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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping.

Mahon BZ, Mead JA, Chernoff BL, Sims MH, Garcea FE, Prentiss E, Belkhir R, Haber SJ, Gannon SB, Erickson S, Wright KA, Schmidt MZ, Paulzak A, Milano VC, Paul DA, Foxx K, Tivarus M, Nadler JW, Behr JM, Smith SO, Li YM, Walter K, Pilcher WH.

J Vis Exp. 2019 Aug 12;(150). doi: 10.3791/59592.


Direct electrical stimulation of the left frontal aslant tract disrupts sentence planning without affecting articulation.

Chernoff BL, Sims MH, Smith SO, Pilcher WH, Mahon BZ.

Cogn Neuropsychol. 2019 May - Jun;36(3-4):178-192. doi: 10.1080/02643294.2019.1619544. Epub 2019 Jun 18.


Impaired dynamic cerebral autoregulation in trained breath-hold divers.

Moir ME, Klassen SA, Al-Khazraji BK, Woehrle E, Smith SO, Matushewski BJ, Kozić D, Dujić Ž, Barak OF, Shoemaker JK.

J Appl Physiol (1985). 2019 Jun 1;126(6):1694-1700. doi: 10.1152/japplphysiol.00210.2019. Epub 2019 May 9.


Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.

Tang TC, Kienlen-Campard P, Hu Y, Perrin F, Opsomer R, Octave JN, Constantinescu SN, Smith SO.

J Biol Chem. 2019 Apr 12;294(15):5854-5866. doi: 10.1074/jbc.RA118.006061. Epub 2019 Feb 12.


The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.

Defour JP, Levy G, Leroy E, Smith SO, Constantinescu SN.

Leukemia. 2019 Feb;33(2):563-564. doi: 10.1038/s41375-018-0356-x. Epub 2019 Jan 11. No abstract available.


A Novel Transgenic Rat Model of Robust Cerebral Microvascular Amyloid with Prominent Vasculopathy.

Davis J, Xu F, Hatfield J, Lee H, Hoos MD, Popescu D, Crooks E, Kim R, Smith SO, Robinson JK, Benveniste H, Van Nostrand WE.

Am J Pathol. 2018 Dec;188(12):2877-2889. doi: 10.1016/j.ajpath.2018.07.030. Epub 2018 Nov 13.


Disaggregation of Aβ42 for Structural and Biochemical Studies.

Chung H, Crooks EJ, Ziliox M, Smith SO.

Methods Mol Biol. 2018;1777:321-330. doi: 10.1007/978-1-4939-7811-3_20.


A Role for the Frontal Aslant Tract in Speech Planning: A Neurosurgical Case Study.

Chernoff BL, Teghipco A, Garcea FE, Sims MH, Paul DA, Tivarus ME, Smith SO, Pilcher WH, Mahon BZ.

J Cogn Neurosci. 2018 May;30(5):752-769. doi: 10.1162/jocn_a_01244. Epub 2018 Mar 23.


β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.

Hu Y, Kienlen-Campard P, Tang TC, Perrin F, Opsomer R, Decock M, Pan X, Octave JN, Constantinescu SN, Smith SO.

Sci Rep. 2017 Dec 7;7(1):17159. doi: 10.1038/s41598-017-17144-0.


Direct Electrical Stimulation in the Human Brain Disrupts Melody Processing.

Garcea FE, Chernoff BL, Diamond B, Lewis W, Sims MH, Tomlinson SB, Teghipco A, Belkhir R, Gannon SB, Erickson S, Smith SO, Stone J, Liu L, Tollefson T, Langfitt J, Marvin E, Pilcher WH, Mahon BZ.

Curr Biol. 2017 Sep 11;27(17):2684-2691.e7. doi: 10.1016/j.cub.2017.07.051. Epub 2017 Aug 24.


G Protein-Coupled Receptors Contain Two Conserved Packing Clusters.

Sanchez-Reyes OB, Cooke ALG, Tranter DB, Rashid D, Eilers M, Reeves PJ, Smith SO.

