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Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions.

Pearson JA, Tai N, Ekanayake-Alper DK, Peng J, Hu Y, Hager K, Compton S, Wong FS, Smith PC, Wen L.

Front Immunol. 2019 Nov 12;10:2654. doi: 10.3389/fimmu.2019.02654. eCollection 2019.


Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-mediated Uptake.

Morse BL, Kolur A, Hudson LR, Hogan AT, Chen LH, Brackman RM, Sawada GA, Fallon JK, Smith PC, Hillgren KM.

Drug Metab Dispos. 2019 Nov 26. pii: dmd.119.088781. doi: 10.1124/dmd.119.088781. [Epub ahead of print]


Evaluation of human primary intestinal monolayers for drug metabolizing capabilities.

Speer JE, Wang Y, Fallon JK, Smith PC, Allbritton NL.

J Biol Eng. 2019 Nov 4;13:82. doi: 10.1186/s13036-019-0212-1. eCollection 2019.


PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.

Fontaine SD, Santi AD, Reid R, Smith PC, Ashley GW, Santi DV.

Cancer Chemother Pharmacol. 2019 Nov 9. doi: 10.1007/s00280-019-03987-z. [Epub ahead of print]


Common Goods for Health: Economic Rationale and Tools for Prioritization.

Gaudin S, Smith PC, Soucat A, Yazbeck AS.

Health Syst Reform. 2019 Oct 29:1-13. doi: 10.1080/23288604.2019.1656028. [Epub ahead of print]


Concentration-dependent Toxicity after Subcutaneous Administration of Meloxicam to C57BL/6N Mice (Mus musculus).

Sarfaty AE, Zeiss CJ, Willis AD, Harris JM, Smith PC.

J Am Assoc Lab Anim Sci. 2019 Nov 1;58(6):802-809. doi: 10.30802/AALAS-JAALAS-19-000037. Epub 2019 Sep 20.


Practice Transformation Under the University of Colorado's Primary Care Redesign Model.

Smith PC, Lyon C, English AF, Conry C.

Ann Fam Med. 2019 Aug 12;17(Suppl 1):S24-S32. doi: 10.1370/afm.2424.


Neuroendocrine Control of Sleep.

Smith PC, Mong JA.

Curr Top Behav Neurosci. 2019 Aug 9. doi: 10.1007/7854_2019_107. [Epub ahead of print]


Antiretroviral Drug Concentrations in Lymph Nodes: A Cross-Species Comparison of the Effect of Drug Transporter Expression, Viral Infection, and Sex in Humanized Mice, Nonhuman Primates, and Humans.

Burgunder E, Fallon JK, White N, Schauer AP, Sykes C, Remling-Mulder L, Kovarova M, Adamson L, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

J Pharmacol Exp Ther. 2019 Sep;370(3):360-368. doi: 10.1124/jpet.119.259150. Epub 2019 Jun 24.


Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper.

Prasad B, Achour B, Artursson P, Hop CECA, Lai Y, Smith PC, Barber J, Wisniewski JR, Spellman D, Uchida Y, Zientek MA, Unadkat JD, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2019 Sep;106(3):525-543. doi: 10.1002/cpt.1537. Epub 2019 Jul 26.


Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model.

Khatri R, Fallon JK, Rementer RJB, Kulick NT, Lee CR, Smith PC.

J Pharmacol Toxicol Methods. 2019 Jul - Aug;98:106590. doi: 10.1016/j.vascn.2019.106590. Epub 2019 May 31.


Health system modelling research: towards a whole-health-system perspective for identifying good value for money investments in health system strengthening.

Verguet S, Feldhaus I, Jiang Kwete X, Aqil A, Atun R, Bishai D, Cecchini M, Guerra Junior AA, Habtemariam MK, Jbaily A, Karanfil O, Kruk ME, Haneuse S, Norheim OF, Smith PC, Tolla MT, Zewdu S, Bump J.

BMJ Glob Health. 2019 Apr 28;4(2):e001311. doi: 10.1136/bmjgh-2018-001311. eCollection 2019. Review.


Potential determinants of health system efficiency: Evidence from Latin America and the Caribbean.

