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Items: 1 to 50 of 92

1.

Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer.

Samala R, Thorsheim HR, Goda S, Taskar K, Gril B, Steeg PS, Smith QR.

Pharm Res. 2016 Dec;33(12):2904-2919. Epub 2016 Aug 19.

PMID:
27541873
2.

CNS Anticancer Drug Discovery and Development Conference White Paper.

Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC.

Neuro Oncol. 2015 Nov;17 Suppl 6:vi1-26. doi: 10.1093/neuonc/nov169.

3.

A balanced view of choroid plexus structure and function: Focus on adult humans.

Spector R, Keep RF, Robert Snodgrass S, Smith QR, Johanson CE.

Exp Neurol. 2015 May;267:78-86. doi: 10.1016/j.expneurol.2015.02.032. Epub 2015 Mar 4. Review.

4.

Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study.

Morikawa A, Peereboom DM, Thorsheim HR, Samala R, Balyan R, Murphy CG, Lockman PR, Simmons A, Weil RJ, Tabar V, Steeg PS, Smith QR, Seidman AD.

Neuro Oncol. 2015 Feb;17(2):289-95. doi: 10.1093/neuonc/nou141. Epub 2014 Jul 11. Erratum in: Neuro Oncol. 2015 Oct;17(10):1423.

5.

Paclitaxel-hyaluronic nanoconjugates prolong overall survival in a preclinical brain metastases of breast cancer model.

Mittapalli RK, Liu X, Adkins CE, Nounou MI, Bohn KA, Terrell TB, Qhattal HS, Geldenhuys WJ, Palmieri D, Steeg PS, Smith QR, Lockman PR.

Mol Cancer Ther. 2013 Nov;12(11):2389-99. doi: 10.1158/1535-7163.MCT-13-0132. Epub 2013 Sep 3.

6.

Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.

Kalvass JC, Polli JW, Bourdet DL, Feng B, Huang SM, Liu X, Smith QR, Zhang LK, Zamek-Gliszczynski MJ; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):80-94. doi: 10.1038/clpt.2013.34. Epub 2013 Feb 14. Review.

PMID:
23588303
7.

Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer.

Taskar KS, Rudraraju V, Mittapalli RK, Samala R, Thorsheim HR, Lockman J, Gril B, Hua E, Palmieri D, Polli JW, Castellino S, Rubin SD, Lockman PR, Steeg PS, Smith QR.

Pharm Res. 2012 Mar;29(3):770-81. doi: 10.1007/s11095-011-0601-8. Epub 2011 Oct 20.

8.

Brain metastases as preventive and therapeutic targets.

Steeg PS, Camphausen KA, Smith QR.

Nat Rev Cancer. 2011 May;11(5):352-63. doi: 10.1038/nrc3053. Epub 2011 Apr 7. Review.

PMID:
21472002
9.

Kinetic studies of drug-protein interactions by using peak profiling and high-performance affinity chromatography: examination of multi-site interactions of drugs with human serum albumin columns.

Tong Z, Schiel JE, Papastavros E, Ohnmacht CM, Smith QR, Hage DS.

J Chromatogr A. 2011 Apr 15;1218(15):2065-71. doi: 10.1016/j.chroma.2010.10.070. Epub 2010 Oct 23.

10.

Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer.

Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR.

Clin Cancer Res. 2010 Dec 1;16(23):5664-78. doi: 10.1158/1078-0432.CCR-10-1564. Epub 2010 Sep 9.

11.

Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood-brain barrier.

Matharu J, Oki J, Worthen DR, Smith QR, Crooks PA.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3688-91. doi: 10.1016/j.bmcl.2010.04.086. Epub 2010 Apr 24.

12.

Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.

Palmieri D, Lockman PR, Thomas FC, Hua E, Herring J, Hargrave E, Johnson M, Flores N, Qian Y, Vega-Valle E, Taskar KS, Rudraraju V, Mittapalli RK, Gaasch JA, Bohn KA, Thorsheim HR, Liewehr DJ, Davis S, Reilly JF, Walker R, Bronder JL, Feigenbaum L, Steinberg SM, Camphausen K, Meltzer PS, Richon VM, Smith QR, Steeg PS.

Clin Cancer Res. 2009 Oct 1;15(19):6148-57. doi: 10.1158/1078-0432.CCR-09-1039. Epub 2009 Sep 29.

13.

Achieving equivalent academic performance between campuses using a distributed education model.

Fike DS, McCall KL, Raehl CL, Smith QR, Lockman PR.

