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Are we overestimating risk of enteric pathogen spillover from wild birds to humans?

Smith OM, Snyder WE, Owen JP.

Biol Rev Camb Philos Soc. 2020 Jan 31. doi: 10.1111/brv.12581. [Epub ahead of print]


Landscape context affects the sustainability of organic farming systems.

Smith OM, Cohen AL, Reganold JP, Jones MS, Orpet RJ, Taylor JM, Thurman JH, Cornell KA, Olsson RL, Ge Y, Kennedy CM, Crowder DW.

Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2870-2878. doi: 10.1073/pnas.1906909117. Epub 2020 Jan 27.


Organ Donation at the End of Life: Experiences From the 3 Wishes Project.

Takaoka A, Honarmand K, Vanstone M, Tam B, Smith OM, Baker A, LeBlanc A, Swinton M, Neville TH, Clarke FJ, Hancock J, McMullen S, Meade MO, Rose T, Arora S, Cook DJ.

J Intensive Care Med. 2020 Jan 21:885066619900125. doi: 10.1177/0885066619900125. [Epub ahead of print]


Highly diversified crop-livestock farming systems reshape wild bird communities.

Smith OM, Kennedy CM, Owen JP, Northfield TD, Latimer CE, Snyder WE.

Ecol Appl. 2020 Mar;30(2):e02031. doi: 10.1002/eap.2031. Epub 2019 Dec 2.


Protocol for a multi-centered, stepped wedge, cluster randomized controlled trial of the de-adoption of oral chlorhexidine prophylaxis and implementation of an oral care bundle for mechanically ventilated critically ill patients: the CHORAL study.

Dale CM, Rose L, Carbone S, Smith OM, Burry L, Fan E, Amaral ACK, McCredie VA, Pinto R, Quiñonez CR, Sutherland S, Scales DC, Cuthbertson BH.

Trials. 2019 Oct 24;20(1):603. doi: 10.1186/s13063-019-3673-0.


A sticky situation: honeydew of the pear psylla disrupts feeding by its predator Orius sauteri.

Ge Y, Liu P, Zhang L, Snyder WE, Smith OM, Shi W.

Pest Manag Sci. 2020 Jan;76(1):75-84. doi: 10.1002/ps.5498. Epub 2019 Jul 8.


Different predation capacities and mechanisms of Harmonia axyridis (Coleoptera: Coccinellidae) on two morphotypes of pear psylla Cacopsylla chinensis (Hemiptera: Psyllidae).

Ge Y, Zhang L, Qin Z, Wang Y, Liu P, Tan S, Fu Z, Smith OM, Shi W.

PLoS One. 2019 Apr 23;14(4):e0215834. doi: 10.1371/journal.pone.0215834. eCollection 2019.


Editorial retraction.

Berg JM, Smith OM.

Sci Transl Med. 2018 Dec 12;10(471). pii: eaaw2634. doi: 10.1126/scitranslmed.aaw2634. No abstract available.


Nrf2 regulates CD4+ T cell-induced acute graft-versus-host disease in mice.

Tsai JJ, Velardi E, Shono Y, Argyropoulos KV, Holland AM, Smith OM, Yim NL, Rao UK, Kreines FM, Lieberman SR, Young LF, Lazrak A, Youssef S, Fu YY, Liu C, Lezcano C, Murphy GF, Na IK, Jenq RR, Hanash AM, Dudakov JA, van den Brink MRM.

Blood. 2018 Dec 27;132(26):2763-2774. doi: 10.1182/blood-2017-10-812941. Epub 2018 Oct 31.


Feasibility of the electrolarynx for enabling communication in the chronically critically ill: The EECCHO study.

Rose L, Istanboulian L, Smith OM, Silencieux S, Cuthbertson BH, Amaral ACK, Fraser I, Grey J, Dale C.

J Crit Care. 2018 Oct;47:109-113. doi: 10.1016/j.jcrc.2018.06.013. Epub 2018 Jun 12.


Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.

Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525b.


Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

Staffas A, Burgos da Silva M, Slingerland AE, Lazrak A, Bare CJ, Holman CD, Docampo MD, Shono Y, Durham B, Pickard AJ, Cross JR, Stein-Thoeringer C, Velardi E, Tsai JJ, Jahn L, Jay H, Lieberman S, Smith OM, Pamer EG, Peled JU, Cohen DE, Jenq RR, van den Brink MRM.

Cell Host Microbe. 2018 Apr 11;23(4):447-457.e4. doi: 10.1016/j.chom.2018.03.002. Epub 2018 Mar 22.


Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration.

