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Items: 1 to 50 of 267

1.

Analysis of the B cell receptor repertoire in six immune-mediated diseases.

Bashford-Rogers RJM, Bergamaschi L, McKinney EF, Pombal DC, Mescia F, Lee JC, Thomas DC, Flint SM, Kellam P, Jayne DRW, Lyons PA, Smith KGC.

Nature. 2019 Oct;574(7776):122-126. doi: 10.1038/s41586-019-1595-3. Epub 2019 Sep 25.

PMID:
31554970
2.

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.

Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M, Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M, Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD, Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD, Thaventhiran JED.

J Exp Med. 2019 Sep 2;216(9):1986-1998. doi: 10.1084/jem.20190344. Epub 2019 Jun 24.

3.

Germline selection shapes human mitochondrial DNA diversity.

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC, Brennan P, Elliott P, Flinter FA, Floto RA, Houlden H, Irving M, Koziell A, Maher ER, Markus HS, Morrell NW, Newman WG, Roberts I, Sayer JA, Smith KGC, Taylor JC, Watkins H, Webster AR, Wilkie AOM, Williamson C; NIHR BioResource–Rare Diseases; 100,000 Genomes Project–Rare Diseases Pilot, Ashford S, Penkett CJ, Stirrups KE, Rendon A, Ouwehand WH, Bradley JR, Raymond FL, Caulfield M, Turro E, Chinnery PF.

Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520. Epub 2019 May 23.

4.

B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses.

Bagchi-Chakraborty J, Francis A, Bray T, Masters L, Tsiantoulas D, Nus M, Harrison J, Broekhuizen M, Leggat J, Clatworthy MR, Espéli M, Smith KGC, Binder CJ, Mallat Z, Sage AP.

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi: 10.1161/ATVBAHA.118.312272. Epub 2019 May 16.

5.

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

Zhang Z, Gothe F, Pennamen P, James JR, McDonald D, Mata CP, Modis Y, Alazami AM, Acres M, Haller W, Bowen C, Döffinger R, Sinclair J, Brothers S, Zhang Y, Matthews HF, Naudion S, Pelluard F, Alajlan H, Yamazaki Y, Notarangelo LD, Thaventhiran JE, Engelhardt KR, Al-Mousa H, Hambleton S, Rooryck C, Smith KGC, Lenardo MJ.

J Exp Med. 2019 Jun 3;216(6):1311-1327. doi: 10.1084/jem.20182304. Epub 2019 Apr 30.

PMID:
31040185
6.

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human.

Espéli M, Bashford-Rogers R, Sowerby JM, Alouche N, Wong L, Denton AE, Linterman MA, Smith KGC.

Nat Commun. 2019 Apr 29;10(1):1970. doi: 10.1038/s41467-019-09434-0.

7.

A blood-based prognostic biomarker in IBD.

Biasci D, Lee JC, Noor NM, Pombal DR, Hou M, Lewis N, Ahmad T, Hart A, Parkes M, McKinney EF, Lyons PA, Smith KGC.

Gut. 2019 Aug;68(8):1386-1395. doi: 10.1136/gutjnl-2019-318343. Epub 2019 Apr 27. Erratum in: Gut. 2019 Oct;68(10):1909-1912.

8.

A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress.

Chen YW, Das M, Oyarzabal EA, Cheng Q, Plummer NW, Smith KG, Jones GK, Malawsky D, Yakel JL, Shih YI, Jensen P.

Mol Psychiatry. 2019 May;24(5):625. doi: 10.1038/s41380-019-0418-0. No abstract available.

PMID:
31019268
9.

Task-Related Differences in Eye Movements in Individuals With Aphasia.

Smith KG, Schmidt J, Wang B, Henderson JM, Fridriksson J.

Front Psychol. 2018 Dec 18;9:2430. doi: 10.3389/fpsyg.2018.02430. eCollection 2018.

10.

PRedicting Outcomes For Crohn's dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial.