Am J Pharm Educ. 2009 Aug 28;73(5):88.

14.

Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer.

Thomas FC, Taskar K, Rudraraju V, Goda S, Thorsheim HR, Gaasch JA, Mittapalli RK, Palmieri D, Steeg PS, Lockman PR, Smith QR.

Pharm Res. 2009 Nov;26(11):2486-94. doi: 10.1007/s11095-009-9964-5. Epub 2009 Sep 23.

15.

Studies of imipramine binding to human serum albumin by high-performance affinity chromatography.

Yoo MJ, Smith QR, Hage DS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 15;877(11-12):1149-54. doi: 10.1016/j.jchromb.2009.02.070. Epub 2009 Mar 10.

16.

Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug.

Zhang SQ, Thorsheim HR, Penugonda S, Pillai VC, Smith QR, Mehvar R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):927-32. doi: 10.1016/j.jchromb.2009.02.028. Epub 2009 Feb 21.

17.

Using WebCt to implement a basic science competency education course.

Lockman PR, Gaasch JA, Borges K, Ehlo A, Smith QR.

Am J Pharm Educ. 2008 Apr 15;72(2):39.

18.

Chemotherapy delivery issues in central nervous system malignancy: a reality check.

Muldoon LL, Soussain C, Jahnke K, Johanson C, Siegal T, Smith QR, Hall WA, Hynynen K, Senter PD, Peereboom DM, Neuwelt EA.

J Clin Oncol. 2007 Jun 1;25(16):2295-305. Review.

PMID:
17538176
19.

Brain metastases of breast cancer.

Palmieri D, Smith QR, Lockman PR, Bronder J, Gril B, Chambers AF, Weil RJ, Steeg PS.

Breast Dis. 2006-2007;26:139-47. Review.

PMID:
17473372
20.

Brain uptake, pharmacokinetics, and tissue distribution in the rat of neurotoxic N-butylbenzenesulfonamide.

Kumar G, Smith QR, Hokari M, Parepally J, Duncan MW.

Toxicol Sci. 2007 Jun;97(2):253-64. Epub 2007 Mar 15. Erratum in: Toxicol Sci. 2007 Aug;98(2):607-8.

PMID:
17369196
21.

Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.

Niture SK, Velu CS, Smith QR, Bhat GJ, Srivenugopal KS.

Carcinogenesis. 2007 Feb;28(2):378-89. Epub 2006 Aug 31.

PMID:
16950796
22.

Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin.

Parepally JM, Mandula H, Smith QR.

Pharm Res. 2006 May;23(5):873-81. Epub 2006 May 2.

PMID:
16715377
23.

Role of site-specific binding to plasma albumin in drug availability to brain.

Mandula H, Parepally JM, Feng R, Smith QR.

J Pharmacol Exp Ther. 2006 May;317(2):667-75. Epub 2006 Jan 12.

PMID:
16410405
24.

In situ brain perfusion technique.

Smith QR, Allen DD.

Methods Mol Med. 2003;89:209-18. No abstract available.

PMID:
12958422
25.

A review of blood-brain barrier transport techniques.

Smith QR.

Methods Mol Med. 2003;89:193-208. Review. No abstract available.

PMID:
12958421
26.

Fatty acid uptake and incorporation in brain: studies with the perfusion model.

Smith QR, Nagura H.

J Mol Neurosci. 2001 Apr-Jun;16(2-3):167-72; discussion 215-21.

PMID:
11478371
27.

Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique.

Allen DD, Smith QR.

J Neurochem. 2001 Feb;76(4):1032-41. Erratum in: J Neurochem 2001 Apr;77(2):704.

28.

Transport of glutamate and other amino acids at the blood-brain barrier.

Smith QR.

J Nutr. 2000 Apr;130(4S Suppl):1016S-22S. doi: 10.1093/jn/130.4.1016S. Review.

PMID:
10736373
29.

Blood-brain barrier choline transport in the senescent rat.

Allen DD, Smith QR.

Neurosci Lett. 1999 Dec 31;277(3):198-202.

PMID:
10626847
30.

Cerebrovascular Biology and the various neural barriers: challenges and future directions.

Neuwelt EA, Abbott NJ, Drewes L, Smith QR, Couraud PO, Chiocca EA, Audus KL, Greig NH, Doolittle ND.

Neurosurgery. 1999 Mar;44(3):604-8; discussion 608-9.

PMID:
10069598
31.

Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited.

