Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 680


Meeting report: WHO consultation on accelerating Lassa fever vaccine development in endemic countries, Dakar, 10-11 September 2019.

Salami K, Gsell PS, Olayinka A, Maiga D, Formenty P, Smith PG, Moorthy V.

Vaccine. 2020 Jan 14. pii: S0264-410X(20)30032-3. doi: 10.1016/j.vaccine.2020.01.017. [Epub ahead of print]


Metabolic disposition of H3B-8800, an orally available small-molecule splicing modulator, in rats, monkeys, and humans.

Rioux N, Smith S, Colombo F, Kim A, Lai WG, Nix D, Siu YA, Schindler J, Smith PG.

Xenobiotica. 2020 Jan 6:1-14. doi: 10.1080/00498254.2019.1709134. [Epub ahead of print]


Vaccine-attributable severe dengue in the Philippines.

Wilder-Smith A, Flasche S, Smith PG.

Lancet. 2019 Dec 14;394(10215):2151-2152. doi: 10.1016/S0140-6736(19)32525-5. No abstract available.


Estimating the proportion of vaccine-induced hospitalized dengue cases among Dengvaxia vaccinees in the Philippines.

Flasche S, Wilder-Smith A, Hombach J, Smith PG.

Wellcome Open Res. 2019 Oct 31;4:165. doi: 10.12688/wellcomeopenres.15507.1. eCollection 2019.


Direct UV written integrated planar waveguides using a 213 nm laser.

Gow PC, Bannerman RHS, Mennea PL, Holmes C, Gates JC, Smith PGR.

Opt Express. 2019 Sep 30;27(20):29133-29138. doi: 10.1364/OE.27.029133.


Spectroscopic gas detection using a Bragg grating - stabilized external cavity laser, custom written in planar integrated silica-on-silicon.

Davis NM, Lynch SG, Gates JC, Hodgkinson J, Smith PGR, Tatam RP.

Opt Express. 2019 Sep 30;27(20):29034-29044. doi: 10.1364/OE.27.029034.


Approaches to use the WHO respiratory syncytial virus surveillance platform to estimate disease burden.

Pebody R, Moyes J, Hirve S, Campbell H, Jackson S, Moen A, Nair H, Simões EAF, Smith PG, Wairagkar N, Zhang W.

Influenza Other Respir Viruses. 2019 Oct 8. doi: 10.1111/irv.12667. [Epub ahead of print]


The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.

Nguyen TV, Yao S, Wang Y, Rolfe A, Selvaraj A, Darman R, Ke J, Warmuth M, Smith PG, Larsen NA, Yu L, Zhu P, Fekkes P, Vaillancourt FH, Bolduc DM.

J Biol Chem. 2019 Nov 8;294(45):16966-16977. doi: 10.1074/jbc.RA119.010126. Epub 2019 Oct 3.


Leveraging the Global Influenza Surveillance and Response System for global respiratory syncytial virus surveillance-opportunities and challenges.

Broor S, Campbell H, Hirve S, Hague S, Jackson S, Moen A, Nair H, Palekar R, Rajatonirina S, Smith PG, Venter M, Wairagkar N, Zambon M, Ziegler T, Zhang W.

Influenza Other Respir Viruses. 2019 Aug 24. doi: 10.1111/irv.12672. [Epub ahead of print]


Pre-vaccination screening strategies for the use of the CYD-TDV dengue vaccine: A meeting report.

Wilder-Smith A, Smith PG, Luo R, Kelly-Cirino C, Curry D, Larson H, Durbin A, Chu M, Tharmaphornpilas P, Ng LC, Sartori AMC, Luna EJA, Gubler DJ, España G, Yoon IK, Flasche S.

Vaccine. 2019 Aug 23;37(36):5137-5146. doi: 10.1016/j.vaccine.2019.07.016. Epub 2019 Jul 31.


Self-assembled axicon lens in integrated optical fiber.

Holmes C, Smith PGR.

Opt Lett. 2019 Jul 15;44(14):3506-3509. doi: 10.1364/OL.44.003506.


Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study.

Colombo F, Smith S, Lai GW, Nix D, Smith PG, Schindler J, Rioux N.

Xenobiotica. 2019 Aug 2:1-10. doi: 10.1080/00498254.2019.1643941. [Epub ahead of print]


A Randomized Cross-Over Trial Comparing the Effect of Intramuscular Versus Intranasal Naloxone Reversal of Intravenous Fentanyl on Odor Detection in Working Dogs.

Essler JL, Smith PG, Berger D, Gregorio E, Pennington MR, McGuire A, Furton KG, Otto CM.

Animals (Basel). 2019 Jun 22;9(6). pii: E385. doi: 10.3390/ani9060385.


Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.

Korpal M, Puyang X, Wu ZJ, Seiler R, Furman C, Oo HZ, Seiler M, Irwin S, Subramanian V, Joshi JJ, Wang CK, Rimkunas V, Tortora D, Yang H, Kumar N, Kuznetsov G, Matijevic M, Chow J, Kumar P, Zou J, Feala J, Corson L, Henry R, Selvaraj A, Davis A, Bloudoff K, Douglas J, Kiss B, Roberts M, Fazli L, Black PC, Fekkes P, Smith PG, Warmuth M, Yu L, Hao MH, Larsen N, Daugaard M, Zhu P.

Nat Commun. 2019 Jun 4;10(1):2527. doi: 10.1038/s41467-019-10666-3.


Integrated polarizer based on 45° tilted gratings.

Posner MT, Podoliak N, Smith DH, Mennea PL, Horak P, Gawith CBE, Smith PGR, Gates JC.

Opt Express. 2019 Apr 15;27(8):11174-11181. doi: 10.1364/OE.27.011174.


Sensitivity and negative predictive value for a rapid dengue test.

Flasche S, Smith PG.

Lancet Infect Dis. 2019 May;19(5):465-466. doi: 10.1016/S1473-3099(19)30167-7. No abstract available.


The role of immune correlates of protection on the pathway to licensure, policy decision and use of group B Streptococcus vaccines for maternal immunization: considerations from World Health Organization consultations.

Vekemans J, Crofts J, Baker CJ, Goldblatt D, Heath PT, Madhi SA, Le Doare K, Andrews N, Pollard AJ, Saha SK, Schrag SJ, Smith PG, Kaslow DC.

Vaccine. 2019 May 27;37(24):3190-3198. doi: 10.1016/j.vaccine.2019.04.039. Epub 2019 Apr 25. Review.


Thermal approach to classifying sequentially written fiber Bragg gratings.

Scholl SL, Jantzen A, Bannerman RHS, Gow PC, Smith DH, Gates JC, Boyd LJ, Smith PGR, Holmes C.

Opt Lett. 2019 Feb 1;44(3):703-706. doi: 10.1364/OL.44.000703.


Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators.

Aird D, Teng T, Huang CL, Pazolli E, Banka D, Cheung-Ong K, Eifert C, Furman C, Wu ZJ, Seiler M, Buonamici S, Fekkes P, Karr C, Palacino J, Park E, Smith PG, Yu L, Mizui Y, Warmuth M, Chicas A, Corson L, Zhu P.

Nat Commun. 2019 Jan 11;10(1):137. doi: 10.1038/s41467-018-08150-5.


High-birefringence direct UV-written waveguides for use as heralded single-photon sources at telecommunication wavelengths.

Posner MT, Hiemstra T, Mennea PL, Bannerman RHS, Hoff UB, Eckstein A, Steven Kolthammer W, Walmsley IA, Smith DH, Gates JC, Smith PGR.

Opt Express. 2018 Sep 17;26(19):24678-24686. doi: 10.1364/OE.26.024678.


Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERα covalent antagonist (SERCA).

Rioux N, Smith S, Korpal M, O'Shea M, Prajapati S, Zheng GZ, Warmuth M, Smith PG.

Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160. doi: 10.1007/s00280-018-3716-3. Epub 2018 Nov 1.


Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers.

Rioux N, Kim A, Nix D, Bowser T, Warmuth M, Smith PG, Schindler J.

Cancer Chemother Pharmacol. 2019 Jan;83(1):91-96. doi: 10.1007/s00280-018-3708-3. Epub 2018 Oct 27.


Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine.

Wilder-Smith A, Hombach J, Ferguson N, Selgelid M, O'Brien K, Vannice K, Barrett A, Ferdinand E, Flasche S, Guzman M, Novaes HM, Ng LC, Smith PG, Tharmaphornpilas P, Yoon IK, Cravioto A, Farrar J, Nolan TM.

Lancet Infect Dis. 2019 Jan;19(1):e31-e38. doi: 10.1016/S1473-3099(18)30494-8. Epub 2018 Sep 5. Review.


Wideband and continuously-tunable fractional photonic Hilbert transformer based on a single high-birefringence planar Bragg grating.

Zhang Z, Sima C, Liu B, Cai B, Gao Y, Zhang M, Shen L, Yu Y, Huang M, Lian Z, Posner MT, Gates JC, Smith PGR, Liu D.

Opt Express. 2018 Aug 6;26(16):20450-20458. doi: 10.1364/OE.26.020450.


Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Lee SC, North K, Kim E, Jang E, Obeng E, Lu SX, Liu B, Inoue D, Yoshimi A, Ki M, Yeo M, Zhang XJ, Kim MK, Cho H, Chung YR, Taylor J, Durham BH, Kim YJ, Pastore A, Monette S, Palacino J, Seiler M, Buonamici S, Smith PG, Ebert BL, Bradley RK, Abdel-Wahab O.

Cancer Cell. 2018 Aug 13;34(2):225-241.e8. doi: 10.1016/j.ccell.2018.07.003.


Choices in vaccine trial design in epidemics of emerging infections.

Kahn R, Rid A, Smith PG, Eyal N, Lipsitch M.

PLoS Med. 2018 Aug 7;15(8):e1002632. doi: 10.1371/journal.pmed.1002632. eCollection 2018 Aug.


Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer.

Puyang X, Furman C, Zheng GZ, Wu ZJ, Banka D, Aithal K, Agoulnik S, Bolduc DM, Buonamici S, Caleb B, Das S, Eckley S, Fekkes P, Hao MH, Hart A, Houtman R, Irwin S, Joshi JJ, Karr C, Kim A, Kumar N, Kumar P, Kuznetsov G, Lai WG, Larsen N, Mackenzie C, Martin LA, Melchers D, Moriarty A, Nguyen TV, Norris J, O'Shea M, Pancholi S, Prajapati S, Rajagopalan S, Reynolds DJ, Rimkunas V, Rioux N, Ribas R, Siu A, Sivakumar S, Subramanian V, Thomas M, Vaillancourt FH, Wang J, Wardell S, Wick MJ, Yao S, Yu L, Warmuth M, Smith PG, Zhu P, Korpal M.

Cancer Discov. 2018 Sep;8(9):1176-1193. doi: 10.1158/2159-8290.CD-17-1229. Epub 2018 Jul 10.


Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain.

Yang FC, Draper J, Smith PG, Vivian JL, Shapiro SM, Stanford JA.

Cell Transplant. 2018 Apr;27(4):654-665. doi: 10.1177/0963689718766327. Epub 2018 May 30.


Leaky mode integrated optical fibre refractometer.

Gray AC, Jantzen A, Gow PC, Smith DH, Gawith CBE, Smith PGR, Holmes C.

Opt Express. 2018 Apr 2;26(7):9155-9164. doi: 10.1364/OE.26.009155.


Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.

Cretu C, Agrawal AA, Cook A, Will CL, Fekkes P, Smith PG, Lührmann R, Larsen N, Buonamici S, Pena V.

Mol Cell. 2018 Apr 19;70(2):265-273.e8. doi: 10.1016/j.molcel.2018.03.011. Epub 2018 Apr 12.


Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.