Parkes M, Noor NM, Dowling F, Leung H, Bond S, Whitehead L, Upponi S, Kinnon P, Sandham AP, Lyons PA, McKinney EF, Smith KGC, Lee JC.

BMJ Open. 2018 Dec 5;8(12):e026767. doi: 10.1136/bmjopen-2018-026767.

11.

Utility of intermittent online quizzes as an early warning for residents at risk of failing the pediatric board certification examination.

Wallihan R, Smith KG, Hormann MD, Donthi RR, Boland K, Mahan JD.

BMC Med Educ. 2018 Dec 4;18(1):287. doi: 10.1186/s12909-018-1366-0.

12.

EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease.

Thomas DC, Charbonnier LM, Schejtman A, Aldhekri H, Coomber EL, Dufficy ER, Beenken AE, Lee JC, Clare S, Speak AO, Thrasher AJ, Santilli G, Al-Mousa H, Alkuraya FS, Chatila TA, Smith KGC.

J Allergy Clin Immunol. 2019 Feb;143(2):782-785.e1. doi: 10.1016/j.jaci.2018.09.019. Epub 2018 Oct 9. No abstract available.

13.

Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses.

Chen YW, Das M, Oyarzabal EA, Cheng Q, Plummer NW, Smith KG, Jones GK, Malawsky D, Yakel JL, Shih YI, Jensen P.

Mol Psychiatry. 2019 May;24(5):710-725. doi: 10.1038/s41380-018-0245-8. Epub 2018 Sep 13.

14.

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease.

Richard AC, Peters JE, Savinykh N, Lee JC, Hawley ET, Meylan F, Siegel RM, Lyons PA, Smith KGC.

PLoS Genet. 2018 Sep 10;14(9):e1007458. doi: 10.1371/journal.pgen.1007458. eCollection 2018 Sep.

15.

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia.

Petrova VN, Muir L, McKay PF, Vassiliou GS, Smith KGC, Lyons PA, Russell CA, Anderson CA, Kellam P, Bashford-Rogers RJM.

Front Immunol. 2018 Aug 10;9:1784. doi: 10.3389/fimmu.2018.01784. eCollection 2018.

16.

Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial.

Banham GD, Flint SM, Torpey N, Lyons PA, Shanahan DN, Gibson A, Watson CJE, O'Sullivan AM, Chadwick JA, Foster KE, Jones RB, Devey LR, Richards A, Erwig LP, Savage CO, Smith KGC, Henderson RB, Clatworthy MR.

Lancet. 2018 Jun 30;391(10140):2619-2630. doi: 10.1016/S0140-6736(18)30984-X. Epub 2018 Jun 14.

PMID:
29910042
17.

Clinicians' perceptions of usefulness of the PubMed4Hh mobile device application for clinical decision making at the point of care: a pilot study.

Gartrell K, Brennan CW, Wallen GR, Liu F, Smith KG, Fontelo P.

BMC Med Inform Decis Mak. 2018 May 8;18(1):27. doi: 10.1186/s12911-018-0607-9.

18.

Antibody repertoire analysis in polygenic autoimmune diseases.

Bashford-Rogers RJM, Smith KGC, Thomas DC.

Immunology. 2018 Sep;155(1):3-17. doi: 10.1111/imm.12927. Epub 2018 Apr 16. Review.

19.

Genome-wide association studies in Crohn's disease: Past, present and future.

Verstockt B, Smith KG, Lee JC.

Clin Transl Immunology. 2018 Jan 31;7(1):e1001. doi: 10.1002/cti2.1001. eCollection 2018. Review.

20.

Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency.