Moreno-Serra R, Anaya-Montes M, Smith PC.

PLoS One. 2019 May 10;14(5):e0216620. doi: 10.1371/journal.pone.0216620. eCollection 2019.


Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling.

Smith PC, Martínez C, Martínez J, McCulloch CA.

Front Physiol. 2019 Apr 24;10:270. doi: 10.3389/fphys.2019.00270. eCollection 2019. Review.


Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking.

Speer JE, Gunasekara DB, Wang Y, Fallon JK, Attayek PJ, Smith PC, Sims CE, Allbritton NL.

J Biol Eng. 2019 Apr 27;13:36. doi: 10.1186/s13036-019-0165-4. eCollection 2019.


Work and home productivity of people living with HIV in Zambia and South Africa.

Thomas R, Friebel R, Barker K, Mwenge L, Kanema S, Vanqa N, Harper A, Bell-Mandla N, Smith PC, Floyd S, Bock P, Ayles H, Fidler S, Hayes R, Hauck K; HPTN 071 (PopART) Study Team.

AIDS. 2019 May 1;33(6):1063-1071. doi: 10.1097/QAD.0000000000002160.


Developmental Expression of the Cytosolic Sulfotransferases in Human Liver.

Dubaisi S, Caruso JA, Gaedigk R, Vyhlidal CA, Smith PC, Hines RN, Kocarek TA, Runge-Morris M.

Drug Metab Dispos. 2019 Jun;47(6):592-600. doi: 10.1124/dmd.119.086363. Epub 2019 Mar 18.


Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody.

Émond JP, Labriet A, Desjardins S, Rouleau M, Villeneuve L, Hovington H, Brisson H, Lacombe L, Simonyan D, Caron P, Périgny M, Têtu B, Fallon JK, Klein K, Smith PC, Zanger UM, Guillemette C, Lévesque E.

Drug Metab Dispos. 2019 May;47(5):444-452. doi: 10.1124/dmd.119.086330. Epub 2019 Feb 28.


Capsule Commentary on Correa et al., Assessing the Effect of Clinical Inertia on Diabetes Outcomes: a Modeling Approach.

Smith PC.

J Gen Intern Med. 2019 Mar;34(3):443. doi: 10.1007/s11606-018-4809-8. No abstract available.


How can we evaluate the cost-effectiveness of health system strengthening? A typology and illustrations.

Hauck K, Morton A, Chalkidou K, Chi YL, Culyer A, Levin C, Meacock R, Over M, Thomas R, Vassall A, Verguet S, Smith PC.

Soc Sci Med. 2019 Jan;220:141-149. doi: 10.1016/j.socscimed.2018.10.030. Epub 2018 Nov 3.


Does global drug innovation correspond to burden of disease? The neglected diseases in developed and developing countries.

Barrenho E, Miraldo M, Smith PC.

Health Econ. 2019 Jan;28(1):123-143. doi: 10.1002/hec.3833. Epub 2018 Nov 12.


The Association of Patient Satisfaction-Based Incentives with Primary Care Physician Opioid Prescribing.

Carrico JA, Mahoney K, Raymond KM, Mims L, Smith PC, Sakai JT, Mikulich-Gilbertson SK, Hopfer CJ, Bartels K.

J Am Board Fam Med. 2018 Nov-Dec;31(6):941-943. doi: 10.3122/jabfm.2018.06.180067.


A Monolayer of Primary Colonic Epithelium Generated on a Scaffold with a Gradient of Stiffness for Drug Transport Studies.

Gunasekara DB, Speer J, Wang Y, Nguyen DL, Reed MI, Smiddy NM, Parker JS, Fallon JK, Smith PC, Sims CE, Magness ST, Allbritton NL.

Anal Chem. 2018 Nov 20;90(22):13331-13340. doi: 10.1021/acs.analchem.8b02845. Epub 2018 Oct 30.


Comparative effect of platelet-rich plasma, platelet-poor plasma, and fetal bovine serum on the proliferative response of periodontal ligament cell subpopulations.

Martínez CE, Gómez R, Kalergis AM, Smith PC.

Clin Oral Investig. 2019 May;23(5):2455-2463. doi: 10.1007/s00784-018-2637-1. Epub 2018 Oct 11.