Seiler M, Peng S, Agrawal AA, Palacino J, Teng T, Zhu P, Smith PG; Cancer Genome Atlas Research Network, Buonamici S, Yu L.

Cell Rep. 2018 Apr 3;23(1):282-296.e4. doi: 10.1016/j.celrep.2018.01.088.


Clinical development and regulatory points for consideration for second-generation live attenuated dengue vaccines.

Vannice KS, Wilder-Smith A, Barrett ADT, Carrijo K, Cavaleri M, de Silva A, Durbin AP, Endy T, Harris E, Innis BL, Katzelnick LC, Smith PG, Sun W, Thomas SJ, Hombach J.

Vaccine. 2018 Jun 7;36(24):3411-3417. doi: 10.1016/j.vaccine.2018.02.062. Epub 2018 Mar 7.


The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action.

Finci LI, Zhang X, Huang X, Zhou Q, Tsai J, Teng T, Agrawal A, Chan B, Irwin S, Karr C, Cook A, Zhu P, Reynolds D, Smith PG, Fekkes P, Buonamici S, Larsen NA.

Genes Dev. 2018 Feb 1;32(3-4):309-320. doi: 10.1101/gad.311043.117.


Assessing complex movement behaviors in rodent models of neurological disorders.

McCarson KE, Winter MK, Abrahamson DR, Berman NE, Smith PG.

Neurobiol Learn Mem. 2019 Nov;165:106817. doi: 10.1016/j.nlm.2018.02.025. Epub 2018 Feb 21.


H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.

Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S.

Nat Med. 2018 May;24(4):497-504. doi: 10.1038/nm.4493. Epub 2018 Feb 19.


Evanescent field refractometry in planar optical fiber.

Holmes C, Jantzen A, Gray AC, Gow PC, Carpenter LG, Bannerman RHS, Gates JC, Smith PGR.

Opt Lett. 2018 Feb 15;43(4):791-794. doi: 10.1364/OL.43.000791.


Respiratory syncytial virus vaccine research and development: World Health Organization technological roadmap and preferred product characteristics.

Vekemans J, Moorthy V, Giersing B, Friede M, Hombach J, Arora N, Modjarrad K, Smith PG, Karron R, Graham B, Kaslow DC.

Vaccine. 2019 Nov 28;37(50):7394-7395. doi: 10.1016/j.vaccine.2017.09.092. Epub 2018 Feb 1. Review.


WHO consultation on ETEC and Shigella burden of disease, Geneva, 6-7th April 2017: Meeting report.

Hosangadi D, Smith PG, Kaslow DC, Giersing BK; WHO ETEC & Shigella Vaccine Consultation Expert Group.

Vaccine. 2019 Nov 28;37(50):7381-7390. doi: 10.1016/j.vaccine.2017.10.011. Epub 2018 Jan 17.


Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients.

Agrawal AA, Seiler M, Brinton LT, Mantel R, Lapalombella R, Woyach JA, Johnson AJ, Zhu P, Warmuth M, Yu L, Byrd JC, Smith PG, Blachly JS, Buonamici S.

Blood Adv. 2017 Jun 14;1(15):995-1000. doi: 10.1182/bloodadvances.2017007062. eCollection 2017 Jun 27.


Motor, Somatosensory, Viscerosensory and Metabolic Impairments in a Heterozygous Female Rat Model of Rett Syndrome.

Bhattacherjee A, Winter MK, Eggimann LS, Mu Y, Gunewardena S, Liao Z, Christianson JA, Smith PG.

Int J Mol Sci. 2017 Dec 29;19(1). pii: E97. doi: 10.3390/ijms19010097.


H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.

Joshi JJ, Coffey H, Corcoran E, Tsai J, Huang CL, Ichikawa K, Prajapati S, Hao MH, Bailey S, Wu J, Rimkunas V, Karr C, Subramanian V, Kumar P, MacKenzie C, Hurley R, Satoh T, Yu K, Park E, Rioux N, Kim A, Lai WG, Yu L, Zhu P, Buonamici S, Larsen N, Fekkes P, Wang J, Warmuth M, Reynolds DJ, Smith PG, Selvaraj A.