Wertheimer T, Velardi E, Tsai J, Cooper K, Xiao S, Kloss CC, Ottmüller KJ, Mokhtari Z, Brede C, deRoos P, Kinsella S, Palikuqi B, Ginsberg M, Young LF, Kreines F, Lieberman SR, Lazrak A, Guo P, Malard F, Smith OM, Shono Y, Jenq RR, Hanash AM, Nolan DJ, Butler JM, Beilhack A, Manley NR, Rafii S, Dudakov JA, van den Brink MRM.

Sci Immunol. 2018 Jan 12;3(19). pii: eaal2736. doi: 10.1126/sciimmunol.aal2736.


Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury.

Velardi E, Tsai JJ, Radtke S, Cooper K, Argyropoulos KV, Jae-Hung S, Young LF, Lazrak A, Smith OM, Lieberman S, Kreines F, Shono Y, Wertheimer T, Jenq RR, Hanash AM, Narayan P, Lei Z, Moore MA, Kiem HP, van den Brink MRM, Dudakov JA.

Nat Med. 2018 Feb;24(2):239-246. doi: 10.1038/nm.4470. Epub 2018 Jan 8. Erratum in: Nat Med. 2018 Apr 10;24(4):525.


Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease.

Dudakov JA, Mertelsmann AM, O'Connor MH, Jenq RR, Velardi E, Young LF, Smith OM, Boyd RL, van den Brink MRM, Hanash AM.

Blood. 2017 Aug 17;130(7):933-942. doi: 10.1182/blood-2017-01-762658. Epub 2017 Jun 12.


Characteristics, clinical course, and outcomes of homeless and non-homeless patients admitted to ICU: A retrospective cohort study.

Smith OM, Chant C, Burns KEA, Kaur M, Ashraf S, DosSantos CC, Hwang SW, Friedrich JO.

PLoS One. 2017 Jun 12;12(6):e0179207. doi: 10.1371/journal.pone.0179207. eCollection 2017.


Editorial retraction.

Berg JM, Smith OM.

Sci Transl Med. 2017 Jun 7;9(393). pii: eaan8388. doi: 10.1126/scitranslmed.aan8388. No abstract available.


LAMP shines a light on Zika virus.

Smith OM.

Science. 2017 May 5;356(6337):497-498. doi: 10.1126/science.356.6337.497-g. Epub 2017 May 4. No abstract available.


An antimalarial to add to the armamentarium.

Smith OM.

Science. 2017 Apr 28;356(6336):392-394. doi: 10.1126/science.356.6336.392-s. No abstract available.


Mapping a path to HIV elimination.

Smith OM.

Science. 2017 Mar 31;355(6332):1386-1387. doi: 10.1126/science.355.6332.1386-i. No abstract available.


A mitochondrial target for slowing PD.

Smith OM.

Science. 2016 Dec 9;354(6317):1245-1246. Epub 2016 Dec 8. No abstract available.


A mixed-methods systematic review protocol to examine the use of physical restraint with critically ill adults and strategies for minimizing their use.

Rose L, Dale C, Smith OM, Burry L, Enright G, Fergusson D, Sinha S, Wiesenfeld L, Sinuff T, Mehta S.

Syst Rev. 2016 Nov 21;5(1):194.


The Experience of Surrogate Decision Makers on Being Approached for Consent for Patient Participation in Research. A Multicenter Study.

Burns KE, Prats CJ, Maione M, Lanceta M, Zubrinich C, Jeffs L, Smith OM; Canadian Critical Care Trials Group.

Ann Am Thorac Soc. 2017 Feb;14(2):238-245. doi: 10.1513/AnnalsATS.201606-425OC.


The Postcardiac Arrest Consult Team: Impact on Hospital Care Processes for Out-of-Hospital Cardiac Arrest Patients.

Brooks SC, Scales DC, Pinto R, Dainty KN, Racz EM, Gaudio M, Amaral AC, Gray SH, Friedrich JO, Chapman M, Dorian P, Fam N, Fowler RA, Hayes CW, Baker A, Crystal E, Madan M, Rubenfeld G, Smith OM, Morrison LJ.

Crit Care Med. 2016 Nov;44(11):2037-2044.


Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.

Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR.

Sci Transl Med. 2016 May 18;8(339):339ra71. doi: 10.1126/scitranslmed.aaf2311.


Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in Hematologic Malignancies by Blocking NF-κB-Controlled Oxidative Stress Responses.