Lawless D, Geier CB, Farmer JR, Lango Allen H, Thwaites D, Atschekzei F, Brown M, Buchbinder D, Burns SO, Butte MJ, Csomos K, Deevi SVV, Egner W, Ehl S, Eibl MM, Fadugba O, Foldvari Z, Green DM, Henrickson SE, Holland SM, John T, Klemann C, Kuijpers TW, Moreira F, Piller A, Rayner-Matthews P, Romberg ND, Sargur R, Schmidt RE, Schröder C, Schuetz C, Sharapova SO, Smith KGC, Sogkas G, Speckmann C, Stirrups K, Thrasher AJ, Wolf HM, Notarangelo LD, Anwar R, Boyes J, Ujhazi B; NIHR BioResource–Rare Diseases Consortium, Thaventhiran J, Walter JE, Savic S.

J Allergy Clin Immunol. 2018 Jun;141(6):2303-2306. doi: 10.1016/j.jaci.2018.02.007. Epub 2018 Mar 2. No abstract available.

21.

Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans.

Tuijnenburg P, Lango Allen H, Burns SO, Greene D, Jansen MH, Staples E, Stephens J, Carss KJ, Biasci D, Baxendale H, Thomas M, Chandra A, Kiani-Alikhan S, Longhurst HJ, Seneviratne SL, Oksenhendler E, Simeoni I, de Bree GJ, Tool ATJ, van Leeuwen EMM, Ebberink EHTM, Meijer AB, Tuna S, Whitehorn D, Brown M, Turro E, Thrasher AJ, Smith KGC, Thaventhiran JE, Kuijpers TW; NIHR BioResource–Rare Diseases Consortium.

J Allergy Clin Immunol. 2018 Oct;142(4):1285-1296. doi: 10.1016/j.jaci.2018.01.039. Epub 2018 Mar 2.

22.

Metabolic exhaustion in infection, cancer and autoimmunity.

McKinney EF, Smith KGC.

Nat Immunol. 2018 Mar;19(3):213-221. doi: 10.1038/s41590-018-0045-y. Epub 2018 Feb 5. Review.

PMID:
29403049
23.

Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.

Ortiz-Fernández L, Carmona FD, López-Mejías R, González-Escribano MF, Lyons PA, Morgan AW, Sawalha AH, Merkel PA, Smith KGC, González-Gay MA, Martín J; Spanish GCA Study Group, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group.

Ann Rheum Dis. 2018 Apr;77(4):589-595. doi: 10.1136/annrheumdis-2017-212372. Epub 2018 Jan 27. Erratum in: Ann Rheum Dis. 2018 Jun;77(6):950.

24.

Young Adults' Experience of Appearance-Altering Orthognathic Surgery: A Longitudinal Interpretative Phenomenologic Analysis.

Liddle MJ, Baker SR, Smith KG, Thompson AR.

Cleft Palate Craniofac J. 2018 Feb;55(2):238-247. doi: 10.1177/1055665617726533. Epub 2017 Dec 14.

25.

Relocating patients from a specialist homeless healthcare centre to general practices: a multi-perspective study.

Smith KG, Paudyal V, MacLure K, Forbes-McKay K, Buchanan C, Wilson L, MacLeod J, Smith A, Stewart D.

Br J Gen Pract. 2018 Feb;68(667):e105-e113. doi: 10.3399/bjgp18X694577. Epub 2018 Jan 15.

26.

Supporting shared decision-making and people's understanding of medicines: An exploration of the acceptability and comprehensibility of patient information.

Smith KG, Booth JL, Stewart D, Pfleger S, Mciver L, Maclure K.

Pharm Pract (Granada). 2017 Oct-Dec;15(4):1082. doi: 10.18549/PharmPract.2017.04.1082. Epub 2017 Dec 18.

27.

Spatial genetic structure in American black bears (Ursus americanus): female philopatry is variable and related to population history.

Kristensen TV, Puckett EE, Landguth EL, Belant JL, Hast JT, Carpenter C, Sajecki JL, Beringer J, Means M, Cox JJ, Eggert LS, White D Jr, Smith KG.

Heredity (Edinb). 2018 Apr;120(4):329-341. doi: 10.1038/s41437-017-0019-0. Epub 2017 Dec 13.

28.

Speech recognition error patterns for steady-state noise and interrupted speech.

Smith KG, Fogerty D.