Biophys J. 2017 Jun 6;112(11):2315-2326. doi: 10.1016/j.bpj.2017.04.051.


Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure.

Xu F, Fu Z, Dass S, Kotarba AE, Davis J, Smith SO, Van Nostrand WE.

Nat Commun. 2016 Nov 21;7:13527. doi: 10.1038/ncomms13527.


Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation.

Kimata N, Pope A, Eilers M, Opefi CA, Ziliox M, Hirshfeld A, Zaitseva E, Vogel R, Sheves M, Reeves PJ, Smith SO.

Nat Commun. 2016 Sep 2;7:12683. doi: 10.1038/ncomms12683.


Free backbone carbonyls mediate rhodopsin activation.

Kimata N, Pope A, Sanchez-Reyes OB, Eilers M, Opefi CA, Ziliox M, Reeves PJ, Smith SO.

Nat Struct Mol Biol. 2016 Aug;23(8):738-43. doi: 10.1038/nsmb.3257. Epub 2016 Jul 4.


Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells.

Decock M, Stanga S, Octave JN, Dewachter I, Smith SO, Constantinescu SN, Kienlen-Campard P.

Front Aging Neurosci. 2016 May 10;8:107. doi: 10.3389/fnagi.2016.00107. eCollection 2016.


Risk Factors for Proliferative Diabetic Retinopathy in African Americans with Type 2 Diabetes.

Penman A, Hancock H, Papavasileiou E, James M, Idowu O, Riche DM, Fernandez M, Brauner S, Smith SO, Hoadley S, Richardson C, Vazquez V, Chi C, Andreoli C, Husain D, Chen CJ, Sobrin L.

Ophthalmic Epidemiol. 2016;23(2):88-93. doi: 10.3109/09286586.2015.1119287. Epub 2016 Mar 7.


His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.

Leroy E, Defour JP, Sato T, Dass S, Gryshkova V, Shwe MM, Staerk J, Constantinescu SN, Smith SO.

J Biol Chem. 2016 Feb 5;291(6):2974-87. doi: 10.1074/jbc.M115.696534. Epub 2015 Dec 1.


Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.

Decock M, El Haylani L, Stanga S, Dewachter I, Octave JN, Smith SO, Constantinescu SN, Kienlen-Campard P.

FEBS Open Bio. 2015 Sep 6;5:763-73. doi: 10.1016/j.fob.2015.09.002. eCollection 2015.


African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans.

Tandon A, Chen CJ, Penman A, Hancock H, James M, Husain D, Andreoli C, Li X, Kuo JZ, Idowu O, Riche D, Papavasilieou E, Brauner S, Smith SO, Hoadley S, Richardson C, Kieser T, Vazquez V, Chi C, Fernandez M, Harden M, Cotch MF, Siscovick D, Taylor HA, Wilson JG, Reich D, Wong TY, Klein R, Klein BE, Rotter JI, Patterson N, Sobrin L.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3999-4005. doi: 10.1167/iovs.15-16674.


Mechanism of Nucleated Conformational Conversion of Aβ42.

Fu Z, Aucoin D, Davis J, Van Nostrand WE, Smith SO.

Biochemistry. 2015 Jul 14;54(27):4197-207. doi: 10.1021/acs.biochem.5b00467. Epub 2015 Jun 26.


Construction of stable mammalian cell lines for inducible expression of G protein-coupled receptors.

Opefi CA, Tranter D, Smith SO, Reeves PJ.

Methods Enzymol. 2015;556:283-305. doi: 10.1016/bs.mie.2014.12.020. Epub 2015 Mar 20.


Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.

Kimata N, Reeves PJ, Smith SO.

J Magn Reson. 2015 Apr;253:111-8. doi: 10.1016/j.jmr.2014.12.014.


Sequential structural changes in rhodopsin occurring upon photoactivation.

Kimata N, Pope A, Rashid D, Reeves PJ, Smith SO.

Methods Mol Biol. 2015;1271:159-71. doi: 10.1007/978-1-4939-2330-4_11.


Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.

Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero AO, Dewachter I, Octave JN, Smith SO, Constantinescu SN, Kienlen-Campard P.

