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Discovery of a Thiadiazole-Pyridazine Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.

Finlay MRV, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, Charles MD, Cheasty A, Critchlow SE, Culshaw J, Ekwuru T, Hollingsworth I, Jones N, Leroux F, Littleson MM, McCarron HB, McKelvie J, Mooney L, Nissink JWM, Perkins D, Powell S, Quesada MJ, Raubo P, Sabin V, Smith J, Smith PD, Stark A, Ting A, Wang P, Wilson Z, Winter-Holt J, Wood JM, Wrigley G, Yu G, Zhang P.

J Med Chem. 2019 Jun 14. doi: 10.1021/acs.jmedchem.9b00260. [Epub ahead of print]


Suicide Risk and Restricted Emotions in Women: The Diverging Effects of Masculine Gender Norms and Suicide Capability.

Fadoir NA, Kuhlman STW, Smith PN.

Arch Suicide Res. 2019 Jun 14:1-17. doi: 10.1080/13811118.2019.1599480. [Epub ahead of print]


Response to "The "4p1000" initiative: A new name should be adopted" by Baveye and White (2019).

Rumpel C, Amiraslani F, Chenu C, Cardenas MG, Kaonga M, Koutika LS, Ladha J, Madari B, Shirato Y, Smith P, Soudi B, Soussana JF, Whitehead D, Wollenberg E.

Ambio. 2019 Jun 13. doi: 10.1007/s13280-019-01209-7. [Epub ahead of print] No abstract available.


Parkinson's disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth.

Chen R, Park HA, Mnatsakanyan N, Niu Y, Licznerski P, Wu J, Miranda P, Graham M, Tang J, Boon AJW, Cossu G, Mandemakers W, Bonifati V, Smith PJS, Alavian KN, Jonas EA.

Cell Death Dis. 2019 Jun 13;10(6):469. doi: 10.1038/s41419-019-1679-x.


Comment on "Global pattern of nest predation is disrupted by climate change in shorebirds".

Bulla M, Reneerkens J, Weiser EL, Sokolov A, Taylor AR, Sittler B, McCaffery BJ, Ruthrauff DR, Catlin DH, Payer DC, Ward DH, Solovyeva DV, Santos ESA, Rakhimberdiev E, Nol E, Kwon E, Brown GS, Hevia GD, Gates HR, Johnson JA, van Gils JA, Hansen J, Lamarre JF, Rausch J, Conklin JR, Liebezeit J, Bêty J, Lang J, Alves JA, Fernández-Elipe J, Exo KM, Bollache L, Bertellotti M, Giroux MA, van de Pol M, Johnson M, Boldenow ML, Valcu M, Soloviev M, Sokolova N, Senner NR, Lecomte N, Meyer N, Schmidt NM, Gilg O, Smith PA, Machín P, McGuire RL, Cerboncini RAS, Ottvall R, van Bemmelen RSA, Swift RJ, Saalfeld ST, Jamieson SE, Brown S, Piersma T, Albrecht T, D'Amico V, Lanctot RB, Kempenaers B.

Science. 2019 Jun 14;364(6445). pii: eaaw8529. doi: 10.1126/science.aaw8529.


Post-mortem diagnosis of kidney impairment: An experimental study.

Maskell PD, Penney E, Smith PR, Hikin LJ, Morley SR.

Forensic Sci Int. 2019 May 24;301:271-277. doi: 10.1016/j.forsciint.2019.05.034. [Epub ahead of print]


Real pain in the neck: giant cell arteritis presenting with non-necrotising fasciitis and fever.

Dwyer KM, Tai A, Smith P, Buchbinder R.

Intern Med J. 2019 Jun;49(6):802-804. doi: 10.1111/imj.14317. No abstract available.


Towards a Consensus on Applying Quantitative LC-MS/MS Proteomics in Translational Pharmacology Research: A White Paper.