J Acoust Soc Am. 2017 Sep;142(3):EL306. doi: 10.1121/1.5003916.

29.

A new mouse line for cell ablation by diphtheria toxin subunit A controlled by a Cre-dependent FLEx switch.

Plummer NW, Ungewitter EK, Smith KG, Yao HH, Jensen P.

Genesis. 2017 Oct;55(10). doi: 10.1002/dvg.23067. Epub 2017 Sep 19.

30.

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.

Horton SJ, Giotopoulos G, Yun H, Vohra S, Sheppard O, Bashford-Rogers R, Rashid M, Clipson A, Chan WI, Sasca D, Yiangou L, Osaki H, Basheer F, Gallipoli P, Burrows N, Erdem A, Sybirna A, Foerster S, Zhao W, Sustic T, Petrunkina Harrison A, Laurenti E, Okosun J, Hodson D, Wright P, Smith KG, Maxwell P, Fitzgibbon J, Du MQ, Adams DJ, Huntly BJP.

Nat Cell Biol. 2017 Sep;19(9):1093-1104. doi: 10.1038/ncb3597. Epub 2017 Aug 21.

31.

NBEAL2 is required for neutrophil and NK cell function and pathogen defense.

Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, Hoenderdos K, Harcourt K, Marsden M, Abdul-Karim J, Clement M, Antrobus R, Umrania Y, Barton PR, Flint SM, Juss JK, Condliffe AM, Lyons PA, Humphreys IR, Chilvers ER, Ouwehand WH, Dougan G, Smith KG.

J Clin Invest. 2017 Sep 1;127(9):3521-3526. doi: 10.1172/JCI91684. Epub 2017 Aug 7.

32.

Two Subpopulations of Noradrenergic Neurons in the Locus Coeruleus Complex Distinguished by Expression of the Dorsal Neural Tube Marker Pax7.

Plummer NW, Scappini EL, Smith KG, Tucker CJ, Jensen P.

Front Neuroanat. 2017 Jul 20;11:60. doi: 10.3389/fnana.2017.00060. eCollection 2017.

33.

Functional Characterization of the Human Speech Articulation Network.

Basilakos A, Smith KG, Fillmore P, Fridriksson J, Fedorenko E.

Cereb Cortex. 2018 May 1;28(5):1816-1830. doi: 10.1093/cercor/bhx100.

34.

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.

Thomas DC, Clare S, Sowerby JM, Pardo M, Juss JK, Goulding DA, van der Weyden L, Storisteanu D, Prakash A, Espéli M, Flint S, Lee JC, Hoenderdos K, Kane L, Harcourt K, Mukhopadhyay S, Umrania Y, Antrobus R, Nathan JA, Adams DJ, Bateman A, Choudhary JS, Lyons PA, Condliffe AM, Chilvers ER, Dougan G, Smith KG.

J Exp Med. 2017 Apr 3;214(4):1111-1128. doi: 10.1084/jem.20161382. Epub 2017 Mar 28.

35.

Demonstrating the value and importance of combining DNA barcodes and discriminant morphological characters for polystome taxonomy (Platyhelminthes, Monogenea).

Héritier L, Verneau O, Smith KG, Coetzer C, Du Preez LH.

Parasitol Int. 2018 Feb;67(1):38-46. doi: 10.1016/j.parint.2017.03.002. Epub 2017 Mar 20.

PMID:
28336417
36.

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC, Ahmad T, Prescott NJ, Satsangi J, Wilson DC, Jostins L, Anderson CA; UK IBD Genetics Consortium, Traherne JA, Lyons PA, Parkes M, Smith KG.

Nat Genet. 2017 Feb;49(2):262-268. doi: 10.1038/ng.3755. Epub 2017 Jan 9.

37.

Novel aspects of autoimmunity.

Smith KG, Kaser A.

Immunol Cell Biol. 2016 Nov;94(10):917. doi: 10.1038/icb.2016.90. No abstract available.

PMID:
27874875
38.