J Biol Chem. 2015 Mar 13;290(11):7169-84. doi: 10.1074/jbc.M114.601286. Epub 2015 Jan 22.


Capping of aβ42 oligomers by small molecule inhibitors.

Fu Z, Aucoin D, Ahmed M, Ziliox M, Van Nostrand WE, Smith SO.

Biochemistry. 2014 Dec 23;53(50):7893-903. doi: 10.1021/bi500910b. Epub 2014 Dec 11.


Coupling of transmembrane helix orientation to membrane release of the juxtamembrane region in FGFR3.

Tamagaki H, Furukawa Y, Yamaguchi R, Hojo H, Aimoto S, Smith SO, Sato T.

Biochemistry. 2014 Aug 5;53(30):5000-7. doi: 10.1021/bi500327q. Epub 2014 Jul 24.


Early-onset formation of parenchymal plaque amyloid abrogates cerebral microvascular amyloid accumulation in transgenic mice.

Xu F, Kotarba AE, Ou-Yang MH, Fu Z, Davis J, Smith SO, Van Nostrand WE.

J Biol Chem. 2014 Jun 20;289(25):17895-908. doi: 10.1074/jbc.M113.536565. Epub 2014 May 14.


Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.

Tang TC, Hu Y, Kienlen-Campard P, El Haylani L, Decock M, Van Hees J, Fu Z, Octave JN, Constantinescu SN, Smith SO.

Structure. 2014 Mar 4;22(3):387-96. doi: 10.1016/j.str.2013.12.012. Epub 2014 Jan 23.


Amino acid conservation and interactions in rhodopsin: probing receptor activation by NMR spectroscopy.

Pope A, Eilers M, Reeves PJ, Smith SO.

Biochim Biophys Acta. 2014 May;1837(5):683-93. doi: 10.1016/j.bbabio.2013.10.007. Epub 2013 Oct 29. Review.


Retinitis pigmentosa mutants provide insight into the role of the N-terminal cap in rhodopsin folding, structure, and function.

Opefi CA, South K, Reynolds CA, Smith SO, Reeves PJ.

J Biol Chem. 2013 Nov 22;288(47):33912-26. doi: 10.1074/jbc.M113.483032. Epub 2013 Oct 8.


High-level expression, purification and characterization of a constitutively active thromboxane A2 receptor polymorphic variant.

Xu B, Chakraborty R, Eilers M, Dakshinamurti S, O'Neil JD, Smith SO, Bhullar RP, Chelikani P.

PLoS One. 2013 Sep 23;8(9):e76481. doi: 10.1371/journal.pone.0076481. eCollection 2013.


A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae.

Lin CP, Kim C, Smith SO, Neiman AM.

PLoS Genet. 2013;9(8):e1003700. doi: 10.1371/journal.pgen.1003700. Epub 2013 Aug 15.


Fine mapping of the amyloid β-protein binding site on myelin basic protein.

Kotarba AE, Aucoin D, Hoos MD, Smith SO, Van Nostrand WE.

Biochemistry. 2013 Apr 16;52(15):2565-73. doi: 10.1021/bi4001936. Epub 2013 Apr 4.


Magic angle spinning nuclear magnetic resonance spectroscopy of G protein-coupled receptors.

Goncalves J, Eilers M, South K, Opefi CA, Laissue P, Reeves PJ, Smith SO.

Methods Enzymol. 2013;522:365-89. doi: 10.1016/B978-0-12-407865-9.00017-0.


Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.

Defour JP, Itaya M, Gryshkova V, Brett IC, Pecquet C, Sato T, Smith SO, Constantinescu SN.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2540-5. doi: 10.1073/pnas.1211560110. Epub 2013 Jan 28.


Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides.

Matsushita C, Tamagaki H, Miyazawa Y, Aimoto S, Smith SO, Sato T.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1646-51. doi: 10.1073/pnas.1215207110. Epub 2013 Jan 14.


Structural transitions of transmembrane helix 6 in the formation of metarhodopsin I.