How to make sense of health system efficiency comparisons? [Internet].

Cylus J, Papanicolas I, Smith PC; Richardson E, editor.

Copenhagen (Denmark): European Observatory on Health Systems and Policies; 2017.


What is the impact of rerouting a cancer diagnosis from emergency presentation to GP referral on resource use and survival? Evidence from a population-based study.

Laudicella M, Walsh B, Burns E, Li Donni P, Smith PC.

BMC Cancer. 2018 Apr 6;18(1):394. doi: 10.1186/s12885-018-4274-0.


Quantification of membrane transporter proteins in human lung and immortalized cell lines using targeted quantitative proteomic analysis by isotope dilution nanoLC-MS/MS.

Fallon JK, Houvig N, Booth-Genthe CL, Smith PC.

J Pharm Biomed Anal. 2018 May 30;154:150-157. doi: 10.1016/j.jpba.2018.02.044. Epub 2018 Feb 22.


Role of myofibroblasts in normal and pathological periodontal wound healing.

Smith PC.

Oral Dis. 2018 Mar;24(1-2):26-29. doi: 10.1111/odi.12773. Review.


Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles.

Shi P, Liao M, Chuang BC, Griffin R, Shi J, Hyer M, Fallon JK, Smith PC, Li C, Xia CQ.

Xenobiotica. 2018 Nov;48(11):1173-1183. doi: 10.1080/00498254.2017.1397812. Epub 2017 Nov 16.


Chitosan-triclosan particles modulate inflammatory signaling in gingival fibroblasts.

Pavez L, Tobar N, Chacón C, Arancibia R, Martínez C, Tapia C, Pastor A, González M, Martínez J, Smith PC.

J Periodontal Res. 2018 Apr;53(2):232-239. doi: 10.1111/jre.12510. Epub 2017 Oct 24.


Cost-Effectiveness of One-Time Hepatitis C Screening Strategies Among Adolescents and Young Adults in Primary Care Settings.

Assoumou SA, Tasillo A, Leff JA, Schackman BR, Drainoni ML, Horsburgh CR, Barry MA, Regis C, Kim AY, Marshall A, Saxena S, Smith PC, Linas BP.

Clin Infect Dis. 2018 Jan 18;66(3):376-384. doi: 10.1093/cid/cix798.


Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial.

Thomas R, Burger R, Harper A, Kanema S, Mwenge L, Vanqa N, Bell-Mandla N, Smith PC, Floyd S, Bock P, Ayles H, Beyers N, Donnell D, Fidler S, Hayes R, Hauck K; HPTN 071 (PopART) Study Team.

Lancet Glob Health. 2017 Nov;5(11):e1133-e1141. doi: 10.1016/S2214-109X(17)30367-4. Epub 2017 Sep 27.


Do Reduced Hospital Mortality Rates Lead to Increased Utilization of Inpatient Emergency Care? A Population-Based Cohort Study.

Laudicella M, Martin S, Li Donni P, Smith PC.

Health Serv Res. 2018 Aug;53(4):2324-2345. doi: 10.1111/1475-6773.12755. Epub 2017 Sep 14.


Comparison of 6 Injectable Anesthetic Regimens and Isoflurane in Gray Short-tailed Opossums (Monodelphis domestica).

Barnett GJ, Barnett IJ, Wilson SR, Smith PC.

J Am Assoc Lab Anim Sci. 2017 Sep 1;56(5):544-549.


Aged blood factors decrease cellular responses associated with delayed gingival wound repair.

Saldías MP, Fernández C, Morgan A, Díaz C, Morales D, Jaña F, Gómez A, Silva A, Briceño F, Oyarzún A, Maldonado F, Cerda O, Smith PC, Cáceres M.

PLoS One. 2017 Sep 12;12(9):e0184189. doi: 10.1371/journal.pone.0184189. eCollection 2017. Erratum in: PLoS One. 2018 Jan 23;13(1):e0189566.


Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity.

Achour B, Dantonio A, Niosi M, Novak JJ, Fallon JK, Barber J, Smith PC, Rostami-Hodjegan A, Goosen TC.