Encouragement for Faculty to Implement Vision and Change.

Harvey C, Eshleman K, Koo K, Smith KG, Paradise CJ, Campbell AM.

CBE Life Sci Educ. 2016 winter;15(4). pii: es7.

39.

Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis.

Viatte S, Lee JC, Fu B, Espéli M, Lunt M, De Wolf JN, Wheeler L, Reynolds JA, Castelino M, Symmons DP, Lyons PA, Barton A, Smith KG.

Arthritis Rheumatol. 2016 Nov;68(11):2629-2636. doi: 10.1002/art.39760.

40.

Does regional diversity recover after disturbance? A field experiment in constructed ponds.

Woods LM, Biro EG, Yang M, Smith KG.

PeerJ. 2016 Oct 18;4:e2455. eCollection 2016.

41.

Association of a TNFSF13B (BAFF) regulatory region single nucleotide polymorphism with response to rituximab in antineutrophil cytoplasmic antibody-associated vasculitis.

Alberici F, Smith RM, Fonseca M, Willcocks LC, Jones RB, Holle JU, Wieczorek S, Neumann T, Martorana D, Gregorini G, Sinico RA, Bruchfeld A, Gunnarsson I, Ohlsson S, Baslund B, Tesar V, Hruskova Z, Cid MC, Vaglio A, Lyons PA, Smith KGC, Jayne DRW.

J Allergy Clin Immunol. 2017 May;139(5):1684-1687.e10. doi: 10.1016/j.jaci.2016.08.051. Epub 2016 Oct 22. No abstract available.

PMID:
27780742
42.

T cell exhaustion and immune-mediated disease-the potential for therapeutic exhaustion.

McKinney EF, Smith KG.

Curr Opin Immunol. 2016 Dec;43:74-80. doi: 10.1016/j.coi.2016.09.005. Epub 2016 Oct 13. Review.

PMID:
27744240
43.

T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases.

McKinney EF, Smith KG.

Immunol Cell Biol. 2016 Nov;94(10):935-942. doi: 10.1038/icb.2016.81. Review.

PMID:
27577866
44.

Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin.

Damborsky JC, Smith KG, Jensen P, Yakel JL.

Brain Struct Funct. 2017 Apr;222(3):1385-1400. doi: 10.1007/s00429-016-1283-0. Epub 2016 Aug 5.

PMID:
27496091
45.

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM, Lyons PA, Smith KG.

Genome Med. 2016 Jul 19;8(1):76. doi: 10.1186/s13073-016-0329-5.

46.

Integration of partial information for spoken and written sentence recognition by older listeners.

Smith KG, Fogerty D.

J Acoust Soc Am. 2016 Jun;139(6):EL240. doi: 10.1121/1.4954634.

PMID:
27369179
47.

Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases.

Flint SM, Jovanovic V, Teo BW, Mak A, Thumboo J, McKinney EF, Lee JC, MacAry P, Kemeny DM, Jayne DR, Fong KY, Lyons PA, Smith KG.

RMD Open. 2016 May 16;2(1):e000183. doi: 10.1136/rmdopen-2015-000183. eCollection 2016.

48.

Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia.

Fernandez-Egea E, Vértes PE, Flint SM, Turner L, Mustafa S, Hatton A, Smith KG, Lyons PA, Bullmore ET.

PLoS One. 2016 May 31;11(5):e0155631. doi: 10.1371/journal.pone.0155631. eCollection 2016.

49.

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease.

Peters JE, Lyons PA, Lee JC, Richard AC, Fortune MD, Newcombe PJ, Richardson S, Smith KG.

PLoS Genet. 2016 Mar 25;12(3):e1005908. doi: 10.1371/journal.pgen.1005908. eCollection 2016 Mar.

50.

FcγRIIB and autoimmunity.

Espéli M, Smith KG, Clatworthy MR.

Immunol Rev. 2016 Jan;269(1):194-211. doi: 10.1111/imr.12368. Review.

PMID:
26683154

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