Simpson IA, Appel NM, Hokari M, Oki J, Holman GD, Maher F, Koehler-Stec EM, Vannucci SJ, Smith QR.

J Neurochem. 1999 Jan;72(1):238-47.

32.

Beta-amyloid induced increase in choline flux across PC12 cell membranes.

Allen DD, Galdzicki Z, Brining SK, Fukuyama R, Rapoport SI, Smith QR.

Neurosci Lett. 1997 Sep 26;234(1):71-3.

PMID:
9347949
33.

Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid.

Hokari M, Wu HQ, Schwarcz R, Smith QR.

Neuroreport. 1996 Dec 20;8(1):15-8.

PMID:
9051744
34.

Identification of two molecular species of rat brain phosphatidylcholine that rapidly incorporate and turn over arachidonic acid in vivo.

Shetty HU, Smith QR, Washizaki K, Rapoport SI, Purdon AD.

J Neurochem. 1996 Oct;67(4):1702-10.

PMID:
8858956
35.

Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system.

Smith QR.

Pharm Biotechnol. 1996;8:285-307. Review. No abstract available.

PMID:
8791815
36.

Specific activity of brain palmitoyl-CoA pool provides rates of incorporation of palmitate in brain phospholipids in awake rats.

Grange E, Deutsch J, Smith QR, Chang M, Rapoport SI, Purdon AD.

J Neurochem. 1995 Nov;65(5):2290-8.

PMID:
7595518
37.
38.

Rapid brain uptake of manganese(II) across the blood-brain barrier.

Rabin O, Hegedus L, Bourre JM, Smith QR.

J Neurochem. 1993 Aug;61(2):509-17.

PMID:
7687654
39.

Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier.

Stoll J, Wadhwani KC, Smith QR.

J Neurochem. 1993 May;60(5):1956-9.

PMID:
8473910
40.

Drug delivery to brain and the role of carrier-mediated transport.

Smith QR.

Adv Exp Med Biol. 1993;331:83-93.

PMID:
8333351
41.

Amino acid transport at the blood-nerve barrier of the rat peripheral nerve.

Wadhwani KC, Smith QR, Rapoport SI.

Adv Exp Med Biol. 1993;331:101-6. No abstract available.

PMID:
8101422
42.

Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier.

Takada Y, Vistica DT, Greig NH, Purdon D, Rapoport SI, Smith QR.

Cancer Res. 1992 Apr 15;52(8):2191-6.

43.

Facilitated transport of the neurotoxin, beta-N-methylamino-L-alanine, across the blood-brain barrier.

Smith QR, Nagura H, Takada Y, Duncan MW.

J Neurochem. 1992 Apr;58(4):1330-7.

PMID:
1548467
44.

Saturable transport of manganese(II) across blood-nerve barrier of rat peripheral nerve.

Wadhwani KC, Murphy VA, Smith QR, Rapoport SI.

Am J Physiol. 1992 Feb;262(2 Pt 2):R284-8.

PMID:
1539737
45.

Chloride efflux from isolated choroid plexus.

Smith QR, Johanson CE.

Brain Res. 1991 Oct 25;562(2):306-10.

PMID:
1773342
46.

Saturable transport of Ca into CSF in chronic hypo- and hypercalcemia.

Murphy VA, Smith QR, Rapoport SI.

J Neurosci Res. 1991 Oct;30(2):421-6.

PMID:
1798059
47.

Saturable transport of manganese(II) across the rat blood-brain barrier.

Murphy VA, Wadhwani KC, Smith QR, Rapoport SI.

J Neurochem. 1991 Sep;57(3):948-54.

PMID:
1861159
48.

Calcium deficiency enhances cadmium accumulation in the central nervous system.

Murphy VA, Embrey EC, Rosenberg JM, Smith QR, Rapoport SI.

Brain Res. 1991 Aug 23;557(1-2):280-4.

PMID:
1747758
49.

Regional blood-brain barrier transport of cationized bovine serum albumin in awake rats.

Shimon-Hophy M, Wadhwani KC, Chandrasekaran K, Larson D, Smith QR, Rapoport SI.

Am J Physiol. 1991 Aug;261(2 Pt 2):R478-83.

PMID:
1877704
50.

2-amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics and blood-brain barrier permeability in the rat.

Duncan MW, Villacreses NE, Pearson PG, Wyatt L, Rapoport SI, Kopin IJ, Markey SP, Smith QR.

J Pharmacol Exp Ther. 1991 Jul 1;258(1):27-35.

PMID:
2072299

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