvedenou K, Liu B, Marigo I, Chaudhry MS, Rotolo A, Tough DF, Smithers NN, Bassil AK, Chapman TD, Harker NR, Barbash O, Tummino P, Al-Mahdi N, Haynes AC, Cutler L, Le B, Rahemtulla A, Roberts I, Kleijnen M, Witherington JJ, Parr NJ, Prinjha RK, Karadimitris A.

Blood. 2014 Jan 30;123(5):697-705. doi: 10.1182/blood-2013-01-478420. Epub 2013 Dec 13.


BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane.

Alsarraj J, Faraji F, Geiger TR, Mattaini KR, Williams M, Wu J, Ha NH, Merlino T, Walker RC, Bosley AD, Xiao Z, Andresson T, Esposito D, Smithers N, Lugo D, Prinjha R, Day A, Crawford NP, Ozato K, Gardner K, Hunter KW.

PLoS One. 2013 Nov 19;8(11):e80746. doi: 10.1371/journal.pone.0080746. eCollection 2013.


Single-channel electrophysiology of cell-free expressed ion channels by direct incorporation in lipid bilayers.

Friddin MS, Smithers NP, Beaugrand M, Marcotte I, Williamson PT, Morgan H, de Planque MR.

Analyst. 2013 Nov 12;138(24):7294-8. doi: 10.1039/c3an01540h.


Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains.

Mirguet O, Gosmini R, Toum J, Clément CA, Barnathan M, Brusq JM, Mordaunt JE, Grimes RM, Crowe M, Pineau O, Ajakane M, Daugan A, Jeffrey P, Cutler L, Haynes AC, Smithers NN, Chung CW, Bamborough P, Uings IJ, Lewis A, Witherington J, Parr N, Prinjha RK, Nicodème E.

J Med Chem. 2013 Oct 10;56(19):7501-15. doi: 10.1021/jm401088k. Epub 2013 Sep 25.


The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

Schweighoffer E, Vanes L, Nys J, Cantrell D, McCleary S, Smithers N, Tybulewicz VL.

Immunity. 2013 Mar 21;38(3):475-88. doi: 10.1016/j.immuni.2012.11.015. Epub 2013 Feb 28.


Characterizing the fatty acid binding site in the cavity of potassium channel KcsA.

Smithers N, Bolivar JH, Lee AG, East JM.

Biochemistry. 2012 Oct 9;51(40):7996-8002. doi: 10.1021/bi3009196. Epub 2012 Sep 25.


Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors.

Bandukwala HS, Gagnon J, Togher S, Greenbaum JA, Lamperti ED, Parr NJ, Molesworth AM, Smithers N, Lee K, Witherington J, Tough DF, Prinjha RK, Peters B, Rao A.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14532-7. doi: 10.1073/pnas.1212264109. Epub 2012 Aug 21.


Multiple binding sites for fatty acids on the potassium channel KcsA.

Bolivar JH, Smithers N, East JM, Marsh D, Lee AG.

Biochemistry. 2012 Apr 3;51(13):2889-98. doi: 10.1021/bi300153v. Epub 2012 Mar 20.


CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, Watson SP.

Blood. 2012 Feb 16;119(7):1747-56. doi: 10.1182/blood-2011-09-380709. Epub 2011 Dec 20.


Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.

Liddle J, Atkinson FL, Barker MD, Carter PS, Curtis NR, Davis RP, Douault C, Dickson MC, Elwes D, Garton NS, Gray M, Hayhow TG, Hobbs CI, Jones E, Leach S, Leavens K, Lewis HD, McCleary S, Neu M, Patel VK, Preston AG, Ramirez-Molina C, Shipley TJ, Skone PA, Smithers N, Somers DO, Walker AL, Watson RJ, Weingarten GG.

Bioorg Med Chem Lett. 2011 Oct 15;21(20):6188-94. doi: 10.1016/j.bmcl.2011.07.082. Epub 2011 Aug 12.


80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c.

Smithers NP, Hodgkinson CP, Cuttle M, Sale GJ.

J Recept Signal Transduct Res. 2008;28(6):581-9. doi: 10.1080/10799890802598571.


Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling.

Smithers NP, Hodgkinson CP, Cuttle M, Sale GJ.

Biochem J. 2008 Mar 1;410(2):255-60.


The generation and characterisation of antagonist RNA aptamers to MCP-1.

Rhodes A, Smithers N, Chapman T, Parsons S, Rees S.

FEBS Lett. 2001 Oct 5;506(2):85-90.


Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands.

Britten CJ, van den Eijnden DH, McDowell W, Kelly VA, Witham SJ, Edbrooke MR, Bird MI, de Vries T, Smithers N.

Glycobiology. 1998 Apr;8(4):321-7.


Expression of a secreted form of human alpha 1,3 fucosyltransferase VII from insect cells.

Smithers N, Kelly VA, Witham SJ, Edbrooke MR, Britten CJ.

Biochem Soc Trans. 1997 Aug;25(3):426S. No abstract available.


The alpha(1-3)-fucosyltransferases come of age.

Edbrooke MR, Britten CJ, Kelly VA, Martin SL, Smithers N, Winder AJ, Witham SJ, Bird MI.

Biochem Soc Trans. 1997 Aug;25(3):880-6. Review. No abstract available.


A time-resolved immunofluorometric method for the measurement of sialyl Lewis x-synthesizing alpha1,3-fucosyltransferase activity.

Räbinä J, Smithers N, Britten CJ, Renkonen R.

Anal Biochem. 1997 Mar 1;246(1):71-8.


Tissue specific expression of the human alpha(1-3) fucosyltransferase gene family.

Winder A, Smithers N, Witham S, Symons A, Edbrooke M.

Biochem Soc Trans. 1995 May;23(2):165S. No abstract available.


Receptor mediated endocytosis and intracellular fate of interleukin 1.

Solari R, Smithers N, Kennard N, Ray K, Grenfell S.

Biochem Pharmacol. 1994 Jan 13;47(1):93-101.


Acute upregulation of interleukin-1 receptor by ligand.

Grenfell SJ, Smithers N, Solari R.

Cytokine. 1992 Mar;4(2):114-24.


Investigation of guanine-nucleotide-binding protein involvement and regulation of cyclic AMP metabolism in interleukin 1 signal transduction.

Ray K, Thompson N, Kennard N, Rollins P, Grenfell S, Witham S, Smithers N, Solari R.

Biochem J. 1992 Feb 15;282 ( Pt 1):59-67.


Analysis of mutations in the putative nuclear localization sequence of interleukin-1 beta.

Grenfell S, Smithers N, Witham S, Shaw A, Graber P, Solari R.

Biochem J. 1991 Nov 15;280 ( Pt 1):111-6.


Modification of biological responses to interleukin-1 by agents that perturb signal transduction pathways.

Rollins P, Witham S, Ray K, Thompson N, Sadler H, Smithers N, Grenfell S, Solari R.

Cytokine. 1991 Jan;3(1):42-53.


Interleukin 1 responsiveness and receptor expression by murine TH1 and TH2 clones.

Solari R, Smithers N, Page K, Bolton E, Champion BR.

Cytokine. 1990 Mar;2(2):129-41.


Receptor-mediated endocytosis and nuclear transport of human interleukin 1 alpha.

Grenfell S, Smithers N, Miller K, Solari R.

Biochem J. 1989 Dec 15;264(3):813-22.

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