Cancer Res. 2017 Dec 15;77(24):6999-7013. doi: 10.1158/0008-5472.CAN-17-1865.


Inflammatory Renin-Angiotensin System Disruption Attenuates Sensory Hyperinnervation and Mechanical Hypersensitivity in a Rat Model of Provoked Vestibulodynia.

Chakrabarty A, Liao Z, Mu Y, Smith PG.

J Pain. 2018 Mar;19(3):264-277. doi: 10.1016/j.jpain.2017.10.006. Epub 2017 Dec 25.


Targeting splicing abnormalities in cancer.

Agrawal AA, Yu L, Smith PG, Buonamici S.

Curr Opin Genet Dev. 2018 Feb;48:67-74. doi: 10.1016/j.gde.2017.10.010. Epub 2017 Nov 12. Review.


Integrated reconfigurable photonic filters based on interferometric fractional Hilbert transforms.

Sima C, Cai B, Liu B, Gao Y, Yu Y, Gates JC, Zervas MN, Smith PGR, Liu D.

Appl Opt. 2017 Oct 1;56(28):7978-7984. doi: 10.1364/AO.56.007978.


Considerations for using ETEC and Shigella disease burden estimates to guide vaccine development strategy.

Hosangadi D, Smith PG, Giersing BK.

Vaccine. 2019 Nov 28;37(50):7372-7380. doi: 10.1016/j.vaccine.2017.09.083. Epub 2017 Oct 12.


The duration of protection of school-aged BCG vaccination in England: a population-based case-control study.

Mangtani P, Nguipdop-Djomo P, Keogh RH, Sterne JAC, Abubakar I, Smith PG, Fine PEM, Vynnycky E, Watson JM, Elliman D, Lipman M, Rodrigues LC.

Int J Epidemiol. 2018 Feb 1;47(1):193-201. doi: 10.1093/ije/dyx141.


Observations from direct UV-written, non-hydrogen-loaded, thermally regenerated Bragg gratings in double-clad photosensitive fiber.

Jantzen A, Bannerman RHS, Berry SA, Gates JC, Gow PC, Boyd LJ, Smith PGR, Holmes C.

Opt Lett. 2017 Oct 1;42(19):3741-3744. doi: 10.1364/OL.42.003741.


Live-attenuated tetravalent dengue vaccines: The needs and challenges of post-licensure evaluation of vaccine safety and effectiveness.

Wichmann O, Vannice K, Asturias EJ, de Albuquerque Luna EJ, Longini I, Lopez AL, Smith PG, Tissera H, Yoon IK, Hombach J.

Vaccine. 2017 Oct 9;35(42):5535-5542. doi: 10.1016/j.vaccine.2017.08.066. Review.


Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome.

Bhattacherjee A, Mu Y, Winter MK, Knapp JR, Eggimann LS, Gunewardena SS, Kobayashi K, Kato S, Krizsan-Agbas D, Smith PG.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6952-E6961. doi: 10.1073/pnas.1618210114. Epub 2017 Jul 31.


Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.

Korpal M, Puyang X, Jeremy Wu Z, Seiler R, Furman C, Oo HZ, Seiler M, Irwin S, Subramanian V, Julie Joshi J, Wang CK, Rimkunas V, Tortora D, Yang H, Kumar N, Kuznetsov G, Matijevic M, Chow J, Kumar P, Zou J, Feala J, Corson L, Henry R, Selvaraj A, Davis A, Bloudoff K, Douglas J, Kiss B, Roberts M, Fazli L, Black PC, Fekkes P, Smith PG, Warmuth M, Yu L, Hao MH, Larsen N, Daugaard M, Zhu P.

Nat Commun. 2017 Jul 24;8(1):103. doi: 10.1038/s41467-017-00147-w. Erratum in: Nat Commun. 2019 Jun 4;10(1):2527.

Supplemental Content

Loading ...
Support Center