Prasad B, Achour B, Artursson P, Hop CE, Lai Y, Smith PC, Barber J, Wisniewski JR, Spellman D, Uchida Y, Zientek M, Unadkat JD, Rostami-Hodjegan A.

Clin Pharmacol Ther. 2019 Jun 7. doi: 10.1002/cpt.1537. [Epub ahead of print]


Chronic Granulomatous Disorder-Associated Colitis Can Be Accurately Evaluated with MRI Scans and Fecal Calprotectin Level.

Lowe DM, Smith PJ, Moreira F, Workman S, Braggins H, Koukias N, Buckland MS, Wylie P, Taylor SA, Murray CD.

J Clin Immunol. 2019 Jun 6. doi: 10.1007/s10875-019-00651-2. [Epub ahead of print]


Author Correction: Evasion of immunosurveillance by genomic alterations of PPARγ/RXRα in bladder cancer.

Korpal M, Puyang X, Wu ZJ, Seiler R, Furman C, Oo HZ, Seiler M, Irwin S, Subramanian V, Joshi JJ, Wang CK, Rimkunas V, Tortora D, Yang H, Kumar N, Kuznetsov G, Matijevic M, Chow J, Kumar P, Zou J, Feala J, Corson L, Henry R, Selvaraj A, Davis A, Bloudoff K, Douglas J, Kiss B, Roberts M, Fazli L, Black PC, Fekkes P, Smith PG, Warmuth M, Yu L, Hao MH, Larsen N, Daugaard M, Zhu P.

Nat Commun. 2019 Jun 4;10(1):2527. doi: 10.1038/s41467-019-10666-3.


Public goods and cheating in microbes.

Smith P, Schuster M.

Curr Biol. 2019 Jun 3;29(11):R442-R447. doi: 10.1016/j.cub.2019.03.001.


Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS/MS in the sandwich cultured human hepatocyte model.

Khatri R, Fallon JK, Rementer RJB, Kulick NT, Lee CR, Smith PC.

J Pharmacol Toxicol Methods. 2019 May 31:106590. doi: 10.1016/j.vascn.2019.106590. [Epub ahead of print]


Erwinia amylovora auxotrophic mutant exometabolomics and virulence on apple.

Klee SM, Sinn JP, Finley M, Allman EL, Smith PB, Aimufua O, Sitther V, Lehman BL, Krawczyk T, Peter KA, McNellis TW.

Appl Environ Microbiol. 2019 May 31. pii: AEM.00935-19. doi: 10.1128/AEM.00935-19. [Epub ahead of print]


Hip flexor muscle size in ballet dancers compared to athletes, and relationship to hip pain.

Emery S, Cook J, Ferris AR, Smith P, Mayes S.

Phys Ther Sport. 2019 May 20;38:146-151. doi: 10.1016/j.ptsp.2019.05.003. [Epub ahead of print]


Potential genetic causes of miscarriage in euploid pregnancies: a systematic review.

Colley E, Hamilton S, Smith P, Morgan NV, Coomarasamy A, Allen S.

Hum Reprod Update. 2019 May 31. pii: dmz015. doi: 10.1093/humupd/dmz015. [Epub ahead of print]


Are new workers at elevated risk for work injury? A systematic review.

Breslin FC, Dollack J, Mahood Q, Maas ET, Laberge M, Smith PM.

Occup Environ Med. 2019 May 30. pii: oemed-2018-105639. doi: 10.1136/oemed-2018-105639. [Epub ahead of print] Review.


Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network.

Giustino G, Overbey J, Taylor D, Ailawadi G, Kirkwood K, DeRose J, Gillinov MA, Dagenais F, Mayer ML, Moskowitz A, Bagiella E, Miller M, Grayburn P, Smith PK, Gelijns A, O'Gara P, Acker M, Lala A, Hung J.

JACC Heart Fail. 2019 Jun;7(6):481-490. doi: 10.1016/j.jchf.2019.03.001.


PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma.

de Koning L, Decaudin D, El Botty R, Nicolas A, Carita G, Schuller M, Ouine B, Cartier A, Naguez A, Fleury J, Cooke V, Wylie A, Smith P, Marangoni E, Gentien D, Meseure D, Mariani P, Cassoux N, Piperno-Neumann S, Roman-Roman S, Némati F.

Cancers (Basel). 2019 May 29;11(6). pii: E751. doi: 10.3390/cancers11060751.


The protective effects of grit on suicidal ideation in individuals with trauma and symptoms of posttraumatic stress.

Marie L, Taylor SE, Basu N, Fadoir NA, Schuler K, McKelvey D, Smith PN.

J Clin Psychol. 2019 May 29. doi: 10.1002/jclp.22803. [Epub ahead of print]


Health system modelling research: towards a whole-health-system perspective for identifying good value for money investments in health system strengthening.

Verguet S, Feldhaus I, Jiang Kwete X, Aqil A, Atun R, Bishai D, Cecchini M, Guerra Junior AA, Habtemariam MK, Jbaily A, Karanfil O, Kruk ME, Haneuse S, Norheim OF, Smith PC, Tolla MT, Zewdu S, Bump J.

BMJ Glob Health. 2019 Apr 28;4(2):e001311. doi: 10.1136/bmjgh-2018-001311. eCollection 2019. Review.


Analysis of YouTube as a Source of Information for Diabetic Foot Care.

Smith PE, McGuire J, Falci M, Poudel DR, Kaufman R, Patterson MA, Pelleschi B, Shin E.

J Am Podiatr Med Assoc. 2019 Mar;109(2):122-126. doi: 10.7547/16-149.


A Multicenter Observational Cohort Study to Evaluate the Effects of Bisphosphonate Exposure on Bone Mineral Density and Other Health Outcomes in Osteogenesis Imperfecta.

Bains JS, Carter EM, Citron KP, Boskey AL, Shapiro JR, Steiner RD, Smith PA, Bober MB, Hart T, Cuthbertson D, Krischer J, Byers PH, Pepin M, Durigova M, Glorieux FH, Rauch F, Sliepka JM, Sutton VR, Lee B; Members of the BBD Consortium, Nagamani SC, Raggio CL.

JBMR Plus. 2019 Jan 7;3(5):e10118. doi: 10.1002/jbm4.10118. eCollection 2019 May.


Assault predicts time away from work after claims for work-related mild traumatic brain injury.

Shafi R, Smith PM, Colantonio A.

Occup Environ Med. 2019 Jul;76(7):471-478. doi: 10.1136/oemed-2018-105621. Epub 2019 May 24.


Trends of Contraceptive Choices Among Young Women in Inner City Houston.

Patel PR, Abacan A, Smith PB.

J Pediatr Adolesc Gynecol. 2019 May 21. pii: S1083-3188(19)30184-6. doi: 10.1016/j.jpag.2019.05.001. [Epub ahead of print]


An Institutional CT Radiation Dose Reduction Quality Improvement Project.

Smith P, Blackmore C, Sicuro P.

J Am Coll Radiol. 2019 May 21. pii: S1546-1440(19)30531-9. doi: 10.1016/j.jacr.2019.04.024. [Epub ahead of print] No abstract available.


Nitrogen Surplus Benchmarks for Controlling N Pollution in the Main Cropping Systems of China.

Zhang C, Ju X, Powlson D, Oenema O, Smith P.

Environ Sci Technol. 2019 Jun 4. doi: 10.1021/acs.est.8b06383. [Epub ahead of print]


Challenges and Opportunities of Anti-Bullying Intervention Programs.

Smith PK, Bauman S, Wong D.

Int J Environ Res Public Health. 2019 May 22;16(10). pii: E1810. doi: 10.3390/ijerph16101810.


Hiding in Plain Sight: Functional Neurological Disorders in the News.