Shono Y, Tuckett AZ, Liou HC, Doubrovina E, Derenzini E, Ouk S, Tsai JJ, Smith OM, Levy ER, Kreines FM, Ziegler CG, Scallion MI, Doubrovin M, Heller G, Younes A, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Res. 2016 Jan 15;76(2):377-89. doi: 10.1158/0008-5472.CAN-14-2814. Epub 2016 Jan 7.


Nurse Research Experiences and Attitudes Toward the Conduct of Intensive Care Research: A Questionnaire Study.

Smith OM, Dale C, Mehta S, Pinto R, Rose L.

Crit Care Med. 2016 Jan;44(1):153-61. doi: 10.1097/CCM.0000000000001386.


Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM.

Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9.


Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study.

Rewa O, Wald R, Adhikari NK, Hladunewich M, Lapinsky S, Muscedere J, Bagshaw SM, Smith OM, Lebovic G, Kuint R, Klein DJ.

J Crit Care. 2015 Dec;30(6):1359-64. doi: 10.1016/j.jcrc.2015.08.019. Epub 2015 Sep 1.


Canadian Guidelines for the use of targeted temperature management (therapeutic hypothermia) after cardiac arrest: A joint statement from The Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG).

Howes D, Gray SH, Brooks SC, Boyd JG, Djogovic D, Golan E, Green RS, Jacka MJ, Sinuff T, Chaplin T, Smith OM, Owen J, Szulewski A, Murphy L, Irvine S, Jichici D, Muscedere J.

Resuscitation. 2016 Jan;98:48-63. doi: 10.1016/j.resuscitation.2015.07.052. Epub 2015 Sep 28. No abstract available.


Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury.

Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, Klein D, Mazer CD, Richardson RM, Wilcox ME, Friedrich JO, Burns KE, Bagshaw SM; Canadian Critical Care Trials Group.

Kidney Int. 2015 Oct;88(4):897-904. doi: 10.1038/ki.2015.184. Epub 2015 Jul 8.


Is there a role for physician involvement in introducing research to surrogate decision makers in the intensive care unit? (The Approach trial: a pilot mixed methods study).

Burns KE, Rizvi L, Smith OM, Lee Y, Lee J, Wang M, Brown M, Parker M, Premji A, Leung D, Hammond Mobilio M, Gotlib-Conn L, Nisenbaum R, Santos M, Li Y, Mehta S.

Intensive Care Med. 2015 Jan;41(1):58-67. doi: 10.1007/s00134-014-3558-3. Epub 2014 Dec 10.


Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.

Velardi E, Tsai JJ, Holland AM, Wertheimer T, Yu VW, Zakrzewski JL, Tuckett AZ, Singer NV, West ML, Smith OM, Young LF, Kreines FM, Levy ER, Boyd RL, Scadden DT, Dudakov JA, van den Brink MR.

J Exp Med. 2014 Nov 17;211(12):2341-9. doi: 10.1084/jem.20131289. Epub 2014 Oct 20.


A National Survey of Critical Care Physicians' Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs.

Steinberg M, Dresser LD, Daneman N, Smith OM, Matte A, Marinoff N, Bell CM, Morris AM.

J Intensive Care Med. 2016 Jan;31(1):61-5. doi: 10.1177/0885066614541922. Epub 2014 Jul 8.


Deferred consent in a minimal-risk study involving critically ill subarachnoid hemorrhage patients.

Topolovec-Vranic J, Santos M, Baker AJ, Smith OM, Burns KE.

Can Respir J. 2014 Sep-Oct;21(5):293-6. Epub 2014 Jun 10.


Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy.

Tuckett AZ, Thornton RH, Shono Y, Smith OM, Levy ER, Kreines FM, van den Brink MR, Zakrzewski JL.

Blood. 2014 May 1;123(18):2797-805. doi: 10.1182/blood-2013-10-535401. Epub 2014 Mar 20.


A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.

Shono Y, Tuckett AZ, Ouk S, Liou HC, Altan-Bonnet G, Tsai JJ, Oyler JE, Smith OM, West ML, Singer NV, Doubrovina E, Pankov D, Undhad CV, Murphy GF, Lezcano C, Liu C, O'Reilly RJ, van den Brink MR, Zakrzewski JL.

Cancer Discov. 2014 May;4(5):578-91. doi: 10.1158/2159-8290.CD-13-0585. Epub 2014 Feb 18.


Critical illness in homeless persons is poorly studied: a systematic review of the literature.

Chant C, Wang A, Burns KE, dos Santos CC, Hwang SW, Friedrich JO, Smith OM.

Intensive Care Med. 2014 Jan;40(1):123-5. doi: 10.1007/s00134-013-3124-4. Epub 2013 Oct 15. Review. No abstract available.


Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial.

Smith OM, Wald R, Adhikari NK, Pope K, Weir MA, Bagshaw SM; Canadian Critical Care Trials Group.

Trials. 2013 Oct 5;14:320. doi: 10.1186/1745-6215-14-320.


Enhancing the informed consent process for critical care research: strategies from a thromboprophylaxis trial.

Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Fleury S, Krause K, McArdle T, Skrobik Y, Cook DJ.

Intensive Crit Care Nurs. 2013 Dec;29(6):300-9. doi: 10.1016/j.iccn.2013.04.006. Epub 2013 Jul 18.


Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity.

Ghosh A, Dogan Y, Moroz M, Holland AM, Yim NL, Rao UK, Young LF, Tannenbaum D, Masih D, Velardi E, Tsai JJ, Jenq RR, Penack O, Hanash AM, Smith OM, Piersanti K, Lezcano C, Murphy GF, Liu C, Palomba ML, Sauer MG, Sadelain M, Ponomarev V, van den Brink MR.

J Clin Invest. 2013 Jun;123(6):2654-62. doi: 10.1172/JCI66301. Epub 2013 May 15.


Nrf2 regulates haematopoietic stem cell function.

Tsai JJ, Dudakov JA, Takahashi K, Shieh JH, Velardi E, Holland AM, Singer NV, West ML, Smith OM, Young LF, Shono Y, Ghosh A, Hanash AM, Tran HT, Moore MA, van den Brink MR.

Nat Cell Biol. 2013 Mar;15(3):309-16. doi: 10.1038/ncb2699. Epub 2013 Feb 24.


The central nervous system is a target of acute graft versus host disease in mice.

Hartrampf S, Dudakov JA, Johnson LK, Smith OM, Tsai J, Singer NV, West ML, Hanash AM, Albert MH, Liu B, Toth M, van den Brink MR.

Blood. 2013 Mar 7;121(10):1906-10. doi: 10.1182/blood-2012-09-456590. Epub 2013 Jan 8.


Extrathymic development of murine T cells after bone marrow transplantation.

Holland AM, Zakrzewski JL, Tsai JJ, Hanash AM, Dudakov JA, Smith OM, West ML, Singer NV, Brill J, Sun JC, van den Brink MR.

J Clin Invest. 2012 Dec;122(12):4716-26. doi: 10.1172/JCI60630. Epub 2012 Nov 19.


Rates and determinants of informed consent: a case study of an international thromboprophylaxis trial.

Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Meade L, O'Callaghan N, Vallance S, Galt P, Rajbhandari D, Rocha M, Mehta S, Ferguson ND, Hall R, Fowler R, Burns K, Qushmaq I, Ostermann M, Heels-Ansdell D, Cook D; PROTECT Research Coordinators; PROTECT Investigators; Canadian Critical Care Trials Group; Australian, New Zealand Intensive Care Society Clinical Trials Group.

J Crit Care. 2013 Feb;28(1):28-39. doi: 10.1016/j.jcrc.2012.08.005. Epub 2012 Oct 22.


Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.

Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR.

Immunity. 2012 Aug 24;37(2):339-50. doi: 10.1016/j.immuni.2012.05.028.


Surrogate decision makers' attitudes towards research decision making for critically ill patients.

Barrett KA, Ferguson ND, Athaide V, Cook DJ, Friedrich JO, McDonald E, Pinto R, Smith OM, Stevenson J, Scales DC.

Intensive Care Med. 2012 Oct;38(10):1616-23. Epub 2012 Jul 24.


Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation.

Jenq RR, Ubeda C, Taur Y, Menezes CC, Khanin R, Dudakov JA, Liu C, West ML, Singer NV, Equinda MJ, Gobourne A, Lipuma L, Young LF, Smith OM, Ghosh A, Hanash AM, Goldberg JD, Aoyama K, Blazar BR, Pamer EG, van den Brink MR.

J Exp Med. 2012 May 7;209(5):903-11. doi: 10.1084/jem.20112408. Epub 2012 Apr 30.


Interleukin-22 drives endogenous thymic regeneration in mice.

Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR.

Science. 2012 Apr 6;336(6077):91-5. doi: 10.1126/science.1218004. Epub 2012 Mar 1.


Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL.

Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, Smith OM, Rao UK, Dykstra L, Na IK, Holland AM, Dudakov JA, Liu C, Murphy GF, Leonard WJ, Heller G, van den Brink MR.

Blood. 2011 Jul 14;118(2):446-55. doi: 10.1182/blood-2010-07-294785. Epub 2011 May 19.

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