Eilers M, Goncalves JA, Ahuja S, Kirkup C, Hirshfeld A, Simmerling C, Reeves PJ, Sheves M, Smith SO.

J Phys Chem B. 2012 Sep 6;116(35):10477-89. doi: 10.1021/jp3019183. Epub 2012 May 17.


Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity.

Ladiwala AR, Litt J, Kane RS, Aucoin DS, Smith SO, Ranjan S, Davis J, Van Nostrand WE, Tessier PM.

J Biol Chem. 2012 Jul 13;287(29):24765-73. doi: 10.1074/jbc.M111.329763. Epub 2012 Apr 30.


Insights into the activation mechanism of the visual receptor rhodopsin.

Smith SO.

Biochem Soc Trans. 2012 Apr;40(2):389-93. doi: 10.1042/BST20110751. Review.


Synthesis, purification, and characterization of single helix membrane peptides and proteins for NMR spectroscopy.

Itaya M, Brett IC, Smith SO.

Methods Mol Biol. 2012;831:333-57. doi: 10.1007/978-1-61779-480-3_18.


Orientation-specific signalling by thrombopoietin receptor dimers.

Staerk J, Defour JP, Pecquet C, Leroy E, Antoine-Poirel H, Brett I, Itaya M, Smith SO, Vainchenker W, Constantinescu SN.

EMBO J. 2011 Sep 2;30(21):4398-413. doi: 10.1038/emboj.2011.315.


Structural and functional roles of small group-conserved amino acids present on helix-H7 in the β(2)-adrenergic receptor.

Arakawa M, Chakraborty R, Upadhyaya J, Eilers M, Reeves PJ, Smith SO, Chelikani P.

Biochim Biophys Acta. 2011 Apr;1808(4):1170-8. doi: 10.1016/j.bbamem.2011.01.012. Epub 2011 Jan 22.


Highly conserved tyrosine stabilizes the active state of rhodopsin.

Goncalves JA, South K, Ahuja S, Zaitseva E, Opefi CA, Eilers M, Vogel R, Reeves PJ, Smith SO.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19861-6. doi: 10.1073/pnas.1009405107. Epub 2010 Nov 1.


N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly.

Liao MC, Hoos MD, Aucoin D, Ahmed M, Davis J, Smith SO, Van Nostrand WE.

J Biol Chem. 2010 Nov 12;285(46):35590-8. doi: 10.1074/jbc.M110.169599. Epub 2010 Aug 31.


Structure and function of G protein-coupled receptors using NMR spectroscopy.

Goncalves JA, Ahuja S, Erfani S, Eilers M, Smith SO.

Prog Nucl Magn Reson Spectrosc. 2010 Aug;57(2):159-80. doi: 10.1016/j.pnmrs.2010.04.004. Epub 2010 May 12. Review. No abstract available.


Alternative placements for women wearing pedometers.

Ling CG, Smith SO.

J Am Acad Nurse Pract. 2010 May;22(5):264-9. doi: 10.1111/j.1745-7599.2010.00502.x.


What is the role of amyloid precursor protein dimerization?

Khalifa NB, Van Hees J, Tasiaux B, Huysseune S, Smith SO, Constantinescu SN, Octave JN, Kienlen-Campard P.

Cell Adh Migr. 2010 Apr-Jun;4(2):268-72. Epub 2010 Apr 11.


Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils.

Ahmed M, Davis J, Aucoin D, Sato T, Ahuja S, Aimoto S, Elliott JI, Van Nostrand WE, Smith SO.

Nat Struct Mol Biol. 2010 May;17(5):561-7. doi: 10.1038/nsmb.1799. Epub 2010 Apr 11.


Structure and activation of the visual pigment rhodopsin.

Smith SO.

Annu Rev Biophys. 2010;39:309-28. doi: 10.1146/annurev-biophys-101209-104901. Review.


Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints.

Hornak V, Ahuja S, Eilers M, Goncalves JA, Sheves M, Reeves PJ, Smith SO.

J Mol Biol. 2010 Feb 26;396(3):510-27. doi: 10.1016/j.jmb.2009.12.003. Epub 2009 Dec 11.

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