Popkirov S, Nicholson TR, Bloem BR, Cock HR, Derry CP, Duncan R, Dworetzky BA, Edwards MJ, Espay AJ, Hallett M, Lang AE, Leach JP, Lehn A, McGonigal A, Morgante F, Perez DL, Reuber M, Richardson MP, Smith P, Stamelou M, Tijssen MAJ, Tinazzi M, Carson AJ, Stone J.

J Neuropsychiatry Clin Neurosci. 2019 May 23:appineuropsych19010025. doi: 10.1176/appi.neuropsych.19010025. [Epub ahead of print]


Activations of all Bonds to Silicon (Si-H, Si-C) in a Silane with Extrusion of [CoSiCo] Silicide Cores.

Handford RC, Smith PW, Tilley TD.

J Am Chem Soc. 2019 Jun 5;141(22):8769-8772. doi: 10.1021/jacs.9b04265. Epub 2019 May 24.


Impact of Microbiological Organism Type on Surgically Managed Endocarditis.

Williams JB, Shah AA, Zhang S, Jung SH, Yerokun B, Vemulapalli S, Smith PK, Gammie JS, Gaca JG.

Ann Thorac Surg. 2019 May 16. pii: S0003-4975(19)30702-7. doi: 10.1016/j.athoracsur.2019.04.025. [Epub ahead of print]


Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants.

Puia-Dumitrescu M, Smith PB, Zhao J, Soriano A, Payne EH, Harper B, Bendel-Stenzel E, Moya F, Chhabra R, Ku L, Laughon M, Wade KC; Best Pharmaceuticals for Children Act–Pediatric Trials Network Steering Committee.

J Pediatr. 2019 May 14. pii: S0022-3476(19)30510-4. doi: 10.1016/j.jpeds.2019.04.028. [Epub ahead of print]


The proportion of lung cancer patients attending UK lung cancer clinics who would have been eligible for low-dose CT screening.

Gracie K, Kennedy MPT, Esterbrook G, Smith G, Blaxill P, Ameri AT, Rodger KIA, Robson JM, Paramasivam E, Naseer R, Smith P, Ellames DAB, Hawramy B, Callister MEJ.

Eur Respir J. 2019 May 16. pii: 1802221. doi: 10.1183/13993003.02221-2018. [Epub ahead of print] No abstract available.


Invited review: Intergovernmental Panel on Climate Change, agriculture, and food-A case of shifting cultivation and history.

Porter JR, Challinor AJ, Henriksen CB, Howden SM, Martre P, Smith P.

Glob Chang Biol. 2019 May 16. doi: 10.1111/gcb.14700. [Epub ahead of print] Review.


Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster.

Bialistoky T, Manry D, Smith P, Ng C, Kim Y, Zamir S, Moyal V, Kalifa R, Schedl P, Gerlitz O, Deshpande G.

Development. 2019 May 15;146(10). pii: dev168427. doi: 10.1242/dev.168427.


Independent Validation for the Polyskope 1.0 Multiplex Pathogen Detection Assay for the Detection of Shiga Toxin-Producing Escherichia coli non-O157 STEC, Escherichia coli O157, Listeria monocytogenes, and Salmonella species.

Bastin B, Horine L, Bird P, Benzinger MJ Jr, Agin J, Goins D, Smith P, Centola M.

J AOAC Int. 2019 May 14. doi: 10.5740/jaoacint.19-0106. [Epub ahead of print]


Physiologically-Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants.

Gerhart JG, Watt KM, Edginton A, Wade KC, Salerno SN, Benjamin DK Jr, Smith PB, Hornik CP, Cohen-Wolkowiez M, Duara S, Ross A, Shattuck K, Stewart DL, Neu N, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee.

CPT Pharmacometrics Syst Pharmacol. 2019 May 14. doi: 10.1002/psp4.12414. [Epub ahead of print]


A global, empirical, harmonised dataset of soil organic carbon changes under perennial crops.

Ledo A, Hillier J, Smith P, Aguilera E, Blagodatskiy S, Brearley FQ, Datta A, Diaz-Pines E, Don A, Dondini M, Dunn J, Feliciano DM, Liebig MA, Lang R, Llorente M, Zinn YL, McNamara N, Ogle S, Qin Z, Rovira P, Rowe R, Vicente-Vicente JL, Whitaker J, Yue Q, Zerihun A.