Drug Metab Dispos. 2017 Oct;45(10):1102-1112. doi: 10.1124/dmd.117.076703. Epub 2017 Aug 2.


Evaluating transformation with available resources: The influence of APEX on depression screening.

Smith PC, Brown Levey SM, Lyon C.

Fam Syst Health. 2017 Jun;35(2):238-247. doi: 10.1037/fsh0000271.


Multimodal analysis of drug transporter expression in gastrointestinal tissue.

Thompson CG, Fallon JK, Mathews M, Charlins P, Remling-Mulder L, Kovarova M, Adamson L, Srinivas N, Schauer A, Sykes C, Luciw P, Garcia JV, Akkina R, Smith PC, Kashuba ADM.

AIDS. 2017 Jul 31;31(12):1669-1678. doi: 10.1097/QAD.0000000000001554.


Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts.

Retamal IN, Hernández R, Melo F, Zapata P, Martínez C, Martínez J, Smith PC.

J Periodontol. 2017 Sep;88(9):926-935. doi: 10.1902/jop.2017.160730. Epub 2017 May 18.


Multidisciplinary Mentoring Programs to Enhance Junior Faculty Research Grant Success.

Freel SA, Smith PC, Burns EN, Downer JB, Brown AJ, Dewhirst MW.

Acad Med. 2017 Oct;92(10):1410-1415. doi: 10.1097/ACM.0000000000001620.


Ageing, dental caries and periodontal diseases.

López R, Smith PC, Göstemeyer G, Schwendicke F.

J Clin Periodontol. 2017 Mar;44 Suppl 18:S145-S152. doi: 10.1111/jcpe.12683. Review.


Should Countries Set an Explicit Health Benefits Package? The Case of the English National Health Service.

Smith PC, Chalkidou K.

Value Health. 2017 Jan;20(1):60-66. doi: 10.1016/j.jval.2016.01.004.


Procedural outcomes of fluoroless catheter ablation outside the traditional catheterization lab.

Bigelow AM, Smith PC, Timberlake DT, McNinch NL, Smith GL, Lane JR, Clark JM.

Europace. 2017 Aug 1;19(8):1378-1384. doi: 10.1093/europace/euw207.


Healthy Life-Years Lost and Excess Bed-Days Due to 6 Patient Safety Incidents: Empirical Evidence From English Hospitals.

Hauck KD, Wang S, Vincent C, Smith PC.

Med Care. 2017 Feb;55(2):125-130. doi: 10.1097/MLR.0000000000000631.


Priorities for action on the social determinants of health: Empirical evidence on the strongest associations with life expectancy in 54 low-income countries, 1990-2012.

Hauck K, Martin S, Smith PC.

Soc Sci Med. 2016 Oct;167:88-98. doi: 10.1016/j.socscimed.2016.08.035. Epub 2016 Aug 22.


Demodex musculi Infestation in Genetically Immunomodulated Mice.

Smith PC, Zeiss CJ, Beck AP, Scholz JA.

Comp Med. 2016;66(4):278-85.


Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells.

Kallens V, Tobar N, Molina J, Bidegain A, Smith PC, Porras O, Martínez J.

J Cell Biochem. 2017 May;118(5):994-1002. doi: 10.1002/jcb.25650. Epub 2017 Jan 5.


Decision rules for allocation of finances to health systems strengthening.

Morton A, Thomas R, Smith PC.

J Health Econ. 2016 Sep;49:97-108. doi: 10.1016/j.jhealeco.2016.06.001. Epub 2016 Jun 24.


Quantification of Four Efflux Drug Transporters in Liver and Kidney Across Species Using Targeted Quantitative Proteomics by Isotope Dilution NanoLC-MS/MS.

Fallon JK, Smith PC, Xia CQ, Kim MS.

Pharm Res. 2016 Sep;33(9):2280-8. doi: 10.1007/s11095-016-1966-5. Epub 2016 Jun 29.


Cost of care for cancer patients in England: evidence from population-based patient-level data.

Laudicella M, Walsh B, Burns E, Smith PC.

Br J Cancer. 2016 May 24;114(11):1286-92. doi: 10.1038/bjc.2016.77. Epub 2016 Apr 12.

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