Sci Data. 2019 May 13;6(1):57. doi: 10.1038/s41597-019-0062-1.


Implementation of 3D Printing Technology in the Field of Prosthetics: Past, Present, and Future.

Manero A, Smith P, Sparkman J, Dombrowski M, Courbin D, Kester A, Womack I, Chi A.

Int J Environ Res Public Health. 2019 May 10;16(9). pii: E1641. doi: 10.3390/ijerph16091641.


Psychosocial Work Conditions and Mental Health: Examining Differences Across Mental Illness and Well-Being Outcomes.

Fan JK, Mustard C, Smith PM.

Ann Work Expo Health. 2019 May 21;63(5):546-559. doi: 10.1093/annweh/wxz028.


Long-term actions of interleukin-1β on K+, Na+ and Ca2+ channel currents in small, IB4-positive dorsal root ganglion neurons; possible relevance to the etiology of neuropathic pain.

Noh MC, Stemkowski PL, Smith PA.

J Neuroimmunol. 2019 Jul 15;332:198-211. doi: 10.1016/j.jneuroim.2019.05.002. Epub 2019 May 4.


Potential determinants of health system efficiency: Evidence from Latin America and the Caribbean.

Moreno-Serra R, Anaya-Montes M, Smith PC.

PLoS One. 2019 May 10;14(5):e0216620. doi: 10.1371/journal.pone.0216620. eCollection 2019.


Role of Fibroblast Populations in Periodontal Wound Healing and Tissue Remodeling.

Smith PC, Martínez C, Martínez J, McCulloch CA.

Front Physiol. 2019 Apr 24;10:270. doi: 10.3389/fphys.2019.00270. eCollection 2019. Review.


VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.

Smith P, Godde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L.

Sci Rep. 2019 May 8;9(1):7079. doi: 10.1038/s41598-019-43444-8.


Disrupting wildlife crime: The benefits of meaningful collaboration.

Smith PA, Pamment N, Cox C, Reed J, Chappell B, Plowman C.

Forensic Sci Int. 2019 Jun;299:e1-e2. doi: 10.1016/j.forsciint.2019.04.021. Epub 2019 Apr 29. No abstract available.


The changing pattern of synthetic cannabinoid use within England, April 2014 to March 2018.

Sharp P, Hudson S, Hikin L, Smith PR, Morley SR.

Med Sci Law. 2019 May 8:25802419845796. doi: 10.1177/0025802419845796. [Epub ahead of print]


Correlation of hair and plasma efavirenz concentrations in HIV-positive South Africans.

Johnston J, Wiesner L, Smith P, Maartens G, Orrell C.

South Afr J HIV Med. 2019 Apr 29;20(1):881. doi: 10.4102/sajhivmed.v20i1.881. eCollection 2019.


Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking.

Speer JE, Gunasekara DB, Wang Y, Fallon JK, Attayek PJ, Smith PC, Sims CE, Allbritton NL.

J Biol Eng. 2019 Apr 27;13:36. doi: 10.1186/s13036-019-0165-4. eCollection 2019.


Smoking across the menopausal transition in a 10-year longitudinal sample: The role of sex hormones and depressive symptoms.

Peltier MR, Flores JM, Smith PH, Roberts W, Verplaetse TL, Moore KE, Hacker R, Oberleitner LM, McKee SA.

Nicotine Tob Res. 2019 May 6. pii: ntz069. doi: 10.1093/ntr/ntz069. [Epub ahead of print]


Integrated polarizer based on 45° tilted gratings.

Posner MT, Podoliak N, Smith DH, Mennea PL, Horak P, Gawith CBE, Smith PGR, Gates JC.

Opt Express. 2019 Apr 15;27(8):11174-11181. doi: 10.1364/OE.27